Collaborative Publications

CR campus ARC leaders are denoted in red color

CR campus ARC leaders are denoted in red color

CR campus ARC leaders are denoted in red color

Both technologies have tremendous potential for the quantitative assessment of fibrosis in the respective organs.

Caporarello N, Lee J, Pham TX, Jones DL, Guan J, Link PA, Meridew JA, Marden G, Yamashita T, Osborne CA, Bhagwate AV, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, and Ligresti G. Dysfunctional ERG signaling drives pulmonary vascular aging and fibrosis. Nature Comm, 13, 4170 (2022). https://doi.org/10.1038/s41467-022-31890-4

CR campus ARC leaders are denoted in red color

Co-Directors: Vipul Chitalia, Katya Ravid, Jean Francis

Matsuura S, Thompson CR, Belghasem ME, Bekendam RH, Piasecki A, Leiva O, Ray A, Italiano J, Yang M, Merill-Skoloff G, Chitalia VC, Flaumenhaft R, Ravid K. Platelet Dysfunction and Thrombosis in JAK2 ^V617F-Mutated Primary Myelofibrotic Mice. Arterioscler Thromb Vasc Biol. 2022 Oct;40(10):e262-e272.

2.     Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination. J Mol Neurosci 2015; DOI: 10.1007/s12031-015-0598-2

3.     Saha S, Ash PE, Gowda V, Shirihai O, Wolozin B. Mutations in LRRK2 potentiate age-related Impairment of autophagic flux. Mol Neurodegen 2015; 10:26. PMID: 26159606

4.     Wolozin B, Apicco D. RNA binding proteins and the genesis of neurodegenerative diseases. Adv Exp Med Biol 2015; 822:11-15.

5.     Nho K, Kim S, Risacher S, Shen L, Corneveaux J, Swaminathan S, Lin H, Ramanan V, Liu Y, Foroud T, Inlow M, Siniard A, Reiman R, Aisen P, Petersen R, Green R, Jack C, Weiner M, Baldwin C, Lunetta K, Farrer L, Furney S, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, McDonald B, Farlow M, Huentelman M, Saykin AJ for the Indiana Memory, Aging Study, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)†, for the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study and for the AddNeuroMed Consortium. Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol 2015; 77:547-552. PMID: 25559091

6.     Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer’s disease. Neurobiol Aging 2015; pii: S0197-4580(15)00393-0.

7.     Lee HK, Morin PJ, Wells J, Hanlon EB, Xia W. Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient’s peripheral blood mononuclear cells. Stem Cell Res. 2015; 15; 325-327.

8.     Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI,  Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Lee JH, Schellenberg GD, St George-Hyslop P, Mayeux RM, Rogaeva E, Alzheimer Disease Genetics Consortium.  Association of long runs of homozygosity with Alzheimer’s disease among African Americans. JAMA Neurology 2015; 72:1313-1323. PMID: 26366463

9.     Farrer LA. Expanding genomic roadmap for Alzheimer disease. Lancet Neurol 2015; 14:783-785. PMID: 26141618

10.  Jones L, Bellenguez C, Wang L-S, Choi S-H, Harold D, Vedernikov A, Escott-Price V, Stone T, Richards A, Charles Lambert -C, Ibrahim-Verbaas CA, Naj AC, Sims R, Gerrish A, Jun G, DeStefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin C-F, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau M-T, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letteneur L, J Morón FJ, Rubinsztein  DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleὀ A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez Garcia F, Fox N, Hardy J, Candida Deniz Naranjo M, Razquin C, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, MRC CFA, Moebus S, Mecocci P, del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Jessen F, Dichgans M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alavarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combonovan MC, Cantwell LB, Soininen H, Blacker D, Mead S,  Mosley  TM Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RFAG, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JSK, Boerwinkle E, Riemenschneider M,  Boada M, Hiltunen M, Martin ER, Pastor P, Schmidt R, Rujescu D, Dartigues J-F, Mayeux R, Tzourio C, Hofman A, Nöthen MN, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broekhoven C, Ramirez A, Schellenberg GD, Seshadri S, Amouyel P, Williams J, Holmans PA. Convergent evidence from genetic association and gene expression data implicate immunity in Alzheimer’s disease. Alzheimers Dement 2015; 11:658-671. PMID:  25533204

11.  Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Chasman DL, McEvoy LK, Holland D, Chen C-H, Devor A, Karow DS, Brewer JB, Hess CP, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Jernigan TL, Hardy J, Hyman BT, Snaedal J, Gudbjartsson D, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM; Inflammation Working Group and International Genomics of Alzheimer’s Disease Project (IGAP) and DemGene Investigators. Polygenic overlap between inflammation, plasma lipids and Alzheimer’s disease: discovery of three loci associated with increased Alzheimer’s disease risk. Circulation 2015; 131:2061-2069. PMID: 25862742

12.  Asai H, Ikezu S, Tsunoda S, Madalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kugler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci 2015; 18: 1584-1593.  PMID: 26436904

13.  Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack FJ, Ikezu T. miR-155 is essential for inflammation-induced hippocampal neurogenic dysfunction. J Neurosci 2015; 35:9764-9781

14.  Hohman TJ, Cooke-Bailey J,  Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM,  Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA for the Alzheimer Disease Genetics Consortium. Global and local ancestry in African Americans: implications for Alzheimer’s disease risk. Alzheimers Dement 2016; 12:233-243. PMID: 26092349

15.  Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, da Rocha EL, Jansen-West K, Frame AA, Citro A, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, Wolozin B, Interaction with tau with RNA binding protein TIA1 regulates tau pathophysiology and toxicity. Cell Reports 2016; 15: 1-12. PMID: 27160897

16.  Meier S, Bell M, Lyons DN, Rodriguez-Rivera J, Fontaine S, Mechas E, Chen J, Wolozin B, Levine H, Zhu H, Abisambra JF. Pathological tau promotes neuronal damage by impairing ribosomal function and decreasing protein synthesis. J Neuroscience 2016; 36:1001-1007. PMID: 26791227.

17.  Jaeger PA, Lucin K, Britschgi M, Vardarajan B, Huang R-P, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford N, Head, Hofree M, Huang R, Hudson J, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhikov A, Pradhan S, Rademakers R, Sun C-H, Younkin S, Miller BL, Ideker T, Wyss-Coray T. Network-driven plasma proteomics expose molecular changes in Alzheimer’s brain.  Mol Neurodegener 2016; 11(1):31. PMID:  27112350

18.  Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three dimensional human neuro-spheroid model of Alzheimer’s disease based on differentiated induced pluripotent stem cells. PLoS One. 2016; 11(9):e0163072. PMID: 27684569

19.  Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho is a neuroprotective and cognition-enhancing protein. In Gerald Litwack, editor: Klotho, Vol 101, VH, UK: Academic Press, 2016, pp. 215-238.

20.  Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert J-C, Chung J, Naj AC, Kunkle BW, Wang L-S, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, Beecham GW, Smith AV, Chouraki V, Hamilton-Nelson KL, Ikram MA, Fievet N, Denning N, Martin ER, Schmidt H, Kamatani Y, Dunstan ML, Valladares O, Ruiz A, Zelenika D, Ramirez A, Foroud TM, Choi S-H, Boland A, Becker T, Kukull WA, van der Lee SJ, Pasquier F, Cruchaga C, Beekly D, Fitzpatrick AL, Hanon O, Gill M, Barber R, Gudnason V, Campion D,  Love S, Bennett DA, Amin N, Berr C, Tsolaki M, Buxbaum JD, Lopez OL, Deramecourt V, Fox NC, Cantwell LB, Tárraga L, Dufouil C, Hardy J, Crane PK, Eriksdottir G, Hannequin D, Clarke R, Evans D, Mosley, TH Jr., Letenneur L, Brayne C, Goate AM, Maier W, De Jager P, Emilsson V, Franҫois Dartigues J-F, Hampel H, Kamboh MI, de Bruijn RFAG, Tzourio C, Pastor P, Larson EB, Rotter JI, O’Donovan MC, Montine TJ, Nalls MA, Mead S, Reiman EM, Jonsson PV, Holmes C, St. George-Hyslop PH, Boada M, Passmore P, Wendland JR, Schmidt R, Morgan K, Winslow AR, Powell JF, Carasquillo M, Younkin SG, Jakobsdóttir J, Kauwe JSK, Wilhelmsen KC, Rujescu D, Nöthen MM, Hofman A, Jones L, IGAP Consortium, Haines JL, Psaty BM, Van Broeckhoven C, Holmans P, Launer LJ, Mayeux R, Lathrop M ,Escott-Price V, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM Schellenberg GD, Farrer LA. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psych 2016; 21:108-117. PMID: 25778476

21.  Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary study of plasma exosomal Tau as a potential biomarker for chronic traumatic encephalopathy. J Alzheimers Dis 2016; 51:1099-1109.

22.  Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber M, Wolozin B, Ikezu T, Bolotina VM. Impairment of PARK14-dependent Ca2+ signaling is a novel trigger for autophagic dysfunction and Parkinson’s disease. Nat Commun 2016; 7:10332. PMID: 26755131

23.  Cukier HN, Kunkle BW, Vardarajan BN, Rolati S, Hamilton-Nelson KL, Kohli MA, Whitehead PL, Booven DV, Lang R, Dykxhoorn DM, Farrer LA, Cuccaro ML, Vance JM, Gilbert JR, Beecham GW, Martin ER, Carney RM, Mayeux R, Schellenberg GD, Byrd GS, Haines JL, Pericak-Vance MA, Alzheimer Disease Genetics Consortium. ABCA7 frameshift deletion associated with Alzheimer’s disease in African Americans. Neurol Genet 2016; 2:e79.

24.  Lee HK, Velazquez Sanchez C, Chen M, Morin PJ, Wells JM, Hanlon EB, Xia W. Three dimensional human neuro-spheroid model of Alzheimer’s disease based on differentiated induced pluripotent stem cells. PLoS One. 2016 Sep29;11(9):e0163072.

25.  Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ, Alzheimer Disease Genetics Consortium, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA.  Identification of two novel loci, COBL and SLC10A2, for Alzheimer’s disease in African Americans using informed conditioning on clinical covariates. Alzheimers Dement 2017; 13:119-129 PMID:  27770636

26.  Jun G, Chung J, Mez, J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carasquillo M, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Logue MW, Manly JJ, Larson EB, Martin ER, Montine TJ, Naj A, Reiman EM, Reitz C, Sherva R, St. George-Hyslop PH, Younkin SG, Vardarajan BN, Wang L-S, Wendlund JR, Winslow AR, Alzheimer Disease Genetics Consortium, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta K, Farrer LA. Transethnic Genome-Wide Scan Identifies Novel Alzheimer Disease Loci. Alzheimers Dement 2017; 13:727-738. PMID: 28183528.

27.  Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Shendure J, Raskin WH, Cruchaga C, Schellenberg G, Joseph B, Brkanac Z. CASP8, association with Alzheimer’s disease and functional analysis of rare variants. PLoS One. 2017; 12(10):e0185777. PMID: 28985224

28.  Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen C-H, Brewer JB, Karow DS, Galasko DR, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HR, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM for the ADNI and ADGC investigators. Genetic assessment of age-associated Alzheimer’s disease risk: development and validation of a polygenic hazard score. PLoS Med 2017; 14(3):e1002258. PMID: 28323831

29.  Haddick PCG, Larson JL, Rathore N, Bhangal TR, Phung QT, Srinivasan K, Hansen DV, Lill JR, Alzheimer’s Disease Genetic Consortium (ADGC), Alzheimer’s Disease Neuroimaging Initiative (ADNI), Pericak-Vance MA, Haines J, Farrer LA, Kauwe JS, Schellenberg GD, Cruchaga C, Goate AM, Behrens TW, Watts RJ, Graham RR, Kaminker JS, van der Brug M. A common variant of IL-6R is associated with elevated IL-6 pathway activity in Alzheimer’s disease brains. J Alzheimers Dis 2017; 56: 1037-1054. PMID: 28106546

30.  Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang K, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Kim S, Saykin AJ, De Jager PL, Albert M, Moghekar A, O’Brien R, Riemenschneider M, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin Lee VM-Y, Shaw LM, Trojanowski JQ, Schellenberg G, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Peskind ER, Li G, DiNarzo AF, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetic Consortium (ADGC), Kauwe J, Goate A, Cruchaga C. Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers. Acta Neuropath 2017; 133:839-856. PMID: 28247064

31.  Clayton KA, Van Enoo AA, Ikezu T. Alzheimer’s Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Front Neurosci. 2017; 11:680.

32.      Cukier HN, Kunkle BW, Hamilton-Nelson KL, Rolati S, Kohli MA, Whitehead PL, Vance JM, Cuccaro M, Carney RM, Gilbert JR, Farrer LA, Martin ER, Beecham GW, Haines JL, Pericak-Vance MA. Exome sequencing of extended families with Alzheimer’s disease identifies novel genes implicated in cell immunity and neuronal function. J Alz Dis Parkinsonism. 2017; 7(4). Pii 355. PMID: 29177109.

33.      Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Partch A, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi S-H, Beecham GW, Dulary C, Herms S, Smith AV, Funk, CF, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sanchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Sanchez Garcia F, Denning N, Fornage M, Malamon J, Deniz Naranjo MC, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber, RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth, WT Jr, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Boada M, Ghetti B, Sánchez-Juan P, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido MJ, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O’Donnell CJ, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Wendland JR, Bonuccelli U, Winslow AR, Daniele A, Wu C-K, GERAD/PERADES, CHARGE, ADGC, EADI, Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, RubinszteinDC, Bras J, Guerreiro R, Hardy J, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarimón J, Sussams R, Lovestone S, O’Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Cambarros O, Psaty BM, Passmore P, Younkin SG,  Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues J-F, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines J, Tzourio C, Launer LJ, Escott-Price V, Mayeux R, Deleuze J-F, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang L-S, Lambert JC, Seshadri S, Williams J, Schellenberg GD. Novel coding variants in PLCG2, ABI3 and TREM2 associate with Alzheimer’s disease implicating innate immunity pathways. Nature Genetics 2017; 49(9):1373-1384. PMID: 28714976

34.      Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau phosphorylation is impacted by rare AKAP9 mutations associated with Alzheimer disease. Neuroimmune Pharm 2018; 13:254-264. PMID: 29516269

35.      Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, The Alzheimer’s Disease Neuroimaging Initiative, Lunetta KL, Farrer LA, Jun GR. Genome-wide association study of Alzheimer disease endophenotypes at prediagnosis stages. Alzheimers Dement 2018; 14:623-633. PMID: 29274321

36.      DeLeo AM, Ikezu T. Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy. J Neuroimmune Pharmacol. 2018; 13:292-308. PMID: 29185187

37.      Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, Alzheimer Disease Genetics Consortium, Mayeux R, Haines J, Pericak-Vance M, Schellenberg G, Jun GR, Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer disease. Alzheimers Res Ther 2018;10:22. PMID:29458411

38.      Qamar S, Wang GZ, Randle S, Ruggeri FS, Varela JA, Lin JQ, Phillips E, Miyashita A, Williams D, Stroehl F, Meadows W, Ferry RR, Tartaglia GG, Farrer LA, Kaminski Schierle GS, Kaminski CF, Holt C, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P. Physiological and pathological phase transition of FUS is modulated by its methylation and interaction with TNPO1. Cell 2018; 173:720-734. PMID: 29677515

39.      Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj A, Thornton T, DeStefano A, Martin E, Wang L-S, Brown L, Bush W, van Duijn C, Goate A, Farrer L, Haines JL, Boerwinkle E, Schellenberg G, Wijsman E, Pericak-Vance MA, Mayeux R, for The Alzheimer’s Disease Sequencing Project. Whole genome sequence of Caribbean Hispanic families with late-onset Alzheimer’s disease. Ann Clin Transl Neurol 2018; 5:406-417. PMID: 29688227

40.      Lancour D, Naj A, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GC, Crovella M, Farrer LA, Kasif S. One for all and all for one: improving replication of genetic studies through network diffusion. PLoS Genet 2018; ; 14(4):e1007306. PMID: 29684019

41.      Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017; 292:10651-10656.

42.      Chen CD, Zeldich Z, Li X Yuste A, Abraham CR. Activation of the anti-aging and cognition-enhancing gene Klotho by CRISPR-dCas9 transcriptional effector complex. J Molec Neurosci. 2018; 64:175-184. PMID:29352444

43.      Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol 2018; 137:259-277. PMID: 30465259.

44.      Yeh H, Ikezu T. Transcriptional and epigenetic regulation of microglia in health and disease. Trends Mol Med 2018; S1471-4914(18)30222-3. PMID:30578089.

45.      Logue MW, Lancour D, Farrell J, Simkina I, Fallin MD, Lunetta KL, Farrer LA. Targeted sequencing of Alzheimer disease genes in African Americans implicates novel risk variants. Front Neurosci 2018; 12: 592. PMID: 30210277

46.      Rajabli F, Feliciano B, Celis K, Hamilton K, Whitehead P, Adams LD, Bussies PL, Rodriguez A, Starks T, Byfield GE, Sierra Lopez CB, McCauley JL, Acosta H, Chinea A, Reitz C, Farrer LA, Schellenberg GD, Vance JM, Vardarajan BN, Cuccaro ML, Martin ER, Haines JL, Byrd GS, Beecham GW, Pericak-Vance MA. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLOS Genetics 2018; 14(12):e1007791. PMID: 30517106

47.      Li D, Wang L, Maziuk BF, Yao X, Wolozin B, Yong Ku Cho. Directed evolution of a picomolar affinity, high-specificity antibody fragment targeting phosphorylated tau. J Biol Chem 2018; 293:12081-12094. PMID: 29899114.

48.      Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud Faus A, Botelho E, Balance H, Dhawan U, Boudeau S, Lourdes-Cruz A, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung C, Kanaan NM, Tripodis Y, Ikezu T, Cottone P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B, Reducing TIA1 protects against tau-mediated neurodegeneration in vivo. Nature Neurosci, 2018; 21:72080. PMC5745051

49.      Beecham GW, Vardarajan B, Blue E, Bush W, Jaworski J, Barral S, DeStefano A, Hamilton K, Kunkle B, Martin ER, Naj A, Rajabli F, Reitz C, Thornton T, van Duijn C, Goate A, Seshadri S, Farrer LA, Boerwinkle E, Schellenberg G, Haines JL, Wijsman E, Mayeux R, Pericak-Vance MA for The Alzheimer’s Disease Sequencing Project. Whole genome sequencing in non-Hispanic white multiplex late-onset Alzheimer disease families implicates rare variation in Alzheimer disease risk. Neurol Genet 2018; 4(6):e286. PMID: 30569016

50.      Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH, Leszyk J, Abisambra JF, Li H, Wolozin B. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun 2018; 6:71. PMID: 30068389.

51.      Ruan QT, Yazdani N, Beierle JA, Hixson KM, Hokenson KE, Apicco DJ, Luttik KP, Zheng K, Maziuk BF, Ash PEA, Szumlinski KK, Russek SJ, Wolozin B, Bryant CD. Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Neurosci Lett 2018; 684:109-114. PMID: 30003938

52.      Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Protein phase separation: a new phase in cell biology. Trends Cell Biol 2018; 28:420-435. PMID: 29602697

53.      Wolozin B. Disrupted in dementia. Biol Psych 2018; 84:474-5. PMID: 30176990

54.      Robinson AA, Abraham CR, Rosene DL. Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys. Geroscience. 2018; 40:31-47. PMID:29357021

55.      Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo AI, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, Morin P, Hooper NM, Porter R, Preston J, Al-Shawi R, Baillie G, Lovestone S, Cuadrado A, Harte M, Simons P, Srivastava DP, Killick R. Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimers Dement 2018; 14:306-317. PMID: 29055813

56.      Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics 2018; 182:121-33. PMID: 29709615

57.      Elliott C, Rojo AI, Ribe E, Broadstock M, Xia W, Morin P, Semenov M, Baillie G, Cuadrado A, Al-Shawi R, Ballard CG, Simons P, Killick R. A role for APP in Wnt signalling links synapse loss with β-amyloid production. Transl Psychiatry 2018; 8:179. PMID: 30232325

58.      Patel D, Mez J, Vardarajan B, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Alzheimer Disease Sequencing Project, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA. Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry. JAMA Network Open 2019; 2(3):e191350. PMID: 30924900

59.      Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. J Alzheimers Dis 2019; 67:1089-1106. PMID: 30776010

60.      Ash PEA, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna LFA, Boomhower SR, Newland MC, Sherr DH, Wolozin B. Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology. Tox Sci 2019; 167:105-115. PMID: 30371865

61.      Delpech JC, Herron S, Botros M, Ikezu T. Neuroimmune crosstalk through extracellular vesicles in health and disease. Trends Neurosci 2019; S0166-2236(19)30024-4

62.      Xia W. γ-Secretase and its modulators: Twenty years and beyond. Neurosci Lett 2019; 701:162-169. PMID: 30763650

63.      Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amile-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Aloso R, Raybould R,  Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O,  Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D,  Denning N, Jian X, Zhao Y, Zompo MD, Fox NC, Grove ML, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Garcia FS, Patel Y, Brody JA, Dombroski B, Naranjo MCD, Daniilidou M, Eiriksdottir G,  Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewics M, Fin B, Scarpini E, Sarnowski C, Bush W, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Pichler S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Fernadez CM, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Comic H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT Jr, Montine TJ, Frisardi V, Ortega-Cubero S, Rivadeneira F, Petersen RC, Deramecourt V, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Caltagirone C, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, Moreno-Grau S, Sano M, Brice A, Cecchetti R, St George-Hyslop P, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Baldwin CT, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston J, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Cribbs DH, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies G, Jin LW, Leonenko G, Jun G, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM,  Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O’Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry W, Mead S, Peskind E, Rosser M, Pierce A, Ryan N, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Bossù P, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett DA, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, McDonough S, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG,  Dartigues JF, Corcoran C, Ikram MA, Dickson DW, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, O’Donovan MC, DeStefano AL, Jones L, Haines JL, Deleuze JF, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang LS, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert JC, Pericak-Vance MA. Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing. Nature Genet 2019; 51:414-430. PMID: 30820047

64.      Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton KL, Bush WS, Salerno W, Lancour D, Ma Y, Renton AE, Marcora EM, Farrell J, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues J-F, Debette S, Deleuze J-F, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havulinna AS, Helisalmi S, Hiltunen M, Howrigan DP, Ikram MA, Kaprio J, Konrad J, Kuzma A, Lander ES, Lathrop M, Lehtimäki T, Lin H, Mattila K, Mayeux R, Muzny DM, Nasser W, Neale B, Nho K, Nicolas G, Patel D, Pericak-Vance M, Perola M, Psaty BM, Quenez O, Rajabli F, Redon R, Reitz C, Remes A, Salomaa V, Sarnowski C, Schmidt H, Schmidt M, Schmidt R, Soininen H, Thornton T, Tosto G, Tzourio C, van der Lee SJ, van Duijn CM, Vardarajan BN, Wang W, Wijsman E, Wilson RK, Witten D, Worley K, Zhang X, Alzheimer’s Disease Sequencing Project, Bellenguez C, Lambert J-C, Kurki M, Palotie A, Daly M, Boerwinkle E, Lunetta KL, Destefano AL, Dupuis J, Martin ER, Schellenberg GD, Seshadri S, Naj AC, Fornage M, Farrer LA. Whole exome sequencing study identifies novel rare and common Alzheimer’s-associated variants involved in immune response and transcriptional regulation. Mol Psychiatry 2019. In press. PMID: 30108311

65.      Ma Y, Zhang X, Jun G, Chung J, Naj AC, Belinguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Alzheimer Disease Sequencing Project, ADES-FR, Bis JC, DeStefano AL, Fornage M, van Duijn C, Bennett D, DeJager P, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert J-C, Schellenberg GD, Lunetta KL, Farrer LA. Novel Alzheimer disease loci identified in subsets of whole exome sequencing data stratified by APOE genotype. JAMA Neurol 2019. In press.

66.      Silva JM, Rodrigues S, Sampaio-Marques B, Gomes P, Neves-Carvalho A, Dioli C, Soares-Cunha C, Takashima A, Ludovico P, Wolozin B, Sousa N, Sotiropoulos I, Dysregulation of autophagy and stress-granule related proteins in stress-driven tau pathology. Cell Death Differ 2019. In press. PMID: 30442948.

67.      Wolozin B, Ivanov P. Stress granules and neurodegeneration. Nature Rev Neurosci 2019. In press.

68.      Wolozin B. The evolution of phase separated TDP-43 in stress. Neuron invited commentary 2019. In press.

69.      Ma Y, Jun GR, Chung J, Zhang X, Kunkle BW, Naj AC, White CC, De Jager PL, Bennett DA, Alzheimer’s Disease Genetics Consortium, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Farrer LA, Lunetta KL. CpG-related SNPs in the MS4A Region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging Cell 2019. In press.

70.      Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Zhang X, Zhu C; Choi YY, Lim HJ, Park JE, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko P-W, Han J-W, Farrell J, Alzheimer’s Disease Neuroimaging Initative, Lunetta KL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, An SSA, Won S, Choi S-M, Ha J-M, Lee H-W, Park KW, Lee YM, Choi SH, Rhee S, Kim K-W, Song WK, Lee JS, Song MK, Nho K, Jun GR, Kim SY, Choo IH, Lee DY, Kim BC, Kim H, Ikeuchi T, Farrer LA, Lee KH. APOE promoter polymorphism -219T/G is an effect modifier of the Association of APOE ε4 with Alzheimer’s disease. Submitted.

71.      Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Myers AJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene C, Kamboh MI, Kofler JK, Mash DC, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Kramer P, Dickson DW, Frosch MP, Ghetti B, Wang L-S, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA,  Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg G, Beecham GW, Montine TJ, Jun GR for the Alzheimer’s Disease Genetics Consortium. Exceptionally low risk of Alzheimer’s dementia in APOE2 homozygotes. Submitted.

Abstracts Presented at Meetings:

72.  Abraham CR, Zeldich E, Brown LE, Porco JA Jr, Chen CD. Deciphering the mechanisms by which inhibiting app dimerization reduces abeta production. Presented at the annual AD/PD Conference, Nice, France, 2015

73.  Abraham CR, Chen CD, Avila R, Medicetty S, Zeldich E. Klotho enhances remyelination following cuprizone-induced demyelination. Presented at the annual AD/PD Conference, Nice, France, 2015.

74.  Woodbury ME, Ikezu S, Luebke JL, Chao PH, Ikezu T. Microglial dysregulation: a mechanism for abnormal behavior, spine density and neuronal activity in a mouse model of autism spectrum disorder. Presented at the 45th Annual Meeting for the Society of Neuroscience, Chicago, 2015.

75.  Ikezu T, Asai H, Ikezu S, Wolozin B, Farraye F, Wszolek Z. Parkinson’s and Crohn’s disease-associated LRRK2 mutations and LRRK2 inhibitors alter type II interferon responses of human peripheral blood monocyte ex vivo. Presented at the 45th Annual Meeting for the Society of Neuroscience, Chicago, 2015.

76.  Varnum MM, Yonemoto G, Ikezu S, Asai H, Ikezu T. Characterization of TREM2-TYROBP signaling through novel real-time TREM2-TYROBP coupling reporter system with split-luciferase complementation. Presented at the 45th Annual Meeting for the Society of Neuroscience, Chicago, 2015.

77.  Zeldich E, Chen CD, Abraham, CR. Klotho protects hippocampal neurons from glutamate and oligomeric Abeta-induced toxicity. Massachusetts Alzheimer Disease Center, Mass General Hospital,. Boston, 2015.

78.  Mullen PC, Chen CD, Zeldich E, Brown LE, Porco JA, Abraham, CR. A novel mechanism for lowering Abeta. Presented at Society for Neuroscience Meeting, Chicago, 2015.

79.  Abraham CR, Zeldich E, Chen, CD Wang E, Hodgetts K. Klotho boosters: Novel therapies for neurodegenerative diseases. 2nd Zing Neurodegeneration Conference. Cancun, Mexico, 2015.

80.  Chung J, Farrer LA, Alzheimer’s Disease Neuroimaging Initiative, Jun G. Genome-wide association study in different clinical stages of Alzheimer disease. Presented at the Alzheimer’s Association International Conference on Alzheimer Disease (AAIC), Washington DC, USA, July 2015

81.  Jun G, Chung J, Tosto G, Vardarajan B, Reitz C, Lunetta K, Manly J, Byrd G, Haines J, Pericak-Vance M, Kuwano R, Mayeux R, Schellenberg G, Farrer L. Trans-ethnic genome-wide meta-analysis for Alzheimer disease. Presented at the Alzheimer’s Association International Conference on Alzheimer Disease (AAIC), Washington DC, USA, July 2015.

Co-Directors: Drs. Maria Kukuruzinska (mkukuruz@bu.edu – GDSM, Molecular and Cell Biology, Assoc Dean for Research), Avrum ‘Avi’ Spira (aspira@bu.edu – MED, Section Chief), Maria Trojanowska (trojanme@bu.edu – MED, Medicine)

1.     Bais, M. V., Kukuruzinska, M., and Trackman, P. C. (2015) Orthotopic non-metastatic and metastatic oral cancer mouse models. Oral oncology. 51, 476-482.

2.     Bais, M. V., Ozdener, G. B., Sonenshein, G. E., and Trackman, P. C. (2015) Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways. Oncogene. 34, 1928-1937

3.     Hiemer, S. E., Zhang, L., Kartha, V. K., Packer, T. S., Almershed, M., Noonan, V., Kukuruzinska, M., Bais, M. V., Monti, S., and Varelas, X. (2015) A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Molecular Cancer Research: MCR. 13, 957-968.

4.     Krisciunas GP, Platt M, Trojanowska M, Grillone GA, Haines PC, Langmore SE. A Novel In Vivo Protocol for Molecular Study of Radiation-Induced Fibrosis in Head and Neck Cancer Patients. Ann Otol Rhinol Laryngol. 2015 Oct 8. pii: 0003489415607527. [Epub ahead of print]

5.     Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. PMID: 25502501

6.     Malloy JR., Valentin JC. Hands GL., Stevens CA., Langmore SE., Noordzij JP., Stepp CE. Visuomotor control of neck surface electromyography in Parkinson’s disease, Neurorehabilitation

7.     Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10;34(3):283-96. doi: 10.1016/j.devcel.2015.06.020. Epub 2015 Jul 30. PMID: 26235047: 25043473

In Review

8.     Sengupta, P., Packer, T., Li, J., Young, C., Rodriguez, A., Noonan, V., Salama, A., Bais, M., Heimer, S., Varelas, X., Kartha, V., Zhang, L., Monti, S., and Kukuruzinska, M.A. (2015). N-glycosylation Gene DPAGT1 Promotes Oncogenic Activities of Oral Squamous Cell Carcinoma.

9.     Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, and Sherr DH. 2016. An aryl hydrocarbon receptor-mediated positive feedback loop that enforces cell migration in ER^–/PR^–/Her2^– human breast cancer cells. Molecular Pharmacology, In Press.

10. Ozdener GB, Bais MV, Trackman PC. Determination of cell uptake pathways for tumor inhibitor lysyl oxidase propeptide. Mol Oncol. 2016;10(1):1-23. doi: 10.1016/j.molonc.2015.07.005. PubMed PMID: 26297052; PMCID: PMC4549800.

11. Saxena, D., Mahjour, F., Findlay, A. D., Mously, E.A., Kantarci, A., Trackman, P.C. Multiple functions of lysyl oxidase like-2 in oral fibroproliferative processes. (2018) J. Dent. Res.

12. Smith BW, Stanford EA, Sherr DH, Murphy GJ: Genome editing of the Cyp1a1 locus in iPSCs as a platform to map AHR expression throughout human development. Stem Cell International 2016, 2016:2574152. PMID: 27148368

13. Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, 7Monti S, Bais MV, Sherr DH. Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis. Mol Cancer Res. 2016;14(8):696-706. doi: 10.1158/1541-7786.MCR-16-0069. PubMed PMID: 27130942; PMCID: PMC4987205

14.  Stanford E., Wang Z,  Novikov O, Mulas F, Landesman-Bolag E., Monti S, Smith B, Muprhy GJ, and Sherr DH. 2016. The role of the aryl hydrocarbon receptor in the development of cells with molecular and functional characteristics of breast cancer stem cells. BMC Biology. 14:20.

