Publications
Disentangling the Roles of Disability and Morbidity in Survival to Exceptional Old Age
Terry, D.F., Sebastiani, P., Andersen, S.L., & Perls, T.T., 2008. Disentangling the Roles of Disability and Morbidity in Survival to Exceptional Old Age. Archives of Internal Medicine. 168(3), 277-283.
Characteristics of Framingham Offspring Participants With Long-lived Parents
Terry, D.F., Evans, J.C., Pencina, M.J., Murabito, J.M., Vasan, R.S., Wolf, P.A., Kelly-Hayes, M., Levy, D., D’Agostino, R.B., & Benjamin, E.J., 2007. Characteristics of Framingham Offspring Participants With Long-lived Parents. Arch Internal Medicine. 167, 438-444.
Survival of Parents and Siblings of Supercentenarians
Perls, T.T., Kohler, I., Andersen, S., Schoenhofen, E., Pennington, J., Young, R., Terry, D., Elo, I.T., 2007. Survival of Parents and Siblings of Supercentenarians. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 62, 1028-1034.
The Different Paths to 100
Perls, T.T., 2006. The Different Paths to 100. The American Journal of Clinical Nutrition. 83 supp., 484S-7S.
Serum heat shock protein 70 level as a biomarker of exceptional longevity
Terry, D.T., Wyszynski, D.F., Nolan, V.G., Atzmon, G., Schoenhofen, E.A., Pennington, J.Y., Anderson, S.A., Wilcox, M.A., Farrer, L.A., Barzilai, N., Baldwin, C.T., & Asea, A., 2006. Serum heat shock protein 70 level as a biomarker of exceptional longevity. Mechanisms of Ageing and Development. 127, 862-868.
Characteristics of 32 Supercentenarians
Schoenhofen, E., Wyszynski, D.F., Andersen, S., Pennington, J., Young, R., Terry, D.F., & Perls, T.T., 2006. Characteristics of 32 Supercentenarians. Journal of the American Geriatrics Society. 54, 1237-1240.
Scanning the Beta-globin Gene for Mutations in Large Populations by Denaturing Capillary and Gel Electrophoresis
Li-Sucholeiki, X., Hu, G., Perls, T.T., Tomita-Mitchell, A., & Thilly, W.G., 2005. Scanning the Beta-globin Gene for Mutations in Large Populations by Denaturing Capillary and Gel Electrophoresis. Electrophoresis. 26, 2531-2538.
Science Fact and the SENS Agenda
Warner, H., Anderson, J., Austad, S., Bergamini, E., Bredesen, D., Butler, R., Carnes, B.A., Clark, B.R.C., Cristofalo, V., Faulkner, J., Guarente, L., Harrison, D.E., Kirkwood, T., Lithgow, G., Martin, G., Masoro, E., Melov, S., Miller, R.A., Olshansky, S.J., Partridge, L., Pereira-Smith, O., Perls, T.T., Richardson, A., Smith, J., Zglinicki, T., Wang, E., Wei, J.Y., & Williams, T.F., 2005. Science Fact and the SENS Agenda. European Molecular Biology Organization. 6(11), 1006-1008.
Cardiovascular Risk Factors Predictive for Survival and Morbidity-Free Survival in the Oldest-Old Framingham Heart Study Participants
Terry, D.F., Pencina, M.J., Vasan, R.S., Murabito, J.M., Wolf, P.A., Hayes, M.K., Levy, D., Agostino, R.B., & Benjamin, E.J., 2005. Cardiovascular Risk Factors Predictive for Survival and Morbidity-Free Survival in the Oldest-Old Framingham Heart Study Participants. Journal of American Geriatrics Society. 53, 1944-1950.
Cancer in Oldest Old
Andersen, S.A, Terry, D.F., Wilcox, M.A., Babineau, T., Malek, K., & Perls, T.T., 2005. Cancer in Oldest Old. Mechanisms of Ageing and Development. 126(2), 263–267.
Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring
Terry, D.F., Wilcox, M.A., McCormick, M.A., Pennington, J.Y., Schoenhofen, E.A., Andersen, S.L., & Perls, T.T., 2004. Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring. Journal of American Geriatrics. 52(12), 2074-2076.
