Markus Bosmann (, Pulmonary Center; Mohsan Saeed (, NEIDL


SARS-CoV-2 has caused a global pandemic, leading to an unprecedented public health crisis within a few months. There is an urgent need to gain better insights into the pathogenesis of localized SARS-CoV-2 infection in the lung and its distant organ complications. In this Affinity Research Collaborative (ARC), a multi-disciplinary researcher team of Boston University (BUMC, CRC) will develop and test novel cell cultures systems to dissect how this virus invades the lung and other organs, how it replicates inside cells, and how it is recognized and counteracted by the host immune defence. Using mouse models of the disease, studies will also focus on life-threatening complications, such as Acute Respiratory Distress Syndrome (ARDS), sepsis, multi-organ failure, coagulopathy, and the role of co-infections, co-morbidities, sex and age. These directions will serve as a translational platform for pre-clinical models of SARS-CoV-2 infection to design innovative diagnostics, preventive agents and facilitate the drug development process. Bidirectional translational interactions between basic scientists, clinicians and epidemiologists will be embedded in the existing infrastructures, science networks and the collaborative culture of BU. In a broader perspective, this ARC initiative aspires to strengthen the preparedness for outbreaks of contagious respiratory viruses in the future. Hence, we envision this ARC platform to set the stage for self-sustaining extramurally funded research programs of other respiratory viral illnesses modelled on investigative pursuits carried out here.


Markus Bosmann, MD, Pulmonary Center Pathology & Laboratory Medicine
Mohsan Saeed, PhD, NEIDL, Biochemistry
Kristine Abo, Post Doc,
Yuriy Alekseyev, PhD, Clinical Pathology & Laboratory Medicine
Konstantinos Dionysios Alysandratos, MD, PhD, Pulmonary Center, CReM
Manu Anantpadma, PhD, NEIDL
Nahid Bhadelia, MD, Infectious Disease
Kevin Brueck, PhD Student, Pulmonary
Eric Burks, MD, Pathology & Laboratory Medicine
Joshua Campbell, PhD, Computational Biomedicine
David Center, MD, CTSI Director, Pulmonary Center
Kevin Chandler, PhD, Biochemistry
Felicia Chen, PhD, Pulmonary
Vipul Chitalia, MD, Medicine, Nephrology
Daniel Cifuentes Buira, PhD, Biochemistry
John Connor, PhD, NEIDL, Microbiology
Rena Conti, PhD, Questrom, Markets, Public Policy & Law
Ronald Corley, PhD, NEIDL Director
Catherine Costello, PhD, Center for Biomedical Mass Spectrometry Director
Nicholas Crossland, DVM, Pathology & Laboratory Medicine
Robert Davey, PhD, NEIDL, Microbiology
Lynn Deng, PhD, Research Implementation
Florian Douam, PhD, NEIDL, Microbiology
Andrew Emili, PhD, Biology
Kara Farquharson, PhD Student, Pulmonary
Alan Fine, MD, Pulmonary
Lucien Garo, PhD student, Pulmonary Center Pathology & Laboratory Medicine
Valerie Gouon-Evans, PhD,PharmD, Gastroenterology, CReM
Anthony Griffiths, PhD, NEIDL, Microbiology
Rahm Gummuluru, PhD, NEIDL, Developmental Core Director, Providence/Boston Center for AIDS Res (Prov/Bos CFAR)
Jim Hamilton, PhD, Physiology & Biophysics
Finn Hawkins, MBBCh, Medicine CReM
Olivia Tsai Hix, Resesarch Study Technician, CReM
Jessie Huang, Post Doc, CReM
Adam Hume, PhD, NEIDL, Microbiology
Elaine Hylek, MD, General Internal Medicine
Laertis Ikonomou, PhD, CReM, Pulmonary Center
Karen Jacobson, MD, MPH, Medicine
Archana Jayaraman,  Post Doc, Pulmonary
Yang Jin, MD, PhD, Medicine
Matthew Jones, PhD, Pulmonary Center
Konstantinos Kontodimas, Research Assistant, Pulmonary
Darrell Kotton, MD, CReM, Pulmonary Center
Wendy Kuohung, MD, Obstetrics & Gynecology / Reproductive Endocrinology
Ben Linas, MD, MPH, Infectious Diseases
Weining Lu, MD, MS, FASN, Pathology & Laboratory Medicine
Jose Carlos Villacorta Martin, PhD
Sarah Anne Mazzilli, PhD, Computational Biomedicine
Jay Mizgerd, ScD, Pulmonary, Microbiology
Gustavo Mostoslavsky, PhD, Gastroenterology, CReM
Elke Mühlberger, PhD, NEIDL, Microbiology, Biomolecule Production Core Director
Melissa Pesta, Technician, Pulmonary
Valentina Perissi, PhD, Biochemistry
Lee Quinton, PhD, Medicine
Nader Rahimi, PhD, Pathology
Vasan Ramachandran, MD, Preventative Medicine & Epidemiology Section Chief
Katya Ravid, DSc, Medicine, Biochemistry, Whitaker Cardiovascular Center, Boston University Interdisciplinary Biomedical Research Office & Evans Center for Interdisciplinary Biomedical Research Director
Daniel Remick, MD, Pathology & Laboratory Medicine
Nathan Sanders, MD-PhD Student, Pulmonary
Francesca Seta, PhD, Vascular Biology, Whitaker Cardiovascular Institute, Metabolic Phenotyping & IVIS Imaging Core Director
Arjun Sharma, Research Fellow, Pulmonary
Chantelle Simone, Research Assistant, Center for Biomedical Mass Spectrometry
Saravanan Subramaniam, PhD, Infectious Diseases and Coagulation Disorders
Ellen Suder, PhD Student, Microbiology
Jacquelyn Turcinov, PhD Student, NEIDL
Katrina Traber, Md, PhD, Medicine
Xaralabos ‘Bob’ Varelas, PhD, Biochemistry
Sarah Walachowski, Post Doc, Infectious Diseases and Coagulation Disorders
Ruby Wang, MD, Pulmonary Medicine
Rhiannon Werder, Post Doc, CReM, Pulmonary
Lee Wetzler, MD, Infectious Diseases
Andrew Wilson, MD, CReM, Pulmonary
Ben Wolozin, PhD, Pharmacology & Exp Therapeutics
Chaoshuang Xia, Post Doc
Grace Zhao, MD, PhD, Chief & Vice Chair for Anatomic Pathology, Pathology & Laboratory Medicine