New Publication from Bosmann Lab

Bacterial polyphosphates interfere with the innate host defense to infection Polyphosphates are linear polymers of inorganic phosphate residues that are ubiquitous in living organisms. The recent publication from Dr. Bosmann and colleagues in Nature Communications highlights that long polyphosphates from bacteria are mediators of death in sepsis. Bacterial polyphosphates interfere with multiple functions of macrophages. […]

Jacob and Kotton Publish Tools for Making Lung Epithelial Cells

  Jacob, Kotton, and colleagues have developed a method for producing self-renewing lung alveolar epithelial cells from any patient. Their protocol, published in the December 2019 issue of Nature Protocols follows on their recent Cell Stem Cell publication (Jacob et al. Cell Stem Cell, 2017) where the team was able to reprogram patient blood specimens […]

Trainee Successes in Securing Funding

Several Pulmonary Center trainees got great news from the NIH on recent grant applications, including:   Pulmonary Fellow Nicholas Bosch, M.D. Nick will be receiving an F32 award from the NIGMS titled “Normalizing vasopressor dose to standardize vasopressors practice in septic shock.” This award will allow him, under the mentorship of Dr. Allan Walkey, to […]

Yang Jin new J Exp Med paper

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are complex syndromes with three overlapping phases characterized by the reduction of pulmonary compliance, disruption of the epithelial and endothelial barrier, and recruitment of inflammatory cells into the alveoli. However, how lung cells communicate with each other remains unclear. This work uncovers a novel mechanism and […]

Jay Mizgerd R01 renewal

Congratulations to Professor Jay Mizgerd for renewing his R01 award from the NIH titled “Lung-resident antibacterial heterotypic immunity.” The new award is for 5  years, through June 2024, and will be used to discover mechanisms that localize and instruct the memory T cells in the lung tissue that provide effective protection against pneumonia.

Filiz Korkmaz New F32

Dr. Korkmaz, can you please tell us about the new award you received? My work studying the acute response to lower respiratory infection was recently funded as an F32 postdoctoral fellowship by the National Heart, Lung and Blood Institute at the NIH. This provides me the opportunity to delve into the previously unknown role of […]

PJ Maglione New Paper

This work demonstrated that B cells, which typically protect us against infection, function abnormally and promote interstitial lung disease in patients with common variable immunodeficiency (CVID). CVID is a primary immunodeficiency, a type of disorder where individuals have an immune system that does not function properly – causing infections and, for reasons not understood, also […]

Emad Arafa New F31

Congratulations to PhD student Emad Arafa in Professor Jay Mizgerd’s group for receiving an F31 award from the NIH on “Pneumonia and alveolar macrophage resilience”

Meet our newest faculty member, Dr. PJ Maglione

On February 1, 2019, Paul J. (PJ) Maglione, MD, PhD, joined the Pulmonary Center as Assistant Professor in the Section of Pulmonary, Allergy, Critical Care and Sleep Medicine What is your educational background? I attended elementary through high school in the Hudson Valley of New York near Peekskill, about a 45 minute train ride from Manhattan. […]