Thrombosis and Hemostasis ARC Program




Dr. Vipul Chitalia, Internal Medicine, Nephrology

Dr. Katya Ravid, Medicine, Biochemistry

Dr. Jean Francis, Medicine, Nephrology, Clinician


Over past five years, the Thrombosis to Hemostasis (TtoH) ARC has successfully brought together basic and translational research through a cross-disciplinary approach to gain deeper understanding of thrombosis pathogenesis and to develop novel personalized predictive tools and therapeutic targets. As reported earlier, ARC members have initiated and developed the first Thrombotic Microangiopathy (TMA) program in BUSM. In 2020, our ARC provided extensive support to the development of a new ARC focused on pre-clinical studies related to Covid-19. As thrombosis and vascular complications are significant outcomes of Covid-19, our ARC members shared methodology and offered conceptual support to the newly formed ARC “ Respiratory viruses- a focus on Covid-19.”  This has led to few collaborative studies now in preparation for publication. This later collaboration has been facilitated by our TtoH ARC innovative focus on organ pathology-induced changes in thrombosis and vascular hemostasis, which in the past two years centered on studies related to mechanisms of cancer-induced thrombosis. In addition, leveraging upon interdisciplinary approaches and expertise, the TtoH ARC also probed thrombotic mechanisms related to chronic kidney disease and bone marrow myelofibrosis; both used as model systems to examine this newly studied paradigm, resulting in notable publications and new grant support.  Our collaborative pursuits led to identifying certain human plasma metabolites retained in chronic kidney disease, such as Kynurenine, as thrombogenic. Further, the secreted enzyme in myelofibrosis, lysyl oxidase, was found to enhance platelet activation and thrombosis in vivo in mice, and more recently new collaborative proteomic approaches led to identifying in in bone marrow malignant cells modified integrins known to participate in promoting thrombosis. Here, we aspire continue our prolific ARC Program, building upon our array of developments, seeking to continue through new research directions (as listed below) our research and education missions, while placing BU as a new hub of expertise in organ pathology-associated cardiovascular disease.




Departments/school affiliation


Vipul Chitalia

ARC co-Director

Associate Prof of Medicine Internal Medicine/Renal section (member of Northeastern Megakaryocyte/platelet club)
Katya Ravid

ARC co-Director

Professor of Medicine and Biochemistry, Director, Evans Center Departments of Medicine and Biochemistry (member of Northeastern Megakaryocyte/platelet club)
Jean Francis

ARC co-Director

ARC clinician

Associate Professor of Medicine Renal section, Department of Medicine
Catherine Costello Prof of Biochemistry,  William Fairfield Warren Distinguished Professor
Director, Center for Biomedical Mass Spectrometry
Department of Biochemistry
Joseph Zia Prof of Biochemistry Department of Biochemistry
Azer Bestavros

Consultant on Data Science projects

Professor of Computer Science Computer Science; Data Science Faculty
Shinobu Matsuura Instructor of Medicine Whitaker Cardiovascular Institute
Alik Farber Professor of Surgery Vascular Surgery
Mark Sloan

ARC clinical co-director

Assistant Professor of Medicine Section of Hematology and Oncology, Department of Medicine
David Salant

(ARC project advisor)

Professor of Medicine Renal section, Department of Medicine
Elaine Hylek

ARC Advisor of Translational Research

Professor of Medicine General Internal Medicine
Janice Weinberg

ARC Advisor of Stat Analysis

Professor; BU School of Public Health Department of Public Health and Department of Medicine
Naomi Hamburg Associate Professor of Medicine Cardiology/ Medicine
James Hamilton Professor of Physiology and Biophysics Physiology & Biophysics
Joyce Wong Professor of Biomedical Engineering Biomedical Engineering
Karen Quillen Associate Professor of Pathology and Laboratory Medicine/Associate Professor of Medicine Internal Medicine/Hematology-Oncology
George Murphy Assistant Professor of Medicine Internal Medicine/Hematology-Oncology (member of Northeastern Megakaryocyte/platelet club)
Vijaya Kolachalama Adjunct Assistant Professor Whitaker Cardiovascular Institute
Shinichiro Kurosawa Associate Professor of Pathology and Laboratory Medicine Department of Pathology
Anqi Zhang


Research Instructor (Core Director) Medicine/ endocrinology
Sibji Sarkar Assistant Professor of Medicine Medicine/Cancer Center
Hannah Bader Professor of Medicine Harvard Medical School

(member of Northeastern Megakaryocyte/platelet club)

Chris Andry Professor of Pathology Department of Pathology and Laboratory Medicine
Carl Ohara Professor of Pathology Department of Pathology and Laboratory Medicine
Bhavesh Shah Department of Pharmacology Administrative Director, Hem-Onc Pharmacology
Caitlin Neri Department of Pediatrics Pediatric Nephrologist, Boston Medical Center
Adam Lerner Professor Department of Hematology & Oncology
John Connors Associate Professor Department of Microbiology
Claire Avillach Pathology Resident Renal section, Department of Medicine
Yilan Jiangliu Post Graduate School of Medicine
Deborah Stearns-Kurosawa

(guest member)

Assoc Provost/ Dean ad Interim Division of Graduate Medical Sciences Division of Graduate Medical Sciences (member of Northeastern Megakaryocyte/platelet club)