Genome Science Institute Announces Research Symposium Award Winners

November 13th, 2009

The Genome Science Institute held its inaugural Research Symposium, an interdisciplinary research symposium that explores genetic and genomic science, in the Boston Medical Campus’ Hiebert Lounge on October 8, 2009. There were 63 abstracts submitted from students, post-doctoral fellows, and faculty from Institutions throughout the Boston area. Prizes were awarded in undergraduate, graduate and postdoctoral fellow categories. Six abstracts were chosen for oral distinction and the first authors were invited to give an oral presentation at the symposium. Seven researchers were awarded outstanding poster prizes. Winners of both oral distinction and poster prizes received an award of one hundred dollars.

Award Winners for Oral Distinction:

Graduate Level

Adam Gower, “openSESAME: A new tool for discovering biologically relevant connections in public gene expression data.” Faculty advisors: Marc Lenburg, PhD., and Avrum Spira, MD., PhD., BUSM.

Paul Romesser, “Cancer biomarker discovery by genome-wide transcriptome vs. proteome profiling: problems, advantages, limitations and insights.” Faculty advisor: Gerald Denis, PhD., BUSM.

Undergraduate Level

Vishal Patel, BU, Biology, “Understanding the Molecular Nature of the Loss of Function Mutation, THREAD 1.” Faculty Advisor: Kim McCall, PhD., BU.

Arun Rai, BUSM, Biochemistry, “GM-CSF is a novel target of p53-related p63.” Faculty Advisor: Jim Xiao, PhD., BUSM.

Post-Doctoral Level

Hamid M Abdolmaleky, BUSM, Genetics Program, “Epigenetic dysregulation of serotonin receptors type-2 (5HTR2A) in post-mortem brains of patients with schizophrenia and bipolar disorder.” Faculty advisor: Sam Thiagalingam, PhD., BUSM.

Jean-Bosco Tagne, BUSM, Pulmonary Center, “Genome-wide Identification of Titf1 Target Genes in the Developing Lung.” Faculty advisor: Maria Ramirez, PhD., BUSM.

Outstanding Poster Prizes:

Graduate

Alexandra Silveira, Massachusetts Eye and Ear Infirmary, Harvard Medical School, “Haplotypes Within The Vitamin D Metabolism Gene CYP24A1 Are Associated With the Development Neovascular AMD.” Faculty Advisor: Margaret DeAngelis, MD., PhD., Harvard Medical School.

Ari Friedland, BUSM, Biomedical Engineering, “A Synthetic Gene Network that Counts.” Faculty Advisor: James Collins, PhD., BUSM.

Jenny Loew, BUSM, Medical Nutrition Program, Cancer Research Center, “CpG Demethylation of ARHI Gene and Synergistic Inhibition of Ovary and Breast Cancer Cells by HDAC Inhibitors and Natural Isoflavonoid Product Genistein.” Faculty Advisor: Sibaji Sarkar, PhD., BUSM.

Joseph Gerrein, BU, Bioinformatics Program, “Deep-sequencing identifies smoking and lung-cancer associated changes to the large airway transcriptome.” Faculty Advisor: Avrum Spira, MD., PhD., BUSM.

Josh Campbell, BUSM, Pulmonomics, “Changes in gene expression with progression of emphysematous destruction in COPD.” Faculty Advisor: Avrum Spira, MD., PhD., BUSM.

Postdoc

Alexia Eliades, BUSM, Biochemistry, “New roles for cyclin E in megakaryocyte polyploidization.” Faculty Advisor: Katya Ravid, PhD., BUSM.

Alex Ensminger, Tufts University, Molecular Biology and Microbiology, “From broad host range to isogenic prison: genotypic plasticity in experimentally evolved strains of Legionella.” Faculty Advisor: Ralph Isberg, PhD., Tufts University.

Kelly Harrington, VA Boston, “Reexamining the Associations of DRD4 and 5-HTT with ADHD Using an Alternative Comorbid ADHD Phenotype.” Faculty advisor: Irwin Waldman, PhD. Emory University.

GSI Symposium – October 8

July 14th, 2009

Dear academic researchers:

The Boston University Genome Science Institute (GSI) is proud to announce the first inaugural GSI Symposium -an interdisciplinary research symposium that explores genetic and genomic science.

The GSI symposium is scheduled for Oct 08, 2009, from 1-5 PM in Hiebert Lounge (Boston University School of Medicine, 80 E. Concord Street, 14th Floor), overlooking the Boston skyline on the Boston University Medical Campus.  Students and researchers from all research backgrounds that emphasize genetics or genomics are invited to submit abstracts for oral presentations, poster presentations, or both. Abstracts will be selected for oral presentation distinction. Additional prizes will be awarded for the best posters in multiple categories.

Participation in the oral presentations is open to all undergraduate students, graduate students in MA, MSc, DSc, PhD, MD, MPH and MD/PhD programs, and postdoctoral fellows. Participation in the poster session and attendance at the GSI Symposium is open to all Boston area researchers listed above, including junior faculty.

Applications are now open. The abstract submission deadline for oral and poster presentations is Tuesday, September 15th, 5PM. To apply, please download the GSI Symposium abstract submission form and return to gsi@bu.edu.

For questions, please contact Becky Washburn or Monty Montano.

See you October 8th!

GSI Education Committee

Biostats Student Wins Dean’s Award at BU Science and Engineering Day

May 1st, 2009

Nadia Timofeev, a doctoral candidate in Biostatistics, has won the BU School of Public Health Dean’s Award, presented at the 2009 BU Science and Engineering Day, for work she is doing to develop an algorithm that will help researchers use genetic information to build better risk-prediction models.

