Pharmacokinetic and Pharmacodynamic Simulators

The simulators on this page were built by the late Dr. Terrell T. Gibbs to help students gain a conceptual understanding of pharmacokinetics and pharmacodynamics.  Dr. Gibbs played a key role in the design and implementation of the curriculum for the Biomolecular Pharmacology Predoctoral Training Program at Boston University and guided innumerable PhD candidates.  He taught medical, dental, and master’s degree students at BUSM the principles of pharmacology and the actions of drugs affecting the peripheral and central nervous system.   Numerous medical students learned the principles of pharmacodynamics under his tutelage.

Pharmacokinetic simulators:

1..Multiple dose 1.1  This simulator is designed to allow students to experiment with effects dose and dosing interval as well as the effects of individual differences in total clearance and volume of distribution.  Simulation of Cp vs t for a multiple i.v. dosing regimen: effect of maintenance dose, Vd, Cltot, dosing interval (t), and number of doses.

2. Infusion kinetics 1.1  This simulator is designed to allow students to experiment with the effects of changing loading dose, infusion rate, duration as well as the effects of individual differences in total clearance and volume of distribution.  Simulation of Cp vs t for a continuous iv infusion: effect of infusion rate (ko), Vd, Cltot, infusion time (Tinf), and loading dose (L.D.).

Pharmacodynamic simulators:

1. ExploratoryTheorPham1.251 Simulator includes: a) Effects of uncompetitive inhibitor on agonist binding and response; b) Spare receptors and noncompetitive inhibition; c) Spare receptors and competitive inhibition; and d) Two-state models of receptor activation