15. Szymaniak AD, Mi R, McCarthy SE, Gower AC, Reynolds TL, Mingueneau M, Kukuruzinska M, Varelas X. The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland. Elife. 2017 May 11;6. pii: e23499. doi: 10.7554/eLife.23499. [PMID: 28492365]

16. Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R, Szymaniak AD, Varelas X, Trojanowska M. Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis. J Invest Dermatol. 2018 Jan;138(1):78-88. doi: 10.1016/j.jid.2017.08.024. Epub 2017 Sep 1. PMID: 28870693

17. Trackman, P.C. (2016) Lysyl oxidase isoforms and potential therapeutic opportunities for fibrosis and cancer. Expert Opinion Ther. Targets 3, 1-11.

18. Varelas X, Bouchie MP, Kukuruzinska MA. Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling. Glycobiology. 2014 Jul;24(7):579-91. doi: 10.1093/glycob/cwu031. Epub 2014 Apr 17

19. Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis, and disease. Development. 2014 Apr;141(8):1614-26. doi: 10.1242/dev.102376.

1. Varelas, X. Kukuruzinska, M.A. (2014). Head and Neck Cancer: from research to therapy and cure. Ann. NY Acad Sci.
2. Vargas DA, Sun M, Sadykov K, Kukuruzinska MA, Zaman MH. The Integrated Role of Wnt/ß-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics. PLoS Comput Biol. 2016 Jul; 12(7):e1005007. PMID: 27427963.

22. Yang C-S, Zhang L, Stampouloglou E, Monti S, Varelas X. Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells. 2018 EMBO Reports. (In Press).

23.  Yost, Susan, Philip Stashenko, Yoonhee Choi, Scharukh Jalisi, Maria Kukuruzinska, Caroline Genco, Jorge Frias-Lopez. Increase virulence of the oral microbiome in oral squamous cell carcinoma (OSCC) revealed by metatranscriptome analyses. Int. J. of Oral Sciences, 2018 Nov 12;10(4):32. doi: 10.1038/s41368-018-0037-7

1. Zhang L, Yang C-S, Varelas X, Monti S. Altered RNA editing in 3’ UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors. Sci Rep. 2016;6:23226. doi:10.1038/srep23226.

Submitted / In Preparation:

25.  Katsunari Makino, Tomoko Makino, Lukasz Stawski, Eric Reed, Xaralabos Varelas, Ann Marie Egloff, Stefano Monti, Maria Trojanowska. Dimethyl fumarate attenuates head and neck ionizing radiation-induced skin injury , Radiation Research, in revision

26.  Anna C. Belkina, Christopher O. Ciccolella, Rina Anno, Richard Halpert, Josef Spilden, Jennifer Synder-Cappione. Automated optimal parameters for T-distributed stochastic neighbor embedding improve visualization and allow analysis of large datasets. Submitted to Nature Communications.

27.  Walker, J., L., Bouchie, M.P., Bleaken, B., Menko, A.S. and Kukuruzinska, M.A. (2018). Specification of the Patterning of a Ductal Tree During Branching Morphogenesis of the Submandibular Gland. Scientific Reports, Accepted pending revision.

28.  Stampouloglou E , Federico A,  Slaby E, Monti S, Szeto GL and Varelas X. Yap is a repressor of T cell activation and function. (2019) submitted to Science Immunology.

29.  Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. iEDGE (integration of Epi-DNA and Gene Expression) and applications to the discovery of somatic copy number-associated drivers in cancer. (2019) Submitted.

30. Mulas F, Li A, Sherr D, Monti S. Network-Based Analysis of Chemical Perturbations to Identify Mechanisms of Action Associated to Adverse Phenotypes. BMC Bioinformatics. 2016:In press.

31. Kaneoka AS, Langmore SE, Krisciunas GP, Field K, Scheel R, McNally E, Walsh MJ, O’Da MB, Cabral H. The Boston Residue and Clearance Scale; Preliminary reliability and validity testing. Folia Phoniatr Logop Jul 12:65(6):312-317.

32. Kartha VK, Stawski L, Han R, Haines P, Gallagher G, Noonan V, Kukuruzinska M, Monti S, Trojanowska M. PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas. PLoS One. 2016;11(4):e0154645. doi:10.1371/journal.pone.0154645.

1. Kartha, V.K., Alamoud, K.A., Sadykov, K., Nguyen, B-C., Laroche, F., Feng, H., Lee, J., Pai, S. I., Varelas, X., Egloff, A.M., Snyder-Cappione, J.E., Belkina, A.C., Bais, M.V., Monti, S., and Kukuruzinska, M.A. (2018). Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer, Genome Medicine, 10:54

34.  Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S, CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features. Front Genet. 2019 Feb 19;10:121. doi: 10.3389/fgene.2019.00121. eCollection 2019. PMID: 30838036

35.  Faranak Mahjour, Vrinda Dambal, Neha Shrestha, Varun Singh, Vikki Noonan, Alpdogan Kantarci, Philip C. Trackman. Mechanism for Oral Tumor Cell Lysyl Oxidase Like-2 in Cancer Development: Synergy with PDGF-AB. Oncogenesis,

36. de la Cueva, A., Emmerling, M., Lim, S.L., Yang, S., Trackman, P.C., Sonenshein, G.E., Kirsch, K.H. (2018) A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer. Carcinogenesis 2018 Mar 22. doi: 10.1093/carcin/bgy045. [Epub ahead of print].

37.  Elias, Rawad, Kevan Hartshorn, Osama Rahma, Nina Lin, and Jennifer E. Snyder-Cappione. Aging, Immune senescence, and immunotherapy: A Comprehensive Review, Seminars in Oncology, 2018 Aug;45(4):187-200. doi: 10.1053/j.seminoncol.2018.08.006. Epub 2018 Oct 24.

38.  Alamoud, K., and Kukuruzinska, M.A. (2018) Diversity of Wnt/β-catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-Mesenchymal Transition and Tumor Microenvironment. In Molecular Determinants of Head and Neck Cancer, 2nd Edition, Editors: Dr. Barbara Burtness and Dr. Erica Golemis. Springer Nature, In press

39.  Alamoud, K., and Kukuruzinska, M.A. (2018) Emerging Insights into Wnt/β-catenin Signaling in Head and Neck Cancer. Journal of Dental Research, In press

40.  Alsaqer SF, Tashkandi MM, Kartha VK, Yang YT, Alkheriji Y, Salama A, Varelas X, Kukuruzinska M, Monti S, Bais MV. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget. 2017 Jul 27;8(43):73372-73386. doi: 10.18632/oncotarget.19637. eCollection 2017 Sep 26. PMID: 29088714

41.  Bais MV. Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma. Journal of Dental Research. 2019;98(3):268-76. doi: 10.1177/0022034518816947. PubMed PMID: 30615537; PubMed Central PMCID: PMC6385352.

42.  Bais MV. Targeting oral cancer epigenome via LSD1. Aging (Albany NY). 2017, 9(12):2455-2456

43.  Bais, M. V., Kukuruzinska, M., and Trackman, P. C. (2015) Orthotopic non-metastatic and metastatic oral cancer mouse models. Oral Oncology. 51, 476-482.

44.  Bais, M. V., Ozdener, G. B., Sonenshein, G. E., and Trackman, P. C. (2015) Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways. Oncogene. 34, 1928-1937

45. Belkina, A. C. and Snyder-Cappione, J. E. (2016), 16-color panel to measure inhibitory receptor signatures from multiple human immune cell subsets. Cytometry. doi:10.1002/cyto.a.22983

Presentations and Posters

46. Bais M, Stanford E, Novikov O, Sherr D, Kukuruzinska MA, Trackman PC. Orthotopic Oral Cancer Mouse Model for Anti-oral Cancer Drug Screening. Poster session presented at: AADR meeting, March 11, 2015; Boston, MA.

47. Belkina A. Automated analysis of 16-color flow cytometry data maps rare immune cell populations and reveals Inhibitory Receptor signatures in systemic sclerosis patients. Presented at: CYTO, 2015; Glasgow, Scotland.

48. Frias-Lopez, J. Metatranscriptome of Inflammatory Diseases: Lessons Learned from Periodontitis. Presented at Head and Neck Cancer Symposium, Sep 21, 2015; Boston, MA.

49. Haines P, Grzegorzewska A, Stawski L,Baker B, Varelas X, and Trojanowska M. The profibrotic functions of TAZ and YAP are inhibited by dimethyl fumarate in systemic sclerosis fibroblasts. Presented at: International Workshop on Scleroderma Research. Cambridge, England, 2015.

50. Varelas X. A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Presented at Keystone Symposia, May 2015; Taos, NM.

51. Varelas X. A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Poster presented at Experimental Biology Conference, Mar 2015; Boston, MA.

52. Stanford, AE, Kukurizinska, MA, Bais, MV, and Sherr, DH. The role of the aryl hydrocarbon receptor and its diverse ligands in oral squamous cell carcinoma migratin and tumorigenesis. Presented at: Society of Toxicology Annual Meeting, 2016; New Orleans, LA.

53. Trackman, PC. Boston University Cancer Seminar Series. Lysyl Oxidases and Cancer, December 4, 2015

54. Trackman, PC. Amine Oxidase Conference, Birmingham, England, LOXL2 Inhibition in Oral Cancer Models and Insights into Mechanisms, July 27, 2016

55. Varelas, X. Yap Taz in fibrosis. International Workshop on Scleroderma Research, Pittsburgh, August 2017

56. Varelas, X. Understanding YAP/TAZ-regulated micro-environment changes in disease. YAP/TAZ and TEAD: At the Crossroads of Cancer. Telluride Science Research Center, August 2017

57. Varelas, X. The Hippo Pathway Effector YAP Is an Essential Regulator of Submandibular Gland Ductal Progenitor Patterning. Salivary Glands & Exocrine Biology Gordon Research Conference, Galveston, February 2017

58. D. Sherr, J. Kenison-Whte, Z. Wang. The aryl hydrocarbon receptor as driver of cancer immunity, American Association for Cancer Research, Chicago, April 2018

59. Sherr, David. The aryl hydrocarbon receptor (AHR) and its role as an immune checkpoint regulator. Head and Neck Cancer SPORE Workshop, 2018, August 17; NCI, Rockville, MD.

60. Stanford, AE, Kukuruzinska, MA, Bais, MV, and Sherr, DH. The role of the aryl hydrocarbon receptor and its diverse ligands in oral squamous cell carcinoma migratin and tumorigenesis. Presented at: Society of Toxicology Annual Meeting, 2016; New Orleans, LA.

61. Manish V. Bais, Elizabeth Stanford; Olga Novikov; David Sherr; Maria Kukuruzinska; Philip C. Trackman, Orthotopic Oral Cancer Mouse Model to Validate the Anti-Cancer Activity of LOX-PP, Tunicamycin and AHR Modulators. AADR meeting 2015, Boston.  March 11, 2015 Session Title: Mechanisms of Neoplasia.

62. Mahjour, F. and Trackman, P.C. Lysyl oxidase like-2 mediates tumor to stromal cell communication in oral cancer, American Association for Cancer Research, Chicago, April 2018

63. Rongjuan Mi, Vinay Kartha, Ariana Dela Cruz, Taylor Reynolds, Michael Mingueneau, Stefano Monti, Janicke Jensen, Kathrine Skarstein, Xaralabos Varelas and Maria Kukuruzinska. Global transcriptome analysis of salivary gland epithelia from Sjögren’s and non-Sjögren’s patients reveals a novel subpopulation with mixed clinical and histopathological features. International Symposium on Sjogren’s Syndrome, Washington, DC, April 2018.

64. Kukuruzinska, M.A. Boston University- Dana Farber OCRI: a collaborative for basic and translational oral cancer research. Head and Neck Cancer SPORE Workshop, 2014, March 3; NIH/NCI, Rockville, MD.

65. Kukuruzinska, M.A. Oncogenic roles of N-glycosylation. March 22, 2016; Boston, MA.

66. Kukuruzinska, M.A. Inhibition of β-catenin-CBP in Oral Cancer. August 10, 2016; Boston, MA.

67. Kukuruzinska, M.A. Cell Polarity in Autoimmunity and Cancer. September 28, 2016; Conference on Fibrosis and Tissue regeneration, Rhodes, Greece.

68. Kukuruzinska, M.A. Targeting Wnt-β-catenin Pathway in Oral Cancer. October 22, 2016: Cancer Research and Therapy Meeting, Baltimore, MD.

69. Kukuruzinska, MA. Collaborative Research at Boston University. November 4, 2016; Manchester, UK.

70. Kukuruzinska, MA. Targeting β-catenin/CBP activity for anti-OSCC therapy. Head and Neck Cancer SPORE Workshop, 2018, August 16; NCI, Rockville, MD.

71. Haines P, Grzegorzewska A, Stawski L,Baker B, Varelas X, and Trojanowska M. The profibrotic functions of TAZ and YAP are inhibited by dimethyl fumarate in systemic sclerosis fibroblasts. Presented at: International Workshop on Scleroderma Research. Cambridge, England, 2015.

72. Dela Cruz, Ariana, Weihao Wang, Andrew Tilston-Lunel, Kathrine Skarstein, Maria Kukuruzinska, Xaralabos Varelas, Understanding Pathologies Associated With Deficient LATS1/2 Kinase in Salivary Glands, American Association for Dental Research, Fort Lauderdale, March 2018.

73. Frias-Lopez, J. Metatranscriptome of Inflammatory Diseases: Lessons Learned from Periodontitis. Presented at Head and Neck Cancer Symposium, Sep 21, 2015; Boston, MA.

74.  Belkina A. Automated analysis of 16-color flow cytometry data maps rare immune cell populations and reveals Inhibitory Receptor signatures in systemic sclerosis patients. Presented at: CYTO, 2015; Glasgow, Scotland.

75. K. B. Chandler, K. Alamoud, V. K. Kartha, K. Sadykov, S. Monti, M. A. Kukuruzinska, C. E. Costello. Inhibition of Β-catenin/CBP signaling in oral cancer alters EGFR N-glycosylation and abundance, American Association for Cancer Research, Chicago, April 2018

76. Bais M, Stanford E, Novikov O, Sherr D, Kukuruzinska MA, Trackman PC. Orthotopic Oral Cancer Mouse Model for Anti-oral Cancer Drug Screening. Poster session presented at: AADR meeting, March 11, 2015; Boston, MA.

77. Bais, M. LSD1 Promotes Oral Cancer. American Association for Dental Research, Fort Lauderdale, March 2018.

78. Alsaqer, Saqer, Mustafa Tashkandi, Vinay Kartha, Ya-Ting Yang, Yazeed Alkheriji, Andrew Salama, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti, Manish Bais. LSD1 is a Potential Biomarker and Therapeutic Target of OSCC. American Association for Dental Research, San Francisco, March 2017.

79. Alamoud, Khalid, Sadykov, Khikmet, Bais, Manish, Kukuruzinska, Maria. Oncogenic Roles of N-glycosylation-Wnt/Beta-catenin Axis in Oral Cancer. Presented at American Head & Neck Society 9th International Conference on Head and Neck Cancer, July 18, 2016, Seattle, WA.

Abstracts and Presentations

1.     Moses E, Corbett S, Wang T, Campbell J, Perdomo C, Lu X, Natoli T, Narayan R, Subramanian A, Lenburg ME, Spira A. The Lung Connectivity Map: A high-throughput genomics approach to identifying novel therapeutics. Abstract for poster presentation, 2015 Boston University Evans Research Day, Boston, MA

2.     Mulas F, Gusenleitner D, Sherr D, Monti S. ACS 2015 Annual Meeting, Boston, MA.

3.     Li A, Mulas F, Sherr D, Monti S. Invited Speaker. Superfund Research Program Annual Meeting, Puerto Rico.

Publications

1. Narasimhan S, Stanford E, Novikov O, Parks AJ, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr D., Towards Resolving the Pro-and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. Int J Mol Sci. 2018 May; 19(5): 1388. Published online 2018 May 7. doi: 10.3390/ijms19051388

PMCID: PMC5983651

2. Stanford EA, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin D, Murphy GJ, Sherr DH., The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-link cells. BMC Biol. 2016; 14: 20. Published online 2016 Mar 16. doi: 10.1186/s12915-016-0240-y

PMCID: PMC4794823

3. Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH., Role for the aryl hydrocarbon receptor and diverse ligands in oral squamous cell carcinoma migration and tumorigenesis. Mol Cancer Res. 2016 Aug; 14(8): 696–706. PMCID: PMC4987205

4. Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Landesman E, Laklouk I, Sarita-Reyes C, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, Sherr DH, An aryl hydrocarbon receptor-mediated amplification loop that enforces cell migration in ER^– /PR^– Her2^– Human Breast Cancer Cells. Mol Pharmacol. 2016 Nov; 90(5): 674–688. Published online 2016 Nov. PMCID: PMC5074452

Published in final edited form as: Obesity (Silver Spring). 2016 May; 24(5): 1090–1096. Published online 2016 Mar 26. doi: 10.1002/oby.21460

PMCID: PMC5084456

2. Pickering RT, Lee M-J, Karastergiou K, Gower A, Fried SK, Depot dependent effects of dexamethasone on gene expression in human omental and abdominal subcutaneous adipose tissues from obese women. PLoS One. 2016; 11(12): e0167337. Published online 2016 Dec 22. doi: 10.1371/journal.pone.0167337  PMCID: PMC5179014

1. Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. (2015) Improved Insulin

Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 64(9):3155-9. PMCID: PMC4542447.

2.     Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A, Ravid K. Upregulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets. Blood. 2017 Aug 10;130(6):829-831.

3.   Vijaya B. Kolachalama, Moshe Shashar, Faisal Alousi, Sowmya Shivanna, Keshab Rijal, Mostafa Belghasem, Joshua Walker, Shinobu Matsuura, C Michael Gibson, Laura M. Dember, Jean M. Francis, Katya Ravid, Vipul C. Chitalia. Uremic solute-Aryl Hydrocarbon Receptor- Tissue Factor Axis Associates with Post-Vascular Injury Thrombosis in Humans. Journal of American Society of Nephrology (epub January 17, 2018)

4.     Abbonante V, Chitalia V, Rosti V, Leiva O, Matsuura S, Balduini A and Ravid K. Up-regulation of lysyl oxidase and adhesion to collagen of human megakaryocytes and platelets in primary myelofibrosis. Blood, 2017 Aug 10;130(6):829-831

5.     Moshe Shashar*, Mostafa E. Belghasem*, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi, Keshab Rijal, Vijaya B. Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M. Henderson, Amitabh Gautam, Richard Rushmore, Jean Francis, Daniel Kirchhofer, Kumaran Kolandaivelu, David H. Sherr, Elazer R. Edelman, Katya Ravid, Vipul C. Chitalia. Targeting STUB1-tissue factor axis normalizes the hyperthrombotic uremic phenotype without increasing the bleeding risk. Science Translational Medicine 2017 Nov 22;9(417) * = shared first co-authors

6.     Zhang A, Rijal K, Kah Ng S, Ravid K, Chitalia V. A mass spectrometric method for quantification of tryptophan-derived uremic solutes in human serum. Journal of Biological Methods, 2017, 4 (3), e75.

7.     Gordon C, Chitalia V, Sloan M, Salant DJ, Coleman D, Quillen K, Ravid K, and Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. American Journal of Kidney Diseases, 2017, epub 05.2017.

8.     MatsuuraS,MiR,KoupenovaM,EliadesA,PattersonS,ToselliP,ThonJ,ItalianoJEJr, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity Blood 2016 :2015-02-629667

2.     Wang E, Zhu H, Wang X, Gower A, Wallack M, Blusztajn JK, Kowall N, Qiu WQ, Amylin treatment reduces neuroinflammation and ameliorates abnormal patterns of gene expression in the cerebral cortex of Alzheimer’s disease mouse model. J Alzheimer Disease 2017; 56:47-61.

3.     Zhu H, Stern RA, Tao Q, Bourlas A, Essis MD, Chivukula M, Rosenzweig J, Steenkamp D, Xia W, Mercier GA, Tripodis Y, Farlow M, Kowall N, Qiu WQ. An amylin analog used as a challenge test for Alzheimer’s disease. Alzheimer Disease Dement Translational Res Clin Intervent 2017; 3:33-43.

4.     Zhu H, Xue X, Wallack M, Na H, Hooker JM, Kowall N, Tao Q, Stein TD, Wolozin B, Qiu WQ. Amylin receptor ligands reduce the pathological cascade of Alzheimer’s disease. Neuropharmacol 2017. Pli:S0028-3908

5.     Mohamed LA, Zhu H, Mousa YM, Wang E, Qiu WQ*, Kaddoumi A*, Amylin enhances amyloid-β peptide brain to blood efflux across the blood-brain barrier. J Alzheimers Dis 2017; 56:1087-1099.

6.     Qiu WQ. Amylin and its G-protein-coupled receptor: a probable pathological process and drug target for Alzheimer’s disease, Neuroscience 2017 Jul 25;356:44-51

7.     Kim H, Au R, Thomas RJ, Yun CH, Lee SK, Han C, Shin C. Cognitive performance norms from the Korean genome and epidemiology study (KoGES). Int Psychogeriatr 2017; 29:1909-1924. PMID: 28703093

8.     Neu SC, Pa J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Ruiz A, Johnson SC, Koscik R, Wang JJ, Hsu WC, Chen YL, Toga AW. Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis. JAMA Neurol 2017; 74:1178-1189. PMID: 28846757

9.     Au R, Piers RJ, Devine S. How technology is reshaping cognitive assessment: Lessons from the Framingham Heart Study. Neuropsychology 2017; 31:846-861. PMID: 29376667

10.  Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, The Alzheimer’s Disease Neuroimaging Initiative, Lunetta KL, Farrer LA, Jun GR. Genome-wide association study of Alzheimer disease endophenotypes at prediagnosis stages. Alzheimers Dement 2018. In press. PMID: 29274321

11.  Li J, Ogrodnik M, Kolachalama VB, Lin H, Au R. Midlife demographic and lifestyle risk factors of dementia. J Alzheimer Dis 2018; 14:623-633. PMID: 29274321

12.  Qiu S, Chang GH, Panagia M, Gopal DM, Au R, Kolachalama VB. Fusion of deep learning models of MRI scans, Mini-Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment. Alzheimers Dement (Amst) 2018; 10:737-749. PMID: 30480079

13.  Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau phosphorylation is impacted by rare AKAP9 mutations associated with Alzheimer disease. J Neuroimmune Pharmol 2018; 13:254-264. PMID: 29516269

14.  Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, Alzheimer Disease Genetics Consortium, Mayeux R, Haines J, Pericak-Vance M, Schellenberg G, Jun GR, Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer disease. Alzheimers Res Ther 2018;10:22. PMID:29458411

15.  Logue MW, Lancour D, Farrell J, Simkina I, Fallin MD, Lunetta KL, Farrer LA. Targeted sequencing of Alzheimer disease genes in African Americans implicates novel risk variants. Front Neurosci 2018; 12: 592. PMID: 30210277

16.  Whitson H, Cronin-Golomb A, Cruickshanks K, Gilmore G, Owsley C, Peelle J, Recanzone G, Sharma A, Swenor B, Yaffe K, Lin F. American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory impairment and cognitive decline in older adults. J Am Geriatr Soc 2018; 66:2052-2058.

17.  Tao Q, Zhu H, Chen X, Stern RA, Kowall N, Au R, Blusztajn JK, Qiu WQ. Pramlintide: the effects of a single drug injection on blood phosphatidylcholine profile for Alzheimer’s disease. JAD 2018; 62:597-609.

18.  Tao Q, Ang T, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au A, Qiu WQ. Association of chronic low-grade inflammation with risk of Alzheimer disease in ApoE4 carriers. JAMA Network Open 2018; 1(6):e183597.

19.  Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics 2018; 182:121-33. PMID: 29709615

20.  Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J, Alzheimer’s Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA. A rare missense variant in CASP7 is associated with familial late-onset Alzheimer disease. Alzheimer Dement 2019; 15:441-452. PMID: 30503768

21.  Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hansseuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Chen K, Tariot P, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT. Cognitive and brain imaging markers of presenilin1 e280a autosomal dominant Alzheimer’s disease: Findings from the Colombian kindred.  J Prevent Alzheimer Disease 2019: 6:112-120.

22.  Patel D, Mez J, Vardarajan B, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Alzheimer Disease Sequencing Project, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA. Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry. JAMA Network Open 2019; 2(3):e191350.

23.  Xia W. γ-Secretase and its modulators: Twenty years and beyond. Neurosci Lett 2019; 701:162-169. PMID: 30763650

24.  Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Zhang X, Zhu C; Choi YY, Lim HJ, Park JE, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko P-W, Han J-W, Farrell J, Alzheimer’s Disease Neuroimaging Initative, Lunetta KL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, An SSA, Won S, Choi S-M, Ha J-M, Lee H-W, Park KW, Lee YM, Choi SH, Rhee S, Kim K-W, Song WK, Lee JS, Song MK, Nho K, Jun GR, Kim SY, Choo IH, Lee DY, Kim BC, Kim H, Ikeuchi T, Farrer LA, Lee KH. APOE promoter polymorphism -219T/G is an effect modifier of the Influence of APOE ε4 on Alzheimer’s disease risk in a multiracial sample. J Clin Med 2019; 8(8). pii: E1236.

25.  Ang TFA, An N, Ding H, Devine S, Auerbach SH, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R. Lin H. Using data science to diagnose and characterize heterogeneity of Alzheimer’s disease. Alzheimers Dement. 2019; 5:264-271.

26.  Joshi P, Heydari M, Kannan S, Ang TFA, Hong R, Liu X, Massaro J, Mez J, Devine S, Auerbach SH, Au R, Kolachalama VB. Temporal association of neuropsychological performance using unsupervised learning reveals a distinct signature of AD status. Alzheimers Dement. 2019; 5:964-973.

27.  Zhu H, Tao Q, Ang TFA, Gan Q, Salim S, Kolachalama V, Zhang X, Devine S, Auerbach S, Massaro J, Wolf P, DeCarli C, Au R, Qiu QW. Association of plasma amylin concentration with Alzheimer’s disease and brain structure in older adults. JAMA Netw Open 2019; 2(8):e199826.

28.  Gan Q, Yao H, Na H, Balance H, Tao Q, Leung L, Tian H, Zhu H, Wolozin B, Qiu WQ. Amylin’s effects against Aβ induced tauopathy and synapse loss in primary neurons. J Alz Disease 2019; 70(4):1025-1040.

29.  Ang TA, An N, Ding H, Devine S, Auerbach SH, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. A Data-driven approach to designing stepwise diagnostic rules and exploring heterogeneity for Alzheimer’s disease from neuropsychological tests: the Framingham Heart Study. Alzheimer Dement Transl Res Clin Interven 2019; 5:264-271.

30.  Armstrong NM, Bangen KJ, Au R, Gross AL. Associations between midlife (but not late-life) elevated coronary heart disease risk and lower cognitive performance: results from the Framingham Offspring Study. Am J Epidemiol. 2019; 188:2175-2187. PMID: 31576397.

31.  Joshi PS, Heydari M, Kannan S, Alvin Ang TF, Qin Q, Liu X, Mez J, Devine S, Au R, Kolachalama VB. Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer’s disease status. Alzheimers Dement (NY). 2019; 5:964-973. PMID: 31921970.

32.  Conner SC, Benayoun L, Himali JJ, Adams SL, Yang Q, DeCarli C, Blusztajn JK, Beiser A, Seshadri S, Delalle I. Methionine sulfoxide reductase-B3 risk allele implicated in Alzheimer’s disease associates with increased odds for brain infarcts. J Alzheimers Dis. 2019; 68:357-365. PMID: 30775993.

33.  Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019; 138:401–413. PMID: 31183671

34.  Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, Martin B, Cherry JD, Mahar I, Killiany RJ, McClean MD, Au R, Alvarez V, Stern RA, Mez J, McKee AC. Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol. 2019. doi.org/10.1001/jamaneurol.2019.2244. PMID: 31380975

35.  Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Ann Clin Transl Neurol. 2019; 6:2403-2412. PMID: 31691546

36.  Bauman J, Gibbons LE, Moore M, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour M, Mez J, Saykin AJ, Dams-O’Conner K, Bennett DA, Larson EB, Crane PK, Investigators  for the EPA (EPAD). Associations between depression, traumatic brain injury, and cognitively-defined late-onset Alzheimer’s disease subgroups. J Alzheimer Dis. 2019; 70:611–619.

37.  Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O’Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia. Alzheimers Dement. 2019; 15:686-698. PMID: 30852157

38.  Cronin-Golomb A, Reynolds GO, Salazar RD, Saint-Hilaire M-H. Parkinson’s disease and Parkinson-plus syndromes.  In:  Oxford Handbook of Adult Cognitive Disorders, R.A. Stern & M.L. Alosco (eds.). Oxford University Press, 2019.

39.  Puzo C, Labriola C, Sugarman MA, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Stein TD, Kowall NW, McKee AC, Mez J, Killiany RJ, Stern RA, Alosco ML. Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set. Alz Res Therapy. 2019; 11(1):1–13.

40.  Alosco ML, Tripodis Y, Koerte IK, Jackson JD, Chua AS, Mariani M, Haller O, Foley ÉM, Martin BM, Palmisano J, Singh B, Green K, Lepage C, Muehlmann M, Makris N, Cantu RC, Lin AP, Coleman M, Pasternak O, Mez J, Bouix S, Shenton ME, Stern RA. Interactive effects of racial identity and repetitive head impacts on cognitive function, structural MRI-derived volumetric measures, and cerebrospinal fluid tau and Aβ. Front Hum Neurosci. 2019; 13:440.

41.  Glymour MM, Gibbons LE, Gilsanz P, Gross AL, Mez J, Brewster PW, Marden J, Zahodne LB, Nho K, Hamilton J, Li G, Larson EB, Crane PK. Initiation of antidepressant medication and risk of incident stroke: using the Adult Changes in Thought cohort to address time-varying confounding. Ann Epidemiol. 2019; 35:42-47.e1.

42.  DeVivo R, Zajac L, Mian A, Cervantes-Arslanian A, Steinberg E, Alosco ML, Mez J, Stern R, Killany R, Alzheimer’s Disease Neuroimaging Initiative. Differentiating Between Healthy Control Participants and Those with Mild Cognitive Impairment Using Volumetric MRI Data. J Int Neuropsychol Soc. 2019; 1–11. PMID: 31130145

43.  Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Myers AJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene C, Kamboh MI, Kofler JK, Mash DC, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Kramer P, Dickson DW, Frosch MP, Ghetti B, Wang L-S, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA,  Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg G, Beecham GW, Montine TJ, Jun GR for the Alzheimer’s Disease Genetics Consortium. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun 2020; 11:667.

44.  Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype. Sci Rep. 2020; 10(1):2924. PMID: 32076055

45.  Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT, Evers L, Marshall L, Martin BM, Palmisano JN, Nowinski CJ, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Huber BR, Stein TD, Goldstein LE, Katz DI, Cantu RC, Au R, Kowall NW, Stern RA, McClean MD, Weuve J, Tripodis Y, McKee AC. Duration of American football play and chronic traumatic encephalopathy. Ann Neurol. 2020; 87:116–131. PMID: 31589352.

46.  Alosco ML, Tripodis Y, Baucom Z, Mez J, Stein TD, Martin BM, Haller O, Conneely S, McClean MD, Noshey RL, R. Scott M, McKee AC, Weiner MW, Stern RA. The late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology. 2020. In press.

47.  Phelps A, Mez J, Stern RA, Alosco ML. Risk factors for chronic traumatic encephalopathy: a proposed framework. Semin Neurol. 2020. In press.

48.  Abdolmohammadi B, Dupre A, Evers L, Mez J. Genetics of chronic traumatic encephalopathy. Semin Neurol. 2020. In press.

49.  Mariani M, Alosco ML, Mez J, Stern RA. Clinical presentation of chronic traumatic encephalopathy. Semin Neurol. 2020. In press.

50.  Banks SJ, Mez J. New insights into the APOE ε4-soccer heading interaction: handle with care. JAMA Neurol. 2020. In press.

