Tarik F. Haydar, PhD

Professor, Anatomy & Neurobiology

Tarik Haydar
617.638.4249
72 E. Concord St Instructional (L)

Biography

Dr. Haydar received his doctorate at the University of Maryland School of Medicine working on brain development in the Trisomy 16 mouse model of Down syndrome with Dr. Bruce Krueger. He completed postdoctoral studies at Yale University with Dr. Pasko Rakic examining control of forebrain neural precursor development and then started his independent laboratory at Children’s National Medical Center in Washington, DC in 2002. Dr. Haydar joined the Anatomy & Neurobiology Department at BUSM in 2010 where he maintains a vibrant laboratory using state-of-the-art molecular and surgical techniques to study mammalian brain development. Using in utero electroporation, in vivo genetic fate mapping and cell ablation techniques, this project is focused on how the multiple populations of neural stem cells and progenitor cells in the embryonic brain are lineally related and how their combined output leads to proper forebrain development. In addition, the lab is focusing on brain development and function in trisomy mouse models of Down syndrome using cellular, molecular and behavioral techniques. Dr. Haydar’s research is funded by the NIH (NINDS and NICHD).

Education

  • University of Maryland School of Medicine, PhD
  • University of Massachusetts Amherst, BS

Publications

  • Published on 6/12/2018

    Aziz NM, Guedj F, Pennings JLA, Olmos-Serrano JL, Siegel A, Haydar TF, Bianchi DW. Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome. Dis Model Mech. 2018 06 12; 11(6). PMID: 29716957.

    Read at: PubMed
  • Published on 2/3/2018

    Guillamon-Vivancos T, Tyler WA, Medalla M, Chang WW, Okamoto M, Haydar TF, Luebke JI. Distinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner. Cereb Cortex. 2018 Feb 03. PMID: 29415216.

    Read at: PubMed
  • Published on 3/9/2017

    Dillon GM, Tyler WA, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U, Ho A. CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Neuron. 2017 Mar 22; 93(6):1344-1358.e5. PMID: 28285824.

    Read at: PubMed
  • Published on 3/9/2016

    Goodliffe JW, Olmos-Serrano JL, Aziz NM, Pennings JL, Guedj F, Bianchi DW, Haydar TF. Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome. J Neurosci. 2016 Mar 9; 36(10):2926-44. PMID: 26961948.

    Read at: PubMed
  • Published on 2/25/2016

    Olmos-Serrano JL, Kang HJ, Tyler WA, Silbereis JC, Cheng F, Zhu Y, Pletikos M, Jankovic-Rapan L, Cramer NP, Galdzicki Z, Goodliffe J, Peters A, Sethares C, Delalle I, Golden JA, Haydar TF, Sestan N. Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination. Neuron. 2016 Mar 16; 89(6):1208-22. PMID: 26924435.

    Read at: PubMed
  • Published on 2/24/2016

    Olmos-Serrano JL, Tyler WA, Cabral HJ, Haydar TF. Longitudinal measures of cognition in the Ts65Dn mouse: Refining windows and defining modalities for therapeutic intervention in Down syndrome. Exp Neurol. 2016 May; 279:40-56. PMID: 26854932.

    Read at: PubMed
  • Published on 1/1/2016

    Ikezu T, Ikerzu S, Haydar TF, Varnum M et. al. MICROGLIAL EXOSOMES PROPAGATE TAU PROTEIN FROM THE ENTORHINAL CORTEX TO THE HIPPOCAMPUS: AN EARLY PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2016; 12(7):P339-P340.

    Read at: Custom
  • Published on 10/14/2015

    Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. J Neurosci. 2015 Oct 14; 35(41):13843-52. PMID: 26468184.

    Read at: PubMed
  • Published on 10/5/2015

    Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93. PMID: 26436904.

    Read at: PubMed
  • Published on 4/15/2015

    Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52. PMID: 25878286.

    Read at: PubMed

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