News & Spotlights

Actionable Lung Cell Responses to SARS-CoV-2 Infection

      Teams from Pulmonary Center Faculty members Andrew Wilson and Darrell Kotton (and collaborators) recently published exciting new findings about how alveolar epithelial type 2 cells respond to SARS-CoV-2 infection!     "Briefly, we found that there are changes to cellular proteins (the proteome and phosphoproteome) that occur as soon as 1 hour after... More

COVID-19 study spanning 275 hospitals and 23 countries

Dr. Walkey is co-Principal Investigator for the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study. This study, funded in part by the Gordon and Betty Moore Foundation, created an international registry that supplies de-identified clinical data from more than 40,000 patients at 275 hospitals in... More

Past infections with other coronaviruses influence COVID-19

Endemic coronaviruses have been causing human infections for many years, long before the recent emergence of SARS-CoV-2 which causes COVID-19. Jay Mizgerd and Manish Sagar (from the Section of Infectious Diseases) hypothesized that infections with endemic coronavirus, which are molecularly similar to SARS-CoV-2, might elicit cross-reactive immunity that influences what... More

Faculty Promotions

We are very proud to announce that in the past few months we've had several Faculty Promotions! These individuals have proved themselves as dedicated scientists, mentors, and colleagues, and because of this, they have all been promoted from Associate Professors to the rank of Professor. Congratulations to our esteemed faculty!   Renda... More

Collaborative paper (Pulmonary Center, CReM, and NEIDL) on novel model for SARS-CoV-2 infection

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to access these cells from patients, particularly at... More

New Publication from Bosmann Lab

Bacterial polyphosphates interfere with the innate host defense to infection Polyphosphates are linear polymers of inorganic phosphate residues that are ubiquitous in living organisms. The recent publication from Dr. Bosmann and colleagues in Nature Communications highlights that long polyphosphates from bacteria are mediators of death in sepsis. Bacterial polyphosphates interfere with... More

Pulmonary Center Blog

What makes you smile?   Lindsey Stein Administrative Assistant/ Blog Editor   5/1/2020 Mrs. Hughes (aka Katie Steiling) A Splash of Sunshine Joe and I planned to get married in a small ceremony in Boston Public Garden on August 15th. More recently we decided: why wait. We were married on Tuesday, April 28th on the front steps of... More

Celebrating Dr. Jerry Brody

This year, we kick off fund-raising efforts for the Jerry Brody Endowment. The largest and most significant endowment for the Pulmonary Center will be named for Dr. Brody, who helped establish the Pulmonary Center at BUSM, was its longest serving Director, and built it into the world-leading research and training... More

Jacob and Kotton Publish Tools for Making Lung Epithelial Cells

  Jacob, Kotton, and colleagues have developed a method for producing self-renewing lung alveolar epithelial cells from any patient. Their protocol, published in the December 2019 issue of Nature Protocols follows on their recent Cell Stem Cell publication (Jacob et al. Cell Stem Cell, 2017) where the team was able to... More

Trainee Successes in Securing Funding

Several Pulmonary Center trainees got great news from the NIH on recent grant applications, including:   Pulmonary Fellow Nicholas Bosch, M.D. Nick will be receiving an F32 award from the NIGMS titled "Normalizing vasopressor dose to standardize vasopressors practice in septic shock." This award will allow him, under the mentorship of Dr. Allan... More