Nancy S. Miller, MD

Clinical Appointments

  • Medical Director, Clinical Microbiology & Molecular Diagnostics
  • Medical Director, Laboratory Information Systems (2005-2011)

Academic appointment

  • Assistant Professor of Pathology and Laboratory Medicine

Contact information

email: nancy.miller@bmc.org
office: 617 638-8705
1 Boston Medical Center Place
670 Albany Street – Suite 733
Boston, MA 02118

Education/Training

  • M.D., State University of New York at Stony Brook, School of Medicine
  • Internship and Residency, Anatomic & Clinical Pathology, The Johns Hopkins Medical Institutions
  • Post-doctoral fellowship, Medical Microbiology, The Johns Hopkins Medical Institutions

Board certification

  • Diplomate, American Board of Pathology, Anatomic and Clinical Pathology

Membership & Offices in Professional Societies

  • American Society for Microbiology (ASM)
  • Northeast Branch of ASM (NEB-ASM)
  • Fellow, College of American Pathologists (CAP)
  • Fellow, American Society of Clinical Pathologists (ASCP)
  • Fellow, American Society of Clinical Pathologists (ASCP)
2002-present Spokesperson, College of American Pathologists (CAP), hometown radio & television interviews
2008-2010 Contributor, Document Development Committee on User Verification/Validation of Microbial Identification and Antimicrobial Susceptibility Testing Systems, Proposed Guideline M52-P, Clinical and Laboratory Standards Institute (CLSI)
June 2011-2014 Local Councilor, Northeast Branch – American Society for Microbiology
2011-2014 Membership Committee, American Society for Microbiology (ASM)

Membership, Departmental and University Committees

  • 2007-present    Process Improvement Task Force, Department of Laboratory Medicine and Department of Pediatrics, Boston Medical Center
  • 2010-present    Committee on Admissions, Boston University School of Medicine

Membership, Hospital Committees, Boston Medical Center

  • 2004-present    Hospital Infection Control Committee
  • 2004-present    Pharmacy and Therapeutics Antibiotic Subcommittee

Research interests

My present focus is translational research as applied to innovative or improved diagnostics for microbiology and infectious diseases. As clinical co-investigator, I collaborate with several principal investigators from the BUMC and BU campuses. In addition, I am the PI for a variety of industry-related projects involved in developing and testing new diagnostic devices.

The BMC clinical Microbiology Laboratory supports various validations and method-comparison studies of interest to clinical microbiology.  The laboratory also supports a variety of BUMC faculty who are engaged in clinical research protocols. We actively seek collaboration for quality-improvement projects and clinical case reports.

Recent efforts include:
•    BioHelix IsoAmp® HSV Assay (BioHelix Corp.) Clinical Study Protocol
•    Alpha Testing Protocol for the BioHelix IsoAmp® HSV Assay
•    Development of Rapid, Portable Surface Enhanced Raman Scattering (SERS) Platform for Bacterial Detection and Identification, Dr. Lawrence Ziegler, PI, Dept. of Chemistry and The Photonics Center; Dr. Catherine Klapperich, Dept. of Biomedical Engineering
•    Specific Detection of Human Viruses and Microbes in Human Specimens using PNA-based technology. Dr. Maxim Frank-Kamenetskii, PI, BU School of Bioengineering. Initial funding from The Wallace H. Coulter Translational Partners Award/Translational Biomedical Engineering Partnership Program.
•    Comparison of BD Bactec Plus Blood Culture Media to VersaTREK Redox Blood Culture Media for Detection of Bacterial Pathogens in Simulated Adult Blood Cultures Containing Therapeutic Concentrations of Antibiotics
•    Evaluation of S. Aureus PNA FISH (AdvanDx, Inc.) for Identification of Staphylococcus Aureus Directly from Wound Swabs (2 Hour Swab Cultures)

Selected Publications

  • Miller, N.S., J.D. Dick, W.G. Merz.  Phenotypic switching in Candida lusitaniae on copper sulfate indicator agar: association with amphotericin B resistance and filamentation. Journal of Clinical Microbiology 2006; 44(4): 1536-1539. PMC1448677.
  • Miller, N.S., M.C. Dobre, J.M. Liebschutz, T.C. Williams, B.L. Orr, H.W. Farber.  Micrococcus bacteremia in a patient with pulmonary hypertension and long-term central venous catheter: Opportunity knocks and an unexpected pathogen enters.  Clinical Microbiology Newsletter 2007 (November 15); 29(22):173-175.
  • Iroh Tam, P-Y, M. Fisher, N.S. Miller. Corynebacterium falsenii bacteremia occurring in an infant on vancomycin therapy. Journal of Clinical Microbiology 2010; 48(9): 3440-3442. PMC2937743.
  • Smolina, I.V., N.S. Miller, and M.D. Frank-Kamenetskii.  PNA-based microbial pathogen identification and resistance marker detection: an accurate, isothermal rapid assay based on genome-specific features. Artificial DNA PNA XNA. 2010; 1(2): 1–7. PMC2953854.
  • Kim, H-L, Y. Tong, W. Tang, L Quimson, X. Pan, A. Motre, R. Kong, J. Hong, N.S. Miller, M. D. Poulter, D. Kohn, V.A. Cope, H. Kong, Y-W Tang, B. Yen-Lieberman.  A rapid and simple isothermal nucleic acid amplification test for detection of herpes simplex virus types 1 and 2.  Journal of Clinical Virology 2011; 50:26–30. PMID20947417. NIHMS245872.
  • Holtzman C, D. Whitney, T. Barlam, N.S. Miller.  Assessment of the impact of PNA FISH for rapid identification of coagulase-negative staphylococci in the absence of antimicrobial stewardship intervention. Journal of Clinical Microbiology 2011; 49(4): 1581–1582. PMID21270213, PMCID: PMC3122789.
  • Miller, N.S., D. Rogan, B.L. Orr, D. Whitney.  Comparison of BD Bactec Plus blood culture media to VersaTREK Redox blood culture media for detection of bacterial pathogens in simulated adult blood cultures containing therapeutic concentrations of antibiotics. Journal of Clinical Microbiology 2011; 49(4):1624-7. PMID: 21307220, PMCID: PMC3122859.
  • Miller N.S., C. Nader, J. Barinaga, J. Zarin. Unsuspected infection with Listeria monocytogenes infection in a prosthetic knee joint. Clinical Microbiology Newsletter. 2011 (April 15); 33(8): 60-62.
  • Miller, N.S., B. Yen-Lieberman, M.D. Poulter, Y-W.Tang, P.A. Granato. Comparative clinical evaluation of the IsoAmp® HSV assay with ELVIS® HSV culture/ID/typing test system for the detection of herpes simplex virus in genital and oral lesions. Journal of Clinical Virology. 2012; 54: 355-358. PMID pending.