Elena Blokhina, MD, PhD, Co-Investigator
Debbie Cheng, ScD, Biostatistician
Christine Chaisson, MPH, Data Manager
Evgeny Krupitsky, MD, PhD, DMSci, Co-Investigator & Russian PI
Dmitry Lioznov, MD, PhD, Co-Investigator
Anita Raj, PhD, Co-Investigator
Alexander Walley, MD, MSc, Co-Investigator
Edwin Zvartau, MD, PhD, DMSci, Co-Investigator, & Russian Project Director
Carly Bridden, MA, MPH
Sharon Coleman, Statistical Analyst
Emily Quinn, Statistical Analyst
The HIV epidemic in Russia has occurred within the past 10 years and now includes an estimated 1 million people. Russia also has one of the highest levels of per capita alcohol consumption. Thus far, the HIV epidemic in Russia has been primarily propelled by injection drug users (IDUs). However, the risk for viral transmission beyond drug users, as previously observed in other countries when this epidemic progresses, looms large. Many HIV-infected persons with alcohol problems take part in risky sex and drug related behaviors. Thus alcohol use may accelerate HIV transmission to the general population in Russia. The objective of this proposal, HERMITAGE, HIV’s Evolution in Russia – Mitigating Infection Transmission and Alcoholism in a Growing Epidemic, is to test in a randomized controlled trial the effectiveness of a USHIV secondary prevention program, Healthy Relationships Intervention, among HIV-infected patients with risky drinking in a Russian infectious disease hospital. The intervention will be culturally adapted and modified to address substance use and associated risk behaviors. The study will randomize 300 HIV-infected patients with risky alcohol consumption to an adapted Healthy Relationships Intervention (HRI) or attention-control support groups. Subjects participating in the HRI will attend 5, 2-hour structured group sessions in addition to 2, 1-hour individualized sessions. Subjects participating in the attention-control group will be exposed to support groups during the same timeframe. All patients will be assessed at baseline, 6, and 12-months post- randomization. Primary outcomes are HIV sex- and drug risk behaviors, sexually transmitted diseases, and alcohol consumption. Additionally, subjects will be assessed regarding secondary outcomes including addiction severity and disclosure of HIV serostatus. We hypothesize that relative to controls, participants receiving the Healthy Relationships Intervention will reduce HIV sex- and drug risk behaviors, STDs and alcohol consumption. If the intervention is effective among HIV-infected hospitalized patients, it could be used to address other HIV infected persons in a variety of Russian settings potentially reducing the transmission of HIV by decreasing risky sex- and drug-use behaviors.
Tyurina A, Krupitsky E, Cheng DM, Coleman SM, Walley AY, Bridden C, Gnatienko N, Zvartau E, Raj A, Samet JH. Is cannabis use associated with HIV drug and sex risk behaviors among Russian HIV-infected risky drinkers? Drug Alcohol Depend. 2013. In Press. doi: 10.1016/j.drugalcdep.2013.01.009.
Lunze K, Cheng DM, Quinn E, Krupitsky EM, Raj A, Walley AY, Bridden C, Chaisson CE, Lioznov D, Blokhina E, Samet JH. Nondisclosure of HIV Infection to Sex Partners and Alcohol’s Role: A Russian Experience. AIDS and Behavior. 2013;17(1):390.398. DOI: 10.1007/s10461-012-0216-z. Russian Language Summary.
Raj A, Kidd JD, Cheng DM, Coleman S, Bridden C, Blokhina EA, Krupitsky E, Samet JH. Associations between partner violence perpetration and history of STI among HIV-infected substance using men in Russia. AIDS Care. 2013;25(5):646-51. doi: 10.1080/09540121.2012.722188.
Pace CA, Lioznov D, Cheng DM, Wakeman SE, Raj A, Walley AY, Coleman SM, Bridden C, Krupitsky E, Samet JH. Sexually transmitted infections among HIV-infected heavy drinkers in St. Petersburg, Russia. International Journal of STD and AIDS. 2012;23(12)853-8. doi: 10.1258/ijsa.2012.012004.
Samet JH, Krupitsky E, Raj A, Bridden C, Cheng D, Chaisson C, Walley A. Sexually Transmitted Diseases in HIV-Infected Russian Drinkers. Alc Clin Exp Res. 2009: 33(suppl):306A.
Goodness TM, Palfai TP, Cheng DM, Coleman SM, Bridden C, Blokhina EA, Krupitisky, Samet JH. The association between depressive symptoms and Antiretroviral Therapy (ART) uptake among HIV-infected Russian risky drinkers. Presented at 2013 meeting of the Society of Behavioral Medicine.
Tsui JI, Cheng DM, Coleman SM, Blokhina E, Bridden C, Krupitsky E, Samet JH. Pain is associated with illicit drug use in HIV-infected Russian drinkers. Presented at 2012 CPDD.
Lunze K, Cheng DM, Raj An, Quinn E, Bridden C, Krupitsky E, Walley AY, Samet JH. Arrest by police and Related Drug Risk Behavior among HIV-infected Injection Drug Users in Russia. Presented at the 2012 Study of Drug Policy.
Lunze K, Raj A, Cheng DM, Quinn E, Bridden C, Krupitsky E, Walley AY, Samet JH. Police and female drug users interactions in St Petersburg, Russia – syringes and sex. Presented at 2012 CPDD.
Walley AY, Cheng DM, Krupitsky EM, Raj A, Blokhina E, Coleman S, Bridden C, Chaisson CE, Samet JH. Nonfatal overdose in HIV infected Russian alcohol users. Presented at 2011 CPDD.
Blokhina E, Krupitsky E, Cheng DM, Raj A, Walley AY, Coleman SM, Bridden C, Chaisson C, Samet JH. Alcohol and Drug use among HIV-infected drinkers in Russia. Presented at 2011 CPDD.
Krupitsky E, Raj A, Egorova V, Lioznov D, Bridden C, Kalichman S, Cheng D, Chaisson C, Palfai T, Verbitskaya E, Zvartau E, Samet J. An HIV Prevention Intervention for Use with HIV-Infected Russian Drinkers: The HERMITAGE Study. Presented at 2008 RSA/ISBRA.