Glomerular Hypertension

Joel Henderson MD PhD

Systematic Hypertension is associated with changes in glomerular hemodynamics and progressive glomerular damage. As kidney damage progresses, glomerular perfusion pressure increases in remaining viable glomeruli, in order to drive compensatory hyperfiltration. This glomerular capillary hypertension is translated into increased mechanical stress affecting glomerular cells, including podocytes, mesangial, and endothelial cells. The Henderson Lab is studying how these mechanical forces can influence cell signaling and function, leading to glomerular cell injury and irreversible glomerular damage in the long term.