Pathology & Laboratory Medicine News Items – July 2018
Pathology & Laboratory Medicine News Items – July 2018
CONGRATULATIONS: The Accreditation Committee of the College of American Pathologists (CAP) has awarded accreditation to the Department of Pathology and Laboratory Medicine based on the results of our recent on-site inspection. We congratulate everyone within our department on a job well done because this is truly a team effort!
Bravo to our own Liz Duffy!
Liz Duffy also gave an oral presentation at the Annual Association of Pathology Chairs in Coronado, CA on July 18th, 2018 on her work “Pathology’s Role in Biospecimen Science: A Study of Preanalytic Variables’ Impact on Thrombosis Biomarkers”
Dr. Zach Hunter, a graduate of our Pathology Masters AND PhD Programs, is now an Instructor of Medicine at Boston’s Dana-Farber Institute. Zach completed his thesis work in the Steven Treon Lab at MGH. Recently :
- Dr. Hunter received the Robert A. Kyle Award, one of the highest honors in his field
- As well as an American Society of Clinical Oncology Scholar Award, regarded as one of the most prestigious awards in hematology
Dr. Susan Winandy was awarded a CTSI pilot grant to study a “”New pathway regulating the harmful inflammatory phenotype of T cells”. BRAVO!
Troy Sanders, a Masters student in the MAMS program has joined the Winandy Lab. He will be working on defining a new mechanism underlying the control of the inflammatory program in human T cells
Dr. Anna Belkina just got back from presenting an invited seminar at the University of Washington Department of Immunology Seminar Series on July 12; “Revealing disease phenotypes with computational analysis of high-dimensional flow cytometry data”
Dr. Nader Rahimi and Dr. Daniel Remick were awarded a CTSI pilot grant to study the role of IGPR-1 in sepsis. The goal of this proposed study is to investigate the role of IGPR-1 in the vascular leakage associated with sepsis. Sepsis is the second leading cause of death in non-coronary intensive care units, highlighting a significant unmet clinical need.
Dr. Nickolas Crossland was accepted into the Optical Microscopy & Imaging Course hosted by the Marine Biological Laboratory. This 9-day course to be held August 20-30th is highly competitive and is limited to 24 participants to ensure a truly interactive, hands-on experience. It consists of interrelated lectures, laboratory exercises, demonstrations, and discussions that will enable the participants to obtain and interpret high quality microscope data, to understand and assess potential artifacts, to perform quantitative optical measurements, and to generate digital images for documentation and analysis that accurately present the data. Topics to be covered can be found here (http://www.mbl.edu/education/courses/optical-microscopy-imaging/).
Dr. Daniel Remick was a Participant at the Pathology Advocating for Academic Pathology Discussion Group, Association of Pathology Chairs 2018 Annual Meeting
Dr. Remick was also an Invited Speaker, New Pathology Chairs Bootcamp, When, Why, and How to Transition from Being a Chair Participant, Pathology Advocating for Academic Pathology Discussion Group, Association of Pathology Chairs 2018 Annual Meeting
Also from Dr. Remick:
A Wiggers-Bernard Conference on Pre-clinical models of sepsis was held in Vienna, Austria in May, 2017. Four manuscripts are being published in the peer-reviewed literature detailing the conclusions of the conference. All of the manuscripts were recently accepted for publication in the journal Shock
- MINIMUM QUALITY THRESHOLD IN PRE-CLINICAL SEPSIS STUDIES (MQTIPSS): AN INTERNATIONAL EXPERT CONSENSUS INITIATIVE FOR IMPROVEMENT OF ANIMAL MODELING IN SEPSIS
- Marcin F. Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H. Chaudry, Craig M. Coopersmith, Clifford S. Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V. Kozlov,* Claude Libert, John C. Marshall, Lyle L. Moldawer, Peter Radermacher, Heinz Redl, Daniel G. Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W. Joost Wiersinga, Xianzhong Xiao, and Basilia Zingarelli in press, Shock
- PART I: MINIMUM QUALITY THRESHOLD IN PRE-CLINICAL SEPSIS STUDIES (MQTiPSS) FOR STUDY DESIGN AND HUMANE MODELING ENDPOINTS.
