Publications
Welcome to the publications page of the Framingham Heart Study Brain Aging Program (FHS-BAP), where we showcase the groundbreaking research driving advancements in Alzheimer’s Disease (AD) understanding. Our program is committed to revolutionizing AD research through a comprehensive approach that integrates surveillance, discovery, and collaboration. Here, you will find our latest publications, which reflect our work in enhancing cognitive decline assessments, brain imaging techniques, and the revitalization of our brain donation program. These publications highlight key findings in genetic factors, risk markers, and biomarkers related to AD, all aimed at fostering a global research community and accelerating the identification of therapeutic targets. Explore our research to learn more about our mission to uncover the biological foundations of AD and contribute to the preservation of cognitive health.
Plasma p-tau181 shows stronger network association to Alzheimer’s disease dementia than neurofilament light and total tau
Frank B, Ally M, Brekke B, Zetterberg H, Blennow K, Sugarman MA, Ashton NJ, Karikari T, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Turk KW, Budson AE, O’Connor MK, Au R, Goldstein LE, Jun GR, Kowall NW, Stein TD, McKee AC, Killiany R, Qiu WQ, Stern RA, More
A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images
Greve DN, Billot B, Cordero D, Hoopes A, Hoffmann M, Dalca AV, Fischl B, Iglesias JE, Augustinack JC. A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images. Neuroimage. 2021 Dec 1;244:118610. Read More
An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test
Amini S, Zhang L, Hao B, Gupta A, Song M, Karjadi C, Lin H, Kolachalama VB, Au R, Paschalidis IC. An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test. J Alzheimers Dis. 2021;83(2):581-589. Read More
Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease
Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 Oct;26(10):6054-6064. Read More
Detection of dementia on voice recordings using deep learning: a Framingham Heart Study
Xue C, Karjadi C, Paschalidis IC, Au R, Kolachalama VB. Detection of dementia on voice recordings using deep learning: a Framingham Heart Study. Alzheimers Res Ther. 2021 Aug 31;13(1):146. Read More