Gyungah Jun, PhD

Gyungah Jun, PhD

Research Assistant Professor, Dept of Medicine (Biomedical Genetics) and Ophthalmology, BUSM

Research Assistant Professor, Dept of Biostatistics, BUSPH

 
 
 
 

Research Interests

Dr. Jun has worked in a broad spectrum of medical fields including purification and characterization of a B-lymphocyte inducing factor (BIF) using single cell cloning of human myeloma cell line, development of DNA pattern recognition program, investigation of loci involved in progression of type 2 diabetes using Framingham Heart Study, genome-wide scans for druse formation, age-related macular degeneration, and diabetic nephropathy, and identification of causal variants in EPHA2 for age-related cortical cataract using worldwide longitudinal cohorts. She has also been involved in large genetics consortiums for diabetic nephropathy and Alzheimer’s disease. In these collaborative efforts, much of her work is engaged in study design, development of analysis plan, database development and management, and implementation of statistical methods. Her current projects encompass multidisciplinary areas of Alzheimer’s disease, age-related macular degeneration, age-related cataract, and idiopathic membranous nephropathy. The centerpiece of her future study consists of two primary focuses: investigation of shared genetic risk factors between age-related neurodegenerative diseases using bivariate framework and development of bioinformatic tools to identify shared gene-gene interactions among diseases using genome-wide sequencing data.

Selected Publications

Choi SH, Liu C, Dupuis J, Logue MW, Jun G. 2011. Using linkage analysis of large pedigrees to guide association analysis. BMC Genetics Accepted.

Naj AC*, Jun G*, Beecham GW, Wang L-S, Buros J, Vardarajan BN, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PD, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JSK, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, George-Hyslop PS, Alzheimer Disease Genetics Consortium, Cantwell RB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh ML, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants in MS4A4/MS4A6E, CD2AP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease. Nat Genet 2011 April 3. DOI: 10.1038/ng.801 [Epub ahead of print].

Jun G, Naj AC, Beecham GW, Wang L-S, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin D, Friedland R, Inzelberg R, Kramer P, Rogaeva E, George-Hyslop PG, ADGC, Cantwell L, Dombrosk BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples AL, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Petricak-Vance MA, Schellenberg GD. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer’s disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 2010 Dec;67(12):1473-84.

Malhotra A, Igo RP Jr, Thameem F, Kao WH, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI, Goddard KA, Ipp E, Iyengar SK, Kimmel PL, Knowler WC, Kohn O, Leehey D, Meoni LA, Nelson RG, Nicholas SB, Parekh RS, Rich SS, Chen YD, Saad MF, Scavini M, Schelling JR, Sedor JR, Shah VO, Taylor KD, Thornley-Brown D, Zager PG, Horvath A, Hanson RL; Family Investigation of Nephropathy and Diabetes Research Group. 2009. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the family investigation of nephropathy and diabetes research group. Diabetes Metab Res Rev. 2009 Nov;25(8):740-7.

Jun G*, Guo H*, Klein BE, Klein R, Wang JJ, Mitchell P, Miao H, Lee KE, Joshi T, Buck M, Chugha P, Bardenstein D, Klein AP, Bailey-Wilson JE, Gong X, Spector TD, Andrew T, Hammond CJ, Elston RC, Iyengar SK, Wang B. 2009 EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet Jul;5(7):e1000584. Epub 2009 Jul 31.

Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Abboud HE, Adler SG, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Knowler WC, Kohn OF, Kramp K, Leehey DJ, Nicholas SB, Pahl MV, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS; Family Investigation of Nephropathy and Diabetes Research Group. 2008. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 40: 1185-1192.

Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, Guo X, Hanson RL, Igo RP Jr, Ipp E, Kimmel PL, Knowler WC, Molineros J, Nelson RG, Pahl MV, Quade SR, Rasooly RS, Rotter JI, Saad MF, Scavini M, Schelling JR, Sedor JR, Shah VO, Zager PG, Abboud HE; Family Investigation of Nephropathy and Diabetes Research Group. 2008. Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci 49:3839-3845.

