TIARA ARC Seminar

3D Footprints of Active and Latent Tuberculosis: Insights from Bench to Bedside
Dr. Adrie Steyn

Please note:

For those who are interested in arranging a one-on-one meeting with Dr. Steyn on Thursday, please contact Dr. Igor Kramnik directly at ikramnik@bu.edu.

Thursday, January 18, 2024

1:00pm-2:00pm EST

Crosstown 386 (third floor, need BU ID to enter)

Join via Zoom

https://bostonmedicalcenter.zoom.us/j/93318884767?pwd=KzRNQjNXak5jMVlzdEdlNUEvckVyQT09

Meeting ID: 933 1888 4767 | Passcode: tbig

Featuring: Dr. Adrie Steyn

3D Footprints of Active and Latent Tuberculosis: Insights from Bench to Bedside

Dr. Steyn is a Professor of Microbiology, at the University of Alabama (UAB), Birmingham, USA and an Investigator at the Africa Health Research Institute (AHRI) in Durban, South Africa. He leads two laboratories in the US and SA that work at the front edge of basic and translational TB research. His basic science training in yeast genetics and molecular biology was instrumental in the development of novel methods for studying mycobacterial genetics. He made seminal contributions to the current understanding of the roles the redox state of the bacterial and host cells in regulation of TB pathogenesis. More recently, he became interested in translational research leveraging his appointment at the Africa Health Research Institute in South Africa, where he has developed and used high resolution multi-modal imaging to characterize mechanisms of pulmonary TB in human patients. He also studies TB in the context of HIV co-infection. If you are not interested in either of those, you will surely enjoy his engaging presentation, amiable disposition, and humor.

Below are the papers relevant to his upcoming seminar suggested for students (out of about 150 papers):

1. Wells G, Glasgow JN, Nargan K, Lumamba K, Madansein R, Maharaj K, Hunter RL, Naidoo T, Coetzer L, le Roux S, du Plessis A, Steyn AJC. Micro-Computed Tomography Analysis of the Human Tuberculous Lung Reveals Remarkable Heterogeneity in Three-dimensional Granuloma Morphology. Am J Respir Crit Care Med. 2021 Sep 1;204(5):583-595. doi: 10.1164/rccm.202101-0032OC. PubMed PMID: 34015247; PubMed Central PMCID: PMC8491258.

2. Wells G, Glasgow JN, Nargan K, Lumamba K, Madansein R, Maharaj K, Perumal LY, Matthew M, Hunter RL, Pacl H, Peabody Lever JE, Stanford DD, Singh SP, Bajpai P, Manne U, Benson PV, Rowe SM, le Roux S, Sigal A, Tshibalanganda M, Wells C, du Plessis A, Msimang M, Naidoo T, Steyn AJC. A high-resolution 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions. EMBO Mol Med. 2022 Nov 8;14(11):e16283. doi: 10.15252/emmm.202216283. Epub 2022 Oct 26. PubMed PMID: 36285507; PubMed Central PMCID: PMC9641421.

Nargan K, Naidoo T, Msimang M, Nadeem S, Wells G, Hunter RL, Hutton A, Lumamba K, Glasgow JN, Benson PV, Steyn AJ. Detection of Mycobacterium tuberculosis in human tissue via RNA in situ hybridization. bioRxiv. 2023 Oct 5:2023.10.04.560963. doi: 10.1101/2023.10.04.560963. Preprint. PMID: 37873458 Free PMC article.