Cognitive resilience to Alzheimer’s disease characterized by cell-type abundance
Abstract Introduction: The molecular basis of cognitive resilience (CR) among pathologically confirmed Alzheimer’s disease (AD) cases is not well understood. Methods: Abundance of 13 cell types and neuronal subtypes in brain bulk RNA-seq data from the anterior caudate, dorsolateral prefrontal cortex (DLPFC), and posterior cingulate cortex (PCC) obtained from 434 AD cases, 318 cognitively resilient AD cases, […]