Shi Yang, MD, MSc.
Assistant Professor
Department of Pathology and Laboratory Medicine
BUSM
Director
Diagnostic Molecular Pathology
Division of Anatomic Pathology
BMC
Degree(s):
MB (MD equivalent), Hebei Medical College, ShijiaZhuang, China. 1978-1983. Medicine
MSc, Chinese Academy of Medical Sciences, Beijing, China. 1983-1986. Etiology,
Carcinogenesis & Experimental Cancer Pathology.
ACADEMIC APPOINTMENTS:
- 1986-91 Assistant Lecture, Assistant Professor, Department of Pathology, North China Coalminer
Medical College, Tangshan, China. - 1990-92 Research Associate, Mallory Institute of Pathology, Boston University
Medical Center, Boston MA. - 1993-present
Assistant professor, Department of Pathology and Laboratory Medicine,
Boston University School of Medicine, Boston MA. - 2008- Assistant professor and member, Division of Graduate Medical Sciences
Boston University Medical Campus, Boston MA
MEMBERSHIP IN PROFESSIONAL SOCIETIES & INTEREST GROUPS:
10/1991-American Society for Cell Biology (ASCB).
03/2008- Association for Molecular Pathology (AMP-ASIP)
1993- Member, Breast Cancer Research Program, BUSM
2005- Member, Cancer Research Center, BUSM.
2006- Member, Women’s Health Interdisciplinary Research Center (WHIRC), BUMC.
2008- Founding member, Genomic Science Institute (GSI), Boston University.
MAJOR RESEARCH INTERESTS:
1. In-vitro studies of genetic and epigenetic changes in colorectal polyps, concentrate on “Serrated
Polyp Neoplasia pathway”.
2. Breast cancer carcinogenesis and dietary prevention in animal models(green tea).
3. Molecular diagnosis of hematology disorders, solid tumor and infectious diseases.
RECENT PUBLICATIONS:
1. MJ O’Brien, S Yang, JL Clebanoff, E Mulcahy, FA Farraye, M Amorosino, N Swan. Hyperplastic (serrated) Polyps of the Colorectal: Relationship of CpG – Island Methylation Phenotype and K-ras Mutation to Location and Histologic Subtype. AJSP 28(4): 423-434, 2004.
2. Christopher S Huang, Michael J O’Brien, Shi Yang and Francis A Farraye. Hyperplastic polyps, Serrated Adenomas and the Serrated Neoplasia Pathway. Am J Gastroenterol. 99: 2242-2255, 2004.
3. Shi Yang, Francis A. Farraye, Charline Mack, Oksana Posnik and Michael J. O’Brien. BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum. AJSP 28(11): 1452-1459, 2004.
4. Stephen A Murray, Shi Yang, Elizabeth Demicco, Haoqiang Ying, David H Sherr, Laurie J Hafer, Adrianne E Rogers, Gail Sonenshein and ZhiXiong Jim Xiao. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem. 2005 Aug.1;95(5):875-84.
5. Michael J O’Brien, Shi Yang, Charline Mack, Huihong Xu, Christopher S Huang, Elizabeth Mulcahy, Mark Amorosino, Francis A Farraye. Comparison of Microsatellite Instability, CpG Island Methylation Phenotype, BRAF and KRAS Status in Serrated Polyps and Traditional Adenomas Indicates Separate Pathways to Distinct Colorectal Carcinoma Endpoints. AJSP 30: 1491-1501, 2006
6. Andrey A. Sharov, Tatyana Y. Sharova, Andrei N. Mardaryev, Alice Tommasi di Vignano,
Ruzanna Atoyan, Lorin Weiner, Shi Yang, Janice L. Brissette, G. Paolo Dotto, and Vladimir A.
Botchkarev. Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. PNAS(U S A). 2006; 103(48): 18166-18171.
7. Daniel W. Rosenberg, Shi Yang, Devon C. Pleau, Emily J. Greenspan, Richard G. Stevens, Thiruchandurai V. Rajan, Christopher D. Heinen, Joel Levine, Yijian Zhou, and Michael J. O’Brien. Mutations in BRAF and KRAS Differentially Distinguish Serrated versus Non-Serrated Hyperplastic Aberrant Crypt Foci in Humans. Cancer Res 2007; 67(8): 3551-3554.
8. Karine Belguise, Shangqin Guo, Shi Yang, Adrianne E. Rogers, David C. Seldin, David H. Sherr, and Gail E. Sonenshein. Green Tea Polyphenols Reverse Cooperation between c-Rel and CK2 that Induces the Aryl Hydrocarbon Receptor, Slug, and an Invasive Phenotype. Cancer Res 2007;67(24):11742-50.
9. Michael J O’Brien, Shi Yang, Christopher S Huang, Courtney Shepherd, Sandra Cerda, Francis A Farraye. The Serrated Polyp Pathway to Colorectal Carcinoma. Diagnostic Histopathology. 2008;14(2):78-93.
10. Vesela Kovacheva, Jessica Davison, Tiffany Mellott, Adrianne Rogers, Shi Yang, Michael O’Brien and Jan Blusztajn. Raising Gestational Choline Intake Alters Gene Expression in DMBA-evoked Mammary Tumors and Prolongs Survival. The FASEB Journal 2008 Dec. 1(Epub ahead of print).
11. O.E. Dadzie, S. Yang,* A. Emley,_ M. Keady, J. Bhawan and M. Mahalingam. RAS and RAF mutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis. BJD, 2009;160:368-375.
CURRENT FOUNDING:
1. NIH/NIEHS: PO1 ES 11624-05 (PI, G. Sonenshein); Signaling Pathways in Stages of Mammary Tumorigenesis. Dr. Yang is a Co-Investigator in the Animal Bio-model Core.
2. NIH: 57-202-6917-5 (PI, K Kirsch). Dr. Yang has 5% effort in this grant, it ends June 2009.
CONTACT INFO:
Email, shiyang@bu.edu
Phone: 617-414-5057 (O),
617-414-7916 (L).
POSITION AVAILABLE:
Currently none.
