Departmental Seminar – Friday October 2
October 2 – Friday @ 2:00
“How Presenilin Mutations Cause Alzheimer’s Disease”
Raymond Kelleher III, MD, PhD
Associate Professor of Neurology
Principal Investigator, Center for Human Genetic Research
Massachusetts General Hospital; Harvard Medical School
Refreshments at 1:45 p.m.
670 Albany Street – Lobby Level #107/108
Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).
At the conclusion of this activity participants will be able to: 1) ) state that mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial Alzheimer’s disease (FAD); 2) report that Presenilins play essential roles in memory formation, synaptic function, and neuronal survival and 3) recognize that how PSEN1 mutations cause FAD is unclear, and pathogenic mechanisms based on gain or loss of function have been proposed.