First Autopsy Study of an Okinawan Centenarian: Absence of Many Age-Related Diseases
Bernstein, A.M., Willcox, B.J., Tamaki, H., Kunishima, N., Suzuki, M., Willcox, D.C., Yoo, J.K., & Perls, T.T., 2004. First Autopsy Study of an Okinawan Centenarian: Absence of Many Age-Related Diseases. Journal of Gerontology: MEDICAL SCIENCES. 59A(11), 1195–1199.
Cardiovascular Disease Delay in Centenarian Offspring - Role of Heat Shock Proteins
Terry, D.F., McCormick, M., Andersen, S., Pennington, J., Schoenhofen, E., Palaima, E., Bausero, M., Ogawa, K., Perls, T.T., & Asea, A., 2004. Cardiovascular Disease Delay in Centenarian Offspring: The Role of Heat Shock Proteins. Annals of the New York Academy of Sciences. 1019, 502-505.
Cardiovascular Disease Delay in Centenarian Offspring
Terr, D.F., Wilcox, M.A., McCormick, M.A., & Perls, T.T., 2004. Cardiovascular Disease Delay in Centenarian Offspring. Journal of Gerontology: MEDICAL SCIENCES. 59A(4), 385–389.
Centenarians who Avoid Dementia
Perls, T.T., 2004. Centenarians Who Avoid Dementia. Trends in Neurosciences. 27(10), 633-636.
Understanding the Determinants of Exceptional Longevity
Perls, T.T. & Terry, D.F., 2003. Understanding the Determinants of Exceptional Longevity. Annals of Internal Medicine. 139(5), 445-449.
Genetics of Exceptional Longevity
Perls, T.T. & Terry, D.F., 2003. Genetics of Exceptional Longevity. Experimental Gerontology. 38(7), 725-730.
Genetics of Exceptional Longevity
Perls, T.T. & Terry, D.F., 2003. Genetics of Exceptional Longevity. Experimental Gerontology. 38, 725-730.
Morbidity Profiles of Centenarians: Survivors, Delayers, and Escapers
Evert, J., Lawler, E., Bogan, H., & Perls, T.T., 2003. Morbidity Profiles of Centenarians: Survivors, Delayers, and Escapers. Journal of Gerontology: MEDICAL SCIENCES. 58A(3), 232-237.
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
Geesaman, B.J., Benson, E., Brewster, S.J., Kunkel, L.M., Blanche, H., Thomas, G., Perls, T.T., Daly, M.J., & Puca, A.A., 2003. Haplotype-based Identification of a Microsomal Transfer Protein Marker Associated with the Human Lifespan. Proceedings of the National Academy of Sciences of the United States of America. 100(24), 14114-14120.
Cardiovascular Advantages Among the Offspring of Centenarians
Terry, D.F., Wilcox, M., McCormick, M.A., Lawler, E., & Perls, T.T., 2003. Cardiovascular Advantages Among the Offspring of Centenarians. Journal of Gerontology: MEDICAL SCIENCES. 58A(5), 425-431.
Biological Secrets of Exceptional Old Age: Centenarian Study Seeks Insight Into Aging Well
Friedrich, M.J., 2002. Biological Secrets of Exceptional Old Age - Centenarian Study Seeks Insight Into Aging Well. JAMA. 288(18), 2247-2253.
Life-long Sustained Mortality Advantage of Siblings of Centenarians
Perls, T.T., Wilmoth, J., Levenson, R., Drinkwater, M., Cohen, M., Bogan, H., Joyce, E., Brewster, S., Kunkel, L., & Puca, A., 2002. Life-long Sustained Mortality Advantage of Siblings of Centenarians. PNAS. 99(12), 8442-8447.
Distinguising Between Neurodegenerative Disease and Disease-Free Aging: Correlating Neuropsychological Evaluations and Neuropathological Studies in Centenarians
Silver, M.H., Newell, K., Brady, C., Hedley-White, E.T., & Perls, T.T., 2002. Distinguising Between Neurodegenerative Disease and Disease-Free Aging: Correlating Neuropsychological Evaluations and Neuropathological Studies in Centenarians. Psychosomatic Medicine. 64, 493-501.