51.  Ma Y, Zhang X, Jun G, Chung J, Naj AC, Belinguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Alzheimer Disease Sequencing Project, ADES-FR, Bis JC, DeStefano AL, Fornage M, van Duijn C, Bennett D, DeJager P, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert J-C, Schellenberg GD, Lunetta KL, Farrer LA. Novel Alzheimer disease loci identified in subsets of whole exome sequencing data stratified by APOE genotype. JAMA Neurol 2020. In press. PMID: 31180460

52.  Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Bennett D, Chibnik L, Cruchaga C, Farrer LA, Kraft P, Mayeux R, Munsie L, Newhouse S, Saykin A, Schellenberg G, the Alzheimer’s Disease Genetics Consortium, Crane PK, Green RC. Genome-wide association study of rate of cognitive decline in Alzheimer’s disease patients identifies novel genes and pathways. Alzheimer Dement 2020. In press.

53.  Na H, Gan Q, McFarland L, Yang JB, Yao H, Tian H, Zhang Z, Qiu WQ. Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer’s disease. Neuropharmacology 2020. In press

54.  An N, Ding H, Yang J, Yin Y, Ang TFA, Au R. Deep ensemble learning for Alzheimer’s disease classification. J Biomed Informatics. 2020. In press.

55.  Ding H, An N, Ang TFA, Devine S, Auerbach S, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. Exploring the hierarchical influence among cognitive functions for heterogeneous inference of Alzheimer’s disease: the Framingham Heart Study. J Med Internet Res. 2020. In press.

56.  Qiu S*, Joshi PS*, Miller MI*, Xue C*, Zhou X, Karjadi C, Chang GH, Joshi AS, Dwyer B, Zhu S, Kaku M, Zhou Y, Alderazi YJ, Swaminathan A, Kedar S, Saint-Hilaire MH, Auerbach SH, Yuan J, Sartor EA, Au R, Kolachalama VB. Development and validation of an interpretable deep learning framework for Alzheimer’s disease classification. Brain 2020. In press.

57.  Au R, Ritchie M, Hardy S, Ang TFA, Lin H. Aging well: using precision to drive down costs and increase health quality. Manuscript under review.

58.  Stück D, Signorini A, Al Hanai T, Sandoval M, Lemke C, Glass J, Hardy S, Lavallee M, Wasserman B, Ang ATF, Nowak C, Au R. Novel digital voice biomarkers of dementia from the Framingham Study. Manuscript in preparation.

59.  Li J, Joshi P, Ang TFA, Auerbach S, Devine S, Au R. Body Mass Index and relation to dementia risk across four decades of follow-up in the Framingham Heart Study. (Under review)

60.  Au R, Ang TFA, Joshi PS, Simon M, Libon D. Vascular risk factors and their relationship to brain aging: findings from the Framingham Heart Study. In Vascular Disease, Alzheimer’s Disease and Mild Cognitive Impairment: Advancing an Integrated Approach. Libon D, Lamar M, Swenson R, Heilman KM (eds.). 2020: Oxford Press. (Under review).

61.  Ferretti MT, Ang TFA, Massaro J, Devine S, Auerbach S, Au R. Sex differences in neuropsychological measures in the Framingham Heart Study. (in preparation)

Presentations:

1.     Yang J, An N, Kowall NW, Farrer LA, Yuan J, Zhang Z,  Au R. Data driven approaches for predictors selections in determining Alzheimer’s disease. Presented at the Alzheimer’s Association International Conference, Toronto, Canada, July 2016.

2.     Appleman ER, Himali J, Cronin-Golomb A, Frank S, Au, R.  Using multigenerational longitudinal research to examine for cognitive differences pre-diagnosis in Parkinson’s disease. Presented at the International Neuropsychological Society 43rd Annual Meeting, New Orleans, LA, 2017.

3.     Le A, Appleman E, Bohmer E, Liu Y, Neargarder S, Cronin-Golomb A, Au R. Effects of age of onset of hypertension on cognitive decline. Presented at the Dallas Aging Conference, Dallas TX, 2017.

4.     Piers RJ, Ang TFA, Liu Y, Devine S, Auerbach S, Au R. How much risk is genetic risk for dementia? Framingham Heart Study. Presented at the International Neuropsychology Society meeting. New Orleans, LA, 2017.

5.     Piers RJ, Liu Y, Ang TFA, Au R, Qiu QW. Depressive symptoms and cognitive decline In younger- and middle-aged adults: cross-sectional analyses from the Framingham Heart Study. Presented at the International Neuropsychology Society meeting, New Orleans, LA, 2018.

6.     Stück D, Signorini A, Hanai TA, Sandoval M, Lemke C, Glass J, Hardy S, Lavallee M, Wasserman B, Ang TFA, Nowak C, Au R. Novel digital voice biomarkers of dementia from the Framingham Study. Presdented at the Alzheimer’s Association International Conference, Chicago, July, 2018.

7.     Ang TFA, Ferretti MT, Massaro J, Devine S, Auerbach S, Au R. Sex differences in neuropsychological measures in the Framingham Heart Study. Presented at the Alzheimer’s Association International Conference, Chicago, July, 2018.

8.     Guan C, Gangopadhyay A, Au R, Ang A. Improving Prediction of Response Imbalance via Down Sampling Bagging. Presented at the Evans Department of Medicine Research Day poster session. Boston, October 2018.

9.     Jiang K, Hu H, Gangopadhyay A, Kolachalama V, Au R. Predicting Modeling of Alzheimer’s Disease with Rare Events. Presented at the In Evans Department of Medicine Research Day poster symposium. Boston, October 2018.

10.  Cronin-Golomb A. Challenges and opportunities for an aging society: New directions in medicine, health care, and social policy. Presented at “Research on Tap”, Institute for Health System Innovation & Policy and the Boston University Research Office, Boston 2018.

11.  Patel D, Chung J, Mez J, Zhang X, Haines JL, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Rare coding mutations associated with Alzheimer disease and other dementias. Alzheimer Association International Conference, Chicago, 2018

12.  Zhang X, Zhou TJ, Farrell J, Chung J, Naj AC, Lunetta KL, Farrer LA. Identification of mitochondrial variants associated with late-onset Alzheimer disease. Alzheimer Association International Conference, Chicago, 2018

13.  Stück D, Signorini A, Al Hanai T, Sandoval M, Lemke C, Glass J, Hardy S, Lavallee M, Wasserman B, Ang ATF, Nowak C, Au R. Novel digital voice biomarkers of dementia from the Framingham Study. Manuscript in preparation.

14.  Patel D, Mez J, Chung J, Zhang X, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer L. Rare coding mutations in Alzheimer disease and other dementias. American Society of Human Genetics Annual Meeting, San Diego, 2018.

15.  Zhu C, Chung J, Mez J, Lunetta K, Jun G, Farrer L, Zhang X. Genome-wide interaction study of brain and CSF measures of Alzheimer disease on memory impairment. American Society of Human Genetics Annual Meeting, San Diego, 2018.

16.  Ho B, Stein T, Ang TFA, Piers RJ, Au R. Neurofibrillary tangle burden in the dorsolateral frontal cortex is associated with processing speed impairment: A digital neuropathological analysis from the Framingham Heart Study. Presented at the International Neuropsychology Society, New York, NY, February, 2019.

17.  Ang TFA, An N, Ding H, Devine S, Auerbach S, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. A data-driven approach to designing stepwise diagnostic rules for Alzheimer’s disease from neuropsychological tests: the Framingham Heart Study. Presented at the International Neuropsychology Society, New York, NY, February 2019.

18.  Mahon E, Liu Y, Ang TFA, Boots E, Au R, Lamar M. Cognitive properties detected in graphomotor organization: cross-sectional analyses from the Framingham Heart Study. Presented at the International Neuropsychology Society, New York, NY, February 2019.

19.  Joshi P, Heydari M, Kannan S, Ang TFA, Hong R, Liu X, Massaro J, Devine S, Mez J, Auerbach S, Au R. Kolachalama V. Temporal  association of neuropsychological performance using unsupervised learning reveals early signature of AD status. Presented at the International Neuropsychology Society, New York, NY, February 2019.

20.  Qiu S, Heydari MS, Miller MI, Joshi PS, Wong BC, Au R, Kolachalama VB. Enhancing deep learning model performance for AD diagnosis using ROI-based selection. To be presented at the Alzheimer’s Association International Conference, Los Angeles, CA, July 2019.

21.  Li D, Farrell J, Farrer LA, Jun GR, Won S. A Genome-wide association study implicates EHPA6 for Alzheimer disease in family-based analysis. Alzheimer Association International Conference, Los Angeles, 2019.

22.  Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell J, Rynkiewicz MJ, Cannon-Albright L, Teerlink C, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OK, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Kauwe J, Lunetta KL, Farrer LA. Highly penetrant late-onset Alzheimer disease variants in NOTCH3 in Ashkenazi Jews. Alzheimer Association International Conference, Los Angeles, 2019.

23.  Zhang X, Farrell J, Zhu C, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA, Alzheimer’s Disease Sequencing Project (ADSP). Mitochondrial variants and haplogroups associated with late-onset Alzheimer’s disease identified by whole exome sequencing. Alzheimer Association International Conference, Los Angeles, 2019.

24.  Naj A, Sha J, Leonenko G, Chen Y, Chouraki V, Leber M, Sims R, Grenier-Boley B, Bis JC, Zhao Y, Kuzma AB, Kunkle BW, Karamujić-Čomić H, Van Der Lee SJ, Bellenguez C, Frizzati A, Holmans P, Dupuis J, Wang L-S, Farrer LA, van Duijn CM, Haines JL, Destefano AL, Pericak-Vance MA, Ramirez A, Amouyel P, Lambert J-C, Seshadri S, Williams J, Schellenberg GD, International Genomics of Alzheimer’s Project (IGAP). Genome-wide meta-analysis of late-onset Alzheimer’s disease using rare variant imputation in 64,859 subjects identifies risk loci with roles in innate immunity and cardiovascular traits: the International Genomics of Alzheimer’s Project (IGAP). Alzheimer Association International Conference, Los Angeles, 2019.

25.  Zhu C, Farrell J, Kuzma A, Schellenberg G, Farrer L. Precision genotyping of APOE from whole genome sequencing. American Society of Human Genetics Annual Meeting, Houston, 2019.

26.  Ramos J, Vardarajan B, Rajabli F, Whitehead P, Hamilton-Nelson K, Adams L, Starks T, Vance J, Griswold A, Schellenberg G, Haines J, Farrer L, Wang LS, Byrd G, Martin E, Mayeux R, Beecham G, Pericak-Vance M. Whole-exome sequencing in African American cohort confirms previously identified Alzheimer’s disease genes and suggest new risk variants in SLC25A39 and PHF1 genes. American Society of Human Genetics Annual Meeting, Houston, 2019.

27.  Kunkle BW, Hamilton-Nelson KL, Gomez L, Jean-Francois M, Naj AC, Wang L, Kuzma AB, Beecham GW, Bush WS, Hohman T, Vardarajan BN, Wang LS, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Pericak-Vance MA, Martin ER, Alzheimer’s Disease Genetics Consortium. Genome-wide analyses identify novel sex-specific candidate loci for Alzheimer disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

28.  Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Dufouil C, Bennett DA, Chibnik L, Cruchaga C, del-Aguila J, Farrer LA, Mayeux R, Munsie L, Newhouse SJ, Saykin AJ, Crane PK, Green RC, The Alzheimer’s Disease Genetics Consortium. Genome-wide association study of rate of cognitive decline in Alzheimer’s disease patients identifies novel genes and pathways. American Society of Human Genetics Annual Meeting, Houston, 2019.

29.  Naj A, Sha J, Leonenko G, Jian X, Grenier-Boley B, Leber M, van der Lee S, Sims R, Chouraki V, Bis JC, Zhao Y, Kuzma A, Kunkle BW, Comic H, Pitsillides A, Xia R, Holmans P, Wang L-S, Mayeux RP, Farrer LA, van Duijn C, Haines JL, DeStefano AL, Pericak-Vance MA, Ramirez A, Amouyel P, Lambert J-C, Seshadri S, Williams J, Schellenberg GD, International Genomics of Alzheimer’s Project (IGAP). Genome-wide rare variant imputation in 60,178 subjects identifies novel rare variant candidate loci in late-onset Alzheimer’s disease (LOAD): The International Genomics of Alzheimer’s Project (IGAP). American Society of Human Genetics Annual Meeting, Houston, 2019.

30.  Farrell JJ, Zhu C, Zhang X, Jun G, Mayeux R, Mez J, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. HLA-DQA1*03:01 and DQB1*03:02 are protective alleles for Alzheimer disease, multiple sclerosis, and celiac disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

31.  Rajabli F, Feliciano BE, Celis K, Hamilton-Nelson KL, Whitehead PL, Adams LD, Bussies PL, Manrique CP, Rodriguez V, Starks T, Byfield GE, Sierra Lopez CB, McCauley JL, Acosta H, Chinea A, Kunkle BW, Reitz C, Farrer LA, Schellenberg GD, Vardarajan BN, Vance JM, Cuccaro ML, Martin ER, Haines JL, Byrd GS, Pericak-Vance MA, Beecham GW. Using the lens of local ancestry to focus risk in Alzheimer disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

32.  Lee B, Chen HH, ADGC, Zhao Y, van der Lee S, Hamilton-Nelson KL, Petty L, Kunkle B, Kuzma A, Valladares O, Reitz C, Beecham GW, Martin ER, Wang LS, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Bush WS, Naj AC. Below JE. Analysis and validation of tissue-specific genetic regulated expression in late-onset Alzheimer’s disease in ~160,000 individuals identifies novel genes and function-based fine mapping of known regions. American Society of Human Genetics Annual Meeting, Houston, 2019.

33.  Panitch R, Zhu C, Hu J, Chung J, Farrer LA, Jun GR. Integrative genome and transcriptome analysis reveals link between complement pathway and APOE e2 protective mechanism for Alzheimer’s disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

34.  Mez. Chronic traumatic encephalopathy: exploring neuropathology, clinical presentation and risk factors. Harvard Medical School/Brigham and Women’s Hospital Center for Brain/Mind Medicine Seminar Series. Boston, MA, January 16, 2019.

35.  Mez J. Harmonizing LOAD clinical risk factor data for use in genetic analyses. ADGC Annual Meeting. Miami, FL, February 11, 2019.

36.  Mez J. Keynote Address: ‘Listen to your mother’ and other trite, but important lessons for science and life. Southern New England Junior Science and Humanities Symposium. Boston, MA, March 28, 2019.

37.  Mez J. The neuropathology and Clinical presentation of chronic traumatic encephalopathy. American Academy of Neurology Sports Concussion Conference. Indianapolis, IN, July 28, 2019.

38.  Mez J. Cognitive aging in the Framingham Heart Study. Advanced Psychometrics Methods in Cognitive Aging Research Workshop. Tahoe City, CA, August 19, 2019.

39.  Mez J. Chronic traumatic encephalopathy: clinical presentation and risk. International Neuropsychological Society Annual Meeting. Denver, CO, February 6, 2020.

40.  Mez J. CTE Clinicopathological Correlation and Risk. Concussion Legacy Foundation Family Huddle. Orlando, FL, February 28, 2020.

41.  Pinsky EL, Weizenbaum E, Cronin-Golomb A, Fulford D. Feasibility of collecting smartphone neuropsychological assessment data in Parkinson’s disease. International Neuropsychological Society 45th Annual Meeting, Denver CO, 2020.

42.  Weizenbaum E, Cronin-Golomb A, Pinsky EL, Torous J, Fulford D. Mobile cognitive assessment via smartphones: Studying how context shapes cognition in young adults and persons with Parkinson’s disease. International Neuropsychological Society 45th Annual Meeting, Denver CO, 2020.

43.  Weizenbaum E, Cronin-Golomb A, Torous J, Fulford D. Convergence between smartphone- and lab-based neuropsychological assessment in healthy and neurological samples. International Neuropsychological Society 45th Annual Meeting, Denver CO, 2020.

44.  Islam S, Cronin-Golomb A, Aguilar L, Velilla L, Baena A, Torrico H, Lopera F, Quiroz YT Executive functioning and episodic memory deficits in individuals with the behavioral variant Frontotemporal Dementia.  Psychological Association, Boston MA, 2020.

Published/ Submitted/

Under review

ARC Members

Tweeted in >10 countries in 5 continents

·

·      35 news outlets

·      4 blogs

·      585 tweeters

·      3 Facebook pages

·      1 Redditor

Role of Oncostatin M in activating dermal microvascular endothelial cells in Systemic Sclerosis. J Invest Dermatol (minor revision)

Optical sampling depth in the spatial frequency domain. J Biomed Opt. 2018 Aug;23(8):1-14. doi: 10.1117/1.JBO.23.8.085005.

Multiple Functions of Lysyl Oxidase Like-2 in Oral Fibroproliferative Processes. J Dent Res. 2018 Oct;97(11):1277-1284. doi: 10.1177/0022034518775971. Epub 2018 May 22.

manuscript

manuscript

manuscript

T, Stawski L, Trojanowska M, Georgakoudi I, Black LD III, Pioli PA,

Whitfield LM, Garlick J. Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis through Lysyl Oxidase-like 4: New Evidence from Three-Dimensional Skin-like Tissues. Arthritis Rheumatol, Nov. 9, ahead of print

manuscript

manuscript

manuscript

manuscript

manuscript

manuscript

manuscript

manuscript

manuscript

manuscript

manuscript

Manuscript

Mammary tumors. J of Biophotonics, 2019, e201800379

manuscript

Tilbury K, Saager RB, Gioux S, Roblyer D. OpenSDFI: an open-source guide for constructing a spatial frequency domain imaging system. J Biomed Optics

25: 01602, 2020

manuscript

manuscript

/ Co-Directors: Lindsay Farrer (farrer@bu.edu – MED, Biomedical Genetics), Rhonda Au (rhodaau@bu.edu – MED, Neurology), Alice Cronin-Golomb (alicecg@bu.edu – CAS, Neurology)

62.  Qiu WQ, Himali JJ, Wolf PA, DeCarli DC, Beiser A, Au R. Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study. Int J Geriatr Psychiatry 2017; 32: 214-221.

63.  Wang E, Zhu H, Wang X, Gower A, Wallack M, Blusztajn JK, Kowall N, Qiu WQ, Amylin treatment reduces neuroinflammation and ameliorates abnormal patterns of gene expression in the cerebral cortex of Alzheimer’s disease mouse model. J Alzheimer Disease 2017; 56:47-61.

64.  Zhu H, Stern RA, Tao Q, Bourlas A, Essis MD, Chivukula M, Rosenzweig J, Steenkamp D, Xia W, Mercier GA, Tripodis Y, Farlow M, Kowall N, Qiu WQ. An amylin analog used as a challenge test for Alzheimer’s disease. Alzheimer Disease Dement Translational Res Clin Intervent 2017; 3:33-43.

65.  Zhu H, Xue X, Wallack M, Na H, Hooker JM, Kowall N, Tao Q, Stein TD, Wolozin B, Qiu WQ. Amylin receptor ligands reduce the pathological cascade of Alzheimer’s disease. Neuropharmacol 2017. Pli:S0028-3908

66.  Mohamed LA, Zhu H, Mousa YM, Wang E, Qiu WQ*, Kaddoumi A*, Amylin enhances amyloid-β peptide brain to blood efflux across the blood-brain barrier. J Alzheimers Dis 2017; 56:1087-1099.

67.  Qiu WQ. Amylin and its G-protein-coupled receptor: a probable pathological process and drug target for Alzheimer’s disease, Neuroscience 2017 Jul 25;356:44-51

68.  Kim H, Au R, Thomas RJ, Yun CH, Lee SK, Han C, Shin C. Cognitive performance norms from the Korean genome and epidemiology study (KoGES). Int Psychogeriatr 2017; 29:1909-1924. PMID: 28703093

69.  Neu SC, Pa J, Kukull W, Beekly D, Kuzma A, Gangadharan P, Wang LS, Romero K, Arneric SP, Redolfi A, Orlandi D, Frisoni GB, Au R, Devine S, Auerbach S, Espinosa A, Boada M, Ruiz A, Johnson SC, Koscik R, Wang JJ, Hsu WC, Chen YL, Toga AW. Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis. JAMA Neurol 2017; 74:1178-1189. PMID: 28846757

70.  Au R, Piers RJ, Devine S. How technology is reshaping cognitive assessment: Lessons from the Framingham Heart Study. Neuropsychology 2017; 31:846-861. PMID: 29376667

71.  Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, The Alzheimer’s Disease Neuroimaging Initiative, Lunetta KL, Farrer LA, Jun GR. Genome-wide association study of Alzheimer disease endophenotypes at prediagnosis stages. Alzheimers Dement 2018. In press. PMID: 29274321

72.  Li J, Ogrodnik M, Kolachalama VB, Lin H, Au R. Midlife demographic and lifestyle risk factors of dementia. J Alzheimer Dis 2018; 14:623-633. PMID: 29274321

73.  Qiu S, Chang GH, Panagia M, Gopal DM, Au R, Kolachalama VB. Fusion of deep learning models of MRI scans, Mini-Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment. Alzheimers Dement (Amst) 2018; 10:737-749. PMID: 30480079

74.  Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau phosphorylation is impacted by rare AKAP9 mutations associated with Alzheimer disease. J Neuroimmune Pharmol 2018; 13:254-264. PMID: 29516269

75.  Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, Alzheimer Disease Genetics Consortium, Mayeux R, Haines J, Pericak-Vance M, Schellenberg G, Jun GR, Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer disease. Alzheimers Res Ther 2018;10:22. PMID:29458411

76.  Logue MW, Lancour D, Farrell J, Simkina I, Fallin MD, Lunetta KL, Farrer LA. Targeted sequencing of Alzheimer disease genes in African Americans implicates novel risk variants. Front Neurosci 2018; 12: 592. PMID: 30210277

77.  Whitson H, Cronin-Golomb A, Cruickshanks K, Gilmore G, Owsley C, Peelle J, Recanzone G, Sharma A, Swenor B, Yaffe K, Lin F. American Geriatrics Society and National Institute on Aging Bench-to-Bedside Conference: Sensory impairment and cognitive decline in older adults. J Am Geriatr Soc 2018; 66:2052-2058.

78.  Tao Q, Zhu H, Chen X, Stern RA, Kowall N, Au R, Blusztajn JK, Qiu WQ. Pramlintide: the effects of a single drug injection on blood phosphatidylcholine profile for Alzheimer’s disease. JAD 2018; 62:597-609.

79.  Tao Q, Ang T, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X, Massaro J, Au A, Qiu WQ. Association of chronic low-grade inflammation with risk of Alzheimer disease in ApoE4 carriers. JAMA Network Open 2018; 1(6):e183597.

80.  Chen M, Lee HK, Moo L, Hanlon E, Stein T, Xia W. Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients. J Proteomics 2018; 182:121-33. PMID: 29709615

81.  Zhang X, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J, Alzheimer’s Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer LA. A rare missense variant in CASP7 is associated with familial late-onset Alzheimer disease. Alzheimer Dement 2019; 15:441-452. PMID: 30503768

82.  Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hansseuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Chen K, Tariot P, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT. Cognitive and brain imaging markers of presenilin1 e280a autosomal dominant Alzheimer’s disease: Findings from the Colombian kindred.  J Prevent Alzheimer Disease 2019: 6:112-120.

83.  Patel D, Mez J, Vardarajan B, Staley L, Chung J, Zhang X, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Alzheimer Disease Sequencing Project, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA. Association of rare coding mutations with Alzheimer disease and other dementias among adults of European ancestry. JAMA Network Open 2019; 2(3):e191350.

84.  Xia W. γ-Secretase and its modulators: Twenty years and beyond. Neurosci Lett 2019; 701:162-169. PMID: 30763650

85.  Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Zhang X, Zhu C; Choi YY, Lim HJ, Park JE, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko P-W, Han J-W, Farrell J, Alzheimer’s Disease Neuroimaging Initative, Lunetta KL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, An SSA, Won S, Choi S-M, Ha J-M, Lee H-W, Park KW, Lee YM, Choi SH, Rhee S, Kim K-W, Song WK, Lee JS, Song MK, Nho K, Jun GR, Kim SY, Choo IH, Lee DY, Kim BC, Kim H, Ikeuchi T, Farrer LA, Lee KH. APOE promoter polymorphism -219T/G is an effect modifier of the Influence of APOE ε4 on Alzheimer’s disease risk in a multiracial sample. J Clin Med 2019; 8(8). pii: E1236.

86.  Ang TFA, An N, Ding H, Devine S, Auerbach SH, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R. Lin H. Using data science to diagnose and characterize heterogeneity of Alzheimer’s disease. Alzheimers Dement. 2019; 5:264-271.

87.  Joshi P, Heydari M, Kannan S, Ang TFA, Hong R, Liu X, Massaro J, Mez J, Devine S, Auerbach SH, Au R, Kolachalama VB. Temporal association of neuropsychological performance using unsupervised learning reveals a distinct signature of AD status. Alzheimers Dement. 2019; 5:964-973.

88.  Zhu H, Tao Q, Ang TFA, Gan Q, Salim S, Kolachalama V, Zhang X, Devine S, Auerbach S, Massaro J, Wolf P, DeCarli C, Au R, Qiu QW. Association of plasma amylin concentration with Alzheimer’s disease and brain structure in older adults. JAMA Netw Open 2019; 2(8):e199826.

89.  Gan Q, Yao H, Na H, Balance H, Tao Q, Leung L, Tian H, Zhu H, Wolozin B, Qiu WQ. Amylin’s effects against Aβ induced tauopathy and synapse loss in primary neurons. J Alz Disease 2019; 70(4):1025-1040.

90.  Ang TA, An N, Ding H, Devine S, Auerbach SH, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. A Data-driven approach to designing stepwise diagnostic rules and exploring heterogeneity for Alzheimer’s disease from neuropsychological tests: the Framingham Heart Study. Alzheimer Dement Transl Res Clin Interven 2019; 5:264-271.

91.  Armstrong NM, Bangen KJ, Au R, Gross AL. Associations between midlife (but not late-life) elevated coronary heart disease risk and lower cognitive performance: results from the Framingham Offspring Study. Am J Epidemiol. 2019; 188:2175-2187. PMID: 31576397.

92.  Joshi PS, Heydari M, Kannan S, Alvin Ang TF, Qin Q, Liu X, Mez J, Devine S, Au R, Kolachalama VB. Temporal association of neuropsychological test performance using unsupervised learning reveals a distinct signature of Alzheimer’s disease status. Alzheimers Dement (NY). 2019; 5:964-973. PMID: 31921970.

93.  Conner SC, Benayoun L, Himali JJ, Adams SL, Yang Q, DeCarli C, Blusztajn JK, Beiser A, Seshadri S, Delalle I. Methionine sulfoxide reductase-B3 risk allele implicated in Alzheimer’s disease associates with increased odds for brain infarcts. J Alzheimers Dis. 2019; 68:357-365. PMID: 30775993.

94.  Standring OJ, Friedberg J, Tripodis Y, Chua AS, Cherry JD, Alvarez VE, Huber BR, Xia W, Mez J, Alosco ML, Nicks R, Mahar I, Pothast MJ, Gardner HM, Meng G, Palmisano JN, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, McKee AC, Stein TD. Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy. Acta Neuropathol. 2019; 138:401–413. PMID: 31183671

95.  Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, Martin B, Cherry JD, Mahar I, Killiany RJ, McClean MD, Au R, Alvarez V, Stern RA, Mez J, McKee AC. Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol. 2019. doi.org/10.1001/jamaneurol.2019.2244. PMID: 31380975

96.  Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Ann Clin Transl Neurol. 2019; 6:2403-2412. PMID: 31691546

97.  Bauman J, Gibbons LE, Moore M, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour M, Mez J, Saykin AJ, Dams-O’Conner K, Bennett DA, Larson EB, Crane PK, Investigators  for the EPA (EPAD). Associations between depression, traumatic brain injury, and cognitively-defined late-onset Alzheimer’s disease subgroups. J Alzheimer Dis. 2019; 70:611–619.

98.  Sugarman MA, McKee AC, Stein TD, Tripodis Y, Besser LM, Martin B, Palmisano JN, Steinberg EG, O’Connor MK, Au R, McClean M, Killiany R, Mez J, Weiner MW, Kowall NW, Stern RA, Alosco ML. Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia. Alzheimers Dement. 2019; 15:686-698. PMID: 30852157

99.  Cronin-Golomb A, Reynolds GO, Salazar RD, Saint-Hilaire M-H. Parkinson’s disease and Parkinson-plus syndromes.  In:  Oxford Handbook of Adult Cognitive Disorders, R.A. Stern & M.L. Alosco (eds.). Oxford University Press, 2019.

100.   Puzo C, Labriola C, Sugarman MA, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Stein TD, Kowall NW, McKee AC, Mez J, Killiany RJ, Stern RA, Alosco ML. Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set. Alz Res Therapy. 2019; 11(1):1–13.

101.   Alosco ML, Tripodis Y, Koerte IK, Jackson JD, Chua AS, Mariani M, Haller O, Foley ÉM, Martin BM, Palmisano J, Singh B, Green K, Lepage C, Muehlmann M, Makris N, Cantu RC, Lin AP, Coleman M, Pasternak O, Mez J, Bouix S, Shenton ME, Stern RA. Interactive effects of racial identity and repetitive head impacts on cognitive function, structural MRI-derived volumetric measures, and cerebrospinal fluid tau and Aβ. Front Hum Neurosci. 2019; 13:440.

102.   Glymour MM, Gibbons LE, Gilsanz P, Gross AL, Mez J, Brewster PW, Marden J, Zahodne LB, Nho K, Hamilton J, Li G, Larson EB, Crane PK. Initiation of antidepressant medication and risk of incident stroke: using the Adult Changes in Thought cohort to address time-varying confounding. Ann Epidemiol. 2019; 35:42-47.e1.

103.   DeVivo R, Zajac L, Mian A, Cervantes-Arslanian A, Steinberg E, Alosco ML, Mez J, Stern R, Killany R, Alzheimer’s Disease Neuroimaging Initiative. Differentiating Between Healthy Control Participants and Those with Mild Cognitive Impairment Using Volumetric MRI Data. J Int Neuropsychol Soc. 2019; 1–11. PMID: 31130145

104.   Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Myers AJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene C, Kamboh MI, Kofler JK, Mash DC, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Kramer P, Dickson DW, Frosch MP, Ghetti B, Wang L-S, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA,  Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg G, Beecham GW, Montine TJ, Jun GR for the Alzheimer’s Disease Genetics Consortium. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun 2020; 11:667.

105.   Friedberg JS, Aytan N, Cherry JD, Xia W, Standring OJ, Alvarez VE, Nicks R, Svirsky S, Meng G, Jun G, Ryu H, Au R, Stein TD. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E e4 genotype. Sci Rep. 2020; 10(1):2924. PMID: 32076055

106.   Mez J, Daneshvar DH, Abdolmohammadi B, Chua AS, Alosco ML, Kiernan PT, Evers L, Marshall L, Martin BM, Palmisano JN, Nowinski CJ, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Huber BR, Stein TD, Goldstein LE, Katz DI, Cantu RC, Au R, Kowall NW, Stern RA, McClean MD, Weuve J, Tripodis Y, McKee AC. Duration of American football play and chronic traumatic encephalopathy. Ann Neurol. 2020; 87:116–131. PMID: 31589352.

107.   Alosco ML, Tripodis Y, Baucom Z, Mez J, Stein TD, Martin BM, Haller O, Conneely S, McClean MD, Noshey RL, R. Scott M, McKee AC, Weiner MW, Stern RA. The late contributions of repetitive head impacts and TBI to depression symptoms and cognition. Neurology. 2020. In press.

108.   Phelps A, Mez J, Stern RA, Alosco ML. Risk factors for chronic traumatic encephalopathy: a proposed framework. Semin Neurol. 2020. In press.

109.   Abdolmohammadi B, Dupre A, Evers L, Mez J. Genetics of chronic traumatic encephalopathy. Semin Neurol. 2020. In press.

110.   Mariani M, Alosco ML, Mez J, Stern RA. Clinical presentation of chronic traumatic encephalopathy. Semin Neurol. 2020. In press.

111.   Banks SJ, Mez J. New insights into the APOE ε4-soccer heading interaction: handle with care. JAMA Neurol. 2020. In press.

