Archive mid 2011

Professor George O’Connor and colleagues report in Nature Genetics the results of a major international collaboration identifying genetic loci associated with pulmonary function, analyzing results from nearly 50,000 individuals to implicate 16 gene regions as potential modifiers of lung disease.
 
Professor Wellington Cardoso and colleagues report in Development that the transcription factor Notch prevents cells in the airway from becoming goblet cells which secrete mucus, identifying a signaling pathway which may contribute to the pathophysiology of COPD, asthma, and other chronic lung diseases.
 
Assistant Professor Renda Wiener and colleagues report in the Annals of Internal Medicine that transthoracic needle lung biopsy confers considerable risks of pneumothorax and chest tube placement, of especial significance since CT chest screening is anticipated to increase demand for such biopsies.
 
Several PhD students have recently accomplished the critical milestone of thesis defense, including Dan Green (mentored by Bill Cruikshank), Constantina Christodoulou (mentored by Darrell Kotton), and Matt Blahna (mentored by Jay Mizgerd). Congratulations to the new doctors!