The students of the GPGG are a diverse group. Each has a strong background in research and helps support the strong community and learning environment.
Stefanie Chan (Perissi Lab)
Stefanie is a sixth-year GPGG PhD student with the Perissi laboratory in the Department of Biochemistry. The Perissi laboratory investigates how different inputs are integrated and translated in fine-tuning of transcriptional regulation via the action of signal transduction pathways, ubiquitin conjugating machineries and chromatin remodeling enzymes. Stefanie’s thesis research focuses on finding novel therapeutic targets for triple-negative breast cancer (TNBC; the most aggressive subtype of breast cancer), and her work in the Perissi lab is focused on the role of GPS2 as tumor suppressor regulating the PI3K/AKT pathway in breast cancer.
Gian Sepulveda (Grishok Lab)
Gian is a third-year GPGG PhD student in the lab of Dr. All Grishok. The Grishok lab is currently working on MYC regulation in the context of triple negative breast cancer, as well as the epigenetic regulation of the histone 3 lysine 79 methyltransferase DOT1L. Gian’s project focuses on a putative MYC cleavage that might be essential in MYC-target gene regulation. Preliminary data suggests that MYC may be cleaved to either a 27 or 35 kDa protein. His plans after completion of the PhD are toward science communication and teaching, with a particular interest in journal editing.
George Chen (Dries Lab)
George is a second year student in GPGG working in the lab of Ruben Dries in the department of Hematology Oncology. The lab focuses on spatial transcriptomics and how this technology can be applied to understand the mechanisms and heterogeneity of triple negative breast cancer. In his free time, George enjoys listening to music and drawing.
David Engel (Waxman Lab)
David is a second year PiBS student that just joined the GPGG program. He is a member of Dr. Waxman’s lab on the Charles River Campus. David’s project is focused on the effects of long term exposure to xenobiotics on the epigenetic and expression landscape of PCGs and lncRNAs. His hobbies include creating things through drawing, digital painting, and wood carving. At the same time, David likes pushing his physical limits with boxing, enjoying a good sparring match, and working out.
Taylor Matte (Hawkins Lab)
Taylor is a third year PhD Candidate in the Hawkins Lab at the Center for Regenerative Medicine (CReM). In his thesis work, he seeks to use an iPSC-based multi-omic approach to construct a roadmap of airway development. Outside of the lab, Taylor serves on the BU Anti-Racism Taskforce, where he teaches in the MedSci program seeking to increase equity in STEM education. He also enjoys sensory deprivation tanks, themed parties, and Björk.
Megan Snyder (Sherr Lab)
Megan is a third year GPGG PhD student in the laboratory of Dr. David Sherr. The primary focus of the Sherr lab is to understand the immunological and molecular mechanisms that influence cancer risk through the interactions between the aryl hydrocarbon receptor (AhR) and both environmental and endogenous ligands. Her project involves understanding the role of the AhR as a driver of both tumorigenesis and immune suppression in lung and oral cancers by elucidating the genetic and phenotypic consequences of the AhRàIDOàKynàAhR ligand amplification loop. This research, in conjunction with data from the Precancer Genome Atlas, aims to identify a genetic signature indicating—but prior to—tumor development when AhR inhibitors can be administered to intercept and prevent cancer. Megan’s broader interests include gene therapy, translational research, and a passion for developing novel treatments that utilize personalized and preventative medicine. Outside of the lab, she enjoys keeping up her circus skills, playing soccer, competing in bar trivia, and binging good TV shows..
Dylan Steiner (Lenburg Lab)
Dylan Steiner is a 2nd year student in the Genetics & Genomics PhD program at Boston University School of Medicine in the lab of Marc Lenburg and Avi Spira and the lab of Jennifer Beane. His current research interests are on lung cancer subtype biology, premalignancy, and development of lung cancer biomarkers for early detection and precision medicine. Dylan enjoys live music, surfing (when in his home state of California) and nurturing his houseplants.