Publications
|
Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP. 2013. STAT3 participates in the hepatic unfolded protein response to enhance secretion of acute phase proteins during pneumonia. Infect Immun 1644-53. PubMed Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H. 2013. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest 123:1019-31. PubMed Wilson AA, Kwok LW, Porter EL, Payne JG, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN. 2013. Lentiviral delivery of RNAi for in vivo lineage specific modulation of gene expression in mouse lung macrophages. Mol Ther 21:825-33. PubMed Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie ANJ, Lee CH. 2013. Direct control of hepatic glucose production by interleukin-13. J Clin Invest 123:261-271. PubMed Bartlett NW, Slater L, Glanville N, Haas JJ, Caramori G, Casolari P, Clarke DL, Message SD, Anisenko J, Kebadze T, Mallia P, Mizgerd JP, Belvisi M, Papi A, Kotenko SV, Johnston SL, Edwards MR. 2012. Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus. EMBO Mol Med 4:1244-1260. PubMed Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP. 2012. Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLOS Genet 8(11): e1003105. Full text Quinton LJ. 2012. Evaluating the NET influence of inflammation on pneumonia biology. Am J Respir Crit Care Med 186:943-944. PubMed Yamamoto K, Ferrari JD, Cao YX, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. 2012. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol 189:2450-2459. PubMed Mizgerd JP. 2012. Respiratory infection and the impact of pulmonary immunity on lung health and disease. Am J Respir Crit Care Med 186:824-829. PubMed Quinton LJ, Mizgerd JP, Hilliard KL, Jones MR, Kwon CY, Allen E. 2012. Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol 188:6300-6308. PubMed Quinton LJ, MT Blahna, MR. Jones, E Allen, JD Ferrari, KL Hilliard, X Zhang, V Sabharwal, H Algül, S Akira, RM Schmid, SI Pelton, A Spira, JP Mizgerd. 2012. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest 122:1758-1763. Full Text Blahna MT, Jones MR, Quinton LJ, Matsuura KY, Mizgerd JP. 2011. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity. J Biol Chem 286:42381-42389. PubMed Pittet LA, Quinton LJ, Yamamoto K, Robson BE, Ferrari JD, Algul H, Schmid RM, Mizgerd JP. 2011. Earliest innate immune responses require macrophage RelA during pneumococal pneumonia. Am J Respir Cell Mol Biol 45:573-581. PubMed Quinton LJ, Mizgerd JP. 2011. NF-kB and STAT3 signaling hubs for lung innate immunity. Cell Tissue Res 343:153-165. PubMed Perrone LA, Szretter KJ, Katz JM, Mizgerd JP, Tumpey TM. 2010. Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus. J Infect Dis 202:1161-70. PubMed Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP. 2009. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nature Cell Biol. 11:1157-1163. PubMed Quinton LJ, Jones MR, Robson BE, Mizgerd JP. 2009. Mechanisms of the hepatic acute phase response during bacterial pneumonia. Infect. Immun. 77: 2417-26. PubMed Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S. 2009. The systemic and pulmonary lipopolysaccharide binding protein response to intratracheal lipopolysaccharide. Shock 31: 212-7. PubMed Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR. 2009. Targeted deletion of tumor suppressor PTENaugments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood 113:4930-41. PubMed Lang JE, Williams ES, Mizgerd JP, Shore SA. 2008. Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. Am J Physiol Lung Cell Mol Physiol 294:L1013-20. PubMed Quinton, LJ, MR Jones, BE Robson, BT Simms, JA Whitsett, JP Mizgerd. 2008. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am. J. Respir. Cell Mol. Biol. 38:699-706. PubMed Mizgerd, JP. 2008. Acute lower respiratory infection. N. Engl. J. Med. 14:716-27. pdf Mizgerd, JP, SJ Skerrett. 2008. Animal models of human pneumonia. Am. J. Physiol.: Lung Cell. Mol. Biol. 294:L387-98.pdf Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. 2008. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res 68:9131-6. PubMed Subramanian, KK, Jia Y, Zhu D, Simms BT, Jo H, Hattori H, You J, Mizgerd JP, Luo HR. 2007. Tumor suppressor PTEN is a physiological suppressor of chemoattractant-mediated neutrophil functions. Blood 109:4028-4037.PubMed Nakahira, M, T Tanaka, BE Robson, JP Mizgerd, MJ Grusby. 2007. Regulation of STAT signaling by the tyrosine phosphatase PTP-BL. Immunity 26:163-176.PubMed Quinton, LJ, MR Jones, BT Simms, MS Kogan, BE Robson, SJ Skerrett, JP Mizgerd. 2007. Functions and regulation of NF-?B RelA during pneumococcal pneumonia. J. Immunol. 178:1896-1903.PubMed Johnston, RA, Mizgerd JP, Flynt L, Quinton LJ, Williams ES, Shore SA. 2007. Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice. Am J Respir Cell Mol Biol 37:477-484.PubMed Happel, KI, Rudner, X, Quinton, LJ, Movassaghi, JL, Clark, C, Odden, AR, Zhang, P, Bagby, GJ, Nelson, S, Shellito, JE 2007. Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. Alcohol 41: 325-333 Pubmed Prince, AS, JP Mizgerd, J Wiener-Kronish, J Bhattacharya. 2006. Cell signaling underlying the pathophysiology of pneumonia. Am. J. Physiol.: Lung Cell. Mol. Biol. 291:L297-300. Full text Yano, K, PC Liaw, JM Mullington, SC Shih, H Okada, N Bodyak, PM Kang, L Toltl, B Belikoff, J Buras, BT Simms, JP Mizgerd, P Carmeliet, SA Karumanchi, WC Aird. 2006. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J. Exp. Med. 203:1447-1458. Full text Krishnamurthy, VM, LJ Quinton, LA Estroff, SJ Metallo, JM Isaacs, JP Mizgerd, GM Whitesides. 2006. Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide. Biomaterials 27:3663-3674. PubMed Mizgerd, JP. 2006. Lung infection- A public health priority. PLoS Medicine 3:e76. pdf Jones, MR, LJ Quinton, BT Simms, MM Lupa, MS Kogan, JP Mizgerd. 2006. Roles of interleukin-6 in STAT activation and neutrophil recruitment during Escherichia coli pneumonia. J. Infect. Dis. 193:360-369. PubMed Mizgerd, JP. 2005. Transcription Factors: Nuclear Factor-?B and Inhibitory Protein ?B. In Encyclopedia of Respiratory Medicine, edited by GJ Laurent and SD Shapiro. Elsevier Limited: Oxford, UK, pp. 265-269. Jones, MR, BT Simms, MM Lupa, MS Kogan, JP Mizgerd. 2005. Lung NF-?B activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J. Immunol. 175:7530-7535. Full text Mizgerd, JP. 2005. Mac-1 mediates migration to lymph nodes. Blood 109:2927-2928. pdf Faffe, DS, L Flynt, M Mellema, PE Moore, ES Silverman, V Subramaniam, MR Jones, JP Mizgerd, T Whitehead, A Imrich, RA Panettieri, Jr, SA Shore. 2005. Oncostatin M causes eotaxin release from airway smooth muscle: synergy with IL-4 and IL-13. J. Allergy Clin. Immunol. 115:514-520. PubMed Johnston, R.A., J.P. Mizgerd, S.A. Shore. 