Seminar Series: Fall 2016 ~~ Friday, November 18, 2016 2:00-3:00 PM ...
Jiyoun Kim, PhD
Degree(s) – BS, MS, Ph.D.
Academic Title – Research Assistant Professor
- Korea University, Seoul, Korea: BS Biology 1982
- Korea University, Seoul, Korea: MS Microbiology 1984
- University of Alabama, Tuscaloosa, AL: Ph.D. Immunology 1999
- University of Michigan, Ann Arbor, MI: Research Fellow 1999-2004
Research Interests –
Asthma is a unique form of chronic respiratory disease characterized by reversible airway obstruction and substantial pulmonary inflammation. It represents one of the most common chronic inflammatory diseases affecting an estimated 300 million people worldwide with an expected significant increase to 400 million by 2025. While the sharply rising prevalence and incidence of asthma causes global concern both in the developing and developed countries, understanding of the pathogenesis of asthma at this time is limited.
We have established a novel mouse model of asthma induced by a house dust that was collected for the house that has asthmatic child. This house dust contains high levels of cockroach allergens and low level of bacterial endotoxin. Currently we are using commercially available cockroach allergen that is being use for skin test in clinic.
My studies have been focused on expanding our understanding of asthma by using a well-established mouse model:
1. The role of tumor necrosis factor (TNF) in asthma. TNF is a potentially novel mediator for new insights into the pathogenesis of asthma. In a previous study, we demonstrated a brisk and significant increase in TNF within the bronchoalveolar lavage fluid immediately after pulmonary challenge with the house dust extract. Given the increase in TNF, it would represent a logical target for inhibition and blockade of the pulmonary inflammatory response to the house dust extract. Our studies showed that blockade of TNF resulted in a reduction of the pulmonary inflammation demonstrated by reduced recruitment of inflammatory cells and airway hyper-responsiveness.
2. The association between increased ambient air pollution levels and symptoms of asthma. To shed light on the cause of recent increases of asthma, several factors have been proposed including genetic and environmental changes. Though the relative contribution of genetics and the environment in the development of asthma remain to be elucidated, numerous studies have documented the effects of environmental exposures on the risk of pulmonary diseases. As several epidemiologic and clinical studies emerged, it has become clear that increased ambient air pollutants, including particular matter, are correlated with dramatic increases in the risk of respiratory and cardiovascular diseases. Asthmatics represent a highly sensitive subpopulation that is at increased risk following exposure to particulate matters in the ambient environment. We are studying the biologic mechanisms responsible for the exacerbation of pulmonary inflammation and AHR. Using a well-established mouse model of asthma, our study is focused on whether asthma-like inflammatory responses in mice are exacerbated by the combination of the air pollutant DEP and allergen challenge. Our data demonstrate that KC and MIP-2, two CXC chemokines, orchestrate DEP-induced exacerbation of airway inflammation and airway hyperresponsiveness in vivo.
Heat map analysis and hierarchal clustering of entire data set. Inflammatory cells in bronchoalveolar lavage (BAL), entire respiratory parameters, and inflammatory mediators in BAL (B), plasma (P), and lung homogenates (L) were subject to Z-score normalization. Normalized z-scores were averaged and converted to a heat map. The heat map data were subject to hierarchal clustering by sample group (Naïve, IgG-treated (IgG), and anti CXC antibody-treated (Ab) mice) and by parameter to demonstrate the pattern in each group’s response. The hierarchal clustering demonstrated that anti KC and MIP-2 antibody treated mice shared many features with the naïve mice.
3. Treatment of asthma using herbal extract. While conventional remedies including corticosteroids and β2-agonists are effective in managing asthma symptoms, concerns regarding the side effects of current remedies due to chronic use and the lack of curative therapy lead asthma patients in the Western world to seek complementary and alternative medicine (CAM) treatments. Despite the substantial gain in the popularity of CAM to treat asthma, few studies have reported on the clinical efficacy or mechanisms of the CAM remedies including herbal treatment. A Korean herbal medicine, SO-CHEONG-RYONG-TANG (SCRT), (also known as Xiao-qing-long-tang in traditional Chinese medicine, and as Sho-seiryu-to in Japanese Kampo medicine) has long been prescribed for the treatment of allergic diseases in Korea, China, and Japan. To elucidate the mechanism of how SCRT modulates the allergic response, we evaluated the immunomodulatory effects of SCRT using our murine model of asthma by examining multiple aspects of respiratory function and pulmonary inflammation including the production of inflammatory mediators and the pulmonary recruitment of inflammatory cells.
SCRT treatment decreases BAL eosinophil infiltration (A) and airway expression of the eosinophil-attracting CC chemokines, eotaxin (B) and RANTES (C).
Recent Publications –
- Hemmila MR, Kim J, Sun JM, Cannon J, Arbabi S, Minter RM, Su GL, Remick DG, Wang SC. Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology. J Trauma. 2006 Sep;61(3):598-605; discussion 605-6. PubMed PMID: 16966994.
