GSI faculty member, Sam Thiagalingam, along with GPGG alumni, Panos Papageorgis, discover pathway responsible for epigenetic memory during breast cancer progression.
GSI faculty member, Sam Thiagalingam and GPGG alumni, Panos Papageorgis, from Boston University School of Medicine (BUSM) have determined how the TGFβ-Smad signaling pathway, is responsible for the “epigenetic memory” that maintains unique patterns of regulatory DNA hypermethylation, causing silencing of critical genes that facilitate breast cancer progression. The findings, which appear online in Cancer Research, may lead to the development of new therapeutic strategies for late stage breast and other cancers. For more details click here. Or to view the journal abstract, “Smad signaling is required to maintain epigenetic silencing during breast cancer progression,” online at PubMed click here.