Gang Liu, Ph.D.


Research Assistant Professor of Medicine


B.S.,Department of Biology, Sichuan University, Chengdu, China, 1989
M.S., Department of Animal Sciences, University of Kentucky, Lexington, KY, 1995
Ph.D.,Department of Animal Sciences, University of Kentucky, Lexington, KY, 1999

Contact Information

Office: E634
Phone:  617-358-7257

Research Interests

Translational research in the area of lung diseases using genomic technologies, such as next generation sequencing, microarray analysis, etc.

Selected Publications

Spira, A., Beane, J., Shah, V., Liu, G., Schembri, F., Yang, X., Palma, J. and Brody, J.S. 2004. Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci 101(27): 10143-8.

Spira A., Beane, J., Pinto-Plata, V., Kadar, A, Liu, G., Shah, V., Celli, B. and Brody, J.S. 2004. Gene expression profiling of human lung tissue from smokers with severe emphysema. Am J Respir Cell Mol Biol. 31(6): 601-10.

Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. 2007. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 8(9): R201.

Spira, A., Beane, J., Shah, V., Steiling, K., Liu, G., Schembri, F., Gilman, S., Dumas, Y., Calner, P., Sebastiani, P., Sridhar, S., Beamis, J., Lamb, C., Anderson, T., Gerry, N., Keane, J., Lenburg, M.E. and Brody, J.S. 2007. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med 13(3): 361-6.

Zhang, X., Liu, G., Lenburg, M.E. and Spira, A. 2007. Comparison of smoking-induced gene expression on Affymetrix Exon and 3′-based expression arrays. Genome Inform. 18:247-57.

Sridhar, S., Schembri, F., Zeskind, J., Shah, V., Gustafson, A.M., Steiling, K., Liu, G., Dumas, Y.M., Zhang, X., Brody, J.S., Lenburg, M.E. and Spira, A. 2008. Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics. 9:259.

Schembri, F., Sridhar, S., Perdomo, C., Gustafson, A.M., Zhang, X., Ergun, A., Lu, J., Liu, G., Zhang, X., Bowers, J., Vaziri, C., Ott, K., Sensinger, K., Collins, J.J., Brody, J.S., Getts, R., Lenburg, M.E. and Spira, A. 2009. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci 106(7): 2319-24.

Zhang, X., Sebastiani, P., Liu, G., Schembri, F., Zhang, X., Dumas, Y.M., Langer, E.M., Alekseyev, Y., O’Connor, G.T., Brooks, D.R., Lenburg, M.E. and Spira, A. 2010. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol. Genomics 41(1): 1-8.

Gustafson, A.M., Soldi, R., Anderlind, C., Scholand, M.B., Qian, J., Zhang, X., Cooper, K., Walker, D., McWilliams, A., Liu, G., Szabo, E., Brody, J.S., Massion, P.P., Lenburg, M.E., Lam, S., Bild, A.H. and Spira, A. 2010. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci. Transl. Med. 2(26): 26ra25.

Wang, X., Chorley, B.N., Pittman, G.S., Kleeberger, S.R., Brothers, J. 2nd, Liu G., Spira, A. and Bell, D.A. 2010. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. PLoS One. 5(8):e11934.

Campbell. J.D., J.E. McDonough, J.E. Zeskind, D.V. Pechkovsky, C.-A. Brandsma, M. Suzuki, J.V. Gosselink, G. Liu, Y.O. Alekseyev, J. Xiao, X. Zhang, S. Hayashi, J.D. Cooper, W. Timens, D.S. Postma, D.A. Knight, M.E. Lenburg*, J.C. Hogg*, A. Spira*.  2012. The gene expression signature of emphysematous lung destruction in COPD is reversed by a potential novel therapeutic.  Genome Medicine.4(8):67.  * contributed equally

Beane J, Cheng L, Soldi R, Zhang X, Liu G, Anderlind C, Lenburg ME, Spira A, Bild A. SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. Cancer Res. Sept 2012.