Joyce Y. Wong, PhD


Associate Professor, Biomedical Engineering
Biomimetic Materials Engineering Laboratory
Cellular and Subcellular Mechanics Laboratory
Center for Nanoscience and Nanobiotechnology
Ph.D.,Materials Science and Engineering, Program in Polymer Science and Technology, Massachusetts Institute of Technology
S.B., Materials Science and Engineering, Massachusetts Institute of Technology
Phone: (617) 353-2374; Fax: (617) 353-6766
Office: ERB 520A

Office hours: By appointment

Research Interests

Biomaterials, tailoring cell-material interfaces for drug delivery
and tissue engineering applications; direct, quantitative measurement of
biological interactions.

Current Research

The Biomimetic Materials Engineering Laboratory is focused on the
development of biomaterials to probe how structure, material properties
and composition of the cell-biomaterial interface affect fundamental
cellular processes. Specifically, we are interested in developing
substrata with features that mimic physiological and pathophysiological
environments to study fundamental cellular processes at the
biointerface. Current research projects include tissue engineering of
small diameter blood vessels for bypass and intravascular pharmacology (e.g.
stents); development of targeted nano- and micro-particle contrast
agents for multi-modal (magnetic resonance, ultrasound, and optical)
detection of atherosclerotic and vulnerable plaque; and engineering
biomimetic systems to study restenosis and breast cancer.

Selected Recent Publications

Duncanson, W.J, K. Oum, J.R. Eisenbrey, R.O. Cleveland, M. A. Wheatley, J.Y. Wong “Targeted binding of PEG-lipid    modified polymer ultrasound contrast agents with tiered surface architecture” Biotechnology and Bioengineering. (accepted)

Isenberg, B.C.*, P.A. DiMilla*, M. Walker, S. Kim, and J. Y. Wong (*co-first authors) “Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength” Biophys. J. 97: 1313.  (2009)

Amstad, E., S. Zurcher, A. Mashaghi, J.Y. Wong, M. Textor, and E. Reimhult “Surface Functionalization of Single Superparamagnetic Iron Oxide Nanoparticles for Targeted Magnetic Resonance ImagingSmall. 5 (11): 1334-1342. (2009)

Williams, C., Y. Tsuda, B.C. Isenberg, M. Yamato, T. Shimizu, T. Okano, and J.Y. Wong “Aligned cell sheets grown on thermo-responsive substrates with micro-contact printed protein patterns” Advanced Materials. 21 (21): 2161-2164. (2009)

Williams, C.*, J. Liao*, E.M. Joyce, J.B. Leach, M.S. Sacks, and J.Y. Wong
(*co-first authors) “Changes in structural and mechanical properties in
decellularized arteries: Implications for vascular tissue engineering” Acta Biomaterialia. 5 (4): 993-1005.  (2008)

Jacot, J.G. and J.Y. Wong “Endothelial injury
induces vascular smooth muscle cell proliferation in highly localized
regions of a direct contact co-culture system” Cell Biochemistry and Biophysics. 52 (1): 37-46. (2008)

Isenberg, B.C., Tsuda, Y., Williams, C., Shimizu, T., Yamato, M., Okano, T. and Wong, J.Y. “A Thermoresponsive, Microtextured Substrate for Cell Sheet Engineering with Defined Structural Organization” Biomaterials. 29 (17): 2565-72. (2008)

Duncanson, W.J., Figa, M.A., Hallock, K., Zalipsky, S., Hamilton, J.A. and Wong, J.Y. “Targeted Binding of PLA Microparticles with Lipid-PEG-tethered Ligands” Biomaterials. 28: 4991-4999. (2007)

Koester, S., Leach, J.B., Pfohl, T., and Wong, J.Y. “Visualization of Flow-Aligned Type I Collagen Self-Assembly in Tunable pH-Gradients” Langmuir. 23: 357-359. (2007)

Gaudet, C., Marganski, W.A., Kim, S., Brown, C.T., Gunderia, V., Dembo, M. and Wong, J.Y. “Influence of Substratum Type I Collagen Concentration on Fibroblast Spreading, Motility and Contractility” Biophys. J. 85 (5): 3329-3335. (2003)