Framingham Heart Study Brain Aging Program to Host Clinical Neuropathology Case Conference
The Framingham Heart Study Brain Aging Program will host its upcoming Clinical Neuropathology Case Conference on April 10, 2026, from 10:00 AM to 12:00 PM.
This interactive session, organize
d by the program’s Clinical and Neuropathology Cores, will feature four compelling cases highlighting clinical history, neuroimaging, and neuropathological findings. Each case will explore the alignment—and at times discrepancy—between clinical diagnoses and neuropathological outcomes, fostering discussion aimed at improving diagnostic accuracy.
These conferences play a vital role in strengthening collaboration between clinical and neuropathology teams, ultimately contributing to more precise assessment methods and advancing future treatments in brain aging and neurodegenerative disease.
The event will be held virtually. Registration is required.
https://bu-hipaa.zoom.us/webinar/register/WN_6WHzlVaCRTKns67a9Sv-EQ#/registration
Plasma p-tau181 shows stronger network association to Alzheimer’s disease dementia than neurofilament light and total tau
Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari T, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Turk KW, Budson AE, O’Connor MK, Au R, Goldstein LE, Jun GR, Kowall NW, Stein TD, McKee AC, Killiany R, Qiu WQ, Stern RA, Mez J, Alosco ML. Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau. Alzheimer Dement 2022; 98:e2454-e2464.
A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images
Greve DN, Billot B, Cordero D, Hoopes A, Hoffmann M, Dalca AV, Fischl B, Iglesias JE, Augustinack JC. A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images. Neuroimage. 2021 Dec 1;244:118610.
An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test
Amini S, Zhang L, Hao B, Gupta A, Song M, Karjadi C, Lin H, Kolachalama VB, Au R, Paschalidis IC. An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test. J Alzheimers Dis. 2021;83(2):581-589.
Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease
Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 Oct;26(10):6054-6064.
Detection of dementia on voice recordings using deep learning: a Framingham Heart Study
Xue C, Karjadi C, Paschalidis IC, Au R, Kolachalama VB. Detection of dementia on voice recordings using deep learning: a Framingham Heart Study. Alzheimers Res Ther. 2021 Aug 31;13(1):146.
Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy
Cherry JD, Agus F, Dixon E, Huber B, Alvarez VE, Mez J, McKee AC, Labadorf A, Stein TD. Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free Neuropathol. 2021;2:3453.
Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort
Zhang L, Ngo A, Thomas JA, Burkhardt HA, Parsey CM, Au R, Ghomi RH. Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort. Explor Med. 2021;2:232-252.
1st Annual Symposium on Cognitive Resilience Reserve and Resistance
April 9, 2021
Sponsored by BU Alzheimer's Disease Center, BU Evans Center for Interdisciplinary Biomedical Research, American Heart Association, and the Framingham Heart Study Brain Aging Program.
NIH Grant Will Establish New Framingham Heart Study Brain Aging Program
Since 1976, the Framingham Heart Study (FHS)–the longest running multi-generational epidemiological study in the world–has followed participants for incident dementia.
Thanks to a five-year, $26.56 million grant from the National Institutes of Health, a new program called the Framingham Heart Study Brain Aging Program (FHS-BAP) will continue the surveillance and evaluation of FHS participants for dementia (including cognitive assessments and brain imaging) and invigorate the FHS brain donation program and brain bank. The program will also establish a platform to promote data sharing that will accelerate AD research using FHS data and conduct three interrelated projects using FHS data and specimen resources.
Rhoda Au Receives $2.8M Award from AHA, Bill Gates
The American Heart Association — the world’s leading voluntary organization dedicated to a world of longer, healthier lives — and global philanthropist and technology visionary Bill Gates, have committed to advancing the scientific evidence base related to brain health and dementia by funding a $3.3 million health technology research joint initiative. The project will specifically fund a new brain health and dementia technology research center at Boston University. Additionally, it will support the global exchange of research data to help scientists around the world collectively work in accelerating new discoveries related to heart and brain health, including the early detection and treatment of Alzheimer’s disease and related dementias.