Innovations in Neuroscience Drug Discovery
Friday, November 16th 2018, 8:00 a.m. – 6:30 p.m.
BU Pharmacology & Experimental Therapeutics – Biogen Symposium
Biogen, 300 Binney Street, Cambridge, MA 02142
Free and open to the public.
Registration has now closed. There is no onsite registration.
Registration and Breakfast
David H. Farb, Ph.D., Boston University: Academia-Industry Alliances: Catalyzing Discovery Science
Anabella Villalobos, Ph.D., Biogen: Biogen Opening Remarks
Session 1: Harnessing Cutting-Edge Technology to Enable Drug Discovery
Georgios Skiniotis, Ph.D., Stanford University: CryoEM Insights into GPCR Activation and Signaling
Anthony W. P. Fitzpatrick, Ph.D., Columbia University: Untangling Neurodegenerative Diseases Using Patient-Based Structural Biology
Shelley J. Russek, Ph.D., Boston University: JAK/STATs and the Brain: a Pharmacological Window on the BDNF Transcriptome of Neurological Disease
Hongkui Zeng, Ph.D., Allen Institute for Brain Science: Cell Type Classification and Circuit Mapping in the Brain: Mapping a Path to Discovery
Xue Han, Ph.D., Boston University: Optical Analysis of Biological Neural Networks Across Scales
Session 2: Neuroinflammation at the Nexus of CNS Diseases
Anirvan Ghosh, Ph.D., Biogen: Introductory Remarks
Staci Bilbo, Ph.D., MGH/Harvard Medical School: Neuroimmune Interactions in Development: Implications for Health Throughout the Lifespan
Dorothy P. Schafer, Ph.D., UMASS Medical Center: Microglial Phagocytic Mechanisms Governing Brain Plasticity in Health and Disease
Tsuneya Ikezu, M.D., Ph.D., Boston University: Proteomic and Neuropathological Characterization of Extracellular Vesicles in Alzheimer’s Disease
Benjamin Wolozin, M.D., Ph.D., Boston University: Membrane-Less Organelles and RNA Binding Proteins as Targets for Therapy of Neurodegenerative Diseases
Session 3: Pharmacology, Models and Biomarkers: Bench to Bedside
Leonard Petrucelli, Ph.D., Mayo Clinic-Jacksonville: Therapeutic Insights into Repeat Expansion Disorders
Wendy Qiu, M.D., Ph.D., Boston University: Alzheimer’s Disease: The Brain Disease or the Peripheral System-Brain Axis Disease?
Thomas Kornecook, Ph.D., Biogen: Animal Models in Neuroscience Drug Discovery: The Good, the Bad, and the Ugly
Himanshu Naik, Ph.D., Biogen: Application of Pharmacokinetic and Pharmacodynamic Modeling in Drug Development
Drs. Pietro Cottone and Valentina Sabino become U.S. citizens. Dr. Cottone Records Album/Shares Perspective in the Boston Globe and BU Today.
Congratulations to Drs. Pietro Cottone and Valentina Sabino who recently became U.S. citizens in a ceremony at the John F. Kennedy Presidential Library and Museum with approximately 200 other immigrants. Pietro and Valentina, natives of Italy, are Associate Professors in Pharmacology and Psychiatry and Co-Principal Investigators in the Laboratory of Addictive Disorders. Since joining Boston University in 2008, these talented neuroscientists have distinguished themselves as research leaders in the neuropsychopharmacology of addiction including eating disorders, obesity, and stress-related disorders.
Pietro shared his perspective on becoming a U.S. citizen in an in the July 17, 2019 issue of the Boston Globe, and in the August 9, 2019 issue of BU Today. A musician and composer, he also discusses the thoughts that led to release album he composed, arranged, and produced. "Fight For Their Rights" is a collection of 10 songs "expressing his perspective of the social and political challenges that the world is facing." As Pietro puts it in BU Today, "My album is an attempt to give a voice to the voiceless."
