Gregory Orlowski, MD, PhD

Assistant Professor of Dermatology


Assistant Professor of Dermatology
Assistant Director, Dermatology Residency Program

Professional Summary

Dr. Orlowski is an Assistant Professor of Dermatology and sees general dermatology patients. He also has a specialty clinic focused on neutrophilic dermatoses like Hidradenitis Suppurativa, Pyoderma Gangrenosum, Sweet’s Syndrome and Behcet’s Disease, among others. His research interests include neutrophilic dermatoses, inflammatory skin disorders and skin cancer.


2006 – BS in Gen. Biology, University of Maryland College Park, College Park, MD

2017 – PhD in Immunology, University of Massachusetts Medical School, Worcester, MA

2017 – MD Doctor of Medicine, University of Massachusetts Medical School, Worcester, MA

2018 – Internship in Internal Medicine, St. Vincent’s Hospital, Worcester, MA

2021 – Residency in Dermatology & Chief Resident, UMASS Memorial Medical Center, Worcester, MA


Clinical Specialties & Research Interests

● General Dermatology – including Acne, Skin Cancer, Rashes
● Neutrophilic Dermatoses
● Inflammatory Skin Conditions
● Vitiligo
● Procedural Dermatology – Excisions & Laser
● Research interests – Neutrophilic Dermatoses, Inflammatory Skin Conditions, Skin Cancer

Selected Publications

  1. G.M. Orlowski, S. U. Amano, K. Flanagan, K. Wiss. (2020). Treatment of Junctional Epidermolysis Bullosa with Ataluren: A Single-Patient Prospective Trial. To be Determined. (In Preparation)
  2. G.M. Orlowski, N.K. Leonard, E. Evan-Browning, M. Rashighi. (2020). Primary Cutaneous Gamma-Delta T-Cell Lymphoma Disguised as Lupus Panniculitis. Cutis. (In Review)
  3. G.M. Orlowski, A.J. Tan, E. Evan-Browning, M.J. Scharf. (2020). Primary Cutaneous Nasal-Type NK/T-Cell Lymphoma Presenting as Purpuric Nodules on the Lower Leg. JAAD Case Reports.
  4. K.G. Berrebi, G.M. Orlowski, J.D. Richey, N.A. Levin. (2019). Multiple atypical vascular lesions following breast-conserving surgery and radiation. Cutis.
  5. G.M. Orlowski, S. Sharma, J. D. Colbert, H. Kataoka, M. Bogyo, S. A. Robertson, F.C. Chan and
    K. L. Rock. (2017). Multiple cathepsins promote inflammasome-independent particle-induced cell death during NLRP3-dependent IL-1β activation. Journal of Leukocyte Biology.**Featured in Frontline Science section**
  6. G.M. Orlowski, J. D. Colbert, S. Sharma, M. Bogyo, S. A. Robertson, and K. L. Rock. (2015). Multiple cathepsins promote pro-IL-1β synthesis and NLRP3-mediated IL-1β activation. Journal of Immunology.
  7. A. Sharma, G.M. Orlowski, Y. Zhu, S.Y. Kim, A. Hubel, B. Stadler. (2015). Inducing cells to self-disperse magnetic nanowires via integrin-mediated responses. Nanotechnology.
  8. S. Sharma, A. Campbell, J. Chan-Kim, S.A. Schattgen, G.M. Orlowski, R. Nayar, A.H. Huyler, K. Nundel, C. Mohan, L.J. Berg, M.J. Shlomchik, A.M. Rothstein, K.A. Fitzgerald. (2015) Suppression of autoimmunity by the innate immune adaptor STING. PNAS.
  9. K. Moriwaki, J. Bertin, P.J. Gough, G.M. Orlowski, F.K.M. Chan. (2015). Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Nature: Cell Death & Disease.
  10. H. Kono, G.M. Orlowski, Z. Patel, K.L. Rock. (2012). The IL-1-dependent sterile inflammatory response has a substantial caspase 1-independent component that requires cathepsin C. Journal of Immunology.
  11. C. Liu, H. Miller, G. Orlowski, H. Hang, A. Upadhvava, W. Song. (2012). Actin reorganization is required for the formation of polarized B cell receptor signalosomes in response to both soluble and membrane-associated antigens. Journal of Immunology.
  12. M.D. Siegelin, T. Dohi, C.M. Raskett, G.M. Orlowski, C.M. Powers, C.A. Gilbert, A.H. Ross, J. Plescia, and D.C. Altieri. (2011). Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. JCI.
  13. S. Sharma, G. Orlowski and W. Song. (2009). Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells. Journal of Immunology.