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
Puca, A.A., Daly, M.J., Brewster, S.J., Matise, T.C., Barrett, J., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E., Kunkel, L.M., & Perls, T.T., 2001. A genome-wide scan for linkage to human exceptional longevity a locus on chromosome 4. Proceedings of the National Academy of Sciences. 98(18), 10505-10508.
The evolution of menopause and human life span
Perls, T.T. & Fretts, R.C., 2001. The Evolution of Menopause and Human Life Span. Annals of Human Biology. 28(3), 237-245.
Genetic and Phenotypic Markers Among Centenarians
Perls, T.T., 2001. Genetic and Phenotypic Markers Among Centenarians. Journal of Gerontology: MEDICAL SCIENCES. 56A(2), M67-M70.
Cognitive Functional Status of Age-Confirmed Centenarians in a Population-Based Study
Silver, M.H., Jilinskaia, E., & Perls, T.T., 2001. Cognitive Functional Status of Age-Confirmed Centenarians in a Population-Based Study. Journal of Gerontology: PSYCHOLOGICAL SCIENCES. 56B(3), P134-P140.
Exceptional Familial Clustering for Extreme Longevity in Humans
Perls, T.T., Shea-Drinkwater, M., Bowen-Flynn, J., Ridge, S.B., Kang, S., Joyce, E., Daly, M., Brewster, S.J., Kunkel, L., & Puca, A.A. 2000. Exceptional Familial Clustering for Extreme Longevity in Humans. Journal American Geriatrics Society. 48, 1483-1485.
Correlation of functional abilities and cognitive status in centenarians: Barthel ADL Index vs. Blessed Roth IMC Test
Silver, V., Bowen Flynn, J., Kang, S., Drinkwater, M., Joyce, E., Perls, T.T., & Brewster, S., 2000. Correlation of functional abilities and cognitive status in centenarians: Barthel ADL Index vs. Blessed-Roth IMC Test. Archives of Clinical Neuropsychology. 15, 743.
Centenarians: the older you get, the healthier you have been
Hitt, R., Young-Xu, Y., Silver, M., & Perls, T.T., 1999. The Lancet. 354, 652.
Validity of reported age and centenarian prevalence in New England
Perls, T.T., Bochen, K., Freeman, M., Alpert, L., Silver, M.H., 1999. Validity of Reported Age and Centenarian Prevalence in New England. Age and Ageing. 28, 193-197.
Siblings of Centenarians Live Longer
Perls, T.T., Bubrick, E., Wager, C.G., Vijg, J., & Kruglyak, L., 1998. Siblings of Centenarians Live Longer. The Lancet. 351(9115), 1560.
Unraveling the Mystery of Cognitive Changes in Extreme Old Age: Correlation of Neuropsychological Evaluation With Neuropathological Findings in Centeanarians
Silver, M., Newell, K., Hyman, B., Growdon, J., Hedley-Whyte, E.T., & Perls, T.T., 1998. Unraveling the Mystery of Cognitive Changes in Extreme Old Age: Correlation of Neuropsychological Evaluation with Neuropathological Findings in Centenarians. International Psychogeriatrics. 10(1), 25-41.
Middle-aged Mothers Live Longer
Perls, T.T., Alpert, L., & Fretts, R.C., 1997. Middle-aged Mothers Live Longer. Nature. 389, 133.
The Oldest Old
Perls, T.T., 1995. The Oldest Old. Scientific American. 272(1), 70-75.
These publications are unrelated to the research conducted at the New England Centenarian Study.
Hope Drives Antiaging Hype
Perls, T.T., 2006. Hope Drives Antiaging Hype. Cleveland Clinic Journal of Medicine. 73(12), 1039-1044.
Authors’ response and letters to JAMA regarding Dr. Perls’ and colleagues’ article about growth hormone and anti-aging
Perls, T.T., 2006. Growth Hormone for “Antiaging”. Journal of the American Medical Association. 295, 888-890.
For materials related to Doctor Perls’ article appearing in JAMA on HGH, please click here.
Provision or Distribution of Growth Hormone for “Antiaging” - Clinical and Legal Issues
Perls, T.T., Reisman, N.R., Olshansky, S.J., 2005. Provision or Distribution of Growth Hormone for “Anti-aging”. Journal of the American Medical Association. 294(16), 2086-2090.
Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade - More Dangerous Than Ever
Perls, T.T., 2004. Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade - More Dangerous Than Ever. Journal of Gerontology: BIOLOGICAL SCIENCES. 59A(7), 682-691.
Anti-Aging Medicine: The Hype and the Reality - Part I
Olshansky, S.J., Hayflick, L., & Perls, T.T., 2004. Anti-Aging Medicine: The Hype and the Reality - Part I. Journal of Gerontology: BIOLOGICAL SCIENCES. 59(6), 513-514.
Anti-Aging Medicine: The Hype and the Reality–Part II
Olshansky, S.J., Hayflick, L., & Perls, T.T., 2004. Anti-Aging Medicine: The Hype and the Reality - Part II. Journal of Gerontology: BIOLOGICAL SCIENCES. 59(7), 682-B691.
Anti-Aging Medicine: The Legal Issues: Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade — More Dangerous Than Ever
Perls, T.T., 2004. Anti-Aging Medicine: The Legal Issues: Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade — More Dangerous Than Ever. Journal of Gerontology: BIOLOGICAL SCIENCES. 59(7), 682-691.
Copyright (c) The Gerontological Society of America. Reproduced by permission of the publisher.
Popular Media
“Looking Ahead to the Days of Old” By Rita Zeidner. This article appeared in The Washington Post on October 5th, 2004. It features an interview with study director, Dr. Thomas Perls as well as centenarian Lloyd Brown. The article is available online at The Washington Post. The article is available at no cost, but registration is required.
“How to Live to be 100 (and not regret it)” By Richard Corliss and Michael D. Lemonick. This article appeared in Time Magazine in the August 30th, 2004 issue and was the cover story. It features an interview with study director, Dr. Thomas Perls as well as a shortened version of Dr. Perls’s Life Expectancy Calculator. The article is available online at http://www.time.com. Subscription required.
Dr. Perls’s Life Expectancy Calculator may be accessed by clicking here- http://www.livingto100.com
Life in the Age of Old, Old Age by Susan Dominus
(February 22nd, 2004- New York Times Magazine-registration required)
The Secrets to Longevity by Kathleen Fackelmann
(February 23rd, 2004- USA Today)
Study: Aging Well Runs in Families
(November 18, 2002 - CNN.com/Health)
Present from Mom and Dad: A Longer Life, Children of Centenarians Live Long and Prosper
(November 18, 2002 - MSN Health with WebMD)
Researchers Seek Key To Long Life
(May 2, 2001 - Associated Press)
Are You Ready for 100?
(April 2001 - Money Magazine)
Making Sense of Centenarians
(March 10, 2001 - Science News, Vol. 159, No.10)
Secrets of Centenarians
(January 2, 2001 - Family Circle Magazine)
Researcher Spotlight: Thomas T. Perls, M.D., M.P.H.
(January 2001 - Beth Israel Deaconess Medical Center Clinical Research Update Vol. 5, Issue 1)
People to Watch
(Tuesday, December 26, 2000 - USA Today)
Living to 100
(Thursday, November 20, 2000 - Boston Herald)
Proven Ways To Add Many Very Good Years To Your Life
(October 2000 - Bottom Line Tomorrow Magazine)
Centenarians point the way to healthy ageing
(March 27, 1999 - THE LANCET, Vol. 353)
What Fountain of Youth?
(March 18, 1998 - Letter to the Editor, NY Times)
Foutain of Youth Bubbles in Brains of Oldest Old
(March 8, 1998-Harvard University Gazette)
Centenarians. And They All Lived Happily Ever After.
(February 7, 1998 - The Economist)
How to Live to 100
(June 30, 1997 - Newsweek)
Helpful Links:
www.sciencedirect.com - This website hosts the following journals: Experimental Gerontology, Current Opinion in Genetics and Development, The Lancet, and Trends in Neurosciences.
www.elsevier.com-Elsevier is the parent company to Science Direct.
Journal of Gerontology: Series A- Biological Sciences & Medical Sciences
Journal of Gerontology: Series B- Psychological Sciences & Social Sciences
JAMA- The Journal of the American Medical Association
Proceedings of the National Academy of Sciences of the USA
Journal of the American Geriatrics Society
Boston University Medical Center’s Department of Geriatrics
In The Future:
Stay tuned for upcoming articles, abstracts, on-line presentations, TV announcements, and more !
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