112.   Ma Y, Zhang X, Jun G, Chung J, Naj AC, Belinguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Alzheimer Disease Sequencing Project, ADES-FR, Bis JC, DeStefano AL, Fornage M, van Duijn C, Bennett D, DeJager P, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert J-C, Schellenberg GD, Lunetta KL, Farrer LA. Novel Alzheimer disease loci identified in subsets of whole exome sequencing data stratified by APOE genotype. JAMA Neurol 2020. In press. PMID: 31180460

113.   Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Bennett D, Chibnik L, Cruchaga C, Farrer LA, Kraft P, Mayeux R, Munsie L, Newhouse S, Saykin A, Schellenberg G, the Alzheimer’s Disease Genetics Consortium, Crane PK, Green RC. Genome-wide association study of rate of cognitive decline in Alzheimer’s disease patients identifies novel genes and pathways. Alzheimer Dement 2020. In press.

114.        Na H, Gan Q, McFarland L, Yang JB, Yao H, Tian H, Zhang Z, Qiu WQ. Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer’s disease. Neuropharmacology 2020. In press

115.        An N, Ding H, Yang J, Yin Y, Ang TFA, Au R. Deep ensemble learning for Alzheimer’s disease classification. J Biomed Informatics. 2020. In press.

116.        Ding H, An N, Ang TFA, Devine S, Auerbach S, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. Exploring the hierarchical influence among cognitive functions for heterogeneous inference of Alzheimer’s disease: the Framingham Heart Study. J Med Internet Res. 2020. In press.

117.   Qiu S*, Joshi PS*, Miller MI*, Xue C*, Zhou X, Karjadi C, Chang GH, Joshi AS, Dwyer B, Zhu S, Kaku M, Zhou Y, Alderazi YJ, Swaminathan A, Kedar S, Saint-Hilaire MH, Auerbach SH, Yuan J, Sartor EA, Au R, Kolachalama VB. Development and validation of an interpretable deep learning framework for Alzheimer’s disease classification. Brain 2020. In press.

118.                          Au R, Ritchie M, Hardy S, Ang TFA, Lin H. Aging well: using precision to drive down costs and increase health quality. Manuscript under review.

119.   Stück D, Signorini A, Al Hanai T, Sandoval M, Lemke C, Glass J, Hardy S, Lavallee M, Wasserman B, Ang ATF, Nowak C, Au R. Novel digital voice biomarkers of dementia from the Framingham Study. Manuscript in preparation.

120.   Li J, Joshi P, Ang TFA, Auerbach S, Devine S, Au R. Body Mass Index and relation to dementia risk across four decades of follow-up in the Framingham Heart Study. (Under review)

121.        Au R, Ang TFA, Joshi PS, Simon M, Libon D. Vascular risk factors and their relationship to brain aging: findings from the Framingham Heart Study. In Vascular Disease, Alzheimer’s Disease and Mild Cognitive Impairment: Advancing an Integrated Approach. Libon D, Lamar M, Swenson R, Heilman KM (eds.). 2020: Oxford Press. (Under review).

122.   Ferretti MT, Ang TFA, Massaro J, Devine S, Auerbach S, Au R. Sex differences in neuropsychological measures in the Framingham Heart Study. (in preparation)

Presentations:

45.  Yang J, An N, Kowall NW, Farrer LA, Yuan J, Zhang Z,  Au R. Data driven approaches for predictors selections in determining Alzheimer’s disease. Presented at the Alzheimer’s Association International Conference, Toronto, Canada, July 2016.

46.  Appleman ER, Himali J, Cronin-Golomb A, Frank S, Au, R.  Using multigenerational longitudinal research to examine for cognitive differences pre-diagnosis in Parkinson’s disease. Presented at the International Neuropsychological Society 43rd Annual Meeting, New Orleans, LA, 2017.

47.  Le A, Appleman E, Bohmer E, Liu Y, Neargarder S, Cronin-Golomb A, Au R. Effects of age of onset of hypertension on cognitive decline. Presented at the Dallas Aging Conference, Dallas TX, 2017.

48.  Piers RJ, Ang TFA, Liu Y, Devine S, Auerbach S, Au R. How much risk is genetic risk for dementia? Framingham Heart Study. Presented at the International Neuropsychology Society meeting. New Orleans, LA, 2017.

49.  Piers RJ, Liu Y, Ang TFA, Au R, Qiu QW. Depressive symptoms and cognitive decline In younger- and middle-aged adults: cross-sectional analyses from the Framingham Heart Study. Presented at the International Neuropsychology Society meeting, New Orleans, LA, 2018.

50.  Stück D, Signorini A, Hanai TA, Sandoval M, Lemke C, Glass J, Hardy S, Lavallee M, Wasserman B, Ang TFA, Nowak C, Au R. Novel digital voice biomarkers of dementia from the Framingham Study. Presdented at the Alzheimer’s Association International Conference, Chicago, July, 2018.

51.  Ang TFA, Ferretti MT, Massaro J, Devine S, Auerbach S, Au R. Sex differences in neuropsychological measures in the Framingham Heart Study. Presented at the Alzheimer’s Association International Conference, Chicago, July, 2018.

52.  Guan C, Gangopadhyay A, Au R, Ang A. Improving Prediction of Response Imbalance via Down Sampling Bagging. Presented at the Evans Department of Medicine Research Day poster session. Boston, October 2018.

53.  Jiang K, Hu H, Gangopadhyay A, Kolachalama V, Au R. Predicting Modeling of Alzheimer’s Disease with Rare Events. Presented at the In Evans Department of Medicine Research Day poster symposium. Boston, October 2018.

54.  Cronin-Golomb A. Challenges and opportunities for an aging society: New directions in medicine, health care, and social policy. Presented at “Research on Tap”, Institute for Health System Innovation & Policy and the Boston University Research Office, Boston 2018.

55.  Patel D, Chung J, Mez J, Zhang X, Haines JL, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Rare coding mutations associated with Alzheimer disease and other dementias. Alzheimer Association International Conference, Chicago, 2018

56.  Zhang X, Zhou TJ, Farrell J, Chung J, Naj AC, Lunetta KL, Farrer LA. Identification of mitochondrial variants associated with late-onset Alzheimer disease. Alzheimer Association International Conference, Chicago, 2018

57.  Stück D, Signorini A, Al Hanai T, Sandoval M, Lemke C, Glass J, Hardy S, Lavallee M, Wasserman B, Ang ATF, Nowak C, Au R. Novel digital voice biomarkers of dementia from the Framingham Study. Manuscript in preparation.

58.  Patel D, Mez J, Chung J, Zhang X, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer L. Rare coding mutations in Alzheimer disease and other dementias. American Society of Human Genetics Annual Meeting, San Diego, 2018.

59.  Zhu C, Chung J, Mez J, Lunetta K, Jun G, Farrer L, Zhang X. Genome-wide interaction study of brain and CSF measures of Alzheimer disease on memory impairment. American Society of Human Genetics Annual Meeting, San Diego, 2018.

60.  Ho B, Stein T, Ang TFA, Piers RJ, Au R. Neurofibrillary tangle burden in the dorsolateral frontal cortex is associated with processing speed impairment: A digital neuropathological analysis from the Framingham Heart Study. Presented at the International Neuropsychology Society, New York, NY, February, 2019.

61.  Ang TFA, An N, Ding H, Devine S, Auerbach S, Massaro J, Joshi P, Liu X, Liu Y, Mahon E, Au R, Lin H. A data-driven approach to designing stepwise diagnostic rules for Alzheimer’s disease from neuropsychological tests: the Framingham Heart Study. Presented at the International Neuropsychology Society, New York, NY, February 2019.

62.  Mahon E, Liu Y, Ang TFA, Boots E, Au R, Lamar M. Cognitive properties detected in graphomotor organization: cross-sectional analyses from the Framingham Heart Study. Presented at the International Neuropsychology Society, New York, NY, February 2019.

63.  Joshi P, Heydari M, Kannan S, Ang TFA, Hong R, Liu X, Massaro J, Devine S, Mez J, Auerbach S, Au R. Kolachalama V. Temporal  association of neuropsychological performance using unsupervised learning reveals early signature of AD status. Presented at the International Neuropsychology Society, New York, NY, February 2019.

64.  Qiu S, Heydari MS, Miller MI, Joshi PS, Wong BC, Au R, Kolachalama VB. Enhancing deep learning model performance for AD diagnosis using ROI-based selection. To be presented at the Alzheimer’s Association International Conference, Los Angeles, CA, July 2019.

65.  Li D, Farrell J, Farrer LA, Jun GR, Won S. A Genome-wide association study implicates EHPA6 for Alzheimer disease in family-based analysis. Alzheimer Association International Conference, Los Angeles, 2019.

66.  Patel D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X, Farrell J, Rynkiewicz MJ, Cannon-Albright L, Teerlink C, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OK, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Kauwe J, Lunetta KL, Farrer LA. Highly penetrant late-onset Alzheimer disease variants in NOTCH3 in Ashkenazi Jews. Alzheimer Association International Conference, Los Angeles, 2019.

67.  Zhang X, Farrell J, Zhu C, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA, Alzheimer’s Disease Sequencing Project (ADSP). Mitochondrial variants and haplogroups associated with late-onset Alzheimer’s disease identified by whole exome sequencing. Alzheimer Association International Conference, Los Angeles, 2019.

68.  Naj A, Sha J, Leonenko G, Chen Y, Chouraki V, Leber M, Sims R, Grenier-Boley B, Bis JC, Zhao Y, Kuzma AB, Kunkle BW, Karamujić-Čomić H, Van Der Lee SJ, Bellenguez C, Frizzati A, Holmans P, Dupuis J, Wang L-S, Farrer LA, van Duijn CM, Haines JL, Destefano AL, Pericak-Vance MA, Ramirez A, Amouyel P, Lambert J-C, Seshadri S, Williams J, Schellenberg GD, International Genomics of Alzheimer’s Project (IGAP). Genome-wide meta-analysis of late-onset Alzheimer’s disease using rare variant imputation in 64,859 subjects identifies risk loci with roles in innate immunity and cardiovascular traits: the International Genomics of Alzheimer’s Project (IGAP). Alzheimer Association International Conference, Los Angeles, 2019.

69.  Zhu C, Farrell J, Kuzma A, Schellenberg G, Farrer L. Precision genotyping of APOE from whole genome sequencing. American Society of Human Genetics Annual Meeting, Houston, 2019.

70.  Ramos J, Vardarajan B, Rajabli F, Whitehead P, Hamilton-Nelson K, Adams L, Starks T, Vance J, Griswold A, Schellenberg G, Haines J, Farrer L, Wang LS, Byrd G, Martin E, Mayeux R, Beecham G, Pericak-Vance M. Whole-exome sequencing in African American cohort confirms previously identified Alzheimer’s disease genes and suggest new risk variants in SLC25A39 and PHF1 genes. American Society of Human Genetics Annual Meeting, Houston, 2019.

71.  Kunkle BW, Hamilton-Nelson KL, Gomez L, Jean-Francois M, Naj AC, Wang L, Kuzma AB, Beecham GW, Bush WS, Hohman T, Vardarajan BN, Wang LS, Mayeux R, Haines JL, Farrer LA, Schellenberg GD, Pericak-Vance MA, Martin ER, Alzheimer’s Disease Genetics Consortium. Genome-wide analyses identify novel sex-specific candidate loci for Alzheimer disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

72.  Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Dufouil C, Bennett DA, Chibnik L, Cruchaga C, del-Aguila J, Farrer LA, Mayeux R, Munsie L, Newhouse SJ, Saykin AJ, Crane PK, Green RC, The Alzheimer’s Disease Genetics Consortium. Genome-wide association study of rate of cognitive decline in Alzheimer’s disease patients identifies novel genes and pathways. American Society of Human Genetics Annual Meeting, Houston, 2019.

73.  Naj A, Sha J, Leonenko G, Jian X, Grenier-Boley B, Leber M, van der Lee S, Sims R, Chouraki V, Bis JC, Zhao Y, Kuzma A, Kunkle BW, Comic H, Pitsillides A, Xia R, Holmans P, Wang L-S, Mayeux RP, Farrer LA, van Duijn C, Haines JL, DeStefano AL, Pericak-Vance MA, Ramirez A, Amouyel P, Lambert J-C, Seshadri S, Williams J, Schellenberg GD, International Genomics of Alzheimer’s Project (IGAP). Genome-wide rare variant imputation in 60,178 subjects identifies novel rare variant candidate loci in late-onset Alzheimer’s disease (LOAD): The International Genomics of Alzheimer’s Project (IGAP). American Society of Human Genetics Annual Meeting, Houston, 2019.

74.  Farrell JJ, Zhu C, Zhang X, Jun G, Mayeux R, Mez J, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. HLA-DQA1*03:01 and DQB1*03:02 are protective alleles for Alzheimer disease, multiple sclerosis, and celiac disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

75.  Rajabli F, Feliciano BE, Celis K, Hamilton-Nelson KL, Whitehead PL, Adams LD, Bussies PL, Manrique CP, Rodriguez V, Starks T, Byfield GE, Sierra Lopez CB, McCauley JL, Acosta H, Chinea A, Kunkle BW, Reitz C, Farrer LA, Schellenberg GD, Vardarajan BN, Vance JM, Cuccaro ML, Martin ER, Haines JL, Byrd GS, Pericak-Vance MA, Beecham GW. Using the lens of local ancestry to focus risk in Alzheimer disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

76.  Lee B, Chen HH, ADGC, Zhao Y, van der Lee S, Hamilton-Nelson KL, Petty L, Kunkle B, Kuzma A, Valladares O, Reitz C, Beecham GW, Martin ER, Wang LS, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Bush WS, Naj AC. Below JE. Analysis and validation of tissue-specific genetic regulated expression in late-onset Alzheimer’s disease in ~160,000 individuals identifies novel genes and function-based fine mapping of known regions. American Society of Human Genetics Annual Meeting, Houston, 2019.

77.  Panitch R, Zhu C, Hu J, Chung J, Farrer LA, Jun GR. Integrative genome and transcriptome analysis reveals link between complement pathway and APOE e2 protective mechanism for Alzheimer’s disease. American Society of Human Genetics Annual Meeting, Houston, 2019.

78.  Mez. Chronic traumatic encephalopathy: exploring neuropathology, clinical presentation and risk factors. Harvard Medical School/Brigham and Women’s Hospital Center for Brain/Mind Medicine Seminar Series. Boston, MA, January 16, 2019.

79.  Mez J. Harmonizing LOAD clinical risk factor data for use in genetic analyses. ADGC Annual Meeting. Miami, FL, February 11, 2019.

80.  Mez J. Keynote Address: ‘Listen to your mother’ and other trite, but important lessons for science and life. Southern New England Junior Science and Humanities Symposium. Boston, MA, March 28, 2019.

81.  Mez J. The neuropathology and Clinical presentation of chronic traumatic encephalopathy. American Academy of Neurology Sports Concussion Conference. Indianapolis, IN, July 28, 2019.

82.  Mez J. Cognitive aging in the Framingham Heart Study. Advanced Psychometrics Methods in Cognitive Aging Research Workshop. Tahoe City, CA, August 19, 2019.

83.  Mez J. Chronic traumatic encephalopathy: clinical presentation and risk. International Neuropsychological Society Annual Meeting. Denver, CO, February 6, 2020.

84.  Mez J. CTE Clinicopathological Correlation and Risk. Concussion Legacy Foundation Family Huddle. Orlando, FL, February 28, 2020.

85.  Pinsky EL, Weizenbaum E, Cronin-Golomb A, Fulford D. Feasibility of collecting smartphone neuropsychological assessment data in Parkinson’s disease. International Neuropsychological Society 45th Annual Meeting, Denver CO, 2020.

86.  Weizenbaum E, Cronin-Golomb A, Pinsky EL, Torous J, Fulford D. Mobile cognitive assessment via smartphones: Studying how context shapes cognition in young adults and persons with Parkinson’s disease. International Neuropsychological Society 45th Annual Meeting, Denver CO, 2020.

87.  Weizenbaum E, Cronin-Golomb A, Torous J, Fulford D. Convergence between smartphone- and lab-based neuropsychological assessment in healthy and neurological samples. International Neuropsychological Society 45th Annual Meeting, Denver CO, 2020.

88.  Islam S, Cronin-Golomb A, Aguilar L, Velilla L, Baena A, Torrico H, Lopera F, Quiroz YT Executive functioning and episodic memory deficits in individuals with the behavioral variant Frontotemporal Dementia.  Psychological Association, Boston MA, 2020.

Protein Trafficking and Neurodegenerative Disease / Director: Dr. Lindsay Farrer (farrer@bu.edu – MED, Biomedical Genetics)

2.     Oh S-Y, Chen C-D, Abraham CR.  Cell-type dependent modulation of notch signaling by the amyloid precursor protein.  J Neurochem  2010; 113:262-74.

3.     So P, Chen C-D, Abraham CR.  Detection of wild type and mutant amyloid precursor protein dimerization using beta-galactosidase enzyme fragment complementation.  J Alz Dis 2011. Epub.

4.     King GD, Rosene DL, Abraham CR.  Promoter methylation and age-related downregulation of klotho in rhesus monkey. AGE 2011. Epub.

5.     King GD, Huang, MM, Schuman ER, Chen C-D, Cuny GD, Glicksman, MA, Abraham CR.  Identification of novel small molecules to modulate transcription of Klotho.  Biochem J  2011. Epub.

6.     Abraham CR.  Amyloid beta peptide and the amyloid cascade hypothesis. In The Handbook of Alzheimer’s Disease and Other Dementias, First Edition. Edited by Andrew E. Budson, Neil W. Kowall. 2011. Blackwell Publishing Ltd.

7.     Abraham CR, Nalge MW. Acylaminoacyl-peptidase in Handbook of Proteolytic Enzymes  3rd Edition. 2011.

8.     Cuenco KT, Friedland R, Baldwin CT, Guo J, Vardarajan B, Lunetta KL, Cupples LA, Green RC, DeCarli CD, Farrer LA for the MIRAGE Study Group.  Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.  Neurobiol Aging 2011; 32:249-256.

9.     Reitz C, Rogaeva E, Lee JH, Tokuhiro S, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Kamboh I, Prince J, Maier W, Riemenschneider M, Williams J, van Broeckhoven C, Farrer LA, St.George-Hyslop P, Mayeux R.  Association of SORL1 gene variants with Alzheimer’s disease: A meta-analysis.  Arch Neurol 2011; 68:99-106.

10.  Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel J-P, Palotas A, Lantigua R, Medrano M, Jiménez-Velázquez IZ, Haines JL,Pericak-Vance MA, Farrer LA, Lee JH, Rogaeva E, St. George-Hyslop P, Mayeux R.  SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer’s disease risk.  Ann Neurol 2011; 69:47-64.

11.  Sherva R, Baldwin CT, Inzelberg R, Vardarajan B, Cupples LA, Lunetta K, Bowirrat A, Naj A, Pericak-Vance MA, Friedland RP, Farrer LA.  Identification of novel candidate genes for Alzheimer disease by autozygosity mapping using genome wide SNP data.  J Alz Dis.  2011; 23:349-359.

12.  Sullivan CP, Jay A, Stack E, Pakaluk M, Wadlinger E, Fine RE, Wells JM, Morin PJ. Effects of retromer Disruption on Amyloidogenic APP Processing. Neurobiol Dis  2011; 43:338-345.

13.   Sullivan CP, Berg EA, Elliott-Bryant R, Fishman JB, McKee AC, Morin PJ, Shia MA, Fine RE. Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer’s disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core. Neurosci Lett. 2011; 505:109-112.

14.  Tan Y, Yu F, Pereira A, Morin PJ, Zhou J. Suppression of Nrdp1 toxicity by Parkin in Drosophila models. Biochem Biophys Res Commun 2011; 416: 18-23.

15.  Abraham CR. Amyloid beta peptide and the Amyloid cascade hypothesis. In The Handbook of Alzheimer’s Disease and Other Dementias. Budson AE, Kowall NW (Eds). Blackwell Publishing Ltd, 2012.

16.  Erlich PM, Lunetta KL, Cupples LA, Abraham CR, Green RC, Baldwin CT, Farrer LA.  Measures of serum paraoxonase activity are associated with multiple distinct variants in the PON gene cluster and risk of Alzheimer disease.  Neurobiol Aging 2012; 33:1015.

17.  Vardarajan BN, Bruesegem SY, Harbour ME, St. George-Hyslop P, Seaman MNJ, Farrer LA.  Identification of Alzheimer disease associated variants in genes that regulate retromer function.  Neurobiol Aging  2012; 33:2231.e15-2231.e30.

18.  So P, Chen CD, Abraham, CR. Detection of Wild Type and Mutant Amyloid Precursor Protein Dimerization Using Beta-Galactosidase Enzyme Fragment Complementation. J Alz Dis.2011; 26:647-655.

19.  King GD, Huang MM, Schuman ER, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules to modulate transcription of Klotho. Biochem J 2012; 441:453-461.

20.  So PPL, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of Amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. Am J Neurodegen Dis. 2012; 1:75-87.

21.  Abraham CR, Chen CD, Cuny GD, Glicksman MA, Zeldich E. Small molecule klotho enhancers as novel treatment of neurodegeneration. Fut Med Chem. 2012; 4:1671-9.

22.  Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson III JM, Tomchick DR, Rizo J, Ho A. Autoinhibition of Mint1 adaptor protein regulates APP binding and processing. Proc Natl Acad Sci USA 2012; 109:3802-3807. PMCID:22344143.

23.  Chaufty J, Sullivan SE, Ho A. Intracellular amyloid precursor protein sorting and amyloid-β secretion are regulated by src-mediated phosphorylation of Mint2. J Neurosci 2012; 32:9613-9625.

24.  Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of stress granule proteins TIA-1 and G3BP in tauopathies. J Neurosci.  2012; 32:8270-8283.   PMID: 22699908.

25.  Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: A role in Alzheimer’s disease? J Alz Dis. 2012; 29:329-340 PMID: 22232014.

26.  Youmans K, Wolozin B. TDP-43: A new player in the AD field?  Exp Neurol 2012; 237:90-95. PMID: 22691390.

27.  Melville S, Buros J, Parrado A, Vardarajan B, Shen L, Risacher SL, Alzheimer Disease Neuroimaging Initiative, Kim S, Jun G, DeCarli C, Lunetta KL, Baldwin CT, Saykin AJ, Farrer LA. Genome-wide association study of Alzheimer-related brain MRI traits.  Ann Neurol 2012; 72:65-75.  PMID: 22745009

28.  Xia W, Wong ST, Hanlon EB, Morin PJ. Alzheimers γ-Secretase Modulator: Shifting the End. J Alz Dis 2012; 31(4):685-696.

29.  Miyashita A, Koike A, Jun G, Wang L-S, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakajima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim J-W, Ki C-S, Won HH, NA DL, Seo SW, Mook-Jung I, The Alzheimer Disease Genetics Consortium, St. George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. SORL1 is genetically associated with late-onset Alzheimer’s disease in Japanese, Koreans and Caucasians.  PLoS ONE 2013; 8(4): e58618. PMID: 23565137

30.  Wolozin B. Regulated protein aggregation: Stress granules and neurodegeneration.  Mol Neurodegen 2012; 7:56. PMID: 23164372

31.  Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, Mayeux R, Fraser P, Goffinet AM, St. George-Hyslop P, Farrer LA, Westaway D.  P73 and Alzheimer disease are not associated in a transgenic mouse model or in human cohorts.  Molec Neurodegen 2013; 8:10. PMID 23414597

32.  Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, George-Hyslop PS, Mayeux R. Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Transl Psychiatry 2013;3:e256. PMID: 2367346

33.  Reitz C, Rajbhandary R, Naj AC, Jun G, Vardarajan BN, Wang L-S, Valladares O, Lin C-F, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Murrell J R, Raj T, Ertekin-Taner N, Logue L, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obesisan TO, Manly J, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hall K, Goate AM, Byrd GS, Kukull WA, Foroud TM, the ADGC Consortium, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux.  Variants in the ATP-binding cassette transporter, ABCA7, and the apolipoprotein E ε4 allele substantially and equally influence risk of late-onset Alzheimer’s disease in African Americans. JAMA 2013; 309:1483-1492.  PMID: 23571587.

34.  Huang G, Buckler-Pena D, Nauta T, Singh M, Asmar A, Shi J, Kim JY, Kandror KV. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin.  Mol Biol Cell 2013; 24:3115-3122.

35.  Asai H, Ikezu S, Woodbury M, Ikezu T. Phosphorylation of collapsin response mediator protein-2 and axonal degeneration in transgenic mice expressing a familial Alzheimer’s disease mutant of APP and tau-tubulin kinase 1. Alz Dement 2013; 8 (Suppl): P649-P650.

36.  Leung A, Nah SK, Reid W, Ebata A, Koch CM, Monti S, Genereux JC, Wiseman RL, Wolozin B, Connors LH, Berk JL, Seldin DC, Mostoslavsky G, Kotton DN, Murphy GJ. Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis.  Stem Cell Reports 2013; 1:451-63.  PMID: 24286032

37.  Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke J, Kuro-o M, Abraham CR. The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the central nervous system. J Neurosci 2013; 33:1927-39. PMID: 23365232.

38.  Tucker-Zhou TB, King GD, Chen CD, Abraham CR. Biochemical and functional characterization of the Klotho VS polymorphism implicated in aging and disease risk. J Biol Chem. 2013; 2885:36302-36311. PMID: 24217253

39.  Sherva R, Tripodis Y, Bennett D, Chibnik LB, Crane PK, de Jager P, Farrer LA, Shulman J, Green RC; The GENAROADS Consortium, and The Alzheimer’s Disease Neuroimaging Initiative. Genome wide association study of the rate of cognitive decline in Alzheimer’s disease.  Alz Dement 2013; 10:45-52. PMID: 23535033

40.  Vanderweyde T, Youmans K, Liu-Yesucevitz L, Wolozin B. The Role Stress Granules and RNA Binding Proteins in Neurodegeneration. Gerontology  2013; 59:524-533. PMID: 24008580

41.  Li Y, Lu SH-J, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser P, St George-Hyslop P. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure 2014; 22:125-135.  PMID: 24210759

42.  McKee AC, Stern RA, Nowinski CJ, Stein TD, Daneshvar DH, Alvarez VE, Lee HS, Hall G, Wojtowicz SM, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC.  The spectrum of disease in chronic traumatic encephalopathy. Brain 2013; 136(Pt 1): 43-64. PMID: 23208308

43.  Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.  Am J Pathol 2013; 183:504-515.  PMID: 23747512

44.  Chen C-D, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci 2013; 33:1927-1939. PMID:23365232

45.  Sullivan CP, Elliott-Bryant R, Kanesa-Thesan A, McKee A, Fine RE, Wells JM, Morin PJ. Phosphorylated low-density lipoprotein receptor-related protein 6 is prevalent in hippocampal progenitor cells and circuits of the aged human hippocampus. AAD 2013; 2:126-131.

46.  Tucker-Zhou TB, King GD, Chen CD, Abraham CR. Biochemical and functional characterization of the Klotho VS polymorphism implicated in aging and disease risk. J Biol Chem 2013; 288:36302–36311. PMID:24217253

47.  Saha S, Liu-Yesucevitz L, Wolozin B. Regulation of autophagy by LRRK2 in C. elegans.  Neurodegen Dis 2014; 13:110-113. PMID 24192129

48.  Liu-Yesucevitz L, Lin AL, Xu Y, Kobrin A, Petrucelli L, Wolozin B. ALS-linked mutations cause dysfunction of TDP-43-enriched RNA granules. J Neurosci 2014; 34:4167-4174. PMID: 24647938

49.  Boyd JD, Lee P, Feiler MS, Zauur N, Liu M, Concannon J, Ebata A, Wolozin B*, Glicksman MA.* A high content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity. J Biomol Screening. 2014; 19:44-56.  *Co-senior authors. PMID: 24019256

50.  Mehi SJ, Maltare A, Abraham CR, King, GD. MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age. 2014; 36:141-149. PMID: 23818104

51.  Logue MW, Schu M, Vardarajan BN, Farrell J, Lunetta KL, Jun G, Baldwin CT, DeAngelis M, Farrer LA. A search for genetic risk variants for age-related macular degeneration in Alzheimer disease genes and pathways. Neurobiol Aging 2014; 35: 1510.e7e1510.e18. PMID: 24439028

52.  Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park J-H, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg G, Lunetta KL, Kim J-W, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease risk and modulates tau protein phosphorylation. Ann Neurol 2014; 76:379-392. PMID: 25043464

53.  Dusonchet J, Li H, Guillily M, Stafa K, Pyenson N, Liu M, Derada C, Glauser L, Mamais A, Citro A, Saha S, Liu-Yesucevitz L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman M, Moore DJ, Collins JJ, Wolozin B. A Parkinson’s disease gene regulatory network identifies RGS2 as a modulator of LRRK2 activity.  Hum Mol Genet 2014; 23:4887-4905.  PMID: 25071441

54.  Ash PE, Vanderweyde TE, Youmans KL, Apicco DJ, Wolozin B. Pathological stress granules in Alzheimer’s disease. Brain Res 2014; 1584:52-58. PMID: 25108040

55.  Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D. Klein E, Yu G-Q, Ho K, Eilertson KE, Yu L, Makoto Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Mille BL, Mucke L. Life extension factor klotho enhances cognition. Cell Reports 2014; 7:1–12.

56.  Ikezu S, Ikezu T. Tau-tubulin kinase. Front Mol Neurosci 2014; 7:33. PMCID: PMC4009424.

57.  Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. Am J Pathol 2014; 184:808-818.

58.  Chen C-D, Tung T-Y, Liang J, Zeldich E, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein Klotho. Biochemistry 2014; 53:5579-5587.

59.  Wolozin B. Physiological proteins run amuck: stress granules and the genesis of neurodegenerative disease. Discovery Med 2014; 17:47-52.  PMID: 24411700

60.  Sullivan SE, Dillon GM, Sullivan JM, Ho A. Mint proteins are required for synaptic activity-dependent APP trafficking and amyloid-β generation. J Biol Chem 2014; 289:15374-15383. PMID: 24742670.

61.  Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett , Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh I, Kukull WA, Manly JJ, Alzheimer Disease Genetics Consortium, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Baldwin CT, Fallin MD, Farrer LA. Two rare AKAP9 missense variants are associated with Alzheimer disease in African Americans. Alzheimers Dement 2014; 10:609-618. PMID: 25172201

62.  Logue MW, Schu M, Vardarajan BN, Farrell J, Lunetta KL, Jun  G, Baldwin CT, DeAngelis M, Farrer LA. A search for genetic risk variants for age-related macular degeneration in Alzheimer disease genes and pathways. Neurobiol Aging 2014; 35: 1510.e7e1510.e18. PMID: 24439028

63.  Naj AC, Jun G, Reitz C, Kunkle BW, Perry WR, Park Y, Beecham GW, Rajbhandary R, Hamilton-Nelson KR, Wang L-S, Kauwe JSK, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Nowotny P, Kramer PL, Alzheimer’s Disease Genetics Consortium, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St. George-Hyslop P, Buxbaum JD, Evans D, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux R, Farrer LA, Schellenberg GD, Pericak-Vance MA; and the Alzheimer Disease Genetics Consortium. Effects of multiple genetic loci on age at onset in late onset Alzheimer disease: A genome-wide association study. JAMA Neurol 2014; 7:1394-1404. PMID: 25199842

64.  Chen CD, Hu Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci 2014; 55:76-90. PMID:24907942

65.  Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker-Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem 2014; 289:24700-24715.

Abstracts Presented at Meetings:

1.     Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel J-P, Palotas A, Lantigua R, Medrano M, Jiménez-Velázquez IZ, Haines JL,Pericak-Vance MA, Farrer LA, Lee JH, Rogaeva E, St. George-Hyslop P, Mayeux R.  SORCS1 alters APP processing and variants may increase AD risk.  Abstract presented at the International Conference on Alzheimer Disease, July, 2010.

2.     Vardarajan BN, Logue M, Cupples A, Lunetta K, Jun G, Buros J, Seaman M, Baldwin C, Farrer L.  Candidate gene study in the endosome-to-Golgi retrieval pathway reveals association of retromer genes with Alzheimer disease.  Abstract presented at the International Conference on Alzheimer Disease, July, 2010.

3.     Chen C-D, Abraham CR.  The functions of the anti-aging protein Klotho in the brain.  Abstract presented at the International Conference on Alzheimer Disease, July, 2010.

