Zhe Wang

Ph.D. Candidate, Bioinformatics, BUSMWang+Zhe+CBM
Campbell Lab

Education

B.Sc.(Agr.) Animal Science, Southwest University Rongchang Campus, Chongqing, China, 2013
M.S. Biochemistry and Molecular Biology, Wuhan University, Wuhan, China, 2016

Contact Information

Email: zhe@bu.edu

Research Interests

Lung Cancer Transcriptomics using Single Cell RNA Sequencing

Single cell RNA-sequencing (sc-RNA-seq) is a next generation sequencing technology that examine RNA sequence from individual cells. The goal of this project is to characterize the systematic and genome-wide response of patient airway tissue cells to smoking related lung cancer using sc-RNA-seq technology.

Multi-modal Clustering of CITE-seq Data

Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) is a single-cell sequencing technology with simultaneous epitope and transcriptome measurement. This project includes the development of computational algorithms and procedures to identify distinct cell clusters in this new data type. The developed tools and methods will be applied to real-world datasets to characterize the immune and cancer subpopulations in prostate cancer.

Publications

Wang Z, Hu J, Johnson WE, Campbell JD. (2019) scruff: an R/Bioconductor package for preprocessing single-cell RNA-sequencing data. BMC Bioinformatics. 20(1):222.

Lent S, Xu H, Wang L, Wang Z, Sarnowski C, Hivert MF, and Dupuis J. (2018) Comparison of novel and existing methods for detecting differentially methylated regions. BMC Genet. 19(Suppl 1):84.

Wang, Z., Han, Q. Q., Zhou, M. T., Chen, X., and Guo, L. (2016) Protein turnover analysis in Salmonella Typhimurium during infection by dynamic SILAC, Topograph, and quantitative proteomics. J. Basic Microbiol. 56, 801-811

Yao, Q., Liu, B. Q., Li, H., McGarrigle, D., Xing, B. W., Zhou, M. T., Wang, Z., Zhang, J. J., Huang, X. Y., and Guo, L. (2014) C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2. J. Biol. Chem. 289, 12666-12678