Asian Cohort for Alzheimer’s Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer’s disease among Asian Americans and Canadian
Abstract Introduction: Clinical research in Alzheimer’s disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer’s Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. Methods: The ACAD started fully recruiting in October 2021 with one […]
AI-based differential diagnosis of dementia etiologies on multimodal data
Abstract Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an artificial intelligence (AI) model that harnesses a broad array of data, including demographics, individual and family medical history, medication use, neuropsychological assessments, functional evaluations and […]
The Relationship between Framingham Stroke Risk Profile on Incident Dementia and Alzheimer’s Disease: A 40-Year Follow-Up Study Highlighting Female Vulnerability
Abstract Objective:Sex differences in the association between cardiovascular risk factors and the incident all-cause dementia and the subtype Alzheimer’s disease (AD) risk are unclear. Methods:Framingham Heart Study (FHS) participants (n = 4,171, 54% women, aged 55 to 69 years) were included at baseline and followed up to 40 years. The Framingham Stroke Risk Profile (FSRP) […]
Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study
Devine S, Au R, Liu C. Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study. Alzheimers Dement. 2023. Online ahead of print. Read More