Franco Puleo Receives the 2019-2020 American Physiology Society Porter Physiology Development Fellowship
Congratulations to Franco Puleo who has been awarded the 2019-2020 American Physiology Society Porter Physiology Development Fellowship. His research, "Sympathetic Nervous System Regulation of the NCC in Salt Sensitive Hypertension," focuses on renal mechanisms of blood pressure control in salt sensitive hypertension. The Porter Physiology Development Fellowship provides Franco a year's stipend support for his research.
Franco is a Program in BioMolecular Pharmacology PhD candidate who is doing is dissertation research in the Laboratory for Cardiovascular-Renal Research under the mentorship of Richard D. Wainford, Ph.D., Associate Professor of Pharmacology and Medicine, Section of Cardiovascular Medicine, and member of the Whitaker Cardiovascular Institute at Boston University. Franco joined Dr. Wainford's lab in 2017. He was awarded the Caroline tum Suden/Francis A. Hellebrandt Professor Opportunity Award from the APS at the 2018 Experimental Biology Annual Meeting in San Diego, California.
Again, kudos to Franco Puleo for his continued pursuit of excellence and dedication to his research.
Drs. Valentina Sabino, Camron Bryant, and Chris Gabel Among the 2019 Jack Spivack Excellence in Neuroscience Awards Recipients
Congratulations to Drs. Valentina Sabino, Camron Bryant, and Chris Gabel for being among the 2019 Jack Spivack Excellence in Neuroscience Awards recipients. Drs. Gabel and Sabino have been named as Spivack Emerging Leaders and Dr. Bryant has been honored as the Spivack Young Investgator.
Valentina Sabino, Ph.D., Associate Professor of Pharmacology and Psychiatry, is the co-director of the Laboratory of Addictive Disorders. Her research focuses on the neurobiology of addiction and stress-related disorders.
Camron Bryant, Ph.D., Assistant Professor in Pharmacology and Psychiatry, is the director of the Laboratory of Addiction Genetics. He conducts research on the genetic factors and neurological mechanism underlying substance abuse disorders.
Chris Gabel, Pn.D., Associate Professor of Physiology and Biophysics and Pharmacology, studies neuroregeneration, neurodegeneration, nervous systems Circuits, and behavior and the influence of anesthetics on neurocircuitry.
All three of these talented researchers are members of the NIGMS Program in Biomolecular Pharmacology, actively participating in teaching and mentoring our Ph.D. graduate students towards careers in neuroscience.
Again we say, "Well done!"
Emily Mason-Osann, a fourth year Ph.D. student in the Program in Biomolecular Pharmacology, has received a pre doctoral fellowship in pharmacology/toxicology from the PhRMA Foundation. The research proposed is titled, “Defining Mechanism and Therapeutic Targets in the Alternative Lengthening of the Telomeres Pathway.” She is pursuing her thesis research under the mentorship of Rachel L. Flynn, Ph.D., Assistant Professor of Pharmacology and Medicine, in the Laboratory of Genomic Stability and Cancer Therapeutics.
The award announcement was made at the 2019 Annual Meeting of the American Society for Pharmacology and Experimental Therapeutics in Orlando on April 10, 2019. This award provides $20,000 per year for up to two years for PhD candidates who have completed most of their pre-thesis requirements and are engaged in their thesis research.
Dr. Wendy Qiu is corresponding author on BU Alzheimer’s Study Examining the Role of Inflammation in Alzheimer’s Disease
As reported in the Friday, October 19, 2018 edition of The Boston Globe, Boston University researchers published results of their study on the examining the role of inflammation in Alzheimer's disease in the journal JAMA Network Open. Per the abstract, the research objective was "To study the interaction between the apolipoprotein E (ApoE) genotype and chronic low-grade inflammation and its association with the incidence of AD." Framingham Heart Study data was mined to for subjects who had the ApoE4 gene to examine C-reactive protein levels as an indicator of the amount of body inflammation.
Wendy Qiu, M.D., Ph.D., Professor of Psychiatry and Pharmacology and corresponding author of the study, commented in The Globe, "Since many elders have chronic low-grade inflammation after suffering from common diseases like cardiovascular diseases, diabetes, pneumonia and urinary tract infection, or after having surgeries, rigorously treating chronic systemic inflammation in ApoE4 carriers could be effective for prevention of Alzheimer’s dementia.”
