The Multicenter Osteoarthritis Study (MOST)

This is a longitudinal observational study of the effects of biomechanical, bone and joint structural, and nutritional factors on the incidence and progression of knee symptoms and radiographic and symptomatic knee osteoarthritis (OA). It was the first large-scale epidemiologic study to focus on symptomatic knee OA in a community-based sample of adults with or at high risk for knee OA, based on the presence of knee symptoms, history of knee injury or surgery or being overweight. The wealth of data from this longitudinal cohort of community-dwelling older adults affords valuable opportunities for rehabilitation researchers.
The MOST study is funded by the National Institutes of Health – National Institute on Aging grants AG18820 (David Felson, Boston University), AG18832 (James Torner, University of Iowa), AG18947 (Cora Lewis, University of Alabama at Birmingham), and AG19069 (Michael Nevitt, University of California, San Francisco). Funding period: 2001-2020.