“Translational Genomics and Precision Cancer Medicine” Nikhil Wagle, MD Instructor in Medicine Harvard Medical School Dana-Farber...
Cell Signaling and Cancer
The Panchenko’s lab studies how histone and other factor acetyl transferases control the fine balance between epithelial cell proliferation, differentiation, and ultimately tissue homeostasis. They are discovering novel epigenetic pathways that directly regulate mammalian cell cycle progression and are linked to tissue regeneration or cancer.
The Henderson Lab is studying how these mechanical forces can influence cell signaling and function, leading to glomerular cell injury and irreversible glomerular damage in the long term.
The Rahimi’s Laboratory is studying the molecular mechanisms by which cell signaling molecules and posttranslational modifications such as phosphorylation, ubiquitination, methylation and acetylation regulate angiogenic and tumorigenic signaling events. We are studying how disruption in these events in pathological conditions such as cancer or anti-cancer therapy-associated resistance contributes to aberrant tumor progression. Ultimately, our goal is to determine how inappropriate regulation of cell signaling molecules contributes to tumor progression, angiogenesis and resistance to cancer treatment. This understanding will lead to the identification of novel cancer therapy targets and possible biomarkers”.