The study found that, "It is possible that chronic inflammation, rather than 1 episode of inflammation, interacts with genetic vulnerability to increase the risk for AD." This finding provides an important new insight into the development of Alzheimer's disease.
Dr. Hui Feng has been named the 2018 Arden Quinn Bucher Memorial Fund St. Baldrick’s Foundation Scholar. This award was established in memory of Arden Quinn Bucher who was diagnosed with neuroblastoma in 2007 at the age of 2.
An amplified gene, MYCN, is found in ~30% of neuroblastomas, and is associated with highly aggressive tumors that have extremely poor prognosis. Dr. Feng's work on T-cell leukemia recently showed that when a specific gene is turned off it will prevent tumor growth caused by C-MYC, a close relative of MYCN. This award will support Dr. Feng's research which aims to determine if targeting this gene will suppress neuroblastoma development associated with MYCN activity.
The St. Baldrick's Foundation's mission is to "conquer childhood cancers." In 2014 Dr. Feng was selected by the St. Baldrick Foundation to receive a three year Scholar award totaling $330,000. Based on her research progress, she was awarded an additional $211,154 new grants in 2017 and 2018 to fund two more years of this Scholar award. These awards have enabled Dr. Feng to make great strides in her research on childhood cancers.
We congratulate to Dr. Feng on receipt of this award and take this opportunity to thank the St. Baldrick's Foundation for their generous support of Dr. Feng's research.
Dr. Richard Wainford spoke with Carey Goldberg on WBUR today regarding his study connecting salt sensitivity to mutations in the GNAI2 gene. He noted that 1 in 2 adults in the U.S. have high blood pressure and, according to this study, "if you have this mutation . . . you're three times more likely to be salt sensitive than patients that don't . . ." This is a promising new discovery for clinicians who currently have no way to identify patients who may be salt-sensitive and at risk for "the associated adverse cardiovascular outcomes." The details of this study were published in June 15, 2018 issue of Physiological Genomics.
Dr. Wainford, Associate Professor of Pharmacology and Medicine, Section of Cardiovascular Medicine and member of the BU Whitaker Cardiovascular Institute, is the Director of the Laboratory for Cardiovascular-Renal Research. His research is supported by funding from the National Heart, Lung, and Blood Institute.
Karen Harnett, Ph.D., Assistant Professor of Pharmacology, and Neil J. Ganem, Ph.D., Assistant Professor of Pharmacology and Medicine, Section of Hematology and Medical Oncology are among the nine recipients of 2018 BUSM Educator of the Year honors. Faculty were nominated for awards in each category by medical students and Division of Graduate Medical Sciences students.
Dr. Harnett, a BUSM Pharmacology Ph.D. program graduate, was named Educator of the Year in Pre-Clinical Medical Sciences. She joined the Department of Pharmacology & Experimental Therapeutics in 2013 as Pharmacology educator and joined the Disease and Therapy (DRx) leadership team in 2015. She directs the Dental Pharmacology could for se ond-year dental students (DMDII) and first-year Advanced Standing dental students (ASI) at BU's Henry M. Goldman School of Dental Medicine.
Dr. Ganem, Principal Investigator and Director of the Laboratory of Cancer Cell Biology, is one of two recipients along with Dr. Darrell Kotton of the Educator of the Year in Graduate Medical Sciences, Dissertation Advisors award. Neil's research investigates the causes and consequences of aneuploidy and chromosome instability in human cancer, aims to define tumor suppression mechanisms that limit proliferation of aneuploid cells, and also to identify the common genetic adaptions made by cancer cells to overcome these growth barriers. He currently mentors one Ph.D. graduate student and three M.D./Ph.D. graduate students in the NIGMS supported Program in Biomolecular Pharmacology at Boston University, a BU Cell, Molecular and Genetics program undergraduate student, two postdoctoral researchers and a laboratory technician.
Congratulations to Karen and Neil on their excellent teaching skills, their commitment to their students, and on a job well done.