Publications

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Sweigart B, Andersen SL, Gurinovich A, Cosentino S, Schupf N, Perls TT, Sebastiani P. APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age. J Alzheimers Dis. 2021 Aug 4. doi: 10.3233/JAD-201205

Andersen SL, Du M, Cosentino S, Schupf N, Rosso AL, Perls TT, Sebastiani P; Long Life Family Study. Slower Decline in Processing Speed Is Associated with Familial Longevity. Gerontology. 2021 May 4:1-13. doi: 10.1159/000514950. Epub ahead of print. PMID: 33946077.

Renner SW, Qiao Y, Gmelin T, Santanasto AJ, Boudreau RM, Walston JD, Perls TT, Christensen K, Newman AB, Glynn NW; LLFS Research Group. Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study. Aging Clin Exp Res. 2021 Jul 1. doi: 10.1007/s40520-021-01923-x. Epub ahead of print. PMID: 34196949.

Wojczynski MK, Lin SJ, Sebastiani P, Perls TT, Lee J, Kulminski A, Newman A, Zmuda JM, Christensen K, Province MA. NIA Long Life Family Study: Objectives, Design, and Heritability of Cross Sectional and Longitudinal Phenotypes. J Gerontol A Biol Sci Med Sci. 2021 doi: 10.1093/gerona/glab333. Epub ahead of print. PMID: 34739053.

Gunn S, Wainberg M, Song Z, Andersen S, Boudreau R, Feitosa MF, Tan Q, Montasser ME, O’Connell JR, Stitziel N, Price N, Perls T, Schork NJ, Sebastiani P. Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring. Geroscience. 2022 Apr;44(2):719-729. doi: 10.1007/s11357-022-00518-2. Epub 2022 Feb 4. PMID: 35119614; PMCID: PMC9135909.

Du M, Andersen SL, Cosentino S, Boudreau RM, Perls TT, Sebastiani P. Digitally generated Trail Making Test data: Analysis using hidden Markov modeling. Alzheimers Dement (Amst). 2022 Mar 8;14(1):e12292. doi: 10.1002/dad2.12292. PMID: 35280964; PMCID: PMC8902814.

Barral S, Andersen SL, Perls TT, Bae H, Sebastiani P, Christensen K, Thyagarajan B, Lee J, Schupf N. Association between late maternal age and age-related endophenotypes in the Long Life Family Study. Neurosci Lett. 2022 Jul 27;784:136737. doi: 10.1016/j.neulet.2022.136737. Epub 2022 Jun 13. PMID: 35709880.

Gurinovich A, Li M, Leshchyk A, Bae H, Song Z, Arbeev KG, Nygaard M, Feitosa MF, Perls TT, Sebastiani P. Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data. Front Genet. 2022 Sep 23;13:897210. doi: 10.3389/fgene.2022.897210. PMID: 36212134; PMCID: PMC9544087.

Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patti GJ, Perls TT. A metabolomic signature of the APOE2 allele. GeroScience. 2022 Aug 23. doi: 10.1007/s11357-022-00646-9. Epub ahead of print. PMID: 35997888.

Andersen Stacy L., Sweigart Benjamin, Glynn Nancy W., Wojczynski Mary K., Thyagarajan Bharate, Mengel-From Jonas, Thielke Stephen, Perls Thomas T., Libon David J.,  Au Rhoda, Cosentino Stephanie,  Sebastiani Paola. Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior. Journals of Alzheimer’s Disease. 2021;82(1):17-32.

Andersen S.L., Du M., Cosentino S., Schupf N., Rosso A.L., Perls T.T., Sebastiani P. Slower Decline in Processing Speed Is Associated with Familial Longevity. Gerontology. 2021.

Sebastiani P, Federico A, Morris M, Gurinovich A, Tanaka T, Chandler KB, Andersen SL, Denis G, Costello CE, Ferrucci L, Jennings L, Glass DJ, Monti S, Perls TT. Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. Aging Cell. 2021; 20(2):e13290.

Du, Mengtian et al. Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study. Journal of Alzheimer’s disease. 2021;79(1):117-125.

Xiang, Qingyan, Andersen SL, Perls TT, Sebastiani P. Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression. Frontiers in genetics. 2021; 11:606831

Perls, Thomas T. Cognitive Trajectories and Resilience in Centenarians-Findings From the 100-Plus Study.  JAMA network open. 2021; 4(1):e2032538.

Sebastiani P, Andersen SL, Sweigart B, Du M, Cosentino S, Thyagarajan B, Christensen K, Schupf N, Perls TT . Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. GeroScience. 2020; 42(5):1335-1350.

Lau-Ng R, Caruso LB, Perls TT. COVID-19 Deaths in Long-Term Care Facilities: A Critical Piece of the Pandemic Puzzle. Journal of the American Geriatric Society. 2020;10.1111/jgs.16669.

Feitosa MF, Lunetta KL, Wang L, Wojczynski MK, Kammerer CM, Perls T, Schupf N, Christensen K, Murabito JM, Province MA. Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. Atherosclerosis. 2020; 297:102-110.

Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls T, Andersen SL. Purpose in Life Among Centenarian Offspring. The Journals of Gerontology, Series B: Psychological and Social Sciences. 2020.

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT. A serum protein signature of APOE genotypes in centenarians. Aging Cell. 2019; 00:e13023.

