Walther M. Pfeifer, MD

wpf
Adjunct Assistant Professor

Medical Director, Hematology
Department of Pathology
Mount Auburn Hospital

Education/Training -

1994 – 1995 Internal Medicine, Medizinische Poliklinik, University of Wuerzburg, Germany
1996 – 1997 Anatomic Pathology, Medizinische Hochschule Hannover, Germany
1997 – 1999 Research Fellow, Experimental Pathology, Beth Israel Hospital, Boston, MA
1999 – 2001 Anatomic Pathology, University of Wuerzburg, Germany
2002 – 2005 Residency in Anatomic and Clinical Pathology, Beth Israel Deaconess Medical Center, Boston, MA
2006 – 2006 Clinical Fellow in Pediatric Pathology, Children’s Hospital, Boston, MA
2006 – 2007 Clinical Fellow in Hematopathology, Beth Israel Deaconess Medical Center, Boston, MA

Board Certifications -

Anatomic and Clinical Pathology, 2007

Hematopathology, 2008

American Board of Pathology

Membership in Professional Societies -

  • 2003 United States and Canadian Academy of Pathology
  • 2003 American Society of Clinical Pathologists
  • 2004 College of American Pathologists
  • 2007 Massachusetts Medical Society

Research Interests -

  • Hematopathology
  • Vascular Pathology

Recent Publications -

  • Pfeifer W, Levi E, Petrogiannis-Haliotis T, Lehmann L, Wang Z, Kadin ME. A murine xenograft model for human CD30+ anaplastic large cell lymphoma – successful growth inhibition with an anti-CD30 antibody (HeFi-1). Am J Pathol 1999; 155(4):1353-9.
  • Schiemann WP, Pfeifer WM, Levi E, Kadin ME, Lodish HF. A deletion in the gene for transforming growth factor beta in a cutaneous T-cell lymphoma. Blood 1999; 15;94(8):2854-61.
  • Levi E, Wang Z, Petrogiannis-Haliotis T, Pfeifer WM, Kempf W, Drews R, Kadin ME. Distinct effects of CD30 and Fas signalling in cutaneous anaplastic lymphomas: a possible mechanism for disease progression. J Invest Dermatol 2000; 115(6):1034-40.
  • Mueller-Hermelink HK, Zettl A, Pfeifer W, Ott G. Pathology of lymphoma progression. Histopathology 2001; 38(4):285-306.
  • Griesser H, Rauschert C, Pfeifer W, Monir H, Renner TJ, Embaye U, Neumann M. Different cell reactions upon stimulation of similar surface receptors: CD30 signaling in neoplastic T cell lines. Verh Dtsch Ges Zyt 2001; 22:114-122.
  • Levi E, Pfeifer WM, Kadin ME. CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell cycle arrest? Blood (letter) 2001; 98(5).
  • Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME. Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. J Cutan Pathol 2002 May;29(5):295-300.
  • Schiemann WP, Rotzer D, Pfeifer WM, Levi E, Rai KR, Knaus P, Kadin ME. Transforming growth factor-beta (TGF-beta)-resistant B cells from chronic lymphocytic leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor. Cancer Detect Prev 2004;28(1):57-64.
  • Horn T, Kremer M, Dechow T, Pfeifer WM, Geist B, Perker M, Duyster J, Quintilla-Martinez L, Fend F. Detection of the activating JAK2 V617F mutation in paraffin-embedded trephine bone marrow biopsies of patients with chronic myeloproliferative diseases. J Mol Diagn. 2006 July;8(3):299-304.
  • Maithel SK, Pratt W, Kelleher T, Avigan D, Goldman H, Pfeifer W, Pihan GA. Autoimmune pancreatitis in the setting of Castleman’s disease. Pancreas 2007 Nov:(35(4):384-7.
  • Kremer M, Horn T, Koch I, Dechow T, Gattenloehner S, Pfeifer W, Quintanilla-Martinez L, Fend F. Qantitation of the JAK2V617F mutation in microdissected bone marrow trephines: equal mutational load in myeloid lineages and rare involvement of lymphoid cells. Am J Surg Pathol 2008 Jun;32(6):928-35.

Selected Abstracts -

  1. Pfeifer W, Levi E, Petrogiannis-Haliotis T, Zhenxi W, Kadin ME. Cytokine expression of CD30+ anaplastic large cell lymphoma cell lines – comparison of nodal versus cutaneous ALCL. United States and Canadian Academy of Pathology, San Francisco, 1999. Poster presentation.
  2. Pfeifer W, Levi E, Petrogiannis-Haliotis T, Zhenxi W, Kadin ME. Ki 1+ anaplastic large cell lymphoma expressing the t(2;5) translocation in triple immuno-deficient (SCID BEIGE) mice. German Society of Pathology, Jena, 1999. Platform presentation.
  3. Pfeifer W, Monir M, Neumann M, Berberich H, Griesser H. CD30 mutations and abnormal signal transduction in Hodgkin`s disease (HD)- and large cell anaplastic lymphoma (LCAL)-related cell lines. European Association of Hematopathology, London, 2000. Poster presentation.
  4. Pfeifer W, Vogel P, Griesser H. Analysis of cytokeratin 20 as a potential marker of malignancy. German Society of Pathology, Kiel, 2000. Platform presentation.
  5. Pfeifer W, Bryan B, Avigan D, Pihan G. Osteosclerotic/ myelofibrotic chronic myelogenous leukemia (CML) at presentation: A rare and possibly unique subset of CML. International Academy of Pathology, Athens, 2008, Poster presentation.
  6. Pfeifer W, Vakil H, Kurrer M, Levi E. Phosphorylation Status of retinoblastoma protein predicts survival in rituxan-treated follicular lymphomas. International Academy of Pathology, Athens, 2008, Poster presentation.

Contact Information -

Email – wpfeifer@mah.harvard.edu