Arthritis & Autoimmune Diseases Research Center
The Arthritis & Autoimmune Diseases Research Center (AADRC) is an internationally recognized center in research, patient care and education, established in 1983 to advance basic, clinical, and epidemiological research in rheumatology and to translate laboratory findings into new therapeutic strategies for rheumatic and autoimmune diseases. The center unifies extensive basic, translational and clinical research, as well as medical education and patient care. AADRC members include faculty in general rheumatology, as well as focused programs in scleroderma, musculoskeletal ultrasound, lupus, type 1 diabetes, and clinical epidemiology. Basic research focuses on two broad themes: (1) mechanisms of fibrosis and vasculopathy in scleroderma, lupus and pulmonary disorders, and (2) mechanisms of dysregulated innate and adaptive immune cell activation in inflammation and autoimmunity. Therapeutic potential of targeting novel pathways discovered through our basic research is being evaluated in preclinical models of scleroderma, type 1 diabetes, and idiopathic pulmonary fibrosis. Our multidisciplinary programs in scleroderma and lupus are highly integrated with experts in many specialties, including those in nephrology and dermatology. Clinical care is provided at the Boston Medical Center in state of the art out- and in-patient facilities. The center’s clinical research teams have been at the forefront of developing new approaches to study and test new treatments for scleroderma, osteoarthritis, lupus and other autoimmune disorders.
Maria Trojanowska, PhD