2005. CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure. Am. J. Physiol.: Lung Cell. Mol. Biol. 288:L61-L67. Full text Quinton, LJ, Nelson, S, Zhang, P, Happel, KI, Gamble, L, Bagby, GJ. 2005. Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment. Alcohol: Clin. Exp. Res. 29: 1198-1205. Pubmed Zhang, P, Quinton, LJ, Gamble, L, Bagby, GJ, Summer, WR, Nelson, S 2005. The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemia. Shock. 23: 344-352. Pubmed Happel, KI, Dubin, PJ, Zheng, M, Quinton, LJ, Odden, AR, Shellito, JE, Bagby, GJ, Nelson, S, Kolls, JK 2005. Divergent roles of IL-12 and IL-23 in host defense against Klebsiella pneumoniae. J. Exp. Med. 202: 761-769 Pubmed Badewa, AP, Quinton, LJ, Shellito, JE, Mason, CM 2005. Chemokine receptor 5 and its ligands in the immune response to murine tuberculosis. Tuberculosis. 85 185-195. Pubmed Poonia, B, Nelson, S, Bagby, GJ, Zhang, P, Quinton, LJ, Veazey, RS. 2005. Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Res Hum Retroviruses. 21:863-868. Pubmed Shahbazian, LM, Quinton, LJ, Bagby, GJ, Nelson, S, Wang, G, and Zhang, P. 2004. Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation. Crit. Care Med. 32: 1740-1746. Pubmed Quinton, LJ, Nelson, S, Zhang, P, Boé, DM, Happel, KI, and Bagby, GJ. 2004. Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment. Am. J. Physiol. Lung Cell Mol. Physiol. 286(3): 465-472. Pubmed Mizgerd, JP. 2004. APC: Braking neutrophils to benefit patients? Blood 104:3841. pdf Mizgerd, JP, MM Lupa, MR Spieker. 2004. NF-?B p50 facilitates neutrophil accumulation during LPS-induced pulmonary inflammation. BMC Immunol. 5:10. pdf Mizgerd, JP, MM Lupa, J Hjoberg, JC Vallone, HB Warren, JP Butler, ES Silverman. 2004. Roles for early response cytokines during E. coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am. J. Physiol. 286:L1302-L1310. Full text Wang, Q, CM Doerschuk, JP Mizgerd. 2004. Neutrophils in innate immunity. Semin. Respir. Crit. Care Med. 25:33-42. PubMed Mizgerd, JP. 2003. Competing benefits of tumor necrosis factor- for bacteria and for host defense. Am. J. Respir. Crit. Care Med. 168:1410-1411. pdf Mizgerd, JP, MM Lupa, MS Kogan, HB Warren, L Kobzik, GP Topulos. 2003. Nuclear factor-?B p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia. Am. J. Respir. Crit. Care Med. 168:810-817. pdf Boé, DM, Nelson, S, Zhang, P, Quinton LJ, Bagby, GJ. 2003. Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae. Alcohol: Clin. and Exp. Res. 27: 1838-1845. Pubmed Happel KI, Zheng MQ, Young E, Quinton LJ, Lockhart E, Ramsay AJ, Shellito JE, Schurr JR, Bagby GJ, Nelson S, Kolls JK. 2003. Cutting Edge: Roles of toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J. Immunol.170: 4432-4436. Pubmed Zhang, P, Quinton, LJ, Bagby, GJ, Summer, WR, Nelson, S. 2003. Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge. J. Infect. Dis. 187: 62-69. Pubmed Mizgerd, JP, MR Spieker, MM Lupa. 2002. Exon truncation by alternative splicing of murine ICAM-1. Physiol. Genomics 12:47-51. Full text Mizgerd, JP, ML Scott, MR Spieker, CM Doerschuk. 2002. I?B-beta independent regulation of acute inflammatory responses to E. coli lipopolysaccharide in mouse lungs. Am. J. Respir. Cell Mol. Biol. 27:575-582. pdf Tasaka, S, SE Richer, JP Mizgerd, CM Doerschuk. 2002. Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice. Am. J. Respir. Crit. Care Med. 166:53-60. pdf Mizgerd, J.P. 2002. Molecular mechanisms of neutrophil recruitment elicited by bacteria in the lungs. Semin. Immunol. 14:123-132. pdf Quinton, LJ, Nelson, S, Boé, DM, Zhang, P, Zhong, Q, Kolls, JK, Bagby, GJ. 2002. The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challenges. J. Infect. Dis. 185: 1476-1482. Pubmed Alcamo, E, JP Mizgerd, BH Horwitz, R Bronson, AA Beg, M Scott, CM Doerschuk, RO Hynes, D Baltimore. 2001. Targeted mutation of tumor necrosis factor receptor 1 rescues the RelA-deficient mouse and reveals a critical role for NF-?B in leukocyte recruitment. J. Immunol. 167:1592-1600. pdf Huang, C, GT De Sanctis, PJ O’Brien, JP Mizgerd, DS Friend, JM Drazen, LF Brass, RL Stevens. 2001. Human mast cell tryptase I: Evaluation of its substrate specificity and demonstration of its importance in bacterial infections of the lung. J. Biol. Chem. 276:26276-26284. pdf Mizgerd, JP, MR Spieker, CM Doerschuk. 2001. Early response cytokines and innate immunity: essential roles for TNFR1 and IL1R1 during Escherichia coli pneumonia in mice. J. Immunol. 166: 4042-4048. pdf Horwitz, BH, JP Mizgerd, ML Scott, CM Doerschuk. 2001. Mechanisms of granulocytosis in the absence of CD18. Blood 97: 1578-1583. pdf Mizgerd, JP, JJ Peschon, CM Doerschuk. 2000. Roles of tumor necrosis factor receptor signaling during murine E. coli pneumonia. Am. J. Respir. Cell Mol. Biol. 22: 85-91. pdf Mizgerd, JP, BH Horwitz, HC Quillen, ML Scott, CM Doerschuk. 1999. Effects of CD18-deficiency on the emigration of murine neutrophils during pneumonia. J. Immunol. 163: 995-999. pdf Mizgerd, JP, DC Bullard, MJ Hicks, AL Beaudet, CM Doerschuk. 1999. Chronic Inflammatory Disease Alters Adhesion Molecule Requirements for Acute Neutrophil Emigration in Mouse Skin 1. J. Immunol. 162: 5444-5448. pdf Palombo, JD, SJ DeMichele, PJ Boyce, EE Lydon, J Liu, Y Huang, RA Forse, JP Mizgerd, BR Bistrian. 1999. Short-term enteral feeding with diets containing eicosapentaenoic and ?-linolenic acids modulates alveolar macrophage fatty acid composition and eicosanoid synthesis without compromising bactericidal functions in rats. Crit. Care Med. 27:1908-1915. PubMed Doerschuk, CM, JP Mizgerd, H Kubo, L Qin, T Kumasaka. 1999. Adhesion molecules and cellular biomechanical changes in acute lung injury. Chest 116: 37S-43S. Full text Mizgerd, JP, WM Quinlan, BW LeBlanc, GJ Kutkoski, DC Bullard, AL Beaudet, CM Doerschuk. 1998. Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice. J. Leukoc. Biol. 64: 291-297. pdf Mizgerd, JP, H Kubo, GJ Kutkoski, SD Bhagwan, K Scharffetter-Kochanek, AL Beaudet, CM Doerschuk. 1997. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J. Exp. Med. 186: 1357-1364. pdf Mizgerd, JP, BB Meek, GJ Kutkoski, DC Bullard, AL Beaudet, CM Doerschuk. 1996. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J. Exp. Med. 184: 639-645. pdf Mizgerd, JP, RM Molina, RC Stearns, JD Brain, AE Warner. 1996. Gadolinium induces macrophage apoptosis. J. Leukoc. Biol. 59: 189-195. pdf Mizgerd, JP, L Kobzik, AE Warner, JD Brain. 1995. Effects of sodium concentration on human neutrophil bactericidal functions. Am. J. Physiol. 269: L388-L393. PubMed Mizgerd, JP, JD Brain. 1995. Reactive oxygen species in the killing of Pseudomonas aeruginosa by human leukocytes. Curr. Microbiol. 31:124-128. PubMed |
 Shown are human neutrophils ingesting and killing P. aeruginosa bacteria. |