4.     Abraham CR.  Development of klotho enhancers as novel therapeutics for Alzheimer’s disease.  Abstract presented at the International Conference on Alzheimer Disease, July, 2010.

5.     Sherva R, Baldwin CT, Inzelberg R, Vardarajan B, Cupples LA, Lunetta K, Bowirrat A, Naj A, Pericak-Vance MA, Friedland RP, Farrer LA.  Identification of novel candidate genes for Alzheimer disease by autozygosity mapping using genome wide SNP data.  J Alz Dis.  Abstract Presented at the American Society of Human Genetics Meeting, October, 2010.

6.     Sullivan CP, Jay A, Stack E, Pakaluk M, Wadlinger E, Wells JM, Morin PJ. Retromer disruption promotes amyloidogenic APP processing.  Abstract presented at Society for Neuroscience 2010.

7.     Tucker T, Chen C, Abraham CR.  Investigating Klotho trafficking through lifespan-modulating polymorphisms.  Abstract presented at Biochemistry Student Day, 2010.

8.     Abraham, CR, Sloane, JA, Chen, C-D.  The Anti Aging Protein Klotho Affects Oligodendrocyte Differentiation. Presented at the American Society for Neurochemistry, March, 2011.

9.     Abraham, CR, King, G, Chen, C-D, Glicksman, M, Sloane, JA, Kuro-o, M, Dedeoglu,A. Aytan, N, Klotho enhancers as novel neuroprotective therapeutics for Alzheimer¹s disease and white matter degeneration. Presented at the AD/PD Meeting, Barcelona, March 2011

10.  Wolozin B, Vanderwyede T, Liu-Yesucevitz L, McKee A, Duff K.  Stress granules and Alzheimer’s disease: colocalization with tau pathology. Abstract presented at the International Conference on Alzheimer Disease, July, 2011.

11.  Abraham, CR, Sloane, JA, Aytan, N, Giannaris, NL, King, G, Kuro-o, M, Chen, C-D. The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination. Abstract presented at Society for Neuroscience 2011.

12.  Nagle MW, Chen CD, Abraham, CR. Klotho Regulates the Membrane Abundance of the TRPV1 Ca²⁺ channel in Neuro2a cells. Abstract presented at Society for Neuroscience 2011.

13.  Logue MW, Schu M, Varadarjan BN, Farrell J, Baldwin CT, Farrer LA. Prioritizing novel variants through whole-exome sequencing and pathway discovery in Alzheimer’s Disease. 2011. Presented at the 61st Annual Meeting of The American Society of Human Genetics, Oct 11-15^th 2011, Montreal Canada. http://www.ichg2011.org/abstracts/fulltext/f22011.htm.

14.  Logue MW, Schu M, Varadarjan BN, Farrell J, Baldwin CT, Fallin MD, Farrer LA. 2012. A rare haplotype containg two AKAP9 missense mutations identified by whole-exome sequencing is associated with risk of Alzheimer Disease in African Americans. 2012. Presented at the 62nd Annual Meeting of The American Society of Human Genetics, Nov 6-10^th 2012, San Francisco CA. http://www.ashg.org/2012meeting/abstracts/fulltext/f120122901.htm

15.  Asai H, Woodbury M, Ikezu S, Varnum M, Ikezu T. Accelerated neurodegeneration and phenotypic switch of neuroinflammation in transgenic mice expressing P301L tau-mutant and tau-tubulin kinase 1. Abstract presented at the Alzheimer Association International Conference, July 2012.

16.  Asai H, Ikezu S, Varnum M, Ikezu T. Phosphorylation of collapsin response mediator protein-2 axonal degeneration in transgenic mice expressing a familial Alzheimer’s disease mutant of APP and tau-tubulin kinase 1. Abstract presented at the Alzheimer Association International Conference, July 2012.

17.  Vardarajan BN, Bruesegem S, Harbour M, St. George-Hyslop P, Seaman M, Farrer L. Candidate gene study in the endosome-to-golgi retrieval pathway reveals association of retromer genes with Alzheimer’s disease. Abstract presented at the Alzheimer Association International Conference, July 2012.

18.  Chung J, Sherva R, Koesterer R, Alzheimer Disease Genetics Consortium, Haines J, Pericak-Vance MA, Schellenberg GD, Mayeux R, Farrer LA. Rate of Cognitive Decline is Modulated by Interaction of SNPs in CSFR1 With APOE ε4. Abstract presented at the Alzheimer Association International Conference, July 2013.

19.  Farrer LA. The Role of Common and Rare Variants in Risk for AD Across Populations. Plenary presentation at the Alzheimer Association International Conference, July 2013.

20.  Jun G, Asai H, Zeldich E, Drapeau E, Chung J, Park J-H, Chen C-D, Kim S, Haroutunian V, Foroud T, Lunetta KL, Kim J-W, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease risk and modulates tau protein phosphorylation. Abstract presented at the Alzheimer Association International Conference, July 2013.

21.  Logue MW, Schu M, Vardarajan BN, Farrell J, Baldwin CT, Fallin MD, Farrer LA. Two rare AKAP9 missense variants are associated with Alzheimer disease in African Americans. Abstract presented at the Alzheimer Association International Conference, July 2013.

22.  Asai H, Ikezu S, Ingraham KL, Watanabe T, Kaibuchi K, Ikezu T. A potential molecular mechanism of tau accumulation and dissemination via collapsin response mediator protein-2 and tautubulin kinase 1. New Frontiers in Neurodegenerative Disease Research, Keystone Symposia, Santa Fe, NM (2013).

23.  Asai H, Ikezu S, Kugler S, Ikezu T. The exosomal transcytosis mechanism of tau dissemination through neuron-microglia interaction. Alzheimer Association International Conference, Boston, MA (2013).

24.  Sullivan SE, Dillon GM, Sullivan JM, Ho A. Mint proteins are required for synaptic activity-dependent APP trafficking. Society for Neuroscience, San Diego, California – November 9-13, 2013.

25.  Sullivan SE, Dillon GM, Ho A. Mint proteins are required for synaptic activity-dependent APP trafficking and Ab generation. Protein Trafficking and Neurodegenerative Disease ARC Symposium, Boston MA – June 14, 2013.

26.  Dillon GM, Beffert U, Sullivan JM, Stuart CS, Gilbert JP, Kambouris JA, Ho A. Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. Keystone Symposia on Molecular and Cellular Biology/Neurogenesis and New Frontiers in Neurodegeneration Disease Research, Sante Fe, NM – February 3-8, 2013.

27.  Sullivan SE, Dillon GM, Ho A. Mint proteins are required for synaptic activity-dependent APP trafficking and Ab generation. Keystone Symposia on Molecular and Cellular Biology/Neurogenesis and New Frontiers in Neurodegeneration Disease Research, Sante Fe, NM – February 3-8, 2013.

28.  Jun G, Asai H, Drapeau E, Park J-H, Zeldich E, Chen C, Kim S, Foroud T, Lunetta KL, Kim J-W, Buxbaum JD, Abraham CR, Ikezu T, Mayeux R, Farrer LA. Genetic variation in PLXNA4 associated with susceptibility of Alzheimer disease through tau phosphorylation. Oral presentation at the Alzheimer’s Association International Conference on Alzheimer Disease (AAIC), Boston, MA, July 2013.

29.  Zeldich E, Chen C, Abraham CR. Klotho protects primary hippocampal neurons from oxidative stress. Presented at the Alzheimer’s Association International Conference on Alzheimer Disease (AAIC) Boston, USA, July 2013

30.  Chung J, Farrer L, Jun G. Genome-wide association study in different stages of clinical progression of Alzheimer Disease. Presented at the American Society of Human Genetics meeting, October 19, 2014.

31.  Jun G, Ibrahim-Verbaas C, Bellenguez C, Vronskaya M, Chung J, Bis JC, Williams J, Seshadri S, Schellenberg GD, Lunetta KL, Amouyel P, Holmans P, van Duijn CM, Farrer LA, International Genomics of Alzheimer’s Project (IGAP) Consortium. Genome-wide association study in APOE ε4 negative subjects identifies a novel locus in 17q21.31 for Alzheimer disease. Presented at the American Society of Human Genetics meeting, October 20, 2014.

32.  Mez J, Chung J, Lunetta KL, Haines J, Mayeux RP, Pericak-Vance MA, Schellenberg GD, Farrer LA, Alzheimer’s Disease Genetic Consortium. A variant in Cadherin 1 (CDH1) achieves near genome-wide significance in African Americans using a liability model. Presented at the American Society of Human Genetics meeting, October 21, 2014.

33.  Mez J, Chung J, Schu M, Logue M, Jun G, Lunetta K, Farrer L. A variant in STK24 achieves genome-wide significance in African Americans using a liability model. Alz & Dement 2014; 10:P481.

34.  Kunkle BW, Naj AC, Hamilton-Nelson K, Perry WR, Partch A, Valladares O, Chung J, Jun G, Schmidt M, Beecham G, Wang L-S, Martin M,  Mayeux R, Haines J, Farrer LA, Schellenberg GD, Pericak-Vance M, The Alzheimer’s Disease Genetics Consortium. Low-frequency variant imputation identifies novel disease-associated loci in a genome-wide association study of late-onset Alzheimer’s disease. Alz & Dement 2014; 10:P135.

35.  Chung J, Farrer LA, Jun G. Bivariate genome-wide association study of Alzheimer disease endophenotypes identifies novel loci. Alz & Dement 2014; 10:P316.

36.  Abraham CR, Zeldich E, Chen C-D. The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the central nervous system. Presented at the American Society for Neuroscience Cancun, Mexico, 2013

37.  Abraham CR, Chen C, Zeldich E. Neuroprotection by the anti-aging protein Klotho and its therapeutic potential for neurodegenerative diseases. Presented at the annual ADPD meeting, Florence, Italy, 2013.

38.  Abraham CR, Chen C-D, Medicetty S, Zeldich E. The life extension protein Klotho enhances remyelination following cuprizone-induced demyelination. Presented at ECTRIM 2014

39.  Zeldich E, Chen CD, Abraham CR. Klotho protects neurons via regulation of members of the redox system. Presented at a satellite symposium on neuroprotection at the Society for Neuroscience meeting, 2014.

40.  Abraham CR, Chen CD, Glicksman MA, Hodgetts K, Medicetti S, Zeldich E. The anti-aging protein Klotho as a new target for treating neurodegenerative diseases. Presented at the New York Academy of Science meeting, 2014

41.  Ikezu T, Asai H, Ikezu S, Haydar T, Wolozin B, Kugler S. Microglia and exosome-mediated spread of pathogenic tau in Alzheimer’s disease. Presented at the 44th Annual Meeting for the Society of Neuroscience, Washington, D.C., 2014.

42.  Woodbury ME, Freilich RW, Boucher JD, Ikezu S, Ingraham KL, Asai H, Cheng CJ, Slack FJ, Ikezu T. miR-155/IL-6 Axis regulates microglial inflammation-induced abnormality in neural differentian in the dendate gyrus. Presented at the 44th Annual Meeting for the Society of Neuroscience, Washington, D.C., 2014.

43.  Zhou Q, Yen A, Asai H, Ikezu T, Wolozin B, Bolotina VM. PARK14 Ex2KO mice as a novel model for age-dependent Parkinson’s disease. Presented at the 44th Annual Meeting for the Society of Neuroscience, Washington, D.C., 2014.

44.  Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. AAV2/1-mediated hippocampal gene delivery of CD200 enhances neural differentiation and amyloid clearance in Alzheimer’s disease mouse model. Presented at the 44th Annual Meeting for the Society of Neuroscience, Washington, D.C., 2014.

Arterial stiffness in diet-induced obese mice is reversed by weight loss. Leona Al Sayah, Liana Rubinoff, Tina Shiang, Robert M. Weisbrod, Saumendra Bajpai, Cynthia Reinhart-King, Richard A. Cohen and Francesca Seta (Evans Research Day 2013 Poster; third place winner).

Changes in cellular and extracellular mechanisms of arterial stiffness with aging. Gao YZ, Saphirstein RJ, Suki B, Morgan KG. “” (Biomedical Engineering Society Conference, 2013).

Changes in cellular and extracellular mechanisms of arterial stiffness with aging. Gao YZ, Saphirstein RJ, Suki B, Morgan KG. (Evans Reseach Day 2013).

The focal adhesion: a regulated component of aortic stiffness. Saphirstein RJ, Gao YZ, Jensen MH, Gallant CM, Vetterkind S, Moore JR, Morgan KG. “ (Experimental Biology Annual Meeting 2013).

Regulation of venous stiffness by smooth muscle cell-matrix adhesions. Saphirstein RJ, Gao YZ, Moore JR, Morgan KG. (North American Vascular Biology Organization’s Vascular Biology Conference 2013).

Regulation of venous stiffness by smooth muscle cell-matrix adhesions. Saphirstein RJ, Gao YZ, Moore JR, Morgan KG. (Evans Research Day 2013).

Publications:

29. Arterial Stiffening Precedes Systolic Hypertension in Diet-induced Obesity. Weisbrod M.R., Shiang T., Al Sayah L., Fry L.J., Bajpai S., Reinhart-King A.C., Lob E.H., Santhanam L., Mitchell G., Cohen R.A. and F. Seta. Hypertension 2013; 62: 1105-1110.

30. The Contribution of Vascular Smooth Muscle to Aortic Stiffness Across Length Scales. Saphirstein R.J. and K.G. Morgan. Microcirculation 2013 (invited review).

31. Vasoconstrictor-induced Endocytic Recycling Regulates Focal Adhesion Protein Localization and Function in Vascular Smooth Muscle. Poythress RH, Gallant C, Vetterkind S, Morgan KG. Am J Physiol Cell Physiol. 2013 Jul;305(2):C215-27. doi: 10.1152/ajpcell.00103.2013. Epub 2013 May 22. PMID: 23703522

32. The Focal Adhesion: a Regulated Component of Aortic Stiffness.

Saphirstein RJ, Gao YZ, Jensen MH, Gallant CM, Vetterkind S, Moore JR and KG Morgan. PLoS One. 2013 Apr 23;8(4):e62461. doi: 10.1371/journal.pone.0062461. Print 2013. PMID: 23626821.

33. Relations of Arterial Stiffness and Endothelial Function to Brain Aging in the Community. Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, Au R, Himali JJ, Hamburg NM, Vita JA, Levy D, Larson MG, Benjamin EJ, Wolf PA, Vasan RS, Mitchell GF. Neurology 2013 Aug 9 (e-pub ahead of print).

34. Aortic stiffness, blood pressure progression, and incident hypertension. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. JAMA 2012; 308:875-881.

35. Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study. Thanassoulis G, Lyass A, Benjamin EJ, Larson MG, Vita JA, Levy D, Hamburg NM, Widlansky ME, O’Donnell CJ, Mitchell GF, Vasan RS. Circulation 2012; 125:2836-2843.
 

36. Circulating vascular growth factors and central hemodynamic load in the community. Zachariah JP, Xanthakis V, Larson MG, Vita JA, Sullivan LM, Smith HM, Safa R, Peng X, Hamburg N, Levy D, Sawyer DB, Mitchell GF, Vasan RS. Hypertension 2012; 59:773-779.

37. Circulating angiogenic cell populations, vascular function, and arterial stiffness. Cheng S, Wang N, Larson MG, Palmisano JN, Mitchell GF, Benjamin EJ, Vasan RS, Levy D, McCabe EL, Vita JA, Wang TJ, Shaw SY, Cohen KS, Hamburg NM. Atherosclerosis 2012; 220:145-150.

38. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease. Dohadwala MM, Holbrook M, Hamburg NM, Shenouda SM, Chung WB, Titas M, Kluge MA, Wang N, Palmisano J, Milbury PE, Blumberg JB, Vita JA. Am J Clin Nutr 2011; 93:934-940.

39. Effects of Concord grape juice on ambulatory blood pressure in pre-hypertension and stage 1 hypertension. Dohadwala MM, Hamburg NM, Holbrook M, Kim BH, Duess M-A, Levit A,Titas M, Chung WB, Vincent FB, Caiano TL, Frame AA, Keaney JF, Vita JA. Am J Clin Nutr 2010; 92:1052-1059.

40. Arterial stiffness and cardiovascular events: The Framingham Heart Study. Mitchell GF, Hwang S-J, Ramachandran VS, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ. Circulation 2010; 121:505-511.

41. Effects of basic calponin on the flexural mechanics and stability of F-actin. Jensen MH, Watt J, Hodgkinson J, Gallant C, Appel S, El-Mezgueldi M, Angelini TE, Morgan KG, Lehman W, Moore JR. Cytoskeleton 2012 69:49-58.

42. Structure and Dynamics of the Actin-Based Smooth Muscle Contractile and Cytoskeletal Apparatus. Lehman W, Morgan KG. Journal of Muscle Research and Cell Motility, in press 2012.

43. Src Modulates Contractile Vascular Smooth Muscle Function via Regulation of Focal Adhesions. Min J, Reznichenko M, Poythress P, Gallant C, Vetterkind S, Li Y, Morgan KG. J Cell Physiol. 2012 227: 3585-92. PMID: 22287273  PMC3348426

44. Non-redundant roles of cytoplasmic beta- and gamma-actin isoforms in regulation of epithelial apical junctions. Baranwal S, Naydenov NG, Harris G, Dugina V, Morgan  KG, Chaponnier C,  Andrei I. Ivanov AI.   MBoC 2012 in press.

45. A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V, Ravid K. Circulation, 2012 Jan 17;125(2):354-63. PMCID: PMC3265935.

46. A2 adenosine receptors and vascular pathologies. Johnston-Cox HA, Koupenova M, Ravid K. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):870-8. Review. PMID: 22423039.

47. The A2b adenosine receptor modulates glucose homeostasis and obesity. Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG LeBrasseur N, Ravid K. PLoS One. 2012;7(7):e40584. Epub 2012 Jul 25. PMCID: PMC3405065.

48. Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors. Koupenova M, Johnston-Cox H, Ravid K. Curr Atheroscler Rep. 2012 Oct;14(5):460-8. PMID: 22850979.

49. Nucleotide excision DNA repair is associated with age-related vascular dysfunction. Durik M, Kavousi M, van dP, I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ. Circulation. 2012;126:468-478.

50. Electromechanical and structural alterations in the aging rabbit heart and aorta. Cooper LL, Odening KE, Hwang MS, Chaves L, Schofield L, Taylor CA, Gemignani AS, Mitchell GF, Forder JR, Choi BR, Koren G. Am J Physiol Heart Circ Physiol. 2012;302:H1625-H1635.

51. Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility—Reykjavik study. Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson O, Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ. Brain. 2011;134:3398-3407.

52. Common genetic variation in the 3′-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. Lead author: Mitchell GF, and 30-40 other authors including from BU..,Vasan RS, … Benjamin EJ, …Levy D, … . Circ Cardiovasc Genet. 2012;5:81-90.

53. Aortic stiffness and cerebral blood flow. Mitchell GF. Am J Hypertens. 2011;24:1056.

54. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. ……Mitchell GF, …. Levy D, (amongst >25 authors) Nat Genet. 2011;43:1005-1011.

55. Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study. Mitchell GF, Wang N, Palmisano JN, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS. Circulation. 2010;122:1379-1386.

56. Arterial Stiffness and Wave Reflection: Biomarkers of Cardiovascular Risk. Mitchell GF. Artery Res. 2009;3:56-64.

Co-Directors: Drs. Maria Kukuruzinska (mkukuruz@bu.edu – GDSM, Molecular and Cell Biology, Assoc Dean for Research), Avrum ‘Avi’ Spira (aspira@bu.edu – MED, Section Chief), Maria Trojanowska (trojanme@bu.edu – MED, Medicine)

1. Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL. Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. Cell Reports. 2013 Dec 26;5(6):1611-24. doi: 10.1016/j.celrep.2013.11.021. Epub 2013 Dec 12.
2. Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X. The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and miRNA Biogenesis through Let-7. Journal of Biological Chemistry. 2014 Jan 24;289(4):1886-91. doi: 10.1074/jbc.C113.529362. Epub 2013 Dec 9.
3. Hiemer SE, Szymaniak AD, Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem. 2014 May 9;289(19):13461-74. doi: 10.1074/jbc.M113.529115. Epub 2014 Mar 19. PMID: 24648515
4. Hiemer SE, Varelas X. Stem cell regulation by the Hippo pathway. Biochim Biophys Acta. 2013 Feb;1830(2):2323-34. doi: 10.1016/j.bbagen.2012.07.005. Epub 2012 Jul 20. Review. PMID: 22824335
5. Husaini H, Krisciunas GP, Langmore SE, Mojica JK, Urken ML, Jacobson AS, Lazarus CL. A Survey of Variables Used by Speech-Language Pathologists to Assess Function and Predict Functional Recovery in Oral Cancer Patients. Dysphagia. 2014 Mar 8.
6. Kaneoka AS, Krisciunas GP, Walsh K, Raade A, Langmore SE. A comparison of two methods of endoscopic laryngeal sensory testing: a preliminary study. Annals Otol Rhin Laryng, 2014, 1-7. DOI: 10.1177/0003489414550241.
7. Kaneoka AS, Langmore SE, Krisciunas GP, Field K, Scheel R, McNally E, Walsh MJ, O’Da MB, Cabral H. The Boston Residue and Clearance Scale; Preliminary reliability and validity testing. Folia Phoniatr Logop Jul 12:65(6):312-317.
8. Liu G, Sengupta PK, Jamal B, Yang HY, Bouchie MP, Lindner V, Varelas X, Kukuruzinska MA. N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. J Biol Chem. 2013 Jul 12;288(28):20217-27. doi: 10.1074/jbc.M113.473785. Epub 2013 May 23. PMID: 23703614
9. Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso W. The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors. Developmental Cell. 2014 Jul 16. pii: S1534-5807(14)00374-8. doi: 10.1016/j.devcel.2014.06.003. [Epub ahead of print]
10. Malloy JR., Valentin JC. Hands GL., Stevens CA., Langmore SE., Noordzij JP., Stepp CE. Visuomotor control of neck surface electromyography in Parkinson’s disease, Neurorehabilitation
11. Nguyen, D.H.T., Stapleton, S.C., Yang, M.T., Cha, S.S., Choi, C.K., Galie, P.A., Chen, C.S. (2013) Biomimetic Model to Reconstitute Angiogenic Sprouting Morphogenesis in vitro. PNAS 110 (17): 6712-6717.
12. Varelas X, Bouchie MP, Kukuruzinska MA. N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling. Glycobiology. 2014 Jul;24(7):579-91. doi: 10.1093/glycob/cwu031. Epub 2014 Apr 17
13. Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis, and disease. Development. 2014 Apr;141(8):1614-26. doi: 10.1242/dev.102376.
14. Varelas, X. Kukuruzinska, M.A. (2014). Head and Neck Cancer: from research to therapy and cure. Ann. NY Acad Sci.

Presentations and Posters

1. Almershed M, Bukhari S, Packer T, Li J, Sengupta P, Kukuruzinska MA. N-glycosylation Signaling Drives Oral Cancer Pathogenesis. Poster session presented at: Head and Neck Cancer Symposium, Boston University. 2014 Apr 28; Boston, MA.
2. Bais M, Trackman, PC. Orthotopic Oral Cancer Growth and Metastasis Mouse Models.     Poster session presented at: Head and Neck Cancer Symposium, Boston University, 2014 Apr 28; Boston, MA.
3. Bais M, Stanford E, Novikov O, Sherr D, Kukuruzinska MA,  Trackman PC. Orthotopic Oral Cancer Mouse Model for Validate the Anti-Cancer Activity of LOX-PP, Tunicamycin and AHR Modulators. Presented at: Fourth Annual BU CTSI Translational Science Symposium, Boston University, 2014 Oct 1; Boston, MA.
4. Das B, Bhuyan R, Bayat-Mokhtari R, Bhuyan S, Felsher DW, Yeger H. Hypoxia-mediated stemness switch induces resistance to Epidermal Growth Factor Receptor (EGFR) antagonism in oral squamous carcinoma stem cells. Poster session presented at: Head and Neck Cancer Symposium, Boston University. 2014 Apr 28; Boston, MA.
5. Haines, P, Stawski, L, Varelas, X, Bujor, A, and Trojanowska M. The profibrotic role of YAP and TAZ in systemic sclerosis. Poster presentation at the Keystone Symposia “Fibrosis: From bench to bedside”, Mar 2014; Keystone, CO.
6. Han R, Li A,. Kartha VK, Monti S, Gallagher G, Kukuruzinska MA, Trojanowska M. PDGFRβ as a potential early marker of tumor stroma activation in oral cancer. Poster session presented at: Head and Neck Cancer Symposium, Boston University. 2014 Apr 28; Boston, MA.
7. Hiemer SE. Dysregulated N-linked glycosylation and TAZ/YAP networks drive Oral Squamous Cell Carcinoma progression. Poster session presented at: Head and Neck Cancer Symposium, Boston University, 2014 Apr 28; Boston, MA.
8. Kartha V, Zhang L, Hiemer S, Kukuruzinska M, Varelas X, Monti S (2014). Role of the DPAGT1/β-Catenin/YAP signaling Network in Oral Squamous Cell Carcinoma. BU GSI Symposium 2014. Boston MA.
9. Kramer CD, Weinberg EO, Salama A, Genco CA. The Oral Microbiome in Patients with Oral Cancers. Poster session presented at: ImmunoGenomics Symposium, The Jackson Laboratory for Genomic Medicine, 2014 Nov 13-14; Farmington, CT.
10. Langmore SE, McCulloch T, Logemann J, Lazarus C, Krisciunas G. Efficacy of Electrical Stimulation and Exercise in Head and Neck Cancer Patients with Dysphagia. Presented at: The Annual Dysphagia Research Society, 2013 March 14; Seattle, WA.
11. Ludlow, C,  Yeatts, S, Langmore SE, Kent, R. Designing Clinical Trials Using Adaptive Designs to Develop Treatment Parameters. Presented at: American Speech Language Hearing Association annual meeting. 2013, Nov.14-16.
12. Novikov, O, Stanford, EA, Sherr DH. The role of endogenous and environmental AhR ligands in mammary epithelial cell tumor growth and metastasis. Presented at: CTSI Symposium, 2014; Boston, MA.
13. Packer T, Li J, Bais M, Kukuruzinska MA. Targeting the N-glycosylation regulating gene, DPAGT1, for Oral Cancer. Poster session presented at: Fourth Annual BU CTSI Translational Science Symposium, Boston University, 2014 Oct 1; Boston, MA
14. Pearson, WG, Davidoff AA, Langmore SE. An Anatomical Landmark Coordinates Approach for Analyzing Hyolaryngeal Movement as Visualized in Videofluoroscopic Swallowing Studies. Presented at:  International Workshop on Biomechanical and Parametric Modeling of Human Anatomy. 2013 Jan; Vancouver, CA.
15. Riquelme, L, Langmore SE, Bozko F.  Decision making surrounding the use of tube feeding. Presented at:  American Speech Language Hearing Association annual meeting. 2013 Nov.14-16.
16. Satoh, Asako Kaneoka,  Krisciunas G, Fields K, Scheel R, McNally E Walsh M, Bosley M, Cabral H, Langmore SE.  BRACS:  The Boston Residue and Clearance Scale: Preliminary Validity Testing.  Presented at: the annual Dysphagia Research Society. 2013 March 14; Seattle, WA.
17. Trackman, PC. Lysyl Oxidases and Potential Therapeutic Opportunities. Presented at: The 16th International Amine Oxidase Conference. 16 July 2014; Sydney, Australia.
18. Trackman, PC. Lysyl Oxidases in Fibrosis and Cancer. Presented at: American Society of Matrix Biology. 2014 Oct 12; Cleveland, OH.
19. Varelas X. Molecular mechanisms linking epithelial polarity to the regulation of the Hippo pathway effector Yap. Poster session presented at: Gordon Conference, Cell Polarity Signaling, 2014 Jun 1-6; Waltham, MA.
20. Varelas X. Dysregulated protein N-glycosylation/E-cadherin/Wnt/Hippo signaling network in OSCC. Head and Neck Cancer SPORE Workshop, 2014, March 3; NIH/NCI, Rockville, MD.
21. Varelas X. Epithelial polarity-regulated cues as mediators of airway patterning. Poster presented at FASEB Conference, The Lung Epithelium in Health and Disease, Jul 2014.
22. Varelas X. Dysregulated N-linked glycosylation and TAZ/YAP networks drive Oral Squamous Cell Carcinoma progression. Poster presented at Head and Neck Cancer Symposium, Apr 2014; Boston, MA.
23. Varelas X. Crosstalk between the Hippo and TGFbeta pathways directs tumor-initiating signals. Presented at Keystone Symposia – The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer, May 2013; Monterey, CA.
24. Varelas X. The N-glycosylation and Hippo pathways drive a positive feedback loop that promotes oral cancer. Poster presented at Gordon Conference – Salivary Glands and Exocrine Biology, Feb 2013; Galveston, TX.
25. Kukuruzinska, M.A. Boston University- Dana Farber OCRI: a collaborative for basic and translational oral cancer research. Head and Neck Cancer SPORE Workshop, 2014, March 3; NIH/NCI, Rockville, MD.
26. Arango Vargas D, Kukuruzinska MA, and Zaman M.  Modeling the Effect of Canonical Wnt Signaling in Epithelial Discohesion. Poster session presented at: Head and Neck Cancer Symposium, Boston University, 2014 Apr 28; Boston, MA.

Zhang L, Kartha V, Hiemer S, Kukuruzinska MA, Varelas X, Monti S. Role of the DPAGT1/β-Catenin/YAP signaling Network in Oral Squamous Cell Carcinoma. Presented at: BUSM Evans Symposium 2014. 2014 Sept 23; Boston, MA.

1. Gusenleitner D, Auerbach S, Sherr DH, Monti S.
   Best Poster Presentation award, IBSB 2013, Tokyo, Japan.
2. Gusenleitner D, Gomez H, Meila T, Sherr D, Auerbach S, Monti S. Genomic Signatures of Carcinogenicity. In: EDRN Cancer Biomarker Bioinformatics Workshop. Pasadena, CA; 2013.
3. Gusenleitner D, Auerbach S, Sherr DH, Monti S. Toxicogenomic Models of Chemical Carcinogenicity, RECOMB/ICSB 2013.
4. Gusenleitner D, Auerbach S, Sherr DH, Monti S.
   Best Poster Award, National Superfund Research Program Annual Meeting 2013, Baton Rouge, LA.
5. Gusenleitner D, Auerbach S, Sherr DH, Monti S. Toxicogenomic Models of Chemical Carcinogenicity, National LINCS symposium 2013, Broad Institute, Boston, MA.
6. Wang T, Moses E, Campbell J, Lenburg M, Perdomo C, Spira A. GHK as a candidate therapeutic target for Lung Adenocarcinoma. National LINCS symposium 2013, Broad Institute, Boston, MA.
7. Moses E, Wang T, Campbell J, Perdomo C, Lu X, Natoli T, Narayan R, Subramanian A, Lenburg ME, Spira A. The Lung Connectivity Map: A high-throughput genomics approach to identifying novel therapeutics. Abstract for oral presentation, 2013 Boston University ARC Symposium, Boston, MA.
8. Sherr DH, Parks A, Monti S, Murphy GJ, Novikov O, Ubellacker J, Stanford E. 2014. The AHR controls breast cancer stem cell development and function. The Toxicologist. Symposium, SOT Annual Meeting, Phoenix, Az
9. Novikov O, Parks A, Narasimhan S, Rolf S, Stanford E, Ubellacker J., Sherr DH. 2013. The role of environmental and endogenous ligands in tumor invasion and metastasis. Superfund Research Program Annual Meeting. Baton Rouge, Louisiana.
10. Novikov O, Parks A, Narasimhan S, Rolf S, Stanford E, Ubellacker J., Sherr DH 2014. Regulation of AhR activation in triple negative breast cancer cells by tryptophan metabolites. America Physician Scientist Association, Chicago, Ill
11. Stanford EA, Sherr DH (2014). The aryl hydrocarbon receptor controls breast cancer stem-like cell development and function. The Toxicologist. New England SOT Best Poster. SOT Annual Meeting, Phoenix, Az.
12. Bais M, Stanford E, Novikov, O, Sherr DH, Kukuruzinska M, Trackman P (2014). Orthotopic Oral cancer mouse model to validate the anti-cancer activity of LOX-PP, tunicamycin and AHR modulators. American Assoc. of Dental Res. Annual Meeting, Boston, MA.
13. Novikov O, Parks A, Rolfe S, Narasimhan S, Stanford E, Ubellacker J, Sherr DH (2014). The role of endogenous and environmental AhR ligands in mammary epithelial tumor growth and invasion. Superfund Research Program Annual Meeting, San Jose, CA
14. Gusenleitner D, Gomez H, Meila T, Auerbach S, Sherr DH, Monti S (2014). Genomic models are able to identify cancer causing chemicals and underlying biological mechanisms. Invited Speaker. Superfund Research Program Annual Meeting, San Jose, CA

Peer-Reviewed Publications

1. Smith B, …, Monti S, …, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation (2013) Blood 122(3):376-385.
2. Sherr DH, Monti S. The role of the aryl hydrocarbon receptor in normal and malignant B cell development (2013) Seminars in Immunopathology 35(6):705-716.
3. Leung A, …, Monti S, …, Mostoslavsky G, Kotton DN, Murphy GJ (2013) Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis.  Stem Cell Reports 1(5) p. 451-63.
4. Parks, A.,  Pollastri M, Frangs D,  Haigh-Molina S, Ashton T,  Ubellacker J, Stanford E, Schlezinger JJ, and Sherr DH (2013). Identification of a novel AhR antagonist that blocks breast cancer invasion in vitro and acute AhR-mediated DMBA toxicity in vivo. Mole. Pharmacol. 86:593-608.
5. Kleensang A, …, Monti S, …, Hartung T (2013). Pathways of Toxicity. ALTEX 31, 53–61.
6. Sebastiani P, Bae H, MacIntosh A, Monti S (2013). Bayesian Graphical Models for Gene-Environment Interaction. In Joint Statistical Meeting (pp. 760–766).
7. Gusenleitner D, Auerbach SS., Melia T, Gómez HF, Sherr DH, Monti S (2014). Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. PLoS ONE, 9(7), e102579.

