News & Spotlights

Collaborative paper (Pulmonary Center, CReM, and NEIDL) on novel model for SARS-CoV-2 infection

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to access these cells from patients, particularly at... More

New Publication from Bosmann Lab

Bacterial polyphosphates interfere with the innate host defense to infection Polyphosphates are linear polymers of inorganic phosphate residues that are ubiquitous in living organisms. The recent publication from Dr. Bosmann and colleagues in Nature Communications highlights that long polyphosphates from bacteria are mediators of death in sepsis. Bacterial polyphosphates interfere with... More

Pulmonary Center Blog

What makes you smile?   Lindsey Stein Administrative Assistant/ Blog Editor   5/1/2020 Mrs. Hughes (aka Katie Steiling) A Splash of Sunshine Joe and I planned to get married in a small ceremony in Boston Public Garden on August 15th. More recently we decided: why wait. We were married on Tuesday, April 28th on the front steps of... More

Celebrating Dr. Jerry Brody

This year, we kick off fund-raising efforts for the Jerry Brody Endowment. The largest and most significant endowment for the Pulmonary Center will be named for Dr. Brody, who helped establish the Pulmonary Center at BUSM, was its longest serving Director, and built it into the world-leading research and training... More

Jacob and Kotton Publish Tools for Making Lung Epithelial Cells

  Jacob, Kotton, and colleagues have developed a method for producing self-renewing lung alveolar epithelial cells from any patient. Their protocol, published in the December 2019 issue of Nature Protocols follows on their recent Cell Stem Cell publication (Jacob et al. Cell Stem Cell, 2017) where the team was able to... More

Trainee Successes in Securing Funding

Several Pulmonary Center trainees got great news from the NIH on recent grant applications, including:   Pulmonary Fellow Nicholas Bosch, M.D. Nick will be receiving an F32 award from the NIGMS titled "Normalizing vasopressor dose to standardize vasopressors practice in septic shock." This award will allow him, under the mentorship of Dr. Allan... More

Yang Jin new J Exp Med paper

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are complex syndromes with three overlapping phases characterized by the reduction of pulmonary compliance, disruption of the epithelial and endothelial barrier, and recruitment of inflammatory cells into the alveoli. However, how lung cells communicate with each other remains unclear. This work uncovers... More

Jay Mizgerd R01 renewal

Congratulations to Professor Jay Mizgerd for renewing his R01 award from the NIH titled "Lung-resident antibacterial heterotypic immunity." The new award is for 5  years, through June 2024, and will be used to discover mechanisms that localize and instruct the memory T cells in the lung tissue that provide effective protection... More

Filiz Korkmaz New F32

Dr. Korkmaz, can you please tell us about the new award you received? My work studying the acute response to lower respiratory infection was recently funded as an F32 postdoctoral fellowship by the National Heart, Lung and Blood Institute at the NIH. This provides me the opportunity to delve into the... More