Schelling JR, Abboud HE, Nicholas SB, Pahl MV, Sedor JR, Adler SG, Arar NH, Bowden DW, Elston RC, Freedman BI, Goddard KA, Guo X, Hanson RL, Ipp E, Iyengar SK, Jun G, Kao WH, Kasinath BS, Kimmel PL, Klag MJ, Knowler WC, Nelson RG, Parekh RS, Quade SR, Rich SS, Saad MF, Scavini M, Smith MW, Taylor K, Winkler CA, Zager PG, Shah VO; Family Investigation of Nephropathy and Diabetes Research Group. 2008. Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes 57:235-43.

Thompson C, Jun G, Klein, BEK, Klein R, Capriotti J, Lee KE, Iyengar SK. 2007. Genetics of pigment changes and geographic atrophy. Invest Ophthalmol Vis Sci 48:3005-3013.

Parekh RS, Kao WH, Meoni LA, Ipp E, Kimmel PL, La Page J, Fondran C, Knowler WC, Klag MJ; Family Investigation of Nephropathy and Diabetes Research Group. 2007. Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the Family Investigation of Nephropathy and Diabetes. Clin J Am Soc Nephrol 2:1156-62.

Iyengar SK, Abboud HE, Goddard KA, Saad MF, Adler SG, Arar NH, Bowden DW, Duggirala R, Elston RC, Hanson RL, Ipp E, Kao WH, Kimmel PL, Klag MJ, Knowler WC, Meoni LA, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Quade SR, Rich SS, Rotter JI, Scavini M, Schelling JR, Sedor JR, Sehgal AR, Shah VO, Smith MW, Taylor KD, Winkler CA, Zager PG, Freedman BI; Family Investigation of Nephropathy and Diabetes Research Group. 2007. Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND). Diabetes 56:1577-85.

Xing C, Klein BEK, Klein R, Jun G, Lee KE, Iyengar SK. 2006. A genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study. Hypertension 47:797-802.

Jun G, Song Y, Iyengar SK, and Elston RC. 2005. Optimizing the evidence for linkage by permuting marker order. BMC Genetics 6(S7/S61): 1 – 5.

Jun G, Klein BEK, Klein R, Schick JH, Millard C, Humphrey J, Liptak R, Russo K, Lee KE, Elston RC, and Iyengar SK. 2005. Genome wide analyses demonstrate that novel loci predispose to druse formation. Invest Ophthalmol Vis Sci 46:3081 – 3088.

Knowler WC, Coresh J, Elston EC, Freedman BI, Iyengar SK, Kimmel PL, Olson JM, Plaetke R, Sedor JR, Seldin MF, and Family Investigation of Nephropathy and Diabetes Research Group. 2005. The Family Investigation of Nephropathy and Diabetes (FIND): design and methods. J Diabetes Complications 19:1-9.

Iyengar SK, Klein BEK, Klein R, Jun G, Schick JH, Millard C, Liptak R, Russo K, Lee KE, and Elston RC. 2004. Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. PNAS 101:14485 – 14490.

Iyengar SK, Song, D, Klein BE, Klein R, Schick JH, Humphrey J, Millard C, Liptak R, Reading K, Jun G, Lee KE, Fijal B, and Elston RC. 2004. Dissection of genome-wide scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet 74: 20 – 39.

Jun G, Song Y, Stein CM, and Iyengar SK. 2003. An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression. BMC Genetics 4(S1/S8): 1 – 7.

Stein CM, Song Y, Elston RC, Jun G, Tiwari HK, and Iyengar SK. 2003. Structural equation model-based genome scan for metabolic syndrome. BMC Genetics 4(S1/S99): 1 – 5.

The Family Investigation of Nephropathy and Diabetes Research Group. 2003. Genetic determinants of diabetic nephropathy: The family investigation of nephropathy and diabetes (FIND). J Am Soc Nephrol. 14:S202-204.

Primary teaching affiliate
of BU School of Medicine