Under Review or In Preparation – look these up to see is they got published

1. Mulas, F., Li, A., Auerbach, S., Sherr, D. & Monti, S. Network-Based Analysis of Chemical Perturbations to Identify Mechanisms of Action Associated to Adverse Phenotypes. BMC bioinformatics (under review).
2. Kim, S., Li, A., Monti, S. & Schlezinger, J. Role of Environmental PPAR/RXR ligands in skewing Osteocyte vs. Adipocyte Differentiation. Manuscript in preparation.
3. Stanford, E., Novikov, O., Wang, Z., Muprhy, G. & Sherr, D. Role of the aryl hydrocarbon receptor in generation of breast cancer stem-like cells. Manuscript Submitted.
4. Narasimhan, S. et al. Aryl hydrocarbon receptor (AhR) hyper-expression and constitutive activity drive human mammary tumor cell invasion. Manuscript in preparation.
5. Stanford, E., Ramirez-Cardenas, A., Novikov, O. & Sherr, D. H. The aryl hydrocarbon receptor mediates oral squamous cell carcinoma invasion. Manuscript in preparation.
6. Novikov, O. et al. An aryl hydrocarbon receptor-mediated positive feedback loop that enforces cell migration in ER-/PR-/Her2- human breast cancer cells. Mol. Pharmacol. (under review).
7. Kim, S., Li, A., Monti, S. & Schlezinger, J. Role of Environmental PPAR/RXR ligands in skewing Osteocyte vs. Adipocyte Differentiation. Manuscript in preparation.

Kalypso Karastergiou, Susan K. Fried, Hui Xie, Mi-Jeong Lee, Adeline Divoux, Marcus A. Rosencrantz, R. Jeffrey Chang, Steven R. Smith

J Clin Endocrinol Metab. 2013 Jan; 98(1): 362–371. Published online 2012 Nov 12. doi: 10.1210/jc.2012-2953

PMCID: PMC3537084

1. Mark P. Jedrychowski, Libin Liu, Collette J. Laflamme, Kalypso Karastergiou, Tova Meshulam, Shi-Ying Ding, Yuanyuan Wu, Mi-Jeong Lee, Steven P. Gygi, Susan K. Fried, Paul F. Pilch   Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in  adipocytes  MOLECULAR METABOLISM 4 (2015) 758e770  http://dx.doi.org/10.1016/j.molmet.2015.09.002

• Partial support for this project was directly funded by year 1 or our ARC.  Although only the results for only male mice are reported here for both adiporedoxin (Adrx) knockout and the high fat fed cohort, in the latter, we found that high fat feeding did not down regulate Adrx protein levels in the females, and their fat did not become inflamed.   We have recently identified the reason why we having trouble breeding these mice – lactation fails in the knockout females.  As Adrx is adipocyte-specific, this finding suggests a sex-dependent function for Adrx and adipocyte secretory products in the mammary gland.  Funding for this year’s ARC was instrumental in building the colony for future planned studies, including analysis of sex and depot-differences in Adrx expression and function in males and females

2. Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21;289(12):8473-83. doi: 10.1074/jbc.M113.546242. Epub 2014 Feb 7. PubMed PMID: 24509860; PubMed Central PMCID: PMC3961672

• The cavin-1 knockout mice we have been studying have multiple metabolic abnormalities as well as physical limitations most likely related to muscular dystrophy. They have cardiac defects as well, related to the expression of genes involved in muscle structure/function. Interestingly, females exhibit more profound defect than males and we are following up these findings at the phenotypic and molecular level.

6. Karastergiou K, Smith SR, Greenberg AS, Fried SK. Sex differences in human adipose tissues – the biology of pear shape. Biol Sex Differ. 2012 May 31;3(1):13. doi: 10.1186/2042-6410-3-13. PubMed PMID: 22651247; PubMed Central PMCID: PMC3411490.

• These review articles includes ideas influenced by many ARC discussions and sponsored seminars.

7. Karastergiou K, Fried SK, Xie H, Lee MJ, Divoux A, Rosencrantz MA, Chang RJ, Smith SR. Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. J Clin Endocrinol Metab. 2013 Jan;98(1):362-71. doi: 10.1210/jc.2012-2953. Epub 2012 Nov 12. PubMed PMID: 23150689; PubMed Central PMCID: PMC3537084.

• This is the first publication using this dataset – as proposed in our ARC; we are using this dataset for analyses of genes and pathways that are upregulated by obesity in males and females.  Dr. Kasif’s team has provided additional analysis and we are currently drafting a manuscript and planning future grants related to these results.
• Two related manuscripts using this dataset have been published, one more is review

–        8. Divoux A, Karastergiou K, Xie H, Guo W, Perera RJ, Fried SK, Smith SR.

Identification of a novel lncRNA in gluteal adipose tissue and evidence for its

positive effect on preadipocyte differentiation. Obesity (Silver Spring). 2014

Aug;22(8):1781-5. doi: 10.1002/oby.20793. Epub 2014 May 23. PubMed PMID:

24862299; PubMed Central PMCID: PMC422878

–        9. Depot specific MicroRNA Expression in Human Subcutaneous Adipose Tissue” Adeline Divoux,^1,2 Hui  Xie,^1,2 Jian-Liang Li,² Kalypso Karastergiou,³ Ranjan J. Perera,² Susan K. Fried,³ Steven R. Smith^1,  (under review)

Manuscripts reporting the results of ARC-supported projects that are in late stages of preparation or under review and demonstrate collaborations among ARC members related to the obesity-related metabolic disease.  

10. Wu Y, Lee, MJ, Fried SK. Expression of MMP3 in adipocyte progenitor cells: potential role in sex differences and depot differences in adipose tissue remodeling. (in revision)

• • This manuscript reports the results of a study initiated in year 1-2 of our ARC.  Tissues from the project were also used for the Adrx paper and grants to obtain preliminary data for additional grant submissions (Fried, Pilch, Kandror, Puri).

11. Kalypso Karastergiou, Miriam A. Bredella, Steven R. Smith, Susan K. Fried, Karen K. Miller,  Wu Y, Mi-Jeong Lee. Growth Hormone Receptor in Human Subcutaneous Adipose Tissue: Gluteal Versus Abdominal Depots (submitted for publication)

• • This manuscript leveraged microarray data collected from Drs. Karastergiou, Lee, Smith and Fried to uncover depot differences in the expression of GHR and its targets in abdominal compared to gluteal human adipose tissues of men and women.  These data were used for a NIH grant proposal submission by Drs. Miller, Karastergiou and Fried   (it was scored but not funded and we plan to re-submit as a multi-PI project.  Dr.  Miller has data indicating differential effects of GH on fat distribution and metabolic parameters in men and women, and we will pursue further studies.)

12. Karastergiou K., Pramyothin P., Apovian C.M., Lee M.J., Fried S.K., Abolition of the glucocorticoid circadian rhythm disrupts lipid storage in adipocytes in vitro and circadian changes in human adipose gene expression in vivo. (submitted)

13. Pickering R.T., Lee M.J., Karastergiou K., Gower A., Fried S.K.,   Depot- and dose- dependent responses to dexamethasone in omental and abdominal subcutaneous human adipose tissues

14. Divoux A., Xie H., Li J.L., Karastergiou K., Perera R.J., Fried S.K., Smith S.R., Depot specific MicroRNA Expression in Human Subcutaneous Adipose Tissue. (submitted)

Related recent publications by ARC members that are clearly related to the theme and form the basis for future collaborative work on sex differences that is actively being discussed: 

16. Liu L, Hansen CG, Honeyman BJ, Nichols BJ, Pilch PF. Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. PLoS One. 2014 Jul 18;9(7):e102935. doi: 10.1371/journal.pone.0102935. eCollection 2014. PubMed PMID: 25036884; PubMed Central PMCID: PMC4103889.

18. Divoux A, Karastergiou K, Xie H, Guo W, Perera RJ, Fried SK, Smith SR. Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation. Obesity (Silver Spring). 2014 Aug;22(8):1781-5. doi: 10.1002/oby.20793. Epub 2014 May 23. PubMed PMID: 24862299; PubMed Central PMCID: PMC4228784.

19.Lee MJ, Fried SK. Reply to Armani et al. Can cortisol stimulate adipogenesis without the glucocorticoid receptor? Int J Obes (Lond). 2014 Dec;38(12):1578-9. doi: 10.1038/ijo.2014.71. Epub 2014 May 2. PubMed PMID: 24785104; PubMed Central  PMCID: PMC4339028.

20. Lee MJ, Fried SK. Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol. 2014;538:49-65. doi: 10.1016/B978-0-12-800280-3.00004-9. PubMed PMID: 24529433; PubMed Central PMCID: PMC4336794.

• Cells are being utilized by multiple members of BNORC and our ARC to facilitate relevant studies, and we are proactively building up sufficient numbers of male and female adipocytes to power future in vitro studies.

21. Singh M, Kaur R, Lee MJ, Pickering RT, Sharma VM, Puri V, Kandror KV.  Fat-specific protein 27 inhibits lipolysis by facilitating the inhibitory effect of transcription factor Egr1 on transcription of adipose triglyceride lipase. JBiol Chem. 2014 May 23;289(21):14481-7. doi: 10.1074/jbc.C114.563080. Epub 2014 Apr 17. PubMed PMID: 24742676; PubMed Central PMCID: PMC4031504.

22. Grahn TH, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V. Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem. 2014 Apr 25;289(17):12029-39. doi: 10.1074/jbc.M113.539890. Epub 2014 Mar 13. PubMed PMID: 24627478; PubMed Central PMCID: PMC4002109.

23. Lee MJ, Pickering RT, Puri V. Prolonged efficiency of siRNA-mediated gene silencing in primary cultures of human preadipocytes and adipocytes. Obesity (Silver Spring). 2014 Apr;22(4):1064-9. doi: 10.1002/oby.20641. Epub 2013 Dec 5.  PubMed PMID: 24307633; PubMed Central PMCID: PMC3968221.

24.Hua N, Chen Z, Phinikaridou A, Pham T, Qiao Y, LaValley MP, Bigornia SJ, Ruth MR, Apovian CM, Ruberg FL, Hamilton JA. The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect. J Cardiovasc Magn Reson. 2014 May 23;16:37. doi: 10.1186/1532-429X-16-37. PubMed PMID: 24884541; PubMed Central PMCID: PMC4046092.

25. Dhurandhar EJ, Dawson J, Alcorn A, Larsen LH, Thomas EA, Cardel M, Bourland AC, Astrup A, St-Onge MP, Hill JO, Apovian CM, Shikany JM, Allison DB. The effectiveness of breakfast recommendations on weight loss: a randomized controlled trial. Am J Clin Nutr. 2014 Aug;100(2):507-13. doi: 10.3945/ajcn.114.089573. Epub 2014 Jun 4. PubMed PMID: 24898236; PubMed Central PMCID: PMC4095657.

26. Boonchaya-anant P, Apovian CM. Metabolically healthy obesity–does it exist? Curr Atheroscler Rep. 2014 Oct;16(10):441. doi: 10.1007/s11883-014-0441-1. Review. PubMed PMID: 25092577.

28. Schneider S, Smith T, Hansen U. (2011) SCOREM: Statistical consolidation of redundant expression measures.Nucleic Acids Research, doi: 10.1093/nar/gkr1270.

29. Karastergiou K, Fried SK, Xie H, Lee M-J, Divoux A, Rosencrantz MA, Chang JR, Smith SR. Distinct Developmental Signatures of Human Abdominal and Gluteal Subcutaneous Adipose Tissue Depots. J Clin Endocrinol Metab. 2012 Nov 12. [Epub ahead of print] PMID:23150689

Reviews and commentaries:

30. Karastergiou K, Smith SR, Greenberg AS, Fried SK (2012)  Sex differences in human adipose tissues – the biology of pear shape.  Biol Sex Differ. 2012 May 31;3(1):13.

31. Lee MJ, Wu Y, Fried SK. Adipose tissue remodeling in pathophysiology of obesity. Curr Opin Clin Nutr Metab Care. 2010 Jul; 13(4):371-6.

32. Lee, MJ  and Fried, SK Adipose Tissue in Health and Disease, Chapter 15. Depot-Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk. Pages 285-306 Wiley-VCH Verlag GmbH & Co., 2010

33. Lee MJ, Wu Y, Fried SK. A Modified Protocol to Maximize Differentiation of Human Preadipocytes and Improve Metabolic Phenotypes. Obesity (Silver Spring).2012 May 4. doi: 10.1038/oby.2012.116. [Epub ahead of print] PubMed PMID: 22627913

34. Fried SK, Greenberg AS. Lipocalin 2: a “sexy” adipokine that regulates 17β-estradiol and obesity. Endocrinology. 2012 Apr;153(4):1582-4. Epub 2012 Mar  (invited perspective)  PubMed PMID: 22408176; PubMed Central PMCID: PMC3320254

35. Lee MJ, Wu Y, Fried SK. Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med. 2012 Oct 13. doi:pii: S0098-2997(12)00115-X. 10.1016/j.mam.2012.10.001. [Epub ahead of print] PubMed PMID: 23068073.

ARC-related abstracts presented at recent meetings (selected):

2. Karastergiou K., Pramyothin P., Port A., Apovian C.M., Lee M.J., Fried S.K. Cortisol interacts with meal-induced signals to acutely regulate adipose tissue gene expression. The Obesity Society, Boston, MA, November 2014.

3. Divoux A., Karastergiou K., Xie H., Perera R.J., Fried S.K., Smith S.R. Differential Expression of lncRNA in Human Abdominal and Gluteal Subcutaneous Adipose Tissue Depot. The Obesity Society, Boston, MA, November 2014.

4. Karastergiou K., Bredella M.A., Smith S.R., Miller K.K., Fried S.K. Growth Hormone Receptor In Human Subcutaneous Adipose Tissue: Gluteal Versus Abdominal Depots. Experimental Biology, Boston, MA, April 2013.

5. Karastergiou K., Lee M.J., Smith S.R., Fried S.K. Key characteristics of human gluteal adipocytes are cell autonomous. Adipose Tissue Biology Keystone Symposium, CO, January 2013.

6. Lee, MJ, Puri, V, and Fried, SK  “Thiazolidinediones induction of brite phenotype in subcutaneous human adipose tissue”, The Obesity Society Annual Meeting, Boston, USA.

7. Wu, YY, Lee, MJ, Fried, SK.  Sex-Dependent Depot Differences in MMPs and Inflammation of Adipose Tissue Remodeling in C57/Bl6 Mice.  Submitted to Experimental Biology, April, 2013

8. Kalypso Karastergiou,1 Susan K. Fried, Hui Xie, Shantele Thomas, Marcus A. Rosencrantz, R. Jeffrey Chang, Steven R. Smith  Evidence for Developmental Programming of Human Gluteal versus Abdominal Subcutaneous Adipose Tissue.  Annual meeting of the obesity society, Oct. 2011

9. **Wu, YY, Lee, MJ, Fried, SK, Sex-Dependent Depot Differences in MMPs and Inflammation of Adipose Tissue Remodeling in Mice, 28th Annual Scientific Meeting of the Obesity, OBESITY Volume: 18 Pages: S72-S72,  2010

Publications (2013):

36. Karastergiou K, Fried SK. Multiple adipose depots increase cardiovascular risk via local and systemic effects. Curr Atheroscler Rep. 2013 Oct;15(10):361. doi: 10.1007/s11883-013-0361-5. PubMed PMID: 23982264.

37. Grahn TH, Zhang Y, Lee MJ, Sommer AG, Mostoslavsky G, Fried SK, Greenberg AS, Puri V. FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes. Biochem Biophys Res Commun. 2013 Mar 8;432(2):296-301. doi: 10.1016/j.bbrc.2013.01.113. Epub 2013 Feb 8. PubMed PMID: 23399566; PubMed Central PMCID: PMC3595328.

38. Chakrabarti P, Kim JY, Singh M, Shin YK, Kim J, Kumbrink J, Wu Y, Lee MJ, Kirsch KH, Fried SK, Kandror KV. (2013) Insulin inhibits lipolysis in adipocytes via the evolutionary conserved mTORC1-Egr1-ATGL-mediated pathway. Molecular and Cellular Biology. Sep;33(18):3659-66.

** NOTE:  This paper results from synergistic efforts of the Bariatric Core and the Sex differences Core.

39. Lee MJ, Wu Y, Fried SK (2013) Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications. Molecular Aspects of Medicine 2013, 34:1-11

40. Aprahamian TR. Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity. Metabolism. 2013 Dec;62(12):1730-8. doi: 10.1016/j.metabol.2013.07.010. Epub 2013 Aug 28. PubMed PMID: 23993424; PubMed Central PMCID: PMC3834157.

41. Aprahamian TR, Sam F. Adiponectin in cardiovascular inflammation and obesity. Int J Inflam. 2011;2011:376909. doi: 10.4061/2011/376909. Epub 2011 Sep 15.PubMed PMID: 21941676; PubMed Central PMCID: PMC3175407.

42. DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova YR, Markham D, Strissel KJ, Watkins AA, Zhu M, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian C, Denis GV, Nikolajczyk BS.  B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13): 5133-8. doi: 10.1073/pnas.1215840110. Epub 2013 Mar 11. PubMed PMID: 23479618; PubMed Central PMCID: PMC3612635.

43. Belkina AC, Nikolajczyk BS, Denis GV. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J Immunol. 2013 Apr 1;190(7):3670-8. doi: 10.4049/jimmunol.1202838. Epub 2013 Feb 18. PubMed PMID: 23420887; PubMed Central PMCID: PMC3608815.

44. Snyder-Cappione JE, Nikolajczyk BS. When diet and exercise are not enough, think immunomodulation. Mol Aspects Med. 2013 Feb;34(1):30-8. doi:10.1016/j.mam.2012.10.003. Epub 2012 Oct 16. Review. PubMed PMID: 23078865.

45. Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV. The outliers become a stampede as immunometabolism reaches a tipping point. Immunol Rev. 2012 Sep;249(1):253-75. doi: 10.1111/j.1600-065X.2012.01142.x. Review. PubMed PMID: 22889227; PubMed Central PMCID: PMC3419483.

46. Nikolajczyk BS, Jagannathan-Bogdan M, Shin H, Gyurko R. State of the union between metabolism and the immune system in type 2 diabetes. Genes Immun. 2011 Jun;12(4):239-50. doi: 10.1038/gene.2011.14. Epub 2011 Mar 10. Review. PubMed PMID: 21390053.

Publications submitted:

Manuscripts reporting the results of ARC-supported projects that are in late stages of preparation or under review and demonstrate collaborations among ARC members related to the obesity-related metabolic disease.

1. Wu Y, Lee, MJ, Fried SK. Expression of MMP3 in adipocyte progenitor cells: potential role in sex differences and depot differences in adipose tissue remodeling. (in revision)

• • This manuscript reports the results of a study initiated in year 1-2 of our ARC.  Tissues from the project were also used for the Adrx paper and grants to obtain preliminary data for additional grant submissions (Fried, Pilch, Kandror, Puri).

2. Kalypso Karastergiou, Miriam A. Bredella, Steven R. Smith, Susan K. Fried, Karen K. Miller,  Wu Y, Mi-Jeong Lee. Growth Hormone Receptor in Human Subcutaneous Adipose Tissue: Gluteal Versus Abdominal Depots (submitted for publication)

• • This manuscript leveraged microarray data collected from Drs. Karastergiou, Lee, Smith and Fried to uncover depot differences in the expression of GHR and its targets in abdominal compared to gluteal human adipose tissues of men and women.  These data were used for a NIH grant proposal submission by Drs. Miller, Karastergiou and Fried   (it was scored but not funded and we plan to re-submit as a multi-PI project.  Dr.  Miller has data indicating differential effects of GH on fat distribution and metabolic parameters in men and women, and we will pursue further studies.)

3. Karastergiou K., Pramyothin P., Apovian C.M., Lee M.J., Fried S.K., Abolition of the glucocorticoid circadian rhythm disrupts lipid storage in adipocytes in vitro and circadian changes in human adipose gene expression in vivo. (submitted)

4. Pickering R.T., Lee M.J., Karastergiou K., Gower A., Fried S.K.,   Depot- and dose- dependent responses to dexamethasone in omental and abdominal subcutaneous human adipose tissues

5. Divoux A., Xie H., Li J.L., Karastergiou K., Perera R.J., Fried S.K., Smith S.R., Depot specific MicroRNA Expression in Human Subcutaneous Adipose Tissue. (submitted)

Publications under review

1.     Depot specific MicroRNA Expression in Human Subcutaneous Adipose Tissue” Adeline Divoux,^1,2 Hui  Xie,^1,2 Jian-Liang Li,² Kalypso Karastergiou,³ Ranjan J. Perera,² Susan K. Fried,³ Steven R. Smith^1,  (under review)

2. Xu, X. J., M. S. Gauthier, Ruderman N.B. Insulin sensitive and resistant obesity in

humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue.J Lipid Res 53: 792-80, 2012. PMCID: 3307656

3. Xu, X.J., Pories W, Dohm C.L., Ruderman N.B. What distinguishes adipose tissue of

massively obese individuals who are insulin sensitive and resistant. Current Opinions in Lipidology (Invited review). 24(1):49-56, 2013. PMCID: 3575680

4. Ruderman N.B., Carling D., Prentki, M., Cacicedo, J.M. AMPK, Insulin Resistance and

the Metabolic Syndrome. Journal of Clinical Investigation.123(7):2764–2772, 2013. PMCID: 3696539

5. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. Nutrient Excess in AMPK

Downregulation and Insulin Resistance. 2013 J Endocrinol Diabetes Obes 1(1): 1008.

6. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK Activation: A therapeutic

target for Type 2 Diabetes, the Metabolic Syndrome and Obesity. 2014. In Press. PMCID: 4075959

7. Valentine RJ, Coughlan KA, Ruderman NB, Saha AK. Insulin inhibits AMPK activity and

phosphorylates AMPK Ser485/495 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Archives of Biochemistry and Biophysics 2014 Nov 15; 562:62-9.

8. Xu XJ, Valentine RJ, Ruderman NB. (2014) AMP-activated Protein Kinase (AMPK):

Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Curr Obes Rep. 1;3(2):248-255. PMCID: PMC4039173.

9. Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. (2015) Improved Insulin

Sensitivity 3 Months After RYGB Surgery Is Associated With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased Oxidative Stress. Diabetes. 64(9):3155-9. PMCID: PMC4542447.

Chakrabarti, P., Kim, J-Y, Singh, M., Shin, Y-K., Kim, J., Kumbrink, J., Wu, Y., Lee, M-J., Kirsch, K.H., Fried, S.K., and Kandror, K.V.  Insulin inhibits lipolysis in adipocytes via the evolutionary conserved mTORC1-Egr1-ATGL-mediated pathway, Mol. Cell. Biol., 2013, v.33, #18, 3659-3666.

Fat-specific Protein 27 Inhibits Lipolysis by Facilitating the Inhibitory Effect of Transcription Factor Egr1 on Transcription of Adipose Triglyceride Lipase

Maneet Singh, Rajween Kaur, Mi-Jeong Lee, R. Taylor Pickering, Vishva Mitra Sharma, Vishwajeet Puri, Konstantin V. Kandror

J Biol Chem. 2014 May 23; 289(21): 14481–14487. Published online 2014 Apr 17. doi: 10.1074/jbc.C114.563080

PMCID: PMC4031504

Apovian CM, Huskey KW, Chiodi S, Hess DT, Schneider BE, Blackburn GL, Jones DC, Wee, CC. Patient Factors Associated with Undergoing Laparoscopic Adjustable Gastric Banding vs Roux-en-Y Gastric Bypass for Weight Loss, J Am Coll Surg, pii: S1072-7515(13)01018-1 2013.

Apovian CM, Gokce, N. Obesity and Cardiovascular Disease, Circulation, 6;125(9):1178-82 2012.

Fat-specific Protein 27 (FSP27) Interacts with Adipose Triglyceride Lipase (ATGL) to Regulate Lipolysis and Insulin Sensitivity in Human Adipocytes

Tan Hooi Min Grahn, Rajween Kaur, Jun Yin, Martina Schweiger, Vishva Mitra Sharma, Mi-Jeong Lee, Yasuo Ido, Cynthia M. Smas, Rudolf Zechner, Achim Lass, Vishwajeet Puri

J Biol Chem. 2014 Apr 25; 289(17): 12029–12039. Published online 2014 Mar 13. doi: 10.1074/jbc.M113.539890

PMCID: PMC4002109

Abstracts (2011-2013) (from 2013, I don’t have 2014, none listed 2015)

Xu XJ, Gedik R, Hess DT, Pories WJ, Dohm, L, Apovian, C, Gokce N, Ruderman N. Factor that distinguish adipose tissue of insulin sensitive and insulin resistant obese humans and mice. Obesity Abstract T G79, 2013.

Krasner, N.M. Cacicedo, J.M. Ido, Y, Ruderman N.B.. Glucagon-Like-Peptide-1 (GLP-1) Activates AMPK and Diminishes Inflammation in Human Aortic Endothelial Cells Diabetes 62 (Suppl1) A445, 2013

Valentine,R.J.., Dise, L.E. Ix, J.H. Ruderman, N.B. Metformin Prevents High-Glucose Induced Fetuin A Release from HepG2 Cells. Diabetes 61 (Suppl1) A461,2012.

Raghnild D. Whitaker, Carl Beigie, Julius L. Decano, George Kwong, Yoonjee Park, Nicholas Giordano, Donald Gantz, Nelson Ruiz-Opazo, Joyce Y. Wong, Victoria L.M. Herrera. Janus nanoparticles for targeted tumor-molecular imaging and miRNA-delivery. Nature Materials 2013 (in review).

2) Presentations

1. “Design of Drug-loaded Devices for the Prevention of Lung Tumor Recurrence: From Hydrophobic Films to Superhydrophobic Meshes.” Mark W. Grinstaff. 245th American Chemical Society National Meeting, Symposium: Bottom-Up Design of the Next Generation of Biomaterials, New Orleans, LA, USA 2013 (invited lecture).

2. “Paclitaxel-Loaded Expansile Nanoparticles for the Treatment of Breast Cancer and Intraperitoneal Mesothelioma — dose, duration, and location.” NCI Alliance for Nanotechnology in Cancer, Bethesda, MD, USA 2013 (invited lecture). Date of Meeting: 6/05/13

3. “Paclitaxel-Loaded Expansile Nanoparticles for the Treatment of Cancer.” Mark W. Grinstaff

SupraBio IV, Cassis, France 2013 (invited lecture). Date of Meeting: 6/13/13

4. “Paclitaxel-Loaded Expansile Nanoparticles for the Treatment of Breast Cancer and Intraperitoneal Mesothelioma — dose, duration, and location.” Cancer Nanotechnology Gordon Conference, Dover, VT, USA 2013 (invited lecture).

Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS. Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J  in press.

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013; 5(192):192ra85

Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH, Ardehali H. ATP-Binding Cassette B10 Regulates Early Steps of Heme Synthesis. Circ Res. 2013 113(3):279-87.

Liesa M, Shirihai O. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metabolism.2013; 17: 491-506.

Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug 20;2(4):e000184. doi: 10.1161/JAHA.113.000184.

Ferree AW, Trudeau K, Zik E, Benador IY, Twig G, Gottlieb RA, Shirihai OS. MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy. 2013 Nov 1;9(11):1887-96. doi: 10.4161/auto.26503. Epub 2013 Sep 27.

Nickens KP, Wikstrom JD, Shirihai OS, Patierno SR, Ceryak S. A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion. 2013 Nov;13(6):662-7. doi: 10.1016/j.mito.2013.09.005. Epub 2013 Sep 27.

Patel PK, Shirihai O, Huang KC. Optimal dynamics for quality control in spatially distributed mitochondrial networks. PLoS Comput Biol. 2013 Jul;9(7):e1003108. doi: 10.1371/journal.pcbi.1003108. Epub 2013 Jul 11

Picard M, Shirihai OS, Gentil BJ, Burelle Y. Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R393-406. doi: 10.1152/ajpregu.00584.2012. Epub 2013 Jan 30. Review.

Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF Jr. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res. 2013 Sep 13;113(7):891-901. doi: 10.1161/CIRCRESAHA.113.301319. Epub 2013 Jul 2.

Kluge MA, Fetterman JL, Vita JA.Mitochondria and endothelial function. Circ Res. 2013 Apr 12;112(8):1171-88. doi: 10.1161/CIRCRESAHA.111.300233. Review.

Roy S, Trudeau K, Roy S, Tien T, Barrette KF. Mitochondrial dysfunction and endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights into high glucose-induced retinal cell death. Curr Clin Pharmacol. 2013 Nov;8(4):278-84.

Stanley IA, Ribeiro SM, Giménez-Cassina A, Norberg E, Danial NN.Changing appetites: the adaptive advantages of fuel choice. Trends Cell Biol. 2013 Sep 6. doi:pii: S0962-8924(13)00131-1. 10.1016/j.tcb.2013.07.010. [Epub ahead of print]

Danial NN, Hartman AL, Stafstrom CE, Thio LL.How does the ketogenic diet work? Four potential mechanisms. J Child Neurol. 2013 Aug;28(8):1027-33. doi: 10.1177/0883073813487598. Epub 2013 May 13.

Corkey BE and Shirihai OS. Metabolic master regulators: sharing information among multiple systems. Trends Endocrinol Metab. 2012.

Wikstrom JD, Stiles L, Sereda S, Liesa MR, Ferrick D and Shirihai OS. (2012). A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One, 2012,7, e33023.

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, and Depinho RA (2012) Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer. Cell, 2012, 148, 651-663. PMID3286017

Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, and Bonegio RG (2012) Role of mitofusin 2 in the renal stress response. PLoS One, 2012, 7, e31074. PMID 3266928

Hyde B.    Liesa M    Elorza A  Qiu  W., Haigh SE, Richey L, Mikkola HK,   Schlaeger T, and  Shirihai OS. (2012) The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death and Differentiation, 201219, 1117-1126.

Villasana, L., Rosenthal, R., Doctrow, S., Pfankuch, T., Zuoloaga, D.G., Garfinkel, A.M., Raber, J.  Effects of alpha-lipoic acid on  associative and spatial memory of sham-irradiated and ⁵⁶Fe-irradiated C57BL/6J male mice.  2012. Pharmacology, Biochemistry and Behavior, in press.

