Anurag Singh, Ph.D., receives the American Lung Association Lung Cancer Discovery Award
Congratulations to Anurag Singh, Ph.D., on being awarded the competitive American Lung Association Lung Cancer Discovery Award for his proposal on “Identifying a KRAS-Regulated Micro-RNA Signaling Network in Lung Cancer.”
According to Dr. Singh, “KRAS mutant lung cancers are notoriously refractory to chemotherapeutic agents. This research proposal will seek to identify novel strategies for the clinical management of these cancers with the overall aim of significantly improving the overall survival of cancer patients. The KRAS gene is mutated in 20-30% of non-small cell lung cancers but effective therapeutics that block KRAS function have not been identified thus far. As an alternative approach we will formulate detailed mechanistic information about the mechanisms by which mutant KRAS promotes tumor cell survival and resistance to therapeutic agents. We hypothesize that small non-coding microRNAs play a crucial role in mediating drug resistance. Interfering with the function of these microRNAs will lead to amelioration of drug resistance and will lead to enhanced efficacy of currently available therapeutic agents used to treat to lung cancer.”
Dr. Singh is an assistant professor in the Department of Pharmacology & Experimental Therapeutics and the Department of Medicine, Division of Medical Oncology, Principal Investigator of the Laboratory for Cancer Pharmacogenomics and member of The Cancer Center. For more information on Dr. Singh’s research, please visit his webpage here.
For more information on the Lung Cancer Discovery Award, please visit the American Lung Association website.
Congratulations, Dr. Singh!