Functional Genomics and Bioinformatics Core

Beth Israel Deaconess Medical Center

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The Functional Genomics and Bioinformatics Core provides services to investigators within BNORC and the Boston area looking to expand their research using state-of-the-art genomic applications. It utilizes next generation technologies and sequencing platforms to help identify the complex molecular mechanisms underlying human disease. Core staff can consult with researchers to ensure optimal experimental design on a case-by-case basis. Downstream or stand-alone data analysis pipelines are also offered to help researchers get the most from their datasets.

Core Services:

  1. Pre- and post-experimental consultation to determine proper experimental approach, design, and interpretation
  2. Sample quality assessment of DNA and RNA using the BioAnalyzer and Qubit assays
  3. Library preparation, sequencing, and analysis of transcriptomes (RNA-seq), cistromes (ChIP-seq), chromatin accessibility (ATAC-seq)
  4. Standalone RNA preparation, RNA and DNA Bioanalyzer analyses, chromatin shearing/shear checks
  5. Standalone sequencing on NextSeq500
  6. Single Cell/Nucleus Library RNA-seq Droplet generation, Library Preparation
  7. Basic data analysis: quality assessment and normalization, genomic alignment, differential expression/enrichment, functional enrichment analysis (overrepresentation and GSEA), sample clustering, and motif enrichment
  8. Bespoke data analysis, including integration of complex ChIP-seq and RNA-seq data sets, single-cell sequencing analyses

Core User Request Form | Download Sample Sheet Template (XLSX) Naming Samples (PDF) | Download Pricing Sheet (PDF)  | Useful LinksContact Us

Core Personnel


Evan D. Rosen, MD, PhD

Linus T. Tsai, MD, PhD

Co-Assistant Directors


Adam Essene, MS


Christopher Jacobs, PhD

Research Assistant:

Anton Gulko


Soumya Nagesh

Click here for core presentation on October 18, 2019.