Perls TT, Evans DS, Hadley E. The Longevity Consortium: Multi-Omics Integrative Approach to Discovering Healthy Aging and Longevity Determinants. Innovation in Aging. 2019;3(Suppl 1):S208.

Perls TT, Tan EJ. Healthy Longevity: An Introduction to the Special Issue. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2019; 74(Supplement_1):S1-S3.

Diallo H, Murabito J, Newman AB, Perls TT, Ives D, Honig L. Adjudication Pilot Study of Cause of Death in the Long Life Family Study. Innovation in Aging. 2019;3(Suppl 1):S926.

Tin A, Marten J, et al. Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics. 2019; 51(10):1459-1474.

Deelen J, Evans DS,  et al. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nature Communications. 2019; 10(1):3669.

Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB; Long Life Family Study. Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism. GeroScience. 2019; 41(4):383-393.

Sung YJ, de Las Fuentes L, et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics.  2019; 28(15):2615-2633.

Wuttke M, Li Y, et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics. 2019; 51(6):957-972.

Bae H, Lunetta KL, Murabito JM, Andersen SL, Schupf N, Perls T, Sebastiani P; Long Life Family Study. Genetic associations with age of menopause in familial longevity. Menopause. 2019; 26(10):1204-1212.

Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P. PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects. Bioinformatics. 2019; 35(17): 3046–3054.

Kraja AT, Liu C, et al. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits. American Journal of Human Genetics. 2019; 104(1):112-138.

Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.  The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018; 73(11): 1439-1447.

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018;73(11):1472-1481.

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018;74(1):44-51

Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT. Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018; 74(1):108-113.

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB. A novel healthy blood pressure phenotype in the Long Life Family Study. Journal of Hypertension. 2018; 36(1): 43-53.

Zeng, Y., Nie, C., Min, J., Chen, H., Liu, X., Ye, R., Chen, Z., Bai, C., Xie, E., Yin, Z., Lv, Y., Lu, J., Li, J., Ni, T., Bolund, L., Land, K., Yashin, A., O’Rand, A., Sun, L., Yang, Z., Tao, W., Gurinovich, A., Franceschi, C., Xie, J., Gu, J., Hou, Y., Liu, X., Xu, X., Robine, J., Deelen, J., Sebastiani, P., Slagboom, E., Perls, T., Hauser, E., Gottschalk, W., Tan, Q., Christensen, K., Shi, X., Lutz, M., Tian, X., Yang, H. and Vaupel, J. Sex Differences in Genetic Associations With Longevity.  Journal of the American Medical Association. 2018; 1(4).

Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N; Long Life Family Study. Telomere length is longer in women with late maternal age. Menopause. 2017; 24(5):497-501.

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell. 2017;16(2):329-338.

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.  The Journals of Gerontology, Series A: Biological and Medical Sciences. 2017; 72(11):1453-1464.

Perls TT. Male Centenarians: How and Why Are They Different from Their Female Counterparts? Journal of the American Geriatrics Society. 2017; 65(9): 1904-1906.

Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT. Limitations and risks of meta-analyses of longevity studies.   Mechanisms of Ageing and Development. 2017; 165(Pt B): 139-146.

Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. Assortative Mating by Ethnicity in Longevous Families.  Frontiers in Genetics. 2017; 8: 186.

Perls, TT. Testosterone Treatment in Older Men. New England Journal of Medicine. 2016; 375(1): 88.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study.  Journal of the American Geriatrics Society. 2016; 64(11): e189-e194.

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Familial Risk for Exceptional Longevity. North American Actuarial Journal. 2016; 20(1): 57-64.

Sebastiani P, Sun F, Andersen S, Black M, Perls T. Increasing sibling relative risk of survival to older and older ages and the importance of precise definitions of “aging”, “life span” and “longevity”.  The Journals of Gerontology, Series A: Biological Sciences. 2016; 71(3):340-6

Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the long life family study. Aging (Albany NY). 2015; 7(2):123-32.

Sebastiani P, Bae H, Sun FX, Andersen S, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A,  Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY) 2013; 5(9): 653–661.

Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic Signatures of Exceptional Longevity in Humans.   PloS ONE. 2012.

Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls T. Health span approximates life span among many supercentenarians: Compression of morbidity at the approximate limit of life span  The Journals of Gerontology, Series A: Biological and Medical Sciences. 2012; 67A(4): 395–405.

Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls T. Whole genome sequences of  male and female supercentenairnas, Both ages >114 years. Frontiers in Genetics of Aging. 2011; 2: 90.

Sebastiani P, Perls TT. The genetics of extreme longevity: lessons from the new England centenarian study. Frontiers in Genetics. 2012; 30;3:277.

Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell. 2012; 11(3): 475-481.

Perls TT. The different paths to 100.  The American Journal of Clinical Nutrition. 2006 F; 83(2): 484S-487S.

Perls TT, Kunkel LM, Puca AA. The genetics of exceptional human longevity. Journal of Molecular Neuroscience. 2002;19 (1-2): 233-238.

Puca AA1, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(18): 10505-10508.

Perls TT, Alpert L, Fretts RC. Middle-aged mothers live longer.  Nature. 1997; 389(133).

Perls TT. Centenarians prove the compression of morbidity hypothesis, but what about the rest of us who are genetically less fortunate?  Medical Hypotheses. 1997; 9(5):405-7.