Departmental Seminar – Friday October 16
October – Friday @ 2:00
“Genetic Variation of the Transthyretin Gene May Impact Disease Pathogenesis in Wild-Type Transthyretin Amyloidosis (ATTRwt)”
Jacquelyn Sikora Hanson, PhD Candidate
Department of Pathology; Connors Lab
Boston University School of Medicine
Refreshments at 1:45 p.m.
670 Albany Street – Lobby Level #107/108
Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).
At the conclusion of this activity participants will be able to: 1) Physicians will learn about wild-type Transthyretin amyloidosis (formerly known as senile systemic amyloidosis), a rare heart disease diagnosed mostly in elderly Caucasian males, and genetic risk factors for disease; 2) repeat that wild-type transthyretin amyloidosis (ATTRwt), typically diagnosed as congestive heart failure in elderly Caucasian men, features myocardial amyloid deposits of wild-type plasma protein transthyretin (TTR). ATTRwt is sporadic and 3) recall that genetic studies of variant-associated transthyretin amyloidosis have suggested that non-coding TTR gene variants modulate disease.