Srinivasan S, Leeman SE, Amar S. Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol. 2010 May;17(5):699-704. Epub 2010 Mar 10.
Zhou Q, Leeman SE, Amar S. Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10740-5. Epub 2009 Jun 17
Reed KL, Stucchi AF, Leeman SE, Becker JM. Inhibitory effects of a neurokinin-1 receptor antagonist on postoperative peritoneal adhesion formation. Ann N Y Acad Sci. 2008 Nov;1144:116-26.
Leeman SE. Diversity of neuropathogenic mechanisms and implications for neuromediation of diseases. Ann N Y Acad Sci. 2008 Nov;1144:113-5. No abstract available.
Lai JP, Lai S, Tuluc F, Tansky MF, Kilpatrick LE, Leeman SE, Douglas SE. Differences in the length of the carboxyl teminus mediate functional properties of neurokinin-1 receptor. Proc Natl Acad Sci USA. 2008 Aug 19 [Epub ahead of print].
Lim R, Morrill JM, Prushik SG, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM. An FDA Approved Neurokinin-1 Receptor Antagonists is Effective in Reducing Intraabdominal Adhesions when Administered Intrperitoneally, But Not Orally. J. Gastrointest Surg. 2008 Aug 16 [Epub ahead of print].
Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19796-801. Epub 2007 Dec 3.
Cohen PA, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL. A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity. Wound Repair Regen. 2007 Nov-Dec;15(6):800-8.
Tansky MF, Pothoulakis C, Leeman SE. Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10691-6. Epub 2007 Jun 11.
Singh AJ, Meyer RD, Navruzbekov G, Shelke R, Duan L, Band H, Leeman SE, Rahimi N. A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5413-8. Epub 2007 Mar 19.
Prushik SG, Aarons CB, Matteotti R, Reed KL, Gower AC, Leeman SE, Stucchi AF, Becker JM. A neurokinin 1 receptor antagonist decreases adhesion reformation after laparoscopic lysis of adhesions in a rat model of adhesion formation. Surg Endosc. 2007 Oct;21(10):1790-5. Epub 2007 Mar 14.
Cohen PA, Aarons CB, Gower AC, Stucchi AF, Leeman SE, Becker JM, Reed KL. The effectiveness of a single intraperitoneal infusion of a neurokinin-1 receptor antagonist in reducing postoperative adhesion formation is time dependent. Surgery. 2007 Mar;141(3):368-75. Epub 2007 Feb 6.
Aarons CB, Cohen PA, Gower A, Reed KL, Leeman SE, Stucchi AF, Becker JM. Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg. 2007 Feb;245(2):176-84.
Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O’Brien M, Leeman SE, Kirkland JL, Pothoulakis C. nduction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5207-12. Epub 2006 Mar 20.
Tang X, Marciano DL, Leeman SE, Amar S. (2005) LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5132-7. Epub 2005 Mar 25. [ Abstract ]
Reed KL, Fruin AB, Gower AC, Stucchi AF, Leeman SE, Becker JM. (2004) A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9115-20. Epub 2004 Jun 8. [ Abstract ]
Stucchi AF, Shebani KO, Leeman SE, Wang CC, Reed KL, Fruin AB, Gower AC, McClung JP, Andry CD, O’Brien MJ, Pothoulakis C, Becker JM. (2003) A neurokinin 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the response to a subsequent inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1259-67. Epub 2003 Jul 31. [ Abstract ]
Kennedy PG, Rodgers J, Bradley B, Hunt SP, Gettinby G, Leeman SE, de Felipe C, Murray M. (2003) Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain. 2003 Jul;126(Pt 7):1683-90. Epub 2003 Jun 4. [ Abstract ]
Reed KL, Fruin AB, Bishop-Bartolomei KK, Gower AC, Nicolaou M, Stucchi AF, Leeman SE, Becker JM. (2002) Neurokinin-1 receptor and substance P messenger RNA levels increase during intraabdominal adhesion formation. J Surg Res. 2002 Nov;108(1):165-72. [ Abstract ]
Bremer AA, Tansky MF, Wu M, Boyd ND, Leeman SE. (2001) Direct evidence for the interaction of neurokinin A with the tachykinin NK(1) receptor in tissue. Eur J Pharmacol. 2001 Jul 6;423(2-3):143-7. [ Abstract ]
Macdonald D, Mierke DF, Li H, Pellegrini M, Sachais B, Krause JE, Leeman SE, Boyd ND. (2001) Photoaffinity labeling of mutant neurokinin-1 receptors reveals additional structural features of the substance P/NK-1 receptor complex. Biochemistry. 2001 Feb 27;40(8):2530-9. [ Abstract ]
Bremer AA, Leeman SE, Boyd ND. (2001) Evidence for spatial proximity of two distinct receptor regions in the substance P (SP)*neurokinin-1 receptor (NK-1R) complex obtained by photolabeling the NK-1R with p-benzoylphenylalanine3-SP. J Biol Chem. 2001 Jun 22;276(25):22857-61. Epub 2001 Apr 9. [ Abstract ]
Li H, Macdonald DM, Hronowski X, Costello CE, Leeman SE, Boyd ND. (2000) Further definition of the substance P (SP)/neurokinin-1 receptor complex. MET-174 is the site of photoinsertion p-benzoylphenylalanine4 SP. J Biol Chem. 2001 Apr 6;276(14):10589-93. Epub 2000 Dec 14. [ Abstract ]
Bremer AA, Leeman SE, Boyd ND. (2000) The common C-terminal sequences of substance P and neurokinin A contact the same region of the NK-1 receptor. FEBS Lett. 2000 Dec 1;486(1):43-8. [ Abstract ]
Berg EA, Johnson RJ, Leeman SE, Boyd N, Kimerer L, Fine RE. (2000) Isolation and characterization of substance P-containing dense core vesicles from rabbit optic nerve and termini. J Neurosci Res. 2000 Dec 15;62(6):830-9. [ Abstract ]
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