Thrombosis and Hemostasis ARC Program
INITIATION DATE:
01.01.2014
ARC DIRECTORS AND CO-DIRECTORS:
Dr. Vipul Chitalia, Internal Medicine, Nephrology
Dr. Katya Ravid, Medicine, Biochemistry
Dr. Jean Francis, Medicine, Nephrology, Clinician
ABSTRACT:
Over past five years, the Thrombosis to Hemostasis (TtoH) ARC has successfully brought together basic and translational research through a cross-disciplinary approach to gain deeper understanding of thrombosis pathogenesis and to develop novel personalized predictive tools and therapeutic targets. As reported earlier, ARC members have initiated and developed the first Thrombotic Microangiopathy (TMA) program in BUSM. In 2020, our ARC provided extensive support to the development of a new ARC focused on pre-clinical studies related to Covid-19. As thrombosis and vascular complications are significant outcomes of Covid-19, our ARC members shared methodology and offered conceptual support to the newly formed ARC “ Respiratory viruses- a focus on Covid-19.” This has led to few collaborative studies now in preparation for publication. This later collaboration has been facilitated by our TtoH ARC innovative focus on organ pathology-induced changes in thrombosis and vascular hemostasis, which in the past two years centered on studies related to mechanisms of cancer-induced thrombosis. In addition, leveraging upon interdisciplinary approaches and expertise, the TtoH ARC also probed thrombotic mechanisms related to chronic kidney disease and bone marrow myelofibrosis; both used as model systems to examine this newly studied paradigm, resulting in notable publications and new grant support. Our collaborative pursuits led to identifying certain human plasma metabolites retained in chronic kidney disease, such as Kynurenine, as thrombogenic. Further, the secreted enzyme in myelofibrosis, lysyl oxidase, was found to enhance platelet activation and thrombosis in vivo in mice, and more recently new collaborative proteomic approaches led to identifying in in bone marrow malignant cells modified integrins known to participate in promoting thrombosis. Here, we aspire continue our prolific ARC Program, building upon our array of developments, seeking to continue through new research directions (as listed below) our research and education missions, while placing BU as a new hub of expertise in organ pathology-associated cardiovascular disease.
MEMBERS:
Rank
|
Departments/school affiliation
|
|
Vipul Chitalia
ARC co-Director |
Associate Prof of Medicine | Internal Medicine/Renal section (member of Northeastern Megakaryocyte/platelet club) |
Katya Ravid
ARC co-Director |
Professor of Medicine and Biochemistry, Director, Evans Center | Departments of Medicine and Biochemistry (member of Northeastern Megakaryocyte/platelet club) |
Jean Francis
ARC co-Director ARC clinician |
Associate Professor of Medicine | Renal section, Department of Medicine |
Catherine Costello | Prof of Biochemistry, William Fairfield Warren Distinguished Professor Director, Center for Biomedical Mass Spectrometry |
Department of Biochemistry |
Joseph Zia | Prof of Biochemistry | Department of Biochemistry |
Azer Bestavros
Consultant on Data Science projects |
Professor of Computer Science | Computer Science; Data Science Faculty |
Shinobu Matsuura | Instructor of Medicine | Whitaker Cardiovascular Institute |
Alik Farber | Professor of Surgery | Vascular Surgery |
Mark Sloan
ARC clinical co-director |
Assistant Professor of Medicine | Section of Hematology and Oncology, Department of Medicine |
David Salant
(ARC project advisor) |
Professor of Medicine | Renal section, Department of Medicine |
Elaine Hylek
ARC Advisor of Translational Research |
Professor of Medicine | General Internal Medicine |
Janice Weinberg
ARC Advisor of Stat Analysis |
Professor; BU School of Public Health | Department of Public Health and Department of Medicine |
Naomi Hamburg | Associate Professor of Medicine | Cardiology/ Medicine |
James Hamilton | Professor of Physiology and Biophysics | Physiology & Biophysics |
Joyce Wong | Professor of Biomedical Engineering | Biomedical Engineering |
Karen Quillen | Associate Professor of Pathology and Laboratory Medicine/Associate Professor of Medicine | Internal Medicine/Hematology-Oncology |
George Murphy | Assistant Professor of Medicine | Internal Medicine/Hematology-Oncology (member of Northeastern Megakaryocyte/platelet club) |
Vijaya Kolachalama | Adjunct Assistant Professor | Whitaker Cardiovascular Institute |
Shinichiro Kurosawa | Associate Professor of Pathology and Laboratory Medicine | Department of Pathology |
Anqi Zhang
|
Research Instructor (Core Director) | Medicine/ endocrinology |
Sibji Sarkar | Assistant Professor of Medicine | Medicine/Cancer Center |
Hannah Bader | Professor of Medicine | Harvard Medical School
(member of Northeastern Megakaryocyte/platelet club) |
Chris Andry | Professor of Pathology | Department of Pathology and Laboratory Medicine |
Carl Ohara | Professor of Pathology | Department of Pathology and Laboratory Medicine |
Bhavesh Shah | Department of Pharmacology | Administrative Director, Hem-Onc Pharmacology |
Caitlin Neri | Department of Pediatrics | Pediatric Nephrologist, Boston Medical Center |
Adam Lerner | Professor | Department of Hematology & Oncology |
John Connors | Associate Professor | Department of Microbiology |
Claire Avillach | Pathology Resident | Renal section, Department of Medicine |
Yilan Jiangliu | Post Graduate | School of Medicine |
Deborah Stearns-Kurosawa
(guest member) |
Assoc Provost/ Dean ad Interim Division of Graduate Medical Sciences | Division of Graduate Medical Sciences (member of Northeastern Megakaryocyte/platelet club) |