Doctrow, S.R., Lopez, A.M., Schock, A., Duncan, N., Jourdan, M.M., Olasz, E.B., Moulder, J.E., Fish, B.L.,Lazar, J. and Lazarova, Z. A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin.  2012.  Journal of Investigative Dermatology, in press.

Doctrow, S.R., Liesa, M., Melov, S., Shirihai, O.S., and Tofilon, P.J.  Salen Mn complexes are superoxide dismutase and catalase mimetics that protect the mitochondria. 2012.  Current Inorganic Chemistry 2:325-34

Joyce-Brady, M., Cruikshank, W., and Doctrow, S.R.Antioxidant strategies in the treatment of bronchial asthma.inBronchial Asthma (E. Sapey, ed) InTech (Rijeka, Croatia), 2012, pp. 217-230

Mahmood, J., Jelveh, S., Zaidi, A., Doctrow, S.R. and Hill, R.P. Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats. 2012. Radiation Research, in press.

Gao, F., Fish, B.L., Szabo, A., Doctrow, S.R., Kma, L., Molthen, R.C., Moulder, J.E., Jacobs, E.R., and Medhora, M.  Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation.  2012.  Radiation Research (on-line ahead of print 28-Sep-12)  (Cover story)

Rosenthal, R.A., Fish, B., Hill, R.P., Huffman, K.D., Lazarova, Z., Mahmood, J., Medhora, M., Molthen, R., Moulder, J.E., Sonis, S.T., Tofilon, P.J., and Doctrow, S.R. Salen Mn complexes mitigate radiation injury in normal tissues.  2011, in SOD Enzymes and Their Mimics in Cancer:  Pro- and Anti-Oxidant Mode of Action. Anti-Cancer Agents in Medicinal Chemistry, 11:359-72

Mahmood, J., Jelveh, S., Calveley, V., Zaidi, A., Doctrow, S.R., and Hill, R.P. Mitigation of lung injury after accidental exposure to radiation.2011. Radiation Research 176:770-80

Liesa, M., Luptak, I., Qin, F., Hyde, B.B., Sahin, E., Siwik, D., Zhu, Z., Pimentel, D.R., Xu, X.J., Ruderman, N.B., Huffman, K.D., Doctrow, S.R., Richey, L., Colucci, W.S., and Shirihai, O.S.  Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.  2011.  Circulation124:806-13

Mahmood, J., Jelveh, S., Calveley, V., Zaidi, A., Doctrow, S., and Hill, R.  Mitigation of radiation induced lung injury by genestein and EUK-207.  2011. International Journal of Radiation Biology87:889-901

Role of Mitofusin 2 in the Renal Stress Response.Gall, JM, Wang, Z, Liesa, M, Molina, A, Havasi, A, Shirihai, O, Schwartz, JH, SC Borkan and Bonegio, RG.PLoS One  7, e31074; 2012.

Martinez-Pastor, B. and Mostoslavsky, R. (2012).Sirtuins, metabolism and cancer. Front Pharmacol. 3, Epub ahead of print.

Sebastian, C., Zwaans, B.M., Silberman, D.M., Gymrek, M.A., Goren, A., Zhong, L., Ran, O., Truelove, J., Guimaraes, A.R., Toiber, D., Cosentino, C., Greenson, J.K., MacDonald, A.I., McGlynn, L., Maxwell, F., Edwards, J., Giacosa, S., Guccione, E., Weisledder, R., Bernstein, B.E., Regev, A., Shiels, P.G., Lombard, D.B. and Mostoslavsky, R. The Histone Deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell,

Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Yasmin, Rietzschel ER, Tanaka T, Liu Y, Parsa A, Najjar SS, O’Shaughnessy KM, Sigurdsson S, De Buyzere ML, Larson MG, Sie MP, Andrews JS, Post WS, Mattace-Raso FU, McEniery CM, Eiriksdottir G, Segers P, Vasan RS, van Rijn MJ, Howard TD, McArdle PF, Dehghan A, Jewell E, Newhouse SJ, Bekaert S, Hamburg NM, Newman AB, Hofmann A, Scuteri A, De Bacquer D, Ikram MA, Psaty B, Fuchsberger C, Olden M, Wain LV, Elliott P, Smith NL, Felix JF, Erdmann J, Vita JA, Sutton-Tyrrell K, Sijbrands EJ, Sanna S, Launer LJ, De Meyer T, Johnson AD, Schut AF, Herrington DM, Rivadeneira F, Uda M, Wilkinson IB, Aspelund T, Gillebert TC, Van Bortel L, Benjamin EJ, Oostra BA, Ding J, Gibson Q, Uitterlinden AG, Abecasis GR, Cockcroft JR, Gudnason V, De Backer GG, Ferrucci L, Harris TB, Shuldiner AR, van Duijn CM, Levy D, Lakatta EG, Witteman JC. Common Genetic Variation in the 3-BCL11B Gene Desert Is Associated with Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk: The AortaGen Consortium. Circ Cardiovasc Genet 2012; 5:81-90.

Cheng S, Wang N, Larson MG, Palmisano JN, Mitchell GF, Benjamin EJ, Vasan RS, Levy D, McCabe EL, Vita JA, Wang TJ, Shaw SY, Cohen KS, Hamburg NM. Circulating angiogenic cell populations, vascular function, and arterial stiffness. Atherosclerosis 2012; 220:145-150.

Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF, Jr, Vita JA, Hamburg NM. Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease. Vasc Med 2012; 17:101-107.

Zachariah JP, Xanthakis V, Larson MG, Vita JA, Sullivan LM, Smith HM, Safa R, Peng X, Hamburg N, Levy D, Sawyer DB, Mitchell GF, Vasan RS. Circulating vascular growth factors and central hemodynamic load in the community. Hypertension 2012; 59:773-779.

Thanassoulis G, Lyass A, Benjamin EJ, Larson MG, Vita JA, Levy D, Hamburg NM, Widlansky ME, O’Donnell CJ, Mitchell GF, Vasan RS. Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study. Circulation 2012; 125:2836-2843.

Kizhakekuttu TJ, Wang J, Dharmashankar K, Ying R, Gutterman DD, Vita JA, Widlansky ME. Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Induced Endothelial Dysfunction in Humans. Arterioscl Thromb Vasc Biol 2012; 32:2531-2539.

Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS, Mitchell GF. Aortic stiffness, blood pressure progression, and incident hypertension. JAMA 2012; 308:875-881.

Tabit CE, Holbrook M, Fetterman JL, Shenouda SM, Kiani S, Frame AA, KlugeMA, Held A, Dohadwala M, Gokce N, Farb M, Rosenzweig J, Ruderman N, Vita JA, Hamburg NM. Protein kinase-C beta contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation (in press).

Britton KA, Wang Na, Palmisano J, Corsini E, Schlett CL, Hoffmann U, Larson MG, Vasan RS, Vita JA, Mitchell GF, Benjamin EJ, Hamburg NM, Fox CS. Systemic and Local Perivascular Adipose Tissue Depots and Their Cross-sectional Association with Measures of Vascular Function. Obesity (in press).

Havasi A, Haegele JA., GallJM, BlackmonS, IchimuraT, BonegioRG, Panchenko MV.Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. American Journal of Pathology, accepted for publication

Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response.PLoS One. 2012;7(1):e31074.

Ferree, A., Guillily, M., Li, H., Smith, K., Takashima, A., Squillace, R., Weigele, M., Collins, J.J., Wolozin, B., Regulation of the Physiologic Actions of LRRK2:  Focus on Autophagy.  Neurodegen.Dis., 10:238-41 (2012). PMID: 22204929

Guillily, M., Li, H., Dusonchet, J., Chan, D., Gowda, V., Mamais, A., Pyenson, N., Liu, M., Citro, A., Clare, K., Ferree, A., Lee-Armandt, J.P., Saha, S., Yue, Z., Bandopadhyay, R., Glicksman, M., Collins, J. J., Wolozin, B., A Parkinson’s Disease Gene Regulatory Network Highlights Interactions Between LRRK2 and HDAC6.  (Submitted)

Vanderweyde, T., Yu, H., Varnum, M., Liu-Yesucevitz, L., Citro, A., Ikezu, T., Duff, K., Wolozin, B., Contrasting Pathology of Stress Granule Proteins TIA-1 and G3BP in Tauopathies. J. Neurosci.  32:8270-83  (2012).   PMID: 22699908.

Liu Z., Zhu H., Fang, G.G., Walsh, K., Mwamburi, M., Wolozin, B., Abdul-Hay, S.O., Ikezu, T., Leissring, M.A., Qiu, W.Q., Characterization of Insulin Degrading Enzyme and Other Amyloid-β Degrading Proteases in Human Serum: A Role in Alzheimer’s Disease? J Alzheimers Dis. 2012 Jan 9. [Epub ahead of print], PMID: 22232014

Di Domenico, FD, Sultana, R, Ferree, A, Smith, K., Barone, E., Perluigi, M., Coccia, R., Pierce, W., Cai, J., Mancuso, C., Squillace, R., Wiengele, M., Wolozin, B. and Butterfield, D.A., Redox Proteomics Analyses of the Influence of Coexpression of Wild Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease. Antioxidants & Redox Signaling, 2012 Feb.8. [Epub ahead of print], PMID: 22315971

Wolozin, B.,Statins and therapy of Alzheimer’s disease: questions of efficacy versus trial design, Alzheimer’s Research &Therapy4:3 (2012). PMID: 22264400

Kim G., Meriin A.B., Gabai V.L., Christians E., Benjamin I., Wilson A., Wolozin B., Sherman M.Y., The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell doi: 10.1111/j.1474-9726.2012.00827 (2012). PMID: 22510478.

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC.  Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.  Sci Transl Med. 2012 May 16;4(134):134ra60.  PMID: 22593173

Youmans, K. and Wolozin, B., TDP-43:  A new player in the AD field?  Exp. Neurol. (ePub, 2012).  PMID: 22691390

Vanderweyde, T., Yu, H., Varnum, M., Liu-Yesucevitz, L., Citro, A., Ikezu, T., Duff, K., Wolozin, B., Contrasting Pathology of Stress Granule Proteins TIA-1 and G3BP in Tauopathies. J. Neurosci. 32:8270-83 2012).PMID: 22699908

Wolozin, B., Regulated protein aggregation: Stress granules and neurodegeneration.  Mol. Neurodegen. (in press)

Ravid, K., Wolozin, B., The scientist’s pledge. Academic Medicine (Submitted)

Milka Koupenova, Hillary Johnston-Cox, Alexander Vezeridis, Haralambos Gavras, Dan Yang, Vassilis Zannis and Katya Ravid (2011) The  A_2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation

Caro, P., Kishan, A.U., Norberg, E., Chapuy, B., Stanley, I., Tondera, D., Gounarides, J., Zhang, B., Green, M.R., Chen, L., Monti, S., Shipp, M.A., and Danial, N.N. Metabolic signatures uncover novel targets in diffuse karge B cell lymphoma. Under revision for Cancer Cell

Sahin E, Colla S, Liesa M, Moslehi J, Muller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, and Depinho RA (2011) Telomere dysfunction induces metabolic and mitochondrial compromise. Nature,470, 359-365.

Robson-Doucette AC,  Sultan S, Allister E, Wikstrom JD,  Koshkin V, Bhatacharjee A, Prentice KJ, Sareda SB, Shirhai OS, Wheeler MB. (2011) Uncoupling protein 2 regulates reactive oxygen species production in the beta cell, which influences insulin secretion, alpha cell function and glucose homeostasis. Diabetes, in Press.

Hyde B.    Liesa M    Elorza A  Qiu  W., Haigh SE, Richey L, Mikkola HK,   Schlaeger T, and  Shirihai OS. (2011) The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death and Differentiation, Accepted.

Ivan Luptak, et al Nitric oxide synthase-1 mediates hydroxynonenal-induced inhibition of SERCA and diastolic dysfunction in the heart., submitted

Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S and Schon EA. (2011)  Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet. In Press

Las G, Sereda S, Wikstrom JD, Twig G, and Shirihai OS (2011) Fatty acids suppress autophagic turnover in -cells. J Biol Chem.In Press.

Trudeau K, Molina A, Roy S.  High Glucose Induces Mitochondrial Morphology and Metabolic Changes in Retinal Pericytes. Invest Ophthalmol Vis Sci. 7;52(12):8657-64, 2011.

Liesa, M., Luptak, I., Qin, F., Hyde, B.B., Sahin, E., Siwik, D., Zhu, Z., Pimentel, D.R., Xu, X.J., Ruderman, N.B., Huffman, K.D., Doctrow, S.R., Richey, L., Colucci, W.S., and Shirihai, O.S.  Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.  2011.  Circulation 124:806-13. PMID:21788586

Doctrow, S.R., Liesa, M., Melov, S., Shirihai, O.S. and Tofilon, P.J. Salen Mn complexes are superoxide dismutase/catalase mimetics that protect the mitochondria.  Current Inorganic Chem., 2011

Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess M-A, Levit A, Kim B, Hartman M-L, Joseph L, Shirihai OS, Vita JA. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 2011; 124:444-453.

Liu-Yesucevitz, L., Bassell, G.J., Gitler, A.D., Hart, A.C., Klann, E., Richter, J.D., Warren, S.T. and Wolozin, B., Local RNA Translation at the Synapse and in Disease.  J. Neurosci. 31:16086-93 (2011).PMID 22072660.

Ferree, A., Guillily, M., Li, H., Smith, K., Takashima, A., Squillace, R., Weigele, M., Collins, J.J., Wolozin, B., Regulation of the Physiologic Actions of LRRK2:  Focus on Autophagy.  Neurodegen.Dis., (in press, 2011).

Guillily, M., Li, H., Latourelle, J. C., Pyenson, N., Richter, L., Raghavan, G., Saha, S, Dusonchet, J., Lee-Armandt, J.P., Glicksman, M., Yue, Z., Myers, R.H. Collins, J. J., Wolozin, B., A Reverse Engineered Parkinson’s Disease Gene Regulatory Network Identifies RGS2 as a Direct Modulator of LRRK2 Activity.  (Submitted)

Vanderweyde, T., Yu, H., Varnum, M., Liu-Yesucevitz, L., Citro, A., Ikezu, T., Duff, K., Wolozin, B., Merging of Stress Granules with Tau Pathology During Disease Evolution. (Submitted)

Joyce-Brady, M., Cruikshank, W., and Doctrow, S.R.Antioxidant strategies in the treatment of bronchial asthma.”Bronchial Asthma” (in press, InTech publishing). (role of mitochondrial injury in bronchial asthma, and potential value of “mitoprotective” approaches are addressed)

Rosenthal, R.A., Fish, B., Hill, R.P., Huffman, K.D., Lazarova, Z., Mahmood, J., Medhora, M., Molthen, R., Moulder, J.E., Sonis, S.T., Tofilon, P.J., and Doctrow, S.R.  Salen Mn complexes mitigate radiation injury in normal tissues.  2011. Anti-Cancer Agents in Medicinal Chemistry, 11:359-72, PMID:21453241

Jonathan M. Gall, Zhiyong Wang, Marc Liesa, Anthony Molina., Andrea Havasi, John H. Schwartz, Orian Shirihai, Steven C. Borkan and Ramon G.B. Role of Mitofusin 2 in the Renal Stress Response by authors Bonegio, M.D. PhD;  Resubmitted to PLosOne 11/2011

Trudeau,K., Molina,A.J., Guo,W., and Roy,S. (2010). High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am. J. Pathol. 177, 447-455.

Jonathan M. Gall, Vincent Wong, David Pimental, Andrea Havasi, Zhiyong Wang, Ramon Bonegio, John G. Pastorino, John H. Schwartz and Steven C. Borkan. Hexokinase Regulates Susceptibility to Bax-Mediated Mitochondrial Membrane Injury after Ischemic Stress. Kidney International 2010.

Twig, G., Liu, X., Liesa, M., Wikstrom, J. D., Molina, A. J., Las, G., Yaniv, G., Hajnoczky, G. &Shirihai, O. S.  (2010). Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am.J.Physiol Cell Physiol, 299, C477-C487.

Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA. Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with Type 2 diabetes. Transl Res 2010; 156:15–25.

Hsu CH, Chan D, Wolozin B. LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. Neurodegener Dis. 2010;7(1-3):68-75. Epub 2010 Feb 18.

Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR.The Parkinson’s disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.PLoS One. 2010 Jan 15;5(1):e8730.

Carballo-Carbajal I, Weber-Endress S, Rovelli G, Chan D, Wolozin B, Klein CL, Patenge N, Gasser T, Kahle PJ.  Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.Cell Signal. 2010 May;22(5):821-7. Epub 2010 Jan 13.PMID:

Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B.J Neurochem.  MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2.2010 Mar;112(6):1593-604. Epub 2010 Jan 7.

Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderwyde T, Citro A, Mehta T, Zaarur N, mckee A, Bowser R, Sherman M, Petrucelli L, Wolozin B.  Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.Plos One. 2010 Oct 11;5(10):e13250.PMID: 20948999

Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA. Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with Type 2 diabetes. Transl Res 2010; 156:15–25.

Presentations/Posters:

Sherene M. Shenouda, Guoquan Xu, Monika Holbrook, Alissa Frame, Aaron Levit, Mai-Ann Duess, Corey Tabit, Naomi Hamburg, Joseph A. Vita. The Role of Mitochondrial Dynamics in Diabetes Mellitus.Keystone Conference on Diabetes 2011.

Frame A, Kluge M, Shenouda SM, Hartman ML, Holbrook M, Duess M, Levit A, Kim BH, Caiano TL, Fraser L, Tabit CE, Tampakakis E, Hamburg NM, Vita JA. Effects of resveratrol on endothelial function in patients with Type 2 diabetes mellitus.Vascular Medicine 2011; 16:229 (abstract).

Pilch P. Adiporedoxin, master regulator of adipokine secretion? Keystone Symposia, 2012

Roy S. Downregulation of mitochondrial transport protein ABC-me promotes retinal vascular lesions. Presented at the American Diabetes Association 71st Annual Meeting, San Diego, CA June 24-28, 2011.

Roy S. Diabetes or high glucose-induced apoptosis involves mitochondrial fragmentation in retinal pericytes. Presented at the 47th Annual Meeting of the European Association for the Study of Diabetes, Lisbon, Portugal, Sep 12-16, 2011.

Roy S. High glucose affects mitochondrial metabolic capacity and extracellular acidification in retinal pericytes. Presented at the Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, FL, 2011.

A Elezaby, TD Calamaras, I Luptak, M Liesa, OS Shirihai, EJ Miller, DA Siwik, WS Colucci.Mitochondrial Adaptations in Failing Mouse Heart,  BMC Evan’s Day, 2011

Miller E. Alterations in AMPK Activity Correlate with the Onset of Diastolic Dysfunction in Hearts of Diabetic db/db Mice,  BMC Evan’s Day, 2011

Tabit CE, Shenouda SM, Holbrook M, Frame AA, Kluge MA, Duess M-A, Kim B, Levit A, Vita JA, Hamburg NM. Insulin-mediated eNOS activation is impaired in freshly isolated endothelial cells from patients with Type 2 diabetes mellitus. Vasc Med. 2011; 16:234.

Tampakakis E, Frame A, Dohadwala M, Shenouda SM, Hartman M-L, Tabit C, Holbrook M, Hamburg N, Vita JA. Study of Endoplasmatic Reticulum Stress in Peripheral Mononuclear Cells Isolated from Healthy Adults After Intravenous Lipid Infusion. AHA Council on Arteriosclerosis, Thrombosis, and Vascular Biology 2011 Scientific Sessions April 2011.

Gall J, Havasi A, Shirihai O, Borkan S. Role of Mitofusin 2 in the Renal Stress Response, American Society of Nephrology Annual Meeting, Philadelphia, PA; November 2011.

Gall J, Havasi A, Shirihai O, Borkan S. Mitofusin 2 Promotes Renal Epithelial Cell Survival After Metabolic Stress, Society of General Physiologists (SGP) Annual Meeting Woods Hole, MA; September 2011.

Nika D. Metabolic fingerprints in molecular subtypes of diffuse large B cell lymphoma. NCI Translational Science Meeting, Washington D.C.; 2011

Nika D. Metabolic fingerprints in molecular subtypes of diffuse large B cell lymphoma. Mitochondrial Dynamics: From Mechanism to Disease, Sardinia, Italy; 2011.

Nika D Metabolic fingerprints in molecular subtypes of diffuse large B cell lymphoma. The 19th Euroconference on Apoptosis entitled “Metabolism, Epigenetics and Cell Death”, Stockholm, Sweden; 2011.

Sherene M. Shenouda, Guoquan Xu, Monika Holbrook, Alissa Frame, Aaron Levit, Mai-Ann Duess, Corey Tabit, Naomi Hamburg, Joseph A. Vita. The Role of Mitochondrial Dynamics in Diabetes Mellitus.Keystone Conference on Diabetes 2011.

Ivan Luptak, Marc Liesa, Deborah A. Siwik, Amit Nanavati, Themy Dumlao, Markus Bachschmid, David Pimentel, Richard A. Cohen, Wilson S. Colucci. Nitric oxide synthase-1 mediates hydroxynonenal-induced inhibition of SERCA and diastolic dysfunction in the heart. AHA Meeting, Nov 2010

Andrea Havasi. Albumin Overload Impairs Autophagy in Proximal Tubular Cell. 2010. 11. American Society of Nephrology-Renal Week

N. E. Burritt, T. C. Ferrante, B. E. Corkey J. T. Deeney. Chronic exposure of pancreatic ß-cells to acetoacetate inhibits glucose-induced insulin secretion.  Evans Research Day 2010, BUSM.

Jonathan Gall, Steven Borkan. Hsp70 Inhibits Mitochondrial Fragmentation in ATP Depleted Renal Epithelial Cells. 2010. ASN.

Nika D Energy metabolism in genetically defined subtypes of diffuse large B cell lymphoma.  Nobel Symposium No 144: Cell Cycle and Apoptosis in Disease, Karolinska Institute, Stockholm, Sweden; 2010.

Nika D Energy metabolism in genetically defined subtypes of diffuse large B cell lymphoma.Mito-2010 Mitochondria Function and Dysfunction, Kibutz Ein Gedi, Dead Sea, Israel; 2010.

Hillary Johnston-Cox, Milka Koupenova and Katya Ravid (2010) A new role for A2b adenosine receptor in the control of insulin homeostasis by pancreatic ß-cells.

2010 Boston University School of Medicine Evans Day Award recipient for Basic Science (1^rd Place)

K. Trudeau, A. Molina, S. Roy.European Association for the Study of Diabetes, Stockholm, Sweden (2010) “High glucose alters mitochondrial morphology and membrane potential heterogeneity in retinal pericytes.”

A. Molina, L.Stiles, S. Sereda, O. Shirihai. European Association for the Study of Diabetes, Islet Study Group, Tallberg, Sweden (2010) “Beta Cell Mitochondrial Fusion and the Development of Diabetes and Obesity”

K. Trudeau, A. Molina, S. Roy.High Glucose-Induced Downregulation of Mitochondrial Connexin 43 Expression Triggers Mitochondrial Shape Change and Cytochrome C Release in Retinal Endothelial Cells.

Trudeau, A. Molina, S. Roy.Insulin Reverses High Glucose-Induced Changes of Mitochondrial Morphology and Membrane Potential Heterogeneity in Retinal Endothelial Cells. K.

Widlansky, M. E., Vita, J. A., Wang, J., Kizhakekuttu, T. J., Arthur, E. I. L., Gutterman, D. D. Mitochondrial membrane hyperpolarization and reduced mitochondrial mass characterize the arteriolar endothelium and mononuclear cells of humans with type 2 diabetes mellitus- in vivo and in vitro assessment of endothelial function. Circulation 2009.

Widlansky, M. E., Vita, J. A., Wang, J., Kizhakekuttu, T. J., Arthur, E. I. L., Gutterman, D. D. Mitochondrial membrane hyperpolarization and reduced mitochondrial mass characterize the arteriolar endothelium and mononuclear cells of humans with type 2 diabetes mellitus- in vivo and in vitro assessment of endothelial function. Circulation 2009.

Schafer C, Rymarczyk G, Ding L, Kirber MT, Bolotina VM.  Role of molecular determinants of store-operated Ca²⁺ entry (Orai1, phospholipase A2 group 6 and STIM1) in focal adhesion formation and cell migration. J Biol Chem  2012; PMID:23043102  Oct 5. [Epub ahead of print]     http://www.ncbi.nlm.nih.gov/pubmed/23043102?dopt=Citation

Evangelista A.M., Thompson M.D., Bolotina V.M., Tong X., & Cohen R.A. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic. Biol Med (2012) Oct 23. pii: S0891-5849(12)01777-7. doi: 10.1016/             j.freeradbiomed.2012.10.546. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23089226?dopt=Citation

Zhou Q., Rymarczyk G., Schafer C., Yen A., Kirber M.T., Wolozin B, Ikezu T., Bolotina V.M. Impairment of PARK14 interaction with STIM1 alter store-operated Ca²⁺ entry and results in age- dependent Parkinson’s disease-like phenotype in a new mouse model. (submitted to Nature, in revision)

Thompson MD, Mei Y, Weisbrod R, Bolotina VM, Cohen RA, Tong X.  Redox regulation of cysteine-674 of SERCA 2 is critical for growth factor-induced endothelial angiogenic behavior. (Manuscript in preparation)

Zhou Q., Yen A., Ikezu T., Wolozin B, Bolotina V.M.  PARK14 KO^Ex2 mice as a novel model for age-dependent Parkinson’s disease  (Oct 2013) This poster won the competition and was honored with a First place at the Boston University School of Medicine Evans Days Poster Presentation, Manuscript in preparation.

Segawa M,, Oslowski C.M., Severova S., Yang B., Deeney J. and Bolotina V.M. Store-operated Ca²⁺ entry mechanism is involved in glucose-induced Ca²⁺ responses and insulin secretion, and is critical for preventing ER stress in primary pancreatic β-cells. (April 2013): Poster presented at FASEB – Experimental Biology 2013, Abstract published in FASEB J., manuscript in preparation.

Oslowski C.M., Zhou Q., Yen A., Schafer C., Kirber M. and Bolotina V.M.  A new causal relationship between PLA2g6, store-operated Ca2+ entry, refilling of Ca2+ stores and ER stress in mouse embryonic  fibroblasts. (April 2013) FASEB – Experimental Biology 2013, Abstract published in FASEB J., manuscript in preparation.

Thompson M.D., Mei Y., Hou X., Silver M., Bolotina V.M., Cohen R.A., Tong X.  Redox regulation of cysteine- 674 of SERCA 2 is critical for growth factor- and ischemia-induced angiogenesis. (April 2013): Poster presented at FASEB – Experimental Biology 2013, Abstract published in FASEB J., manuscript in preparation

Yen A., Oslowski C.M., Kirber M., Wolozin B., and Bolotina V.M. Causal relationship between store-operated Ca²⁺ entry, ER Ca²⁺ stores and ER stress/UPR in dopaminergic neurons. (Oct 2013) Poster presented at Boston University School of Medicine Evans Days Poster Presentation, manuscript in preparation.

Thompson MD, Mei Y, Hou X, Silver M, Bolotina VM, Cohen RA, Tong X.  Redox regulation of cysteine-674 of SERCA 2 is critical for growth factor- and ischemia-induced angiogenesis. (Oct 2013) Poster presented at Boston University School of Medicine Evans Days Poster Presentation

Morgan R., Pimentel D, Siwik D, Evangelista A, Cohen R., Colucci, W. Sarcoplasmic Reticulum ATPase is Required for ROS-Mediated Cardiac Myocyte Hypertrophy Poster at Evans Department of Medicine Research Days, Boston, MA, November 2011.

Aziz N., Ingraham K., Rymarczyk G., Zhou Q., Goldstein L., Ikezu T., Bolotina V. A novel transgenic model for progressive age dependent Parkinson’s Disease Poster at Evans Department of Medicine Research Days, Boston, MA, November 2011.

Rymarczyk G., Zaitsev A., Xue R., Xia Y., Bolotina V. Ca2+-Independent Phospholipase A2 (PLA2g6): structure and function Poster at Evans Department of Medicine Research Days, Boston, MA, November 2011.

Segawa M., Severova S., Yang B., Deeney J., Bolotina V. Inhibitors of PLA2g6, store-operated and voltage-gated Ca2+ channels attenuate Ca2+ oscillations and insulin secretion in primary β-cells Poster at Evans Department of Medicine Research Days, Boston, MA, November 2011.

1: Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Plancoulaine S, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature. 2012 Oct 28. doi: 10.1038/nature11583. [Epub ahead of print] PubMed PMID: 23103873.

2: Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, Gouzman M, Teng G, Schatz D, Rais Y, Hanna JH, Mildner A, Jung S, Mostoslavsky G, Cedar H, Bergman Y. Clonal allelic predetermination of immunoglobulin-κ rearrangement. Nature. 2012 Oct 25;490(7421):561-5. doi: 10.1038/nature11496. Epub 2012 Sep 30. PubMed PMID: 23023124.

3: Sommer CA, Mostoslavsky G. The evolving field of induced pluripotency: Recent progress and future challenges. J Cell Physiol. 2013 Feb;228(2):267-75. doi: 10.1002/jcp.24155. PubMed PMID: 22767332

4: Stroncek DF, Berger C, Cheever MA, Childs RW, Dudley ME, Flynn P, Gattinoni L, Heath JR, Kalos M, Marincola FM, Miller JS, Mostoslavsky G, Powell DJ Jr, Rao M, Restifo NP, Rosenberg SA, O’Shea J, Melief CJ. New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer. J Transl Med. 2012 Mar 15;10:48. PubMed PMID: 22420641; PMCID: PMC3362772.

5: Mostoslavsky G. Concise review: The magic act of generating induced pluripotent stem cells: many rabbits in the hat. Stem Cells. 2012 Jan;30(1):28-32. doi: 10.1002/stem.742. Review. PubMed PMID: 21948613.

6: Wang K, Terrenoire C, Sampson KJ, Iyer V, Osteen JD, Lu J, Keller G, Kotton DN, Kass RS. Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. J Physiol. 2011 Dec 15;589(Pt 24):6093-104. Epub 2011 Oct 24. PubMed PMID: 22025662;  PMCID: PMC3286688.

7: Bais MV, Shabin ZM, Young M, Einhorn TA, Kotton DN, Gerstnefeld LC. Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration. Biochem Biophys Res Commun. 2012 Jan 6;417(1):211-6. Epub 2011 Nov 28. PubMed PMID: 22142851; PMCID: PMC3264057.

8: Christodoulou C, Kotton DN. Are embryonic stem and induced pluripotent stem cells the same or different? Implications for their potential therapeutic use. Cell Cycle. 2012 Jan 1;11(1):5-6. Epub 2012 Jan 1. PubMed PMID: 22186787; PMCID: PMC3272228.

9: Kotton DN, Muse VV, Nishino M. Case records of the Massachusetts General Hospital. Case 2-2012. A 63-year-old woman with dyspnea and rapidly progressive respiratory failure. N Engl J Med. 2012 Jan 19;366(3):259-69. PubMed PMID:22256809.

10: Ohle SJ, Anandaiah A, Fabian AJ, Fine A, Kotton DN. Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells. Am J Respir Cell Mol Biol. 2012 Jul;47(1):11-9. Epub 2012 Feb 9. PubMed PMID: 22323363; PubMed Central PMCID: PMC3402798.

11: Cheng X, Ying L, Lu L, Galvão AM, Mills JA, Lin HC, Kotton DN, Shen SS, Nostro MC, Choi JK, Weiss MJ, French DL, Gadue P. Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell Stem Cell. 2012 Apr 6;10(4):371-84. PubMed PMID: 22482503.

12: Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6;10(4):398-411. doi: 10.1016/j.stem.2012.01.019. PubMed PMID: 22482505; PubMed Central PMCID: PMC3322392.

13: Kotton DN. Next-generation regeneration: the hope and hype of lung stem cell research. Am J Respir Crit Care Med. 2012 Jun 15;185(12):1255-60. Epub 2012 Apr 19. Review. PubMed PMID: 22517787.

14: Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y. Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation. 2012 Oct 2;126(14):1695-704. doi:10.1161/CIRCULATIONAHA.112.116996. Epub 2012 Aug 22. PubMed PMID: 22914687.

