Publications

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT. A serum protein signature of APOE genotypes in centenarians. Aging Cell. 2019; 00:e13023.

Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P. PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects. Bioinformatics. 2019; 35(17): 3046–3054.

Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies.  The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018; 73(11): 1439-1447.

Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018;73(11):1472-1481.

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018;74(1):44-51

Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT. Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring. The Journals of Gerontology, Series A: Biological and Medical Sciences. 2018; 74(1):108-113.

Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls T, Andersen SL. Purpose in Life Among Centenarian Offspring   The Journals of Gerontology, Series B: Psychological and Social Sciences. 2018.

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB. A novel healthy blood pressure phenotype in the Long Life Family Study. Journal of Hypertension. 2018; 36(1): 43-53.

Zeng, Y., Nie, C., Min, J., Chen, H., Liu, X., Ye, R., Chen, Z., Bai, C., Xie, E., Yin, Z., Lv, Y., Lu, J., Li, J., Ni, T., Bolund, L., Land, K., Yashin, A., O’Rand, A., Sun, L., Yang, Z., Tao, W., Gurinovich, A., Franceschi, C., Xie, J., Gu, J., Hou, Y., Liu, X., Xu, X., Robine, J., Deelen, J., Sebastiani, P., Slagboom, E., Perls, T., Hauser, E., Gottschalk, W., Tan, Q., Christensen, K., Shi, X., Lutz, M., Tian, X., Yang, H. and Vaupel, J. Sex Differences in Genetic Associations With LongevityJournal of the American Medical Association. 2018; 1(4).

Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N; Long Life Family Study. Telomere length is longer in women with late maternal age. Menopause. 2017; 24(5):497-501.

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell. 2017;16(2):329-338.

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.  The Journals of Gerontology, Series A: Biological and Medical Sciences. 2017; 72(11):1453-1464.

Perls TT. Male Centenarians: How and Why Are They Different from Their Female Counterparts? Journal of the American Geriatrics Society. 2017; 65(9): 1904-1906.

Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT. Limitations and risks of meta-analyses of longevity studies.   Mechanisms of Ageing and Development. 2017; 165(Pt B): 139-146.

Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. Assortative Mating by Ethnicity in Longevous Families.  Frontiers in Genetics. 2017; 8: 186.

Perls, TT. Testosterone Treatment in Older Men. New England Journal of Medicine. 2016; 375(1): 88.

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family StudyJournal of the American Geriatrics Society. 2016; 64(11): e189-e194.

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Familial Risk for Exceptional Longevity. North American Actuarial Journal. 2016; 20(1): 57-64.

Sebastiani P, Sun F, Andersen S, Black M, Perls T. Increasing sibling relative risk of survival to older and older ages and the importance of precise definitions of “aging”, “life span” and “longevity”.  The Journals of Gerontology, Series A: Biological Sciences. 2016; 71(3):340-6

Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the long life family study. Aging (Albany NY). 2015; 7(2):123-32.

Sebastiani P, Bae H, Sun FX, Andersen S, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A,  Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY) 2013; 5(9): 653–661.

Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic Signatures of Exceptional Longevity in Humans.   PloS ONE. 2012.

Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls T. Health span approximates life span among many supercentenarians: Compression of morbidity at the approximate limit of life span  The Journals of Gerontology, Series A: Biological and Medical Sciences. 2012; 67A(4): 395–405.

Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls T. Whole genome sequences of  male and female supercentenairnas, Both ages >114 years. Frontiers in Genetics of Aging. 2011; 2: 90.

Sebastiani P, Perls TT. The genetics of extreme longevity: lessons from the new England centenarian study. Frontiers in Genetics. 2012; 30;3:277.

Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell. 2012; 11(3): 475-481.

Perls TT. The different paths to 100.  The American Journal of Clinical Nutrition. 2006 F; 83(2): 484S-487S.

Perls TT, Kunkel LM, Puca AA. The genetics of exceptional human longevity. Journal of Molecular Neuroscience. 2002;19 (1-2): 233-238.

Puca AA1, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(18): 10505-10508.

Perls TT, Alpert L, Fretts RC. Middle-aged mothers live longer.  Nature. 1997; 389(133).

Perls TT. Centenarians prove the compression of morbidity hypothesis, but what about the rest of us who are genetically less fortunate?  Medical Hypotheses. 1997; 9(5):405-7.