- Kim J, Remick DG. Tumor necrosis factor inhibitors for the treatment of asthma. Curr Allergy Asthma Rep. 2007 May;7(2):151-6. Review. PubMed PMID: 17437686. 24: McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Respir Res. 2006 Oct 17;7:129. PubMed PMID: 17044927; PubMed Central PMCID: PMC1635702.
- Ipaktchi K, Mattar A, Niederbichler AD, Kim J, Hoesel LM, Hemmila MR, Su GL, Remick DG, Wang SC, Arbabi S. Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia model. Crit Care Med. 2007 Sep;35(9):2139-44. PubMed PMID: 17855827.
- Natarajan S, Kim J, Remick DG. Acute pulmonary lipopolysaccharide tolerance decreases TNF-alpha without reducing neutrophil recruitment. J Immunol. 2008 Dec 15;181(12):8402-8. PubMed PMID: 19050257; PubMed Central PMCID: PMC3672419.
- Nemzek JA, Kim J. Pulmonary inflammation and airway hyperresponsiveness in a mouse model of asthma complicated by acid aspiration. Comp Med. 2009 Aug;59(4):321-30. PubMed PMID: 19712571; PubMed Central PMCID: PMC2779206.
- Natarajan S, Kim J, Remick DG. Chronic pulmonary LPS tolerance induces selective immunosuppression while maintaining the neutrophilic response. Shock. 2010 Feb;33(2):162-9. doi: 10.1097/SHK.0b013e3181aa9690. PubMed PMID: 19487981; PubMed Central PMCID: PMC3670960.
- Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG. Assessing pulmonary pathology by detailed examination of respiratory function. Am J Pathol. 2010 Oct;177(4):1861-9. doi: 10.2353/ajpath.2010.100053. Epub 2010 Aug 19. PubMed PMID: 20724595; PubMed Central PMCID: PMC2947281.
- Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG. Oral tolerance inhibits pulmonary eosinophilia in a cockroach allergen induced model of asthma: a randomized laboratory study. Respir Res. 2010 Nov 23;11:160. doi: 10.1186/1465-9921-11-160. PubMed PMID: 21092270; PubMed Central PMCID: PMC3016351.
- Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG. Inbred and outbred mice have equivalent variability in a cockroach allergen-induced model of asthma. Comp Med. 2010 Dec;60(6):420-6. PubMed PMID: 21262127; PubMed Central PMCID: PMC3002100.
- Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG. Reducing LPS content in cockroach allergens increases pulmonary cytokine production without increasing inflammation: a randomized laboratory study. BMC Pulm Med. 2011 Feb 23;11:12. doi: 10.1186/1471-2466-11-12. PubMed PMID: 21345191; PubMed Central PMCID: PMC3050874.
- Kim J, Natarajan S, Bae H, Jung SK, Cruikshank W, Remick DG. Herbal medicine treatment reduces inflammation in a murine model of cockroach allergen-induced asthma. Ann Allergy Asthma Immunol. 2011 Aug;107(2):154-62. doi: 10.1016/j.anai.2011.05.001. Epub 2011 Jun 12. PubMed PMID: 21802024; PubMed Central PMCID: PMC3672053.
- Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011 Dec;179(6):2730-9. doi: 10.1016/j.ajpath.2011.08.008. Epub 2011 Oct 1. PubMed PMID: 21967814; PubMed Central PMCID: PMC3260803.
- Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG. Pulmonary endotoxin tolerance protects against cockroach allergen-induced asthma-like inflammation in a mouse model. Int Arch Allergy Immunol. 2012;158(2):120-30. doi: 10.1159/000330896. Epub 2012 Jan 24. PubMed PMID: 22269653; PubMed Central PMCID: PMC3291890.
- Vaickus LJ, Bouchard J, Kim J, Natarajan S, Remick DG. Cockroach allergens induce biphasic asthma-like pulmonary inflammation in outbred mice. J Asthma. 2012 Jun;49(5):510-21. doi: 10.3109/02770903.2012.678958. Epub 2012 Apr 30. PubMed PMID: 22540923.
- Bouchard JC, Kim J, Beal DR, Vaickus LJ, Craciun FL, Remick DG. Acute oral ethanol exposure triggers asthma in cockroach allergen-sensitized mice. Am J Pathol. 2012 Sep;181(3):845-57. doi: 10.1016/j.ajpath.2012.05.020. Epub 2012 Jul PubMed PMID: 22796441; PubMed Central PMCID: PMC3432429.
- Iskander KN, Craciun FL, Stepien DM, Duffy ER, Kim J, Moitra R, Vaickus LJ, Osuchowski MF, Remick DG. Cecal ligation and puncture-induced murine sepsis does not cause lung injury. Crit Care Med. 2013 Jan;41(1):159-70. doi: 10.1097/CCM.0b013e3182676322. PubMed PMID: 23222255; PubMed Central PMCID: PMC3531667.
- Beal DR, Stepien DM, Natarajan S, Kim J, Remick DG. Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(11):L866-77. doi: 10.1152/ajplung.00120.2013. Epub 2013 Sep 27. PubMed PMID: 24077949; PubMed Central PMCID: PMC3882531.
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