15: Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI. The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation. J Biol Chem. 2012 Oct 26;287(44):37282-95. doi: 10.1074/jbc.M112.408401. Epub 2012 Sep 6. PubMed PMID: 22955271; PMCID: PMC3481326.

16: Sommer AG, Rozelle SS, Sullivan S, Mills JA, Park SM, Smith BW, Iyer AM, French DL, Kotton DN, Gadue P, Murphy GJ, Mostoslavsky G. Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector. J Vis Exp. 2012 Oct 31;(68). doi:pii: 4327. 10.3791/4327. PubMed PMID: 23149977.

17. Programmatic Change: Lung Disease Research in the Era of Induced Pluripotency. Ikonomou L, Hemnes AR, Bilousova G, Hamid R, Loyd JE, Hatzopoulos AK, Kotton DN, Majka SM, Austin ED. Am J Physiol Lung Cell Mol Physiol. 2011 Oct 7. [Epub ahead of print]

18. A shift from cell cultures to creatures: in vivo imaging of small animals in experimental regenerative medicine. Studwell AJ, Kotton DN. Mol Ther. 2011 Nov;19(11):1933-41. doi: 10.1038/mt.2011.194. Epub 2011 Sep 27.

19. The Magic Act of Generating Induced Pluripotent Stem Cells: Many Rabbits in the Hat. Mostoslavsky G. Stem Cells. 2011 Sep 21. doi: 10.1002/stem.742.

20. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Proc Am Thorac Soc. 2011 Jun;8(3):215-22.

21. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. J Clin Invest. 2011 Jun 1;121(6):2313-25. doi: 10.1172/JCI43853. Epub 2011 May 2.

22. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs.Ye JH, Xu YJ, Gao J, Yan SG, Zhao J, Tu Q, Zhang J, Duan XJ, Sommer CA, Mostoslavsky G, Kaplan DL, Wu YN, Zhang CP, Wang L, Chen J. Biomaterials. 2011 Aug;32(22):5065-76. Epub 2011 Apr 13.

23. Telomere dysfunction induces metabolic and mitochondrial compromise.Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Nature. 2011 Feb 17;470(7334):359-65. Epub 2011 Feb 9. Erratum in: Nature. 2011 Jul 14;475(7355):254.

24.Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Cell Stem Cell. 2011 Feb 4;8(2):200-13.

25. FOXO1 modulates osteoblast differentiation.Siqueira MF, Flowers S, Bhattacharya R, Faibish D, Behl Y, Kotton DN, Gerstenfeld L, Moran E, Graves DT. Bone. 2011 May 1;48(5):1043-51. Epub 2011 Jan 28.

26. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. Cell Signal. 2011 Jun;23(6):1030-40. Epub 2011 Jan 22.

27. Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.Gustafsson K, Calounova G, Hjelm F, Kriz V, Heyman B, Grönvik KO, Mostoslavsky G, Welsh M. BMC Immunol. 2011 Jan 11;12:3.

28. An ES-like pluripotent state in FGF-dependent murine iPS cells.Di Stefano B, Buecker C, Ungaro F, Prigione A, Chen HH, Welling M, Eijpe M, Mostoslavsky G, Tesar P, Adjaye J, Geijsen N, Broccoli V. PLoS One. 2010 Dec 30;5(12):e16092.

29. Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.Pessach IM, Ordovas-Montanes J, Zhang SY, Casanova JL, Giliani S, Gennery AR, Al-Herz W, Manos PD, Schlaeger TM, Park IH, Rucci F, Agarwal S, Mostoslavsky G, Daley GQ, Notarangelo LD. J Allergy Clin Immunol. 2011 Jun;127(6):1400-7.e4. Epub 2010 Dec 24.

30. Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus.Novak A, Shtrichman R, Germanguz I, Segev H, Zeevi-Levin N, Fishman B, Mandel YE, Barad L, Domev H, Kotton D, Mostoslavsky G, Binah O, Itskovitz-Eldor J. Cell Reprogram. 2010 Dec;12(6):665-78. Epub 2010 Oct 21.

31. Benefits of utilizing gene-modified iPSCs for clinical applications. Ellis J, Baum C, Benvenisty N, Mostoslavsky G, Okano H, Stanford WL, Porteus M, Sadelain M. Cell Stem Cell. 2010 Oct 8;7(4):429-30.

32. Generation of transgene-free lung disease-specific human iPS   cells using a single excisable lentiviral stem cell cassette.  Somers, A., Jean, JC, Sommer, CA, Ford, CC, Mills, JA, Smith, BW, French, DL., Demierre, MF, Gadue, PA,  Murphy GJ, Mostoslavsky G., Kotton, DN. Stem Cells 2010 Oct;28(10):1728-40.

33. Experimental approaches for the generation of induced pluripotent stem cells. Sommer CA, Mostoslavsky G. Stem Cell Res Ther. 2010 Aug 10;1(3):26.

34. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. Duan X, Tu Q, Zhang J, Ye J, Sommer C, Mostoslavsky G, David K, Yang P, Chen J. J Cell Physiol. 2011 Jan;226(1):150-7. Epub 2010 Jul 23.

35. Regeneration and orthotopic transplantation of a bioartificial lung. Ott HC, Clippinger B, Conrad C, Schuetz C, Pomerantseva I, Ikonomou L, Kotton D, Vacanti JP. Nat Med. 2010 Aug;16(8):927-33. Epub 2010 Jul 13.

36. Reprogramming of human peripheral blood cells to induced pluripotent stem cells.Staerk J, Dawlaty MM, Gao Q, Maetzel D, Hanna J, Sommer CA, Mostoslavsky G, Jaenisch R. Cell Stem Cell. 2010 Jul 2;7(1):20-4. PMID: 20621045

37. miR-129 regulates cell proliferation by downregulating Cdk6 expression. Wu J, Qian J, Li C, Kwok L, Cheng F, Liu P, Perdomo C, Kotton D, Vaziri C, Anderlind C, Spira A, Cardoso WV, Lü J. Cell Cycle. 2010 May;9(9):1809-18. Epub 2010 May 15. PMID: 20404570

38. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G. Stem Cells. 2010 Jan;28(1):64-74. PMID: 19904830

39. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN. J Clin Invest. 2010 Jan 4;120(1):379-89. doi: 10.1172/JCI36666. Epub 2009 Dec 21. PMID: 20038801

40. Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene. Cao Y, Vo T, Millien G, Tagne JB, Kotton D, Mason RJ, Williams MC, Ramirez MI. J Biol Chem. 2010 Jan 15;285(3):2152-64. Epub 2009 Nov10.

41. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.  Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K.  Nat Genet. 2009 Sep;41(9):968-76. Epub 2009 Aug 9.

Year 1 publications (alphabetical by ARC member’s lab; key ARC authors bold and underlined)

1.              Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE, Joseph L, Hess DT,  Apovian CM, Vita JA, Gokce N. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol. 2011 Jul 12;58(3):232-7.

2.     Apovian CM. Management of diabetes across the course of disease: minimizing obesity-associated complications. Diabetes Metab Syndr Obes. 2011;4:353-69.

3.     Boehmer U, Harris J,  Bowen DJ, Schroy PC 3rd. Surveillance after colorectal cancer diagnosis in a safety net hospital. J Health Care Poor Underserved. 2010 Nov; 21(4):1138-51.

4.     Denis GV. Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation. Discov Med. 2010 Dec;10(55):489-99.

5.     Gilmore TD, Garbati MR. Inhibition of NF-κB signaling as a strategy in disease therapy. Curr Top Microbiol Immunol. 2011;349:245-63.

6.     Lê KA, Mahurkar S, Alderete TL, Hasson RE, Adam TC, Kim JS, Beale E, Xie C,  Greenberg AS, Allayee H,  Goran  MI.  Subcutaneous  adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-κB stress pathway. Diabetes. 2011 Nov;60(11):2802-9.

7.     Moore LL. Functional foods and cardiovascular disease risk: building the evidence base. Curr Opin Endocrinol Diabetes Obes. 2011 Oct;18(5):332-5.

8.     Berz JP, Singer MR, Guo X, Daniels SR, Moore LL. Use of a DASH food group score to predict excess weight gain in adolescent girls in the National Growth and Health Study. Arch Pediatr Adolesc Med. 2011 Jun;165(6):540-6.

9.     Nikolajczyk  BS, Jagannathan-Bogdan M, Shin H, Gyurko R. State of the union between metabolism and the immune system in type 2 diabetes. Genes Immun. 2011 Jun;12(4):239-50

10.  Jagannathan-Bogdan  M,  McDonnell  ME,  Shin  H,  Rehman  Q,  Hasturk  H,  Apovian  CM, Nikolajczyk BS. Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol. 2011 Jan 15;186(2):1162-72

11.  Perfield JW 2nd, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN,  Obin MS,  Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 2011 Apr;60(4):1168-76.

12.  Snyder-Cappione,  JE  and  Nikolajczyk,  BS.  When diet and exercise aren’t enough, think immunomodulation. Molecular Aspects of Medicine. 2012 (In press)

Year 2 publications (alphabetical by ARC member’s lab; key ARC authors bold and underlined)

1.              Apovian CM. Obesity medicine: A new specialty in medicine or a focus in endocrinology? Nutrition is the real subspecialty in medicine. Endocr Pract. 2012 Sep 1;18(5):649-50.

2.              Mechanick JI, Apovian CM. Rethinking our approach to the obese patient: time to create the obesity treatment score. Curr Opin Endocrinol Diabetes Obes. 2012 Oct;19(5):339-40. doi: 10.1097/MED.0b013e328357f15a.

3.              McDonnell ME, Ganley-Leal LM, Mehta A, Bigornia SJ, Mott M, Rehman Q, Farb MG, Hess DT, Joseph L, Gokce N, Apovian CM. B lymphocytes in human subcutaneous adipose crown-like structures. Obesity (Silver Spring). 2012 Jul;20(7):1372-8.

4.              Apovian CM, Gokce N. Obesity and cardiovascular disease. Circulation. 2012 Mar 6;125(9):1178-82.

5.              Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr;53(4):792-801.

6.              Igel LI, Powell AG, Apovian CM, Aronne LJ. Advances in medical therapy for weight loss and the weight-centric management of type 2 diabetes mellitus. Curr Atheroscler Rep. 2012 Feb;14(1):60-9.

7.              Farb MG, Ganley-Leal L, Mott M, Liang Y, Ercan B, Widlansky ME, Bigornia SJ, Fiscale AJ, Apovian CM, Carmine B, Hess DT, Vita JA, Gokce N. Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):467-73.

8.              Belkina AC, Denis GV (2012). Bromodomain coregulators in obesity, inflammation and cancer. Nature Reviews Cancer. 2012 Jun 22;12(7):465-77.

9.              Battaglia TA, Murrell SS, Bhosrekar SG, Caron SE, Bowen DJ, Smith E, Kalish R, Rorie JA. Connecting Boston’s public housing developments to community health centers: who’s ready for change? Prog Community Health Partnersh. 2012 Fall;6(3):239-48.

10.           Manne S, Kashy D, Weinberg DS, Boscarino JA, Bowen DJ. Using the interdependence model to understand spousal influence on colorectal cancer screening intentions: a structural equation model. Ann Behav Med. 2012 Jun;43(3):320-9.

11.           Bowen DJ, Hay JL, Mayer J, Kuniyuki A, Meischke H, Harris J, Asgari M, Shoveller J, Press N, Burke W. Predictors of recruited melanoma families into a behavioral intervention project. Contemp Clin Trials. 2012 Jan;33(1):85-92.

12.           Jabson JM, Donatelle RJ, Bowen DJ. Relationship between sexual orientation and quality of life in female breast cancer survivors. J Womens Health (Larchmt). 2011 Dec;20(12):1819-24.

13.           Manne S, Etz RS, Hudson SV, Medina-Forrester A, Boscarino JA, Bowen DJ, Weinberg DS. A qualitative analysis of couples’ communication regarding colorectal cancer screening using the Interdependence Model. Patient Educ Couns. 2012 Apr;87(1):18-22.

14.           Denis GV, Obin MS. ‘Metabolically healthy obesity’: Origins and implications. Mol Aspects Med. 2012 Oct 13. doi:pii: S0098-2997(12)00118-5. 10.1016/j.mam.2012.10.004.

15.           Banerjee C, Archin N, Michaels D, Belkina AC, Denis GV, Bradner J, Sebastiani P, Margolis DM, Montano M. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Aug 8.

16.           Denis GV, Bowen DJ (2013). Uncoupling obesity from cancer: Bromodomain co-regulators that control networks of inflammatory genes. In Energy Balance and Cancer, Vol 7: Obesity, Inflammation and Cancer. A. J. Dannenberg and N. A. Berger, Eds.; Springer, New York. Expected 2013.

17.           Wang F, Deeney JT, Denis GV. (2012). Brd2 gene disruption causes ‘metabolically healthy’ obesity: Epigenetic and chromatin-based mechanisms that uncouple obesity from Type 2 diabetes. Vit Horm. 91. G. Litwack, Ed.; Elsevier Academic Press. In press.

18.           Blanton WP, Belkina AC, Romesser PB, Denis GV. (2012). Aggressive diffuse large B-cell lymphomas of Eμ-Brd2 transgenic mice lack germinal center experience. BMC Cancer. In revision.

19.           Belkina AC, Blanton WP, Denis GV. (2012). The double bromodomain protein Brd2 is essential for hematopoiesis and B cell responsiveness. Blood. In revision

20.           Jornayvaz FR, Wang F, Belkina AC, Shulman GI, Samuel VT, Denis GV. (2012). Improved insulin sensitivity in mice with Brd2 disruption: A potential link between metabolism and the immune system. Am. J. Phys. Endo. Metab. In revision

21.           Belkina AC, Nikolajczyk BS, Denis GV (2012). BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair macrophage inflammatory responses. J. Immunol. In revision.

22.           Wang F, Denis GV (2012). Brd2 controls a PPARγ – RAR cell fate switch in adipogenesis. J. Biol. Chem. Under review.

23.           McDonnell ME, Umpierrez GE. Insulin therapy for the management of hyperglycemia in hospitalized patients. Endocrinol Metab Clin North Am. 2012 Mar;41(1):175-201.

24.           McDonnell ME, Alexanian SM, White L, Lazar HL. A primer for achieving glycemic control in the cardiac surgical patient. J Card Surg. 2012 Jul;27(4):470-7.

25.           Bradlee ML, Singer MR, Daniels SR, Moore LL. Eating patterns and lipid levels in older adolescent girls. Nutr Metab Cardiovasc Dis. 2012 Mar 12. [Epub ahead of print]

26.           Chadid S, Singer MR, Denis GV*, Moore LL* (2012). Elevated blood glucose potentiates the effect of BMI and waist-height ratio on risk of obesity-associated cancers. The Framingham Study. JAMA. Under review as of Dec 1, 2012. *co-senior authors

27.           Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV. 2012. The Outliers become a Stampede as Immunometabolism Reaches a Tipping Point. Immunol. Rev. 249:253-275.

28.           DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova Y, Markham D, Strissel KJ, Watkins A, Allen J, Bouchard J, Torald G, Jasuja R, Obin MS, McDonnell ME, Apovian CM, Denis GV and Nikolajczyk, BS. B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile (In Revision).

29.           Snyder-Cappione, JE and Nikolajczyk BS. When diet and exercise aren’t enough, think immunomodulation. 2012. Molecular Aspects of Medicine. (In Press). doi:pii: S0098-2997(12)00117-3. 10.1016/j.mam.2012.10.003.

30.           Vieira Potter VJ, Strissel KJ, Xie C, Chang E, Bennett G, DeFuria J, Obin MS, Greenberg AS. Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity. Endocrinology. 2012 Sep;153(9):4266-77.

31.           Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J. Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade. EMBO Rep. 2012 Feb 1;13(2):150-6.

Year 1 MEETING ABSTRACTS (outside BU)

1. 2011, Oct: “Failure of macrophage and adipocyte crosstalk in obesity protects obese Brd2 deficient mice from insulin resistance”. Obesity Society 29^th Annual Scientific Meeting, Orlando, FL, USA. October. Anna C Belkina, Wanda P Blanton, Gerald V Denis

2. 09/18–23/2011: “Monocytes and B cells are required for pro-inflammatory T cell function in human type 2 diabetes: Beyond mouse models”. Madhumita Jagannathan-Bogdan,  Marie E. McDonnell, Hyunjin Shin, Hatice Hasturk,  Caroline M Apovian and  Barbara S Nikolajczyk. First International Conference on Immunometabolism, Heraklion, Crete.

3. 05/2011-American Assn of Immunologists, San Francisco, CA. “The immunological ménage à trois promotes inflammation in Type 2 Diabetes”. Madhumita Jagannathan-Bogdan, Marie E McDonnell, Hyunjin Shin, Qasim Rehman, Hatice Hasturk, Caroline M Apovian and Barbara S Nikolajczyk

4. 10/2011 The Obesity Society annual meeting. “Monocytes and B cells are required for pro-inflammatory T cell function in human Type 2 diabetes: Beyond mouse models. Madhumita Jagannathan-Bogdan, Marie E McDonnell, Hyunjin Shin, Hatice Hasturk,  Caroline M Apovian and  Barbara S Nikolajczyk

Year 2 MEETING ABSTRACTS (outside BU)

1. 2012, May: “B cells as master regulators of a pro-inflammatory T cell balance in obesity and glucose intolerance.” AAI Annual Meeting, Boston, MA. Annabel Belkina, Jennifer Snyder-Cappione, Madhumita Jagannathan-Bogdan, Jordan Carr, Jason DeFuria, Douglas Markham, Jessica Allen, Jacqueline Bouchard, Amanda Watkins, Gerald V. Denis and Barbara S. Nikolajczyk

2. 2012, May: “Small-molecule BET inhibitor JQ1 subdues inflammation in vitro and protects mice from LPS-induced shock” AAI Annual Meeting, Boston, MA. Anna C Belkina, Gerald V Denis

3. 2012, Sept: “Elevated blood glucose potentiates the effect of central adiposity on risk of obesity-associated cancers”. The Framingham Study. Obesity Society 30^th Annual Scientific Meeting, San Antonio, TX, USA. Susan Chadid, Martha R Singer, Gerald V Denis, Lynn L Moore.

4. 2012, Sept: “Perceived stress partially mediates the association between income and adiposity among non-Hispanic white women”, Society for Behavioral Medicine Annual Meeting. Shelby Langer, Bonnie McGregor, Alan Kuniyuki, Shirley Beresford, Deborah J Bowen.

1.     Cove CL, Cowan AJ, Magnani JW, Henault E, Benjamin EJ, Hylek EM. Abstracts Submitted for the 2011 SVM 22nd Annual Meeting & Scientific Sessions: June 2-4, 2011 Boston, MA, USA Vascular Medicine, June 2011; vol. 16, 3: pp. 217-236.

2.     De Caterina R , Hylek EM. Stroke prevention in atrial fibrillation: current status and near-future directions. Am J Med. 2011;124:793-9.

2.         Dentali F, Marchesi C, Pierfranceschi MG, Crowther M, Garcia D, Hylek E, Witt DM, Clark NP, Squizzato A, Imberti D, Ageno W. Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost. 2011;106:429-38.

3.         Dentali F, Gianni M, Squizzato A, Ageno W, Castiglioni L, Maroni L, Hylek EM, Grandi AM, Cazzani E, Venco A, Guasti L. Use of statins and recurrence of atrial fibrillation after catheter ablation or electrical cardioversion. A systematic review and meta-analysis. Thromb Haemost. 2011;106:363-70.

4.         Dentali F, Donadini MP, Clark N, Crowther MA, Garcia D, Hylek E, Witt DM, Ageno W. Brand name versus generic warfarin: a systematic review of the literature. Pharmacotherapy. 2011;31:386-93.

5.         Estes NA, III, Sacco RL, Al-Khatib SM, Ellinor PT, Bezanson J, Alonso A, Antzelevitch C, Brockman RG, Chen PS, Chugh SS, Curtis AB, DiMarco JP, Ellenbogen KA, Epstein AE, Ezekowitz MD, Fayad P, Gage BF, Go AS, Hlatky MA, Hylek EM, Jerosch-Herold M, Konstam MA, Lee R, Packer DL, Po SS, Prystowsky EN, Redline S, Rosenberg Y, Van Wagoner DR, Wood KA, Yue L, Benjamin EJ. American Heart Association atrial fibrillation research summit: a conference report from the American Heart Association. Circulation. 2011;124:363-72.

6.         Fontes JD, Lyass A, Massaro JM, Rienstra M, Dallmeier D, Schnabel RB, Wang TJ, Vasan RS, Lubitz SA, Magnani JW, Levy D, Ellinor PT, Fox CS, Benjamin EJ. Insulin Resistance and Atrial Fibrillation (from the Framingham Heart Study). Am J Cardiol. 2011.

7.         Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981-92.

8.         Kirchhof P, Lip GY, Van Gelder IC, Bax J, Hylek E, Kaab S, Schotten U, Wegscheider K, Boriani G, Ezekowitz M, Diener H, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Vardas P, Breithardt G, Camm AJ. Comprehensive risk reduction in patients with atrial fibrillation: Emerging diagnostic and therapeutic options. Executive summary of the report from the 3rd AFNET/EHRA consensus conference. Thromb Haemost. 2011;106.

9.         Kirchhof P, Lip GY, Van Gelder IC, Bax J, Hylek E, Kaab S, Schotten U, Wegscheider K, Boriani G, Brandes A, Ezekowitz M, Diener H, Haegeli L, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Aunes-Jansson M, Blomstrom-Lundqvist C, Borentain M, Breitenstein S, Brueckmann M, Cater N, Clemens A, Dobrev D, Dubner S, Edvardsson NG, Friberg L, Goette A, Gulizia M, Hatala R, Horwood J, Szumowski L, Kappenberger L, Kautzner J, Leute A, Lobban T, Meyer R, Millerhagen J, Morgan J, Muenzel F, Nabauer M, Baertels C, Oeff M, Paar D, Polifka J, Ravens U, Rosin L, Stegink W, Steinbeck G, Vardas P, Vincent A, Walter M, Breithardt G, Camm AJ. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options–a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference. Europace. 2011.

10.       Lip GY, Andreotti F, Fauchier L, Huber K, Hylek E, Knight E, Lane D, Levi M, Marin F, Palareti G, Kirchhof P. Bleeding risk assessment and management in atrial fibrillation patients. Executive Summary of a Position Document from the European Heart Rhythm Association [EHRA], endorsed by the European Society of Cardiology [ESC] Working Group on Thrombosis. Thromb Haemost. 2011;106.

11.       Lip GY, Andreotti F, Fauchier L, Huber K, Hylek E, Knight E, Lane DA, Levi M, Marin F, Palareti G, Kirchhof P, Collet JP, Rubboli A, Poli D, Camm J. Bleeding risk assessment and management in atrial fibrillation patients: a position document from the European Heart Rhythm Association, endorsed by the European Society of Cardiology Working Group on Thrombosis. Europace. 2011;13:723-46.

12.       Lopes RD, Horowitz JD, Garcia DA, Crowther MA, Hylek EM. Warfarin and acetaminophen interaction: a summary of the evidence and biological plausibility. Blood. 2011.

13.       Lopes RD, Becker RC, Alexander JH, Armstrong PW, Califf RM, Chan MY, Crowther M, Granger CB, Harrington RA, Hylek EM, James SK, Jolicoeur EM, Mahaffey KW, Newby LK, Peterson ED, Pieper KS, Van de Werf F, Wallentin L, White HD, Carvalho AC, Giraldez RR, Guimaraes HP, Nader HB, Kalil RA, Bizzachi JM, Lopes AC, Garcia DA. Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, Sao Paulo, Brazil. J Thromb Thrombolysis. 2011;32:242-66.

14.       Lubitz SA, Yin X, Fontes JD, Magnani JW, Rienstra M, Pai M, Villalon ML, Vasan RS, Pencina MJ, Levy D, Larson MG, Ellinor PT, Benjamin EJ. Association between familial atrial fibrillation and risk of new-onset atrial fibrillation. JAMA. 2010;304:2263-9.

15.       Lubitz SA, Magnani JW, Ellinor PT, Benjamin EJ. Atrial fibrillation and death after myocardial infarction: risk marker or causal mediator? Circulation. 2011;123:2063-5.

16.       Magnani JW, Rienstra M, Lin H, Sinner MF, Lubitz SA, McManus DD, Dupuis J, Ellinor PT, Benjamin EJ. Atrial fibrillation: current knowledge and future directions in epidemiology and genomics. Circulation. 2011;124:1982-93.

17.       Magnani JW, Johnson VM, Sullivan LM, Gorodeski EZ, Schnabel RB, Lubitz SA, Levy D, Ellinor PT, Benjamin EJ. P wave duration and risk of longitudinal atrial fibrillation in persons >/= 60 years old (from the Framingham Heart Study). Am J Cardiol. 2011;107:917-21.

18.       Magnani JW, Gorodeski EZ, Johnson VM, Sullivan LM, Hamburg NM, Benjamin EJ, Ellinor PT. P wave duration is associated with cardiovascular and all-cause mortality outcomes: the National Health and Nutrition Examination Survey. Heart Rhythm. 2011;8:93-100.

19.       Magnani JW, Lopez FL, Soliman EZ, Maclehose RF, Crow RS, Alonso A. P Wave Indices, Obesity, and the Metabolic Syndrome: The Atherosclerosis Risk in Communities Study. Obesity (Silver Spring). 2011.

20.       Patton KK, Benjamin EJ, Kosheleva A, Curtis LH, Glymour MM. Early-life antecedents of atrial fibrillation: place of birth and atrial fibrillation-related mortality. Ann Epidemiol. 2011;21:732-8.

21.       Piccini JP, Fraulo ES, Ansell JE, Fonarow GC, Gersh BJ, Go AS, Hylek EM, Kowey PR, Mahaffey KW, Thomas LE, Kong MH, Lopes RD, Mills RM, Peterson ED. Outcomes registry for better informed treatment of atrial fibrillation: rationale and design of ORBIT-AF. Am Heart J. 2011;162:606-12.

22.       Rienstra M, Sun JX, Magnani JW, Sinner MF, Lubitz SA, Sullivan LM, Ellinor PT, Benjamin EJ. White Blood Cell Count and Risk of Incident Atrial Fibrillation (From the Framingham Heart Study). Am J Cardiol. 2011.

23.       Rose AJ, Berlowitz DR, Ash AS, Ozonoff A, Hylek EM, Goldhaber-Fiebert JD. The business case for quality improvement: oral anticoagulation for atrial fibrillation. Circ Cardiovasc Qual Outcomes. 2011;4:416-24.

24.       Rose AJ, Hylek EM, Ozonoff A, Ash AS, Reisman JI, Callahan PP, Gordon MM, Berlowitz DR. Relevance of current guidelines for organizing an anticoagulation clinic. Am J Manag Care. 2011;17:284-9.

25.       Rose AJ, Hylek EM, Berlowitz DR, Ash AS, Reisman JI, Ozonoff A. Prompt repeat testing after out-of-range INR values: a quality indicator for anticoagulation care. Circ Cardiovasc Qual Outcomes. 2011;4:276-82.

26.       Rose AJ, Ozonoff A, Berlowitz DR, Ash AS, Reisman JI, Hylek EM. Reexamining the recommended follow-up interval after obtaining an in-range international normalized ratio value: results from the Veterans Affairs study to improve anticoagulation. Chest. 2011;140:359-65.

27.       Schnabel RB, Kerr KF, Lubitz SA, Alkylbekova EL, Marcus GM, Sinner MF, Magnani JW, Wolf PA, Deo R, Lloyd-Jones DM, Lunetta KL, Mehra R, Levy D, Fox ER, Arking DE, Mosley TH, Muller-Nurasyid M, Young TR, Wichmann HE, Seshadri S, Farlow DN, Rotter JI, Soliman EZ, Glazer NL, Wilson JG, Breteler MM, Sotoodehnia N, Newton-Cheh C, Kaab S, Ellinor PT, Alonso A, Benjamin EJ, Heckbert SR. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute’s Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet. 2011;4:557-64.

28.       Sinner MF, Ellinor PT, Meitinger T, Benjamin EJ, Kaab S. Genome-wide association studies of atrial fibrillation: past, present, and future. Cardiovasc Res. 2011;89:701-9.

29.       Smith JG, Magnani JW, Palmer C, Meng YA, Soliman EZ, Musani SK, Kerr KF, Schnabel RB, Lubitz SA, Sotoodehnia N, Redline S, Pfeufer A, Muller M, Evans DS, Nalls MA, Liu Y, Newman AB, Zonderman AB, Evans MK, Deo R, Ellinor PT, Paltoo DN, Newton-Cheh C, Benjamin EJ, Mehra R, Alonso A, Heckbert SR, Fox ER. Genome-wide association studies of the PR interval in African Americans. PLoS Genet. 2011;7:e1001304.

30.       Walkey AJ, Wiener RS, Ghobrial JM, Curtis LH, Benjamin EJ. Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. JAMA. 2011;306:2248-54.

31.       Wirka RC, Gore S, Van Wagoner DR, Arking DE, Lubitz SA, Lunetta KL, Benjamin EJ, Alonso A, Ellinor PT, Barnard J, Chung MK, Smith JD. A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Circ Arrhythm Electrophysiol. 2011;4:87-93.

32.  Sinner MF, Wang N, Fox CS, Fontes JD, Rienstra M, Magnani JW, Vasan RS, Calderwood AH, Pencina M, Sullivan LM, Ellinor PT, Benjamin EJ. Relation of Circulating Liver Transaminase Concentrations to Risk of New-Onset Atrial Fibrillation. Am J Cardiol. 2012.

33.       Rienstra M, Lubitz SA, Mahida S, Magnani JW, Fontes JD, Sinner MF, Van Gelder IC, Ellinor PT, Benjamin EJ. Symptoms and functional status of patients with atrial fibrillation: state of the art and future research opportunities. Circulation. 2012;125:2933-2943.

34.       Magnani JW, Moser CB, Murabito JM, Nelson KP, Fontes JD, Lubitz SA, Sullivan LM, Ellinor PT, Benjamin EJ. Age of natural menopause and atrial fibrillation: the Framingham Heart Study. Am Heart J. 2012;163:729-734.

35.       Rienstra M, Sun JX, Lubitz SA, Frankel DS, Vasan RS, Levy D, Magnani JW, Sullivan LM, Meigs JB, Ellinor PT, Benjamin EJ. Plasma resistin, adiponectin, and risk of incident atrial fibrillation: the Framingham Offspring Study. Am Heart J. 2012;163:119-124.

36.       Schnabel RB, Baccarelli A, Lin H, Ellinor PT, Benjamin EJ. Next steps in cardiovascular disease genomic research–sequencing, epigenetics, and transcriptomics. Clin Chem. 2012;58:113-126.

38.       Walkey AJ, Wiener RS, Ghobrial JM, Curtis LH, Benjamin EJ. Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. JAMA. 2011;306:2248-2254.

39.       Magnani JW, Rienstra M, Lin H, Sinner MF, Lubitz SA, McManus DD, Dupuis J, Ellinor PT, Benjamin EJ. Atrial fibrillation: current knowledge and future directions in epidemiology and genomics. Circulation. 2011;124:1982-1993.

Software Tool for Researching Annotations of Proteins: Open-Source Protein Annotation Software with Data Visualization, Vivek N. Bhatia, David H. Perlman, Catherine E. Costello and Mark E. McComb, Anal. Chem., 2009, 81 (23), pp 9819–9823, DOI:10.1021/ac901335x.

Top-down analysis of small plasma proteins using an LTQ-Orbitrap. Potential for mass spectrometry-based clinical assays for transthyretin and hemoglobin, Roger Théberge, Giuseppe Infusini, Weiwei Tong, Mark E.McComb, Catherine E.Costello, Int. J. Mass Spectrom., in press.

McDonnell ME, Liang Y,Noronha A, Hetzel J, Coukos J, Kasper DJ, Farraye FA, Ganley-Leal LM Systemic Toll-Like Receptor Ligands Modify B-cell Responses in Human Inflammatory Bowel Disease. Inflammatory Bowel Disease. 2010 in press.

N. Ouchi, A. Higuchi, K. Ohashi, Y. Oshima, N. Gokce, R. Shibata, Y. Akasaki, A. Shimono, K. Walsh (2010). Sfrp5 Is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science. 329:454-457. Accompanied by editorial