- Basilia Zingarelli, Craig M. Coopersmith, Susanne Drechsler, Philip Efron, John C. Marshall, Lyle Moldawer, W. Joost Wiersinga, Xianzhong Xiao, Marcin F. Osuchowski, Christoph Thiemermann in press, Shock
- PART II: MINIMUM QUALITY THRESHOLD IN PRE-CLINICAL SEPSIS STUDIES (MQTiPSS) FOR TYPES OF INFECTIONS AND ORGAN DYSFUNCTION ENDPOINTS.
- Claude Libert, Alfred Ayala, Michael Bauer, Jean-Marc Cavaillon, Clifford Deutschman, Claes Frostell, Sylvia Knapp, Andrey V. Kozlov, Ping Wang, Marcin F. Osuchowski, Daniel G. Remick in press, Shock
- PART III: MINIMUM QUALITY THRESHOLD 1 IN PRE-CLINICAL SEPSIS STUDIES (MQTiPSS) FOR FLUID RESUSCITATION AND ANTIMICROBIAL THERAPY ENDPOINTS.
- Judith Hellman, Soheyl Bahrami, Mihaly Boros, Irshad Chaudry, Gerhard Fritsch, Waldemar Gozdzik, Shigeaki Inoue, Peter Radermacher, Mervyn Singer, Marcin F. Osuchowski, Markus Huber-Lang in press, Shock
Joseph Tashjian, a Pathology master student working with Dr. Mostafa Belghasem, has been selected to participate in “Kidney STARS” 2018 program organized by the American Society of Nephrology (ASN). Joseph also received a $1000 travel grant from ASN to attend Kidney Week 2018.
Dr. Mostafa Belghasem was invited by the Evans Center for Interdisciplinary Biomedical Research to present at the monthly ARC/Cardio seminar on July 24th 2018. The lecture topic:” Murine Models of Renal Disease: Analysis of Thrombotic Tendencies”
Greg Hall, DVM, PhD (Kurosawa Lab) successfully defended his Thesis, “Dextran sulfate sodium colitis facilitates murine colonization by Shiga toxin-producing E. coli: A novel model for the study of Shiga toxicosis” on Tuesday, July 24th; Bravo Greg!!
Gregory Hall, DVM, PhD and his PIs, Dr. Shinichiro Kurosawa and Dr. Deborah Stearns-Kurosawa
Dr. & Mrs. Greg Hall and family, 3-yo Cora and 7-week old Maggie celebrating with dad
Konditor Meister Celebration in Dr. Hall’s honor!!!
- Juan R. Mella, Arthur F. Stucchi, Elizabeth R. Duffy, Daniel G. Remick; Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice; in press, Shock
- Steinbuck MP, Winandy S. A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells. Front Immunol. 2018 Jun 1;9:1230. doi: 10.3389/fimmu.2018.01230. eCollection 2018. Review
- Kartha VK1,2, Alamoud KA3, Sadykov K3, Nguyen BC3, Laroche F4, Feng H4, Lee J5, Pai SI5, Varelas X6, Egloff AM7, Snyder-Cappione JE8,9, Belkina AC8, Bais MV3, Monti S1,2, Kukuruzinska MA10; “Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer” https://www.ncbi.nlm.nih.gov/pubmed/30029671. Genome Med. 2018 Jul 20;10(1):54. doi: 10.1186/s13073-018-0569-7. PMID: 30029671
- Remick DG, Ayala A, Chaudry I, Coopersmith CM, Deutschman C, Hellman J, Moldawer L, Osuchowski M. Premise for Standardized Sepsis Models. Shock. 2018. doi: 10.1097/SHK.0000000000001164. PubMed PMID: 29877959