Publications
Welcome to the publications page of the Framingham Heart Study Brain Aging Program (FHS-BAP), where we showcase the groundbreaking research driving advancements in Alzheimer’s Disease (AD) understanding. Our program is committed to revolutionizing AD research through a comprehensive approach that integrates surveillance, discovery, and collaboration. Here, you will find our latest publications, which reflect our work in enhancing cognitive decline assessments, brain imaging techniques, and the revitalization of our brain donation program. These publications highlight key findings in genetic factors, risk markers, and biomarkers related to AD, all aimed at fostering a global research community and accelerating the identification of therapeutic targets. Explore our research to learn more about our mission to uncover the biological foundations of AD and contribute to the preservation of cognitive health.
Midlife lipid and glucose levels are associated with Alzheimer’s disease
Zhang X, Tong T, Chang A, Ang TFA, Tao Q, Auerbach S, Devine S, Qiu WQ, Mez J, Massaro J, Lunetta KL, Au R, Farrer LA. Midlife measures of high-density lipoprotein and fasting glucose are associated with late-onset Alzheimer disease. Alzheimer Dement. 2023; 19:181-193. Read More
A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease
Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid- cerebrospinal fluid... More
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer’s disease
Jun GR, Zhu C, Chung J, Panitch R, Hu J, The Alzheimer’s Disease Genetics Consortium, Foroud TM, Wang L-S, Ertekin-Taner N, Bennett DA, Haines JL, Mayeux RP, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A, complement component 4, and APOE genotype linked to... More
Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease
Panitch R, Hu J, Xia W, Bennett DA, Stein TD, Farrer LA, Jun GR. Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease. Alzheimers Res Ther. 2022; 14(1):30. Read More
Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer’s disease
Stathas S, Alvarez VE, Xia W, Nicks R, Meng G, Daley S, Pothast M, Shah A, Kelley H, Esnault C, McCormack R, Dixon E, Fishbein L, Cherry JD, Huber BR, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. Tau phosphorylation sites serine202 and serine396 are differently altered in... More