May 2013

Pathology & Laboratory Medicine News Items –

Announcements:

  • 36th ANNUAL CONFERENCE ON SHOCK, June 1 – 4, 2013, San Diego, California:
    • PhD Candidates Evan Chiswick, Dominic Beal, and Surgical Resident/Researcher Juan Rodolfo Mella Remick Lab  will present a poster; “Too Zealous Too Soon: The Shift from Hyper to Hypo Reactive Phagocytes in Polymicrobial Sepsis”
    • Chad Mayer, MD/PhD candidate, Kurosawa Lab, has an abstract accepted for ORAL presentation at the 2013 Shock Society meetings in San Diego.  His abstract is entitled” DAMPs and endothelial dysfunction in a mouse model of Stx2 toxemia” by authors CL Mayer, CS Leibowitz, S Kurosawa, DJ Stearns-Kurosawa.
    • Caitlin Leibowitz, PhD candidate, Kurosawa Lab, has an abstract accepted for POSTER presentation at the 2013 Shock Society meeting in San Diego.  Her abstract is entitled “Neutropenia delays acute kidney injury in a murine Stx2 toxemia model” by authors C.S. Leibowitz, C.L. Mayer, S. Kurosawa, D.J. Stearns-Kurosawa.
    • Daniel Remick, M.D. was invited to give talk “Oxidante Regulation of Chemokine Gene Expression”
    • Daniel Remick, M.D. helped organize a panel discussion by all 5 level 1 trauma centers in the city of  Boston to discuss the trauma center’s experience with the Marathon Day bombings.
    • Daniel Remick, M.D., chaired the International Relations Committee and served as a member of council and Past-President of the Society.
    • Daniel Remick, M.D., organized the annual fun run, always a highlight of the meeting.
  • From the Remick Lab: PhD Candidate Evan Chiswick and Surgical Resident Juan Rodolfo Mella each received a Travel Award to attend next month’s SHOCK Conference in San Diego, California
  • David Stepien , MD/PhD, successfully defended his thesis “The Immune Response to Bacterial Pneumonia Following Traumatic Brain Injury” on Thursday, May 16th
  • MD/PhD Candidate Melody Lun has been awarded a grant from the American Federation for Aging Research (AFAR). The official title of the scholarship is “Glenn/AFAR Scholarship for Research in the Biology of Aging”
  • PhD Candidate Mostafa Belghasem received a fellowship (travel award) to attend the Intravital Microscopy Workshop at Indiana University Medical Center; this workshop was the week of May 5th
  • Barb Nikolajczyk, PhD was an invited to present at several events for May 2013:
    • Childrens Hospital Los Angeles, Childrens Center for Cancer and Blood Diseases, Los Angeles, CA, Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes, 2013.
    • University of California at Los Angeles, Los Angeles, CA, Human B lymphocytes are master regulators of
    • American Association of Immunologists Annual Meeting, Honolulu, HI, Lymphocyte functions in type 2 diabetes, 2013.
    • University of Chicago, Department of Pathology. B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes, 2013.
  • A recent manuscript from the Kurosawa and Henderson labs, in collaboration with a group at Texas A&M was discussed in the May issue of the Kidney International Journal Club (Kidney International (2013) 83, 775–776. doi:10.1038/ki.2013.116).  This journal highlights the latest research from across a wide spectrum of journals in fields relevant to renal research.  The Kurosawa-Henderson manuscript identified differences in renal pathology elicited by toxins from enterohemorrhagic E.coli, a food and water-born pathogen, and supports the notion that therapeutic targeting of both bacterial toxins is of value.
  • Nancy S. Miller, MD lead a presentation and audience interactive session at the AACC Trimark Infectious Disease Conference on May 31, 2013 in Randolph, MA. “Point of Care Meets Microbiology:  What we have, what we need, what is on the way?  Preparing for the next frontier of point-of-care” In collaboration with Jean Ahern, C(ASCP) POC Specialist at BMC.
  • Dr. Carmen Sarita –Reyes has been appointed a member of the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee. Dr. Sarita-Reyes will be attending her first meeting from May 28th – 31st 2013 in Chicago, Illinois.
  • Dr. Kazem Azadzoi presented a moderated poster entitled “Sleep apnea causes bladder oxidative stress and nocturia in rats” at the American Urological Association (AUA) annual meeting in San Diego
  • Dr. Kazem Azadzoi also presented a moderated poster entitled “Upregulation of P2X purinergic receptors in bladder oxidative stress augments smooth muscle contractions” at the American Urological Association (AUA) annual meeting in San Diego

 

Publications: ACCEPTED:

  • Han-Pil Choi, Silvia Juarez, Sergio Ciordia, Marisol Fernandez, Rafael Bargiela, Juan P. Albar, Varun Mazumdar, Brian P. Anton, Simon Kasif, Manuel Ferrer, Martin Steffen. “Biochemical Characterization Of Hypothetical Proteins From Helicobacter pylori” PLoS One

In this paper, we present here the biochemical analysis of six proteins from Helicobacter pylori ATCC 26695. The functional characterization of Open Reading Frames (ORFs) from sequenced genomes remains a bottleneck in our effort to understand microbial biology. In particular, the functional characterization of proteins with only remote sequence homology to known proteins can be challenging, as there may be few clues to guide initial experiments. We provide a path towards this problem using affinity enrichment of proteins from cell lysates, and a global perspective of protein function as provided by COMBREX.

  • Resident Anita Deshpande, PGY-2, USCAP poster presentation held in Baltimore March 2013 on “Leiomyoma of the Gastrointestinal tract with Interstitial cells of Cajal: A mimic of gastrointestinal stromal tumor” has been accepted by American Journal of Surgical Pathology for publication.
  • Smith, B., S. Rozelle, J. Ubellacker, A. Parks, A. Leung, S. Nah, D. French, P. Gadue, S. Monti, D. Chui, M. Steinberg, D. Kotton, G. Mostoslavsky, D. Sherr, and G. Murphy. 2013. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood In Press
  • Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology In Press
  • Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. In Press
  • Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ*, Kurosawa S.* Quiescent complement in nonhuman primates during E.coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy.  Blood, 2013. (impact factor 9.8)

 

Publications: PUBLISHED:

  • Stearns-Kurosawa DJ, Oh S-Y, Cherla RP, Lee M-S, Tesh VL, Papin J, Henderson J, Kurosawa S.  Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic E.coli Shiga toxins in non-human primate models of hemolytic uremic syndrome.  American Journal of Pathology, 182(4):1227-38, 2013

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