Publications

Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies. Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. J Gerontol A Biol Sci Med Sci. 2018 Oct 8.

APOE Alleles and Extreme Human Longevity. Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. J Gerontol A Biol Sci Med Sci. 2018 Jul 27. doi: 10.1093/gerona/gly174.

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.   Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT. J Gerontol A Biol Sci Med Sci. 2018 Jun 20.

Purpose in Life Among Centenarian Offspring  Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls T, Andersen SL. J Gerontol B Psychol Sci Soc Sci. 2018 Mar 7.

Sex Differences in Genetic Associations With LongevityZeng, Y., Nie, C., Min, J., Chen, H., Liu, X., Ye, R., Chen, Z., Bai, C., Xie, E., Yin, Z., Lv, Y., Lu, J., Li, J., Ni, T., Bolund, L., Land, K., Yashin, A., O’Rand, A., Sun, L., Yang, Z., Tao, W., Gurinovich, A., Franceschi, C., Xie, J., Gu, J., Hou, Y., Liu, X., Xu, X., Robine, J., Deelen, J., Sebastiani, P., Slagboom, E., Perls, T., Hauser, E., Gottschalk, W., Tan, Q., Christensen, K., Shi, X., Lutz, M., Tian, X., Yang, H. and Vaupel, J. Journal of the American Medical Association (2018).  

Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT.  J Gerontol A Biol Sci Med Sci. 2017 Mar 15.

Male Centenarians: How and Why Are They Different from Their Female Counterparts? Perls TT. J Am Geriatr Soc. 2017 Sep.

Limitations and risks of meta-analyses of longevity studies. Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT.  Mech Ageing Develop. (2017)

Assortative Mating by Ethnicity in Longevous Families. Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. Front Genet. 2017 Nov 21.

Familial Risk for Exceptional Longevity. Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. N Am Actuar J. 2016 Jan 1.

Increasing sibling relative risk of survival to older and older ages and the importance of precise definitions of “aging”, “life span” and “longevity”. Sebastiani P, Sun F, Andersen S, Black M, Perls T.  J Gerontology Biol Sci. 2015

Burden of disease variants in participants of the long life family study. Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P.Aging (Albany NY). 2015 Feb 5.

Meta-analysis of genetic variants associated with human exceptional longevity. Paola Sebastiani, Harold Bae1, Fangui X. Sun, Stacy L. Andersen, E. Warwick Daw, Alberto Malovini, Toshio Kojima, Nobuyoshi Hirose, Nicole Schupf, Annibale Puca, Thomas T Perls. Aging (Albany NY) 2013 September; 5(9): 653–661.  Published online 2013 August 24.

Genetic Signatures of Exceptional Longevity in Humans. Paola Sebastiani, Nadia Solovieff, Andrew T. DeWan, Kyle M. Walsh, Annibale Puca, Stephen W. Hartley, Efthymia Melista, Stacy Andersen, Daniel A. Dworkis, Jemma B. Wilk, Richard H. Myers, Martin H. Steinberg, Monty Montano, Clinton T. Baldwin, Josephine Hoh, Thomas T. Perls.  PloS ONE 2012. 

Health span approximates life span among many supercentenarians: Compression of morbidity at the approximate limit of life span  Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls T. J Gerontol A Biol Sci Med Sci 2012.

Whole genome sequences of  male and female supercentenairnas, Both ages >114 years.  Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls T.  Frontiers in Genetics of Aging 2012.

The genetics of extreme longevity: lessons from the new England centenarian study. Sebastiani P, Perls TT. Front Genet. 2012 Nov 30

Human longevity and common variations in the LMNA gene: a meta-analysis. Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Aging Cell. 2012 Jun.

The different paths to 100. Perls TT. Am J Clin Nutr. 2006 Feb

Middle-aged mothers live longer. Perls TT, Alpert L, Fretts RC. Nature. 1997 Sep 11

Centenarians prove the compression of morbidity hypothesis, but what about the rest of us who are genetically less fortunate? Perls TT. Med Hypotheses. 1997 Nov