Grant Duclos

Grant DuclosPh.D. Candidate, Molecular and Translational Medicine, BUSM
Spira-Lenburg Lab


B.S. Biology, Boston College, Chestnut Hill, MA, 2010

Contact Information


Research Interest

My research is focused on the use of single cell resolution transcriptomics to identify unique bronchial epithelial subpopulations present in the airways of lung cancer patients. This also involves the characterization of short- and long-term effects of cigarette smoking on epithelial subsets lining the airways of current and former smokers in an effort to understand cellular transitions occurring during smoking-associated disease pathogenesis.

Additional interests include understanding the long-term molecular consequences of cigarette smoking on airway epithelial differentiation and repair as well as the design and implementation of novel approaches to massively multiplexed low input RNA sequencing.


Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, Zhernakova A, Raychaudhuri S, Bowes J, Eyre S, Padyukov L, Gregersen PK, Worthington J; Rheumatoid Arthritis Consortium International (RACI), Gupta N, Clemons PA, Stahl E, Tolliday N, Plenge RM. Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. PLoS Genet. 2013 May;9(5):e1003487.

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O’Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1;187(9):933-42.

Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, Guzman R, Cai T, Gupta N, Gainer V, Schur P, Cui J, Denny JC, Szolovits P, Churchill S, Kohane I, Karlson EW, Plenge RM. Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. Arthritis Rheum. 2013 Mar;65(3):571-81