For full story click here.

GSI Seed Grant Award Recipients Announced

April 16th, 2009

The BUMC Genome Science Institute, established in 2008, fosters collaboration and serves as a resource for Boston University investigators engaged in genetics and genomics research and education. The GSI is pleased to announce the recipients of the first annual GSI Seed Grant Award.

Of fourteen applications, the following recipients were selected following peer review of the proposals.

1. “Changes in Chromatin Accessibility of the Distal and Proximal IL1RL1 Promoter Upon Activation: Dependence on Cell Type
  • Ellen O. Weinberg, PhD, Boston University School of Medicine, Cardiovascular Proteomics Center
  • Barbara Nikolajczyk, PhD, Boston University School of Medicine, Department of Microbiology
2. “Role of microRNAs in thyroid carcinogenesis”
  • Jennifer Rosen, MD, Boston University School of Medicine, Department of General Surgery; Section of Surgical Oncology
  • Stephanie L. Lee, PhD, Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Diabetes & Nutrition
  • Antonio de las Morenas, MD, Boston University School of Medicine, Department of Pathology & Laboratory Medicine
3. “Possible functional diversification of the CP2 and p53 protein families from a common ancestor early in animal evolution—Evidence from the basal animal model, Nematostella vectensis”
  • John R. Finnerty, PhD, Boston University College of Arts and Sciences, Department of Biology
  • Ulla Hansen, PhD, Boston University College of Arts and Sciences, Department of Biology
  • Zhi-Xiong Jim Xiao, PhD, Boston University School of Medicine, Department of Biochemistry
4.  “Integrating genetics and genomics of COPD”
  • Jemma B. Wilk, DSc, Boston University School of Medicine, Department of Neurology
  • Avrum Spira, MD, MSc, Boston University School of Medicine, Department of Medicine, Section of Pulmonary, Critical Care & Allergy Medicine

GSI Seed grants are intended to support:

  • The expansion of research at Boston University by supporting new collaborations between groups with diverse expertise to address an important scientific question in genetics and genomics research.
  • Development of new and emerging areas of genetics and genomics research.
The GSI Seed Grant Committee and GSI Directors thank the applicants and reviewers who participated in this process and look forward to continued growth in genetics and genomics research at Boston University.
Please contact the GSI at gsi@bu.edu with questions or with your ideas on how the GSI can better facilitate or develop genetics and genomics research at BU.

GSI Seed Grant RFA

February 9th, 2009

Deadline: March 16, 2009

The Genome Science Institute is pleased to announce the availability of 1-2 seed grants ranging from $10,000 to $20,000 for 1 year each to enhance genetics and genomics research at Boston University.

PURPOSE:  This RFA is intended to support:  (1) The expansion of research at Boston University by supporting new collaborations between groups with diverse expertise to address an important scientific question in genetics and genomics research.  (2) Development of new and emerging areas of genetics and genomics research.

ELIGIBLITY:  The RFA is open to all BU faculty at the Medical or Charles River campuses.  Joint PIs are allowed. For faculty-level applicants, at least one PI must be a GSI member prior to the submission deadline. The GSI is open to all BU faculty engaged in genetics and/or genomics research. Please contact gsi@bu.edu to apply. Post-doctoral fellows may also apply with letters of support from their faculty supervisor (a GSI member).

PROJECT SCOPE:  This RFA is intended to expand the scope of genetics and genomics research at BU by supporting new areas of research and/or new collaborative efforts between groups that currently do not work together or who are in an early stage of collaboration.  Requests to support on-going research or the expansion of an on-going research project by the applicants will not be considered responsive to this RFA.

APPLICATION INSTRUCTIONS and COMPONENTS:

1.  A two page document outlining the Specific Aims, Rational, Background and Methodology of the project

2. A one page summary describing the expertise of the individuals involved and how this application represents a new collaborative effort, or addresses a new and emerging area of research.

2. NIH-type Biosketch (4 page limit) including other support information for all participants.  Post-doctoral applicants should also provide a Biosketch and other support for their supervisor/mentor.  It is important that a post-doctoral applicant outline in their proposal how the proposed work is not merely an extension of their mentor’s research.

3. A detailed budget.  Requests for faculty salary support will not be allowed.

4. Appropriate assurances must be appended (e.g. IACUC, IBC, Radiation Safety approval).

5. Application must be assembled as a single PDF document and sent to gsi@bu.edu by midnight March 16, 2009.

REVIEW PROCESS:  Applications will be reviewed by the GSI Seed Grant Committee with assistance from outside reviewers who have expertise to review specific projects.  Anyone with a potential Conflict of Interest with a reviewer should make appropriate notes in the application cover letter.

AWARD DATE: Funding award may begin as soon as April 1, 2009.

REPORTING:  Individuals who are funded should appropriately acknowledge support of the GSI in publications and grant applications that may arise from this project. A financial report and scientific report will be made by the PI within 3 months after the end of the funding period. Individuals will also be required to give a seminar in the GSI Seminar Series reporting their findings.

SEED GRANT COMMITTEE:

Clinton Baldwin (Chair)

Lindsay Farrer

Mark Logue

Rick Myers

Miklos Sahin-Toth

Cassandra Smith

Martin Steinberg

Ben Wolozin

Contact|Directory|BUMC
November 13, 2009
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