Darrell N. Kotton, M.D.

Professor of Medicine and Pathology
Director, Center for Regenerative Medicine (CReM)

Medical School: Washington University School of Medicine
Internship: University of Pennsylvania
Residency: University of Pennsylvania
Fellowship: Boston University
Post-Doctoral Research Fellowship: Harvard Medical School

Board Certifications:

  • Internal Medicine
  • Pulmonary Medicine
  • Critical Care Medicine

Special Interests:

Research:

Stem cells, lung regeneration, and lung development

For more information visit the Kotton lab website: www.kottonlab.com

Clinical:

Alpha-1 antitrypsin deficiency

General Pulmonary Medicine

Critical Care Medicine

Dr. Kotton is a Professor in the Department of Medicine and in the Department of Pathology and Laboratory Medicine. He attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center.

Dr. Kotton’s research focuses on stem cell biology and gene therapy related to lung injury and repair. Dr. Kotton’s laboratory currently utilizes several stem cell populations, including embryonic stem cells and induced pluripotent stem (iPS) cells in order to develop novel stem cell-based therapies for lung disease. In addition, Dr. Kotton specializes in the genetic manipulation of stem cells as well as resident lung cells using lentiviral vectors. Projects in his lab are currently focused on utilizing these novel vectors for the study of alpha-1 anti-trypsin deficiency, COPD, Cystic Fibrosis, childhood interstitial lung disease (ChILD), pulmonary vascular disease, and lung inflammatory pathways.

In 2009 Dr Kotton and Dr. Gustavo Mostoslavsky became Co-Directors of a campus-wide research initiative, the Boston University Center for Regenerative Medicine (CReM), bringing together several research groups on campus focused on various aspects of stem cell biology and regenerative medicine. For more information, please visit the CReM website. Dr. Kotton also Co-Directs the Alpha-1 Center, along with Dr. Andrew Wilson. This Center, founded in 2012 is dedicated to advancing clinical care and research focused on individuals and families with inherited alpha-1 antitrypsin deficiency.

For more detailed information on Dr. Kotton’s research, see the Kotton Lab website.

Selected Publications:

For a comprehensive Pubmed listing of our publications, please click here.

  1. Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages.
    Wilson AA, Kwok LW, Porter EL, Payne JG, McElroy GS, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN.
    Mol Ther. 2013 Apr;21(4):825-33. doi: 10.1038/mt.2013.19. Epub 2013 Feb 12. PMID: 23403494
  2. The 2012 Nobel Prize in physiology or medicine: democratizing pluripotency for lung researchers. 
    Kotton DN. Am J Respir Crit Care Med. 2012 Dec 1;186(11):1080-1. PMID: 23204376
  3. Next-generation regeneration: the hope and hype of lung stem cell research. Kotton DN.
    Am J Respir Crit Care Med. 2012 Jun 15;185(12):1255-60. PMID: 22517787
  4. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells.
    Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Cell Stem Cell. 2012 Apr 6;10(4):398-411. PMID: 22482505
  5. Case records of the Massachusetts General Hospital. Case 2-2012. A 63-year-old woman with dyspnea and rapidly progressive respiratory failure. 
    Kotton DN, Muse VV, Nishino M. N Engl J Med. 2012 Jan 19;366(3):259-69. PMID: 22256809
  6. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.
    Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN.
    J Clin Invest. 2011 Jun;121(6):2313-25. doi: 10.1172/JCI43853. Epub 2011 May 2. PMID: 21537085
  7. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.
    Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN. Stem Cells. 2010 Oct;28(10):1728-40. PMID: 20715179
  8. Regeneration and orthotopic transplantation of a bioartificial lung.
    Ott HC, Clippinger B, Conrad C, Schuetz C, Pomerantseva I, Ikonomou L, Kotton D, Vacanti JP.
    Nat Med. 2010 Aug;16(8):927-33. doi: 10.1038/nm.2193. Epub 2010 Jul 13. PMID: 20628374
  9. Specification and patterning of the respiratory system. Cardoso WV, Kotton DNStemBook. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2008 Jul 16.PMID: 20614584
  10. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.
    Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN.
    J Clin Invest. 2010 Jan;120(1):379-89. doi: 10.1172/JCI36666. Epub 2009 Dec 21. PMID: 20038801

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