Representative Publications:

TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses.Cohen HB, Briggs KT, Marino JP, Ravid K, Robson SC, Mosser DM.Blood. 2013 Aug 1. [Epub ahead of print]

Building interdisciplinary biomedical research using novel collaboratives. Ravid K, Faux R, Corkey B, Coleman D. Acad Med. 2013 Feb;88(2):179-84. doi: 10.1097/ACM.0b013e31827c0f79.

Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells. Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9368-73. doi: 10.1073/pnas.1304889110. Epub 2013 Apr 23.

Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide. Eliades A, Papadantonakis N, Matsuura S, Mi R, Bais MV, Trackman P, Ravid K. Cell Cycle. 2013 Apr 15;12(8):1242-50. doi: 10.4161/cc.24312. Epub 2013 Mar 21.

A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Sun Y, Duan Y, Eisenstein AS, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid K, Huang P.  J Cell Sci. 2012 Oct 1;125(Pt 19):4507-17. doi: 10.1242/jcs.105023. Epub 2012 Jul 5.

The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity. Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, and Ravid K. (2012) The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity. PLoS ONE 7(7): e40584. doi:10.1371/journal.pone.0040584. Epub 2012 Jul 25.
Press Release:
http://www.bu.edu/news/2012/07/26/busm-study-identifies-adenosine-receptor%E2%80%99s-role-in-regulating-high-fat-diet-induced-obesity-and-type-2-diabetes/
http://www.sciencedaily.com/releases/2012/07/120726135236.htm

A2B Adenosine Receptor Promotes Mesenchymal Stem Cell Differentiation to Osteoblasts and Bone Formation in Vivo.  Carroll SH, Wigner NA, Kulkarni N, Johnston-Cox H, Gerstenfeld LC, Ravid K.  J Biol Chem. 2012 May 4; 287(19):15718-27.

A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V, Ravid K. Circulation. 2012 Jan 17;125(2):354-63. Epub 2011
Press Release:
BioScholar News:
http://news.bioscholar.com/2011/12/new-therapeutic-target-against-atherosclerosis-identified.html
News Medical
http://www.news-medical.net/news/20111213/Scientists-identify-A2bAR-as-possible-new-therapeutic-target-against-atherosclerosis.aspx
Bioportfolio
http://www.bioportfolio.com/news/article/891493/Researchers-Identify-Agent-Responsible-For-Protection-Against-Early-Stages-Of-Atherosclerosis.html
Medical Express
http://medicalxpress.com/news/2011-12-agent-responsible-early-stages-atherosclerosis.html
Science News
http://esciencenews.com/sources/physorg/2011/12/12/researchers/identify.agent.responsible.protection.against.early.stages.atherosclerosis

 

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. Grenz A et al. J Clin Invest. 2012 Jan 24. pii: 60214. doi: 10.1172/JCI60214. [Epub ahead of print]

 

Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase. Eliades, Alexia, Papadantonakis, Nikolaos, Bhupatiraju, Ajoy, Burridge, Kelley A., Johnston-Cox, Hillary A., Migliaccio, Anna Rita, Crispino, John D., Lucero, Hector A., Trackman, Philip C. and Ravid, K.  J Biol Chem. 2011 Jun 10. [Epub ahead of print].
Press Release:
http://www.sciencedaily.com/releases/2011/06/110623141643.htm,

 

Blood_cover_image

Blood Cover, Volume 116, Number 12, sep 2010.

Survivin localization during endomitosis of high ploidy mouse megakaryocytes. McCrann DJ, Ravid K.

Blood. 2010 Sep 23;116(12):2192-3.

 

New roles for cyclin E in megakaryocytic polyploidization. Eliades A, Papadantonakis N, Ravid K. J Biol Chem. 2010 Jun 11;285(24):18909-17. Epub 2010 Apr 14.

 

A new role for the A2b adenosine receptor in regulating platelet function. Yang D, Chen H, Koupenova-Zamor M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. J Thromb Haemost. 2010 Apr;8(4):817-27. Epub 2010 Jan 21.

 

Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy. McCrann DJ, Eliades A, Makitalo M, Matsuno K, Ravid K. Blood. 2009 Aug 6;114(6):1243-9. Epub 2009 May 26.

 

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. Nguyen HG, Makitalo M, Yang D, Chinnappan D, St Hilaire C, Ravid K. FASEB J. 2009 Aug;23(8):2741-8. Epub 2009 Mar 30.

