“Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine (BUSM) and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made. These findings are published as a Letter in Nature.”
More information here.
Congratulations to Drs. Jing Wang and Esther Bullitt on their new publication in collaboration with Drs. J. Ptacek and K. Kirkegaard,
Double-Membraned Liposomes Sculpted by Poliovirus 3AB Protein
now in press at the Journal of Biological Chemistry.
Congratulations to Mengxiao Lu, a PhD student in the Gursky lab, who is a corresponding author on an invited review “Aggregation and fusion of low-density lipoproteins in vivo and in vitro” accepted for publication in BMC.
The BUSM has just been awarded a Shared Instrument Grant from the NIH to upgrade our Core Facility for Structural NMR. The proposal ”A Console Upgrade and Cryogenic Probe for a 500 MHz NMR System for Biomedical Research” will provide state-of-the art electronics and a superconducting probe that will increase the sensitivity of the instrument approximately ten-fold. This will provide superior spectra with less instrument time and allow research on samples not possible with the current instrument.
The PI of the proposal is C. James McKnight and the Major Users are Assen Marintchev, James Hamilton, Christopher Akey and David Atkinson from the Department of Physiology and Biophysics. The Major Users outside of Physiology and Biophysics are Susan Fisher (Microbiology), David Harris (Biochemistry), Erdjan Salih (Oral Biology) and Stephen Blacklow (Dana Farber Cancer Institute, Harvard Medical School). The upgraded Facility will be managed by Jonathan Vural.
Here is a link to the Core Facility for Structural NMR:
Congratulations to Dr. Olga Gursky for receiving a new RO1 grant to study “Structural stability and functional remodeling of high-density lipoproteins”.
Surface For Catalysis by Poliovirus RNA-dependent RNA Polymerase
by Jing Wang, John M Lyle, and Esther Bullitt
Jing received her PhD in the Bullitt lab in May 2012. Congratulations!
Dr. Chelsea Epler will be working in the Bullitt lab investigating type III secretion and virus replication.
Dr. Alan Huang is a biochemist and molecular biologist who has gained biophysical expertise during the last ten years in the Wang lab.
Dr. Shigeru Komaba, also in the Coluccio laboratory, is studying the role of myosin I in the association of transporters with the actin cytoskeleton at the cell membrane.
Dr. Hiroshi Tokuo will be working with Dr. Coluccio investigating the role of myosin I in cell-cell contact; and myosin X in the formation of filopodia.
Dr. Lynne Coluccio joins us from Boston Biomedical Research Institute to continue her work on the role of class I myosins in the inner ear.
Dr. Albert Wang joins us from Boston Biomedical Research Institute to continue his work on regulation of the actin cytoskeleton in smooth muscle and non-muscle cells.
2012 Commencement ceremony. From left to right Dr. Esther Bullitt, Dr. Jeffrey W.
Brown, MD, PhD, Dr. David Atkinson, Dr. Jing Wang, Dr. Xiaohu Mei, Dr.
Eileen Krenzel-Rojas, Miss Delia Krenzel-Rojas, Dr. James Hamilton, and
Dr. Jamie McKnight (not shown; Dr. Laura Packer, Dr. Ning Hua, and Dr. Matthew Mitsche).
The achievements of Professor Donald M. Small were celebrated at the annual Department Retreat, with a symposium held on October 1, 2011 at the Commonwealth Museum. A few photos of the event are shown below. For more photos, go here.