Nutrition and Metabolism Research

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Caroline Apovian, M.D., Director of the Center for Nutrition and Weight Management, and Professor of Medicine, has been engaged in clinical studies related to various dietary and drug effects on weight reduction. These studies include weight loss in subjects on a VLCD and sibutramine versus placebo; a prospective study of risk factors for heart disease in subjects pre- and post-gastric bypass surgery; an investigation of an MCT oil-based liquid diet and the effects on weight loss; endothelial function in obese subjects on a weight-loss program; hypocaloric-hyperprotein enteral nutrition versus relative normocaloric enteral nutrition in critically ill medical patients; interventions to enhance adherence to obesity guidelines by providing four-hour workshops on obesity treatment to primary care physicians with patient chart follow-up; and a randomized, controlled study to examine the relationship between changes in plasma GIP levels and other gastrointestinal peptides following gastric bypass surgery in obese patients.  You can find more information for Caroline Apovian, M.D. at or please visit her Facebook Page.

Bench research being done by Nawfal Istfan, M.D., Ph.D., Associate Professor of Medicine, in his National Institutes of Health (NIH)-funded laboratory focuses on the mechanisms of S-phase prolongation by fish oil. His main objective is to test the hypothesis that omega-3 fatty acids alter the nuclear structure of mammalian cells in a manner that lengthens DNA replication time. The proposed mechanism involves the complex process of organization of replication foci at specific DNA sites.

Also in the Center for Nutrition and Weight Management, Thomas Moore, M.D., Professor of Medicine, is testing a web-based nutrition (the DASH diet) and exercise education program, offered to the employees of EMC Corp.