Darrell N. Kotton, M.D.

Professor of Medicine and Pathology
Director, Center for Regenerative Medicine (CReM)

Medical School: Washington University School of Medicine
Internship: University of Pennsylvania
Residency: University of Pennsylvania
Fellowship: Boston University
Post-Doctoral Research Fellowship: Harvard Medical School

Board Certifications:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine

Special Interests:

Research:

Stem cells, lung regeneration, and lung development

For more information visit the Kotton lab website: www.kottonlab.com

 

 

Clinical:

Alpha-1 antitrypsin deficiency  ( http://www.bu.edu/alpha-1/ )

General Pulmonary Medicine

Critical Care Medicine

Dr. Kotton is a Professor in the Department of Medicine and in the Department of Pathology and Laboratory Medicine. He attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center.

Dr. Kotton’s research focuses on stem cell biology and gene therapy related to lung injury and repair.  Dr. Kotton’s laboratory currently utilizes several stem cell populations, including embryonic stem cells and induced pluripotent stem (iPS) cells in order to develop novel stem cell-based therapies for lung disease. In addition, Dr. Kotton specializes in the genetic manipulation of stem cells as well as resident lung cells using lentiviral vectors. Projects in his lab are currently focused on utilizing these novel vectors for the study of alpha-1 anti-trypsin deficiency, COPD, Cystic Fibrosis, childhood interstitial lung disease (ChILD), pulmonary vascular disease, and lung inflammatory pathways.

In 2009 Dr Kotton and Dr. Gustavo Mostoslavsky became Co-Directors of a campus-wide research initiative, the Boston University Center for Regenerative Medicine (CReM), bringing together several research groups on campus focused on various aspects of stem cell biology and regenerative medicine. For more information, please visit the CReM website. Dr. Kotton also Co-Directs the Alpha-1 Center, along with Dr. Andrew Wilson. This Center, founded in 2012 is dedicated to advancing clinical care and research focused on individuals and families with inherited alpha-1 antitrypsin deficiency.

For more detailed information on Dr. Kotton’s research, see the Kotton Lab website.

Selected Publications:

  1. Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G. “iPS Cell Generation Using a Single Lentiviral Stem Cell Cassette.” Stem Cells. Dec 18, 2008
  2. Cardoso, W.V. and Kotton, DN, “Specification and patterning of the respiratory system”, StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.10.1, http://www.stembook.org. July 2008
  3. Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN. “Sustained Expression of a1-antitrypsin After Transplantation of Manipulated Hematopoietic Stem Cells”. Am J Respir Cell Mol Biol. 39(2):133-41. Aug 2008.
  4. Kotton DN, Fine A. “Lung Stem Cells.” Cell & Tissue Research. Sept 2007 [epub ahead of print]. Click here to download the PDF.

Selected Reprints:

  1. Exogenous Control of Mammalian Gene Expression via Modification of Translational Termination
  2. Failure of Bone Marrow to Reconstitute Lung Epithelium
  3. Anovel stem-cell population in adult liver with potent hematopoietic-reconstitution activity
  4. Efficiency of Transduction of Highly Purified Murine Hematopoietic Stem Cells by Lentiviral and Oncoretroviral Vectors Under Conditions of Minimal in Vitro Manipulation
  5. Lung stem cells: New paradigms
  6. Stem cell antigen-1 expression in the pulmonary vascular endothelium
  7. Bone marrow-derived cells as progenitors of lung alveolar epithelium

Links: