Presented at CROI 2020 Annual Meeting, Boston, MA, March, 2020

Phase 1 placebo-controlled safety, PK, and PD study of MB66 anti-HIV and anti-HSV film.

Slides and Audio

Cu-Uvin S, Moench T, Politch JA, Tashima KT, Marathe JG, Guthrie K, Cabral H, Nyhuis TJ, Brennan M, Zeitlin L, Spiegel HM, Mayer KH, Whaley KJ, Anderson DJ.


Presented at CROI 2018 Annual Meeting, Boston, MA, March, 2018

Phase 1 trial to assess safety and antiviral activity of MB66 vaginal film.

Cu-Uvin S, Mayer KH, Moench T, Tashima KT, Marathe JG, Politch JA, Nyhuis TJ, Zeitlin L, Spiegel HM, Whaley KJ, Anderson DJ.


Satellite Session at HIV R4P, Cape Town, South Africa, October 27, 2014

Preventing Cell-associated HIV Transmission with Antibodies: Implications for PrEP and Vaccine Development

Host Institutions: Boston University and CEA/IDMIT
Session Chairs: Deborah Anderson and Roger LeGrand

Whereas HIV may be transmitted via infected cells in genital secretions and breast milk, cell-associated HIV transmission has been largely neglected by the HIV prevention research community, which has primarily focused on cell-free virus infection models. Several presentations (many by IPCP investigators) were given on various aspects of cell-mediated HIV transmission with a focus on the use of antibodies, delivered through topical microbicides or vaccines, to prevent this mechanism of HIV transmission.



Presentations by IPCP Members at 2014 HIV R4P


Ayesha Islam (Anderson Lab).  Expression of Innate Immune Genes and Migration of PBMCs in Female Genital Epithelium is Influenced by Endogenous and Exogenous Reproductive Hormones.

Jai Marathe (Anderson Lab).  Antibodies to CD52g, a Secreted Sperm-Coating Antigen, Agglutinate Seminal Leukocytes and Prevent their Infiltration into Vaginal Epithelium.

Oral Presentation

Kadryn Kadasia (Anderson Lab).  Local HIV-specific IgA Antibody Production in the Penile Urethra Mucosal Compartment



Trojan Horse











Workshop: Infected Genital Leukocytes and Cell Associated Virus Transmission

Boston, MA

October 19, 2013

Hosted By Deborah J. Anderson, Boston University

  1. Richard Cone:  Effect of Vaginal Environment on Infected Leukocytes
  2. Deborah Anderson:  In Vitro Models of CA HIV Transmission
  3. Rahm Gummuluru:  Molecular Events Underlying Cell-Cell HIV Transmission
  4. Manish Sagar:  Transmitter/Founder HIV and CA Transmisssion
  5. Thomas Moench:  Small Animal Models
  6. Kevin Whaley:  Customized Plantibodies
  7. Jai Marathe:  Exploring Use of Anti-Sperm Antibody to Prevent Cell-Associated HIV Transmission
  8. Kenneth Mayer:  Microbicides and Antiretroviral Therapy


Posters by IPCP Members at the 2013 International Symposium for Immunology of Reproduction

Ayesha Islam (Anderson Lab).  Effects of Sex Hormones on Reconstructed Vaginal Epithelial Tissues and the Relevance to Sexually Transmitted Infections. 

Jai Marathe (Anderson Lab).  Cell-Associated HIV Transmission:  Does Seminal Plasma Affect the Viability and Migration of Macrophages?

Chunxia Zhao (Villinger Lab).  Nicotiana Produced Broadly Neutralizing Monoclonal Antibodies as a Microbicide Strategy.


Presentations by IPCP Members at the 2012 Microbicides Conference

Deborah Anderson.   Stratum Corneum:  Vaginal Battlefront.  April 15, 2012, 1 pm.

Richard Cone.  When Lactobacilli Dominate, They Inactivate HIV and BV Bacteria with Lactic Acid.  April 16, 2012, 5 pm.

Kevin Whaley.  Monoclonal Antibody-Based Multipurpose Microbicides.  April 18, 2012, 11:30 am.


Other Presentations:

Blaskewicz CD, Pudney J, Ayehunie S, and Anderson DJ. Apical-to-basal macrophage migration through an inflammatory vaginal epithelial tissue model: implications for cell-associated HIV transmission. Conference on Retroviruses and Opportunistic Infections, Boston, MA, 2011.

Chou C-WT, Pudney J, Ayehunie S, Whaley K and Anderson D. Nicotiana-derived monoclonal antibodies against sexually transmitted viruses concentrate and retain biological activity in the vaginal stratum corneum but are not transcytosed across the vaginal epithelium. Am J Reprod Immunol 2013;69:43.

Zhao C, Connor-Stroud F, Sharma P, Oviedo-Moreno P, Whaley K, Bohorov O, Moench T, Anderson DJ and Villinger F. Nicotiana-produced broadly neutralizing anti-HIV monoclonal antibodies as a microbicide strategy in cynomolgus macaques. 31st Annual Symposium on Nonhuman Primate Models for AIDS, Yerkes National Primate Research Center, Atlanta, GA, 2013.