 

Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. McCrann DJ, Yang D, Chen H, Carroll S, Ravid K. Cell Cycle. 2009 Mar 15;8(6):902-8. Epub 2009 Mar 21. PMID: 19221493 [PubMed - indexed for MEDLINE]

 

Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells. Papadantonakis N, Makitalo M, McCrann DJ, Liu K, Nguyen HG, Martin G, Patel-Hett S, Italiano JE, Ravid K. Cell Cycle. 2008 Aug;7(15):2352-6. Epub 2008 May 21. PMID: 18677109 [PubMed - indexed for MEDLINE]

 

The reno-vascular A2B adenosine receptor protects the kidney from ischemia. Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK. PLoS Med. 2008 Jun 24;5(6):e137. PMID: 18578565 [PubMed - indexed for MEDLINE]

 

Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice. McCrann DJ, Yezefski T, Nguyen HG, Papadantonakis N, Liu H, Wen Q, Crispino JD, Ravid K. Blood. 2008 Apr 15;111(8):4092-5. Epub 2008 Feb 1. PMID: 18245663 [PubMed - indexed for MEDLINE]

 

Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Hazony Y, Lu J, St Hilaire C, Ravid K. Nucleic Acids Res. 2006;34(16):4416-28. Epub 2006 Aug 26. PMID: 16936310 [PubMed - indexed for MEDLINE]

 

The A2b adenosine receptor protects against vascular injury. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):792-6. Epub 2008 Jan 9. PMID: 18184815 [PubMed - indexed for MEDLINE]

 

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. J Clin Invest. 2006 Jul;116(7):1913-23. PMID: 16823489 [PubMed - indexed for MEDLINE]

 

Conditional overexpression of transgenes in megakaryocytes and platelets in vivo. Nguyen HG, Yu G, Makitalo M, Yang D, Xie HX, Jones MR, Ravid K. Blood. 2005 Sep 1;106(5):1559-64. Epub 2005 May 12. PMID: 15890684 [PubMed - indexed for MEDLINE]

 

Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression. Jones MR, Ravid K. J Biol Chem. 2004 Feb 13;279(7):5306-13. Epub 2003 Nov 22. PMID: 14634004 [PubMed - indexed for MEDLINE]

 

Properties of ets-1 binding to chromatin and its effect on platelet factor 4 gene expression. Lu J, Pazin MJ, Ravid K. Mol Cell Biol. 2004 Jan;24(1):428-41. PMID: 14673175 [PubMed - indexed for MEDLINE]

Selected Reviews:

Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors. Koupenova M, Johnston-Cox H, Ravid K. Curr Atheroscler Rep. 2012 Oct;14(5):460-8. doi: 10.1007/s11883-012-0263-y.

 

A2 adenosine receptors and vascular pathologies. Johnston-Cox HA, Koupenova M, Ravid K. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):870-8. doi: 10.1161/ATVBAHA.112.246181. Review.

 

Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection. Papadantonakis N, Matsuura S, Ravid K. Blood. 2012 Aug 30;120(9):1774-81. doi: 10.1182/blood-2012-02-402594. Epub 2012 Jul 5. Review.

 

A2 adenosine receptors and vascular pathologies. Johnston-Cox HA, Koupenova M, Ravid K.  Arterioscler Thromb Vasc Biol.  2012 Apr;32(4):870-8.

 

Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes.  Eliades A, Matsuura S, Ravid K.  J Cell Physiol. 2012 Fab 13. doi: 10.1002/jcp.24071.

 

Adenosine and Blood Platelets. Johnston-Cox H and Ravid K. Purinergic Signalling.  2011 Sept;7(3):357-65.

 

Physiological Implications of Adenosine Receptor-Mediated  Platelet Aggregation. Johnston-Cox H, Yang D, Ravid K. J Cell Physiol. 2011 Jan;226(1):46-51.

 

Mechanisms of induction of adenosine receptor genes and its functional significance. St Hilaire C, Carroll SH, Chen H, Ravid K. J Cell Physiol. 2009 Jan;218(1):35-44. Review. PMID: 18767039 [PubMed - indexed for MEDLINE]

 

Vascular smooth muscle cell polyploidy: an adaptive or maladaptive response? McCrann DJ, Nguyen HG, Jones MR, Ravid K. J Cell Physiol. 2008 Jun;215(3):588-92. Review. PMID: 18181174 [PubMed - indexed for MEDLINE]

 

Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins. Nguyen HG, Ravid K. J Cell Physiol. 2006 Jul;208(1):12-22. Review. PMID: 16331679 [PubMed - indexed for MEDLINE]

 

Animal models for the study of adenosine receptor function. Yaar R, Jones MR, Chen JF, Ravid K. J Cell Physiol. 2005 Jan;202(1):9-20. Review. PMID: 15389588 [PubMed - indexed for MEDLINE]

 

Role of apoptotic processes in platelet biogenesis. Kaluzhny Y, Ravid K. Acta Haematol. 2004;111(1-2):67-77. Review. PMID: 14646346 [PubMed - indexed for MEDLINE]

 

Roads to polyploidy: the megakaryocyte example. Ravid K, Lu J, Zimmet JM, Jones MR. J Cell Physiol. 2002 Jan;190(1):7-20. Review. PMID: 11807806 [PubMed - indexed for MEDLINE]

 

Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system. Zimmet J, Ravid K. Exp Hematol. 2000 Jan;28(1):3-16. Review. PMID: 10658672 [PubMed - indexed for MEDLINE]

Books:

dnatransferbook.kravid

http://www.wiley-vch.de/publish/en/books/bySubjectLS00/bySubSubjectLS30/0-471-16572-7/?sID=0f8tr9bpr0j38tpt8tn3tb9q84

tf.kravid.book

http://www.boomerangbooks.com.au/Transcription-Factors/K-Ravid/book_9780471350545.htm

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August 27, 2013
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of BU School of Medicine