Zhaohua Lu, PhD
Instructor
Contact Information
- 617-638-4221
- email: zaohualu@bu.edu
Education
1996 B.S. China Pharmaceutical University, Nanjing, China; Analytical Chemistry
1999 M.S. China Pharmaceutical University, Nanjing, China; Pharmacology
2004 Ph.D. Kyushu University, Fukuoka, Japan; Chemo-pharmaceutical Sciences
Research Interests
I have been interested in infectious disease (hepatitis and tularemia) related mouse models, herbal medicines and antibody related therapeutics. I also have experience with antibody development and engineering. I am currently working on human ex-vivo and in-mouse models of diseases, prophylaxis and therapy. The long term goal of this research is to study human disease and immune responses, and to create and evaluate vaccines and therapies in mice engrafted with human cells.
Publications
1. Jiang J., Wu F., Lu J., Lu Z. and Xu Q. Anti-inflammatory activity of the aqueous extract from Rhizoma Smilacis Glabrae. Pharmacological Research 1997; 36(4): 309-314.
2. Dai D., Huang J., Wang H., Gong X. and Lu Z. The possibility and related mechanisms of the increased mortality rate caused by dihydropyridine calcium antagonists after long-term use. China Journal of Clinical Pharmacology 1999; 15(3): 206-211.
3. Cao J., Lu Z. and Xu, Q. 1999. The role of Ca2+ and Ca2+ channel blocking agents in PCl-DTH liver injury. China Pharmacological Bulletin 15: 124-127.
4. Lu Z., Cao J., Fan H. and Xu Q. 1999. Mechanisms for improving liver injury induced by the aqueous extract from Cortex Ditamni. Journal of China Pharmaceutical University 30(3), 212-215.
5. Xu Q., Lu Z. and Zhang X. 2002. A novel role of alkaline phosphatase in protection from immunological liver injury in mice. Liver 22(1), 8-14.
6. Lu Z., Morinaga O., Tanaka H. and Shoyama Y. 2003. A quantitative ELISA using monoclonal antibody to survey Paeoniflorin and Albiflorin in crude drugs and traditional Chinese herbal medicines. Biol. Pharm. Bull 26, 862-866. PMID: 12808301.
7. Lu Z., Tadashi M., Shoyama Y. and Tanaka H. Construction and expression of a single chain Fv fragment against pharmacologically active paeoniflorin in Escherichia coli, and its potential use in an enzyme-linked immunosorbent assay. Planta Medica 2006 Feb; 72(2):151-5.
8. Lu Z., Roche M. I., Hui J. H., Unal B., Felgner P. L., Gulati S., Madico G., and Sharon J. 2007. Generation and characterization of hybridoma antibodies for immunotherapy of tularemia. Immunol. Letters 112, 92-103. PMID: 17764754.
