Category: Uncategorized

BUSM Researchers Uncover New Possible Approach for Treating Schizophrenia

August 28th, 2014 in Uncategorized

Researchers at Boston University School of Medicine (BUSM) have uncovered important clues about a biochemical pathway in the brain that may one day expand treatment options for cognitive deficits seen in schizophrenia. The study, published online in the journal Molecular Pharmacology, was led by faculty members David H. Farb, PhD, Terrell T. Gibbs, PhD, and Shelley J. Russek, PhD in thedepartment of pharmacology & experimental therapeutics at BUSM.


Patients with schizophrenia suffer from a life-long condition that can produce cognitive deficits, delusions, disordered thinking, and breaks with reality. A number of treatments are available for the treatment of schizophrenia, but many patients do not respond to these therapies or experience side effects that limit their use. There is no current treatment for the cognitive deficits experienced in schizophrenia.

The healthy brain is made up of billions of cells including the primary signaling cells called neurons, that are responsible for managing everything the body does: including movement, eating behavior, and memory formation. These neurons acts like a miniature computer and are controlled by substances called neurotransmitters that, like bits in a computer chip, may be “turned on” or “turned off” depending on the specific signals being integrated. Neurotransmitters latch onto a cell via a specific receptor, like a key fits into a lock.

In schizophrenia, it is thought that certain neurons don’t “turn on” as well when exposed to a certain neurotransmitter, the amino acid glutamate, may not be sensed by one of its key receptors (the NMDA receptor) whose diminished function may be the possible culprit for these sluggish cells. It is thought that this deficit can at least partially be responsible for symptoms seen in schizophrenics.

Currently the therapeutic means for making these cells more “sensitive” to glutamate can be toxic to the brain.

In this study, researchers discovered that another, naturally occurring steroid within the brain, known as PregS, may be able to bypass this toxic effect, and “turn on” neuron communication safely through a novel mechanism. The implication is that a deficit in the amount of this novel steroid may underlie deficits in signaling and that stimulation using therapeutics that elevate its levels in the brain may decrease or eradicate some of the debilitating symptoms seen in schizophrenia.

Although still in the early stages, further research in this area may be instrumental in the identification and development of treatments not only for schizophrenia, but also for other neurological conditions, such as age-related decreases in memory and learning ability.

View the full paper online: A Role for Picomolar Concentrations of Pregnenolone Sulfate in Synaptic Activity-dependent Ca2+ signaling and CREB Activation

Alumni Weekend 2012 Flyer

November 21st, 2011 in Uncategorized

Alumni Weekend Flyer

Read the Summer 2011 Campus and Alumni News

October 18th, 2011 in Uncategorized

View the Summer 2011 Issue of Campus and Alumni News!

Peggy Duggan ’90 featured in the Summer 2011 Bostonia

July 26th, 2011 in Uncategorized

Read the full article here and view a video by Devin Hahn below of Dr. Duggan as she talks about growing up in Chelsea, Massachusetts, and life as a surgeon.

Watch this video on YouTube

BUSM Alumnus named Editor-in-Chief of JAMA

March 28th, 2011 in Uncategorized

The following letter was sent to all associated with the Boston University School of Medicine from Dr. Karen Antman:

HCB125x190I am delighted to congratulate Howard Bauchner, MD, professor of pediatrics and community health sciences at BUSM and BUSPH, vice chair of academic affairs and director of the Division of Pediatrics at BUSM and BMC, on his appointment as the 16th Editor-in-Chief of the Journal of the American Medical Association (JAMA), which was announced earlier today. Howard will begin his tenure there July 1.

JAMA, published continuously since 1883, is the most widely circulated medical journal in the world. Dr. Bauchner follows Catherine D. DeAngelis, MD, MPH, who is leaving the post after 11 years to return to Johns Hopkins School of Medicine in Baltimore.

Howard has published more than 125 papers in peer-reviewed journals. He has had a senior career mentoring award from the NIH (K-24), and research support from NIH, USDA, MCHB, and numerous foundations. Howard has mentored over a dozen fellows and faculty, many of whom have become successful members of academic departments around the country. In 2003, he became Editor-in-Chief of Archives of Disease in Childhood (ADC), the first US Editor, a publication of the Royal College of Paediatrics and Child Health in the United Kingdom. Howard has served on numerous other editorial boards and is currently on the boards of the British Medical Journal and Journal Watch.

Dr. Bauchner also has served on grant review groups for the NIH and Bureau of Health Professions and is currently on the Advisory Board for the National Library of Medicine. He is an Honorary Fellow of the Royal College of Paediatrics and Child Health. He chairs the BUSM Appointment and Promotions Committee and is an Assistant Dean for Continuing Medical Education and Alumni Affairs. In 2009 he received the BUSM Alumni Association’s Distinguished Alumni award.

We congratulate Dr. Bauchner on this crowning achievement and know you all join us in wishing him great success at JAMA.

Karen Antman, MD
Provost, Boston University Medical Campus
Dean, School of Medicine
Professor of Medicine

Additional stories highlighting Dr. Bauchner’s achievement can be found here:

As featured on the BUSM News webpage: American Medical Association Names New JAMA Editor-In-Chief: Howard C. Bauchner, MD, to Become 16th Editor in Journal’s 127-Year History

As featured in’s White Coat Notes blog: BU Pediatrician named editor of leading medical journal

As featured in BU Today: Longtime MED Prof to Lead AMA’s JAMA

As featured in the Boston Globe section “G Force”: Dr. Bauchner discusses his new role as editor of the Journal of the American Medical Association

Outreach Van Project Newsletter – January 2011

February 9th, 2011 in Uncategorized

Read the Outreach Van Project’s January 2011 Newsletter here.

Learn more about the Outreach Van Project here.

Donor Report 2010 Boston University School of Medicine

January 7th, 2011 in Uncategorized

2010 Donor Report for the Boston University School of Medicine


Campus and Alumni News – Summer 2010

September 23rd, 2010 in Uncategorized

Click here to view the latest issue of Campus and Alumni News!

Dean Antman Announces Student Residence Building Approved

September 22nd, 2010 in Uncategorized

Sent 9/20/10

Boston University School of Medicine
Office of the Dean

Dear Faculty, Students, Staff and Alumni:

I am pleased to announce that the Boston University Board of Trustees voted Thursday, September 16, 2010 to approve the building of a new student residence on BU Medical Campus to be located at 817 Albany Street. Construction will take an estimated 18 months. We hope to welcome the Class of 2016 into the new facility in the fall of 2012!

We are tentatively looking forward to celebrating groundbreaking on Friday, October 29th, when our Dean’s Advisory Board is meeting.

A cadre of generous faculty, parents, alumni and friends has helped make the start of construction possible. We will continue to raise funds because every dollar of support will reduce the rent for each student who lives there.

We are committed to maintaining access to a medical education by the most qualified students by controlling expenses for our students. This building comprises one very important component of this commitment.

Best regards,

Karen Antman, MD
Provost, Boston University Medical Campus
Dean, School of Medicine
Professor of Medicine

The New Breed of Doctor Is In

September 22nd, 2010 in Uncategorized

Boston Medical Center hospitalists preview medicine’